Incidental Mutation 'IGL02650:Nanos2'
ID302100
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Nanos2
Ensembl Gene ENSMUSG00000051965
Gene Namenanos C2HC-type zinc finger 2
Synonymsnos2
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02650
Quality Score
Status
Chromosome7
Chromosomal Location18987400-18988962 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 18987869 bp
ZygosityHeterozygous
Amino Acid Change Proline to Serine at position 89 (P89S)
Ref Sequence ENSEMBL: ENSMUSP00000069765 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059331] [ENSMUST00000063563] [ENSMUST00000131087]
Predicted Effect probably benign
Transcript: ENSMUST00000059331
SMART Domains Protein: ENSMUSP00000058718
Gene: ENSMUSG00000048481

DomainStartEndE-ValueType
low complexity region 2 17 N/A INTRINSIC
SANT 20 90 4.06e-5 SMART
low complexity region 125 157 N/A INTRINSIC
low complexity region 212 250 N/A INTRINSIC
low complexity region 278 322 N/A INTRINSIC
low complexity region 323 347 N/A INTRINSIC
low complexity region 358 374 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000063563
AA Change: P89S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000069765
Gene: ENSMUSG00000051965
AA Change: P89S

DomainStartEndE-ValueType
Pfam:zf-nanos 61 114 1.9e-29 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000098778
SMART Domains Protein: ENSMUSP00000096375
Gene: ENSMUSG00000074355

DomainStartEndE-ValueType
signal peptide 1 32 N/A INTRINSIC
low complexity region 84 107 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130268
SMART Domains Protein: ENSMUSP00000120697
Gene: ENSMUSG00000048481

DomainStartEndE-ValueType
low complexity region 2 17 N/A INTRINSIC
SANT 20 90 4.06e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000131087
SMART Domains Protein: ENSMUSP00000117357
Gene: ENSMUSG00000048481

DomainStartEndE-ValueType
low complexity region 2 17 N/A INTRINSIC
SANT 20 90 4.06e-5 SMART
low complexity region 125 157 N/A INTRINSIC
low complexity region 212 250 N/A INTRINSIC
low complexity region 278 322 N/A INTRINSIC
low complexity region 323 347 N/A INTRINSIC
low complexity region 358 374 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205810
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Whereas homozygous mutant female mice are fertile and show no morphological or functional abnormalities of the ovaries, the testes of homozygous mutant male mice are reduced in weight and devoid of germ cells. The spermatogenic defects appear to be associated with increased apoptosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932414N04Rik A G 2: 68,741,537 T586A probably benign Het
Acads G T 5: 115,112,815 T141N probably benign Het
Ankmy1 C T 1: 92,881,023 R721H probably damaging Het
Appl1 A G 14: 26,950,708 V236A possibly damaging Het
Arhgef5 C T 6: 43,272,935 Q207* probably null Het
Atp2a3 C A 11: 72,975,339 H262N probably benign Het
Atp6v0a2 G T 5: 124,712,362 probably benign Het
Cenpf T C 1: 189,652,473 K2537E possibly damaging Het
Cox7a1 A T 7: 30,185,137 E32V possibly damaging Het
Dis3 A T 14: 99,098,785 M95K probably benign Het
Dnah5 A T 15: 28,289,047 probably benign Het
Dock10 T A 1: 80,574,123 Y665F probably damaging Het
Ghsr A T 3: 27,374,855 Q343L probably benign Het
Gm3252 T A 14: 4,746,353 V215E probably damaging Het
Gm9979 A G 13: 40,705,749 noncoding transcript Het
Grik2 A T 10: 49,101,235 M867K probably benign Het
Grm7 A G 6: 111,358,958 T777A probably damaging Het
Hc T A 2: 35,000,874 Q1310L possibly damaging Het
Ifi44 A G 3: 151,745,855 F205L probably damaging Het
Igkv4-86 T C 6: 68,910,633 I40V probably benign Het
Jag1 T C 2: 137,115,585 D69G possibly damaging Het
Lrch1 T C 14: 74,813,698 D333G probably damaging Het
Mapre3 T A 5: 30,864,709 I187N probably damaging Het
Myo15b T C 11: 115,886,511 probably null Het
Olfr1214 T A 2: 88,988,080 M41L probably benign Het
Parp16 G A 9: 65,233,816 V223I probably damaging Het
Rnf123 A G 9: 108,069,748 M231T probably benign Het
Suco C A 1: 161,848,753 probably benign Het
Synj1 G T 16: 90,976,696 T459N probably benign Het
Taf4b C T 18: 14,841,983 Q732* probably null Het
Tas2r102 A G 6: 132,762,210 N27S probably null Het
Tctex1d1 C A 4: 102,988,606 Q12K probably benign Het
Tll1 C T 8: 64,046,997 probably benign Het
Vmn1r168 A G 7: 23,541,491 I258V probably benign Het
Vmn2r71 T A 7: 85,624,327 M783K probably damaging Het
Vmn2r98 G A 17: 19,080,961 V742I probably benign Het
Other mutations in Nanos2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1443:Nanos2 UTSW 7 18987639 missense probably damaging 1.00
R1971:Nanos2 UTSW 7 18987704 missense probably benign 0.04
Posted On2015-04-16