Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02650:Ifi44'

302119

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ifi44

Ensembl Gene

ENSMUSG00000028037

Gene Name

interferon-induced protein 44

Synonyms

A430056A10Rik, p44, MTAP44

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02650

Quality Score

Status

Chromosome

Chromosomal Location

151730922-151749960 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 151745855 bp

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 205 (F205L)

Ref Sequence

ENSEMBL: ENSMUSP00000029671 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000029671]

Predicted Effect

probably damaging
Transcript: ENSMUST00000029671
AA Change: F205L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000029671
Gene: ENSMUSG00000028037
AA Change: F205L

Domain	Start	End	E-Value	Type
Pfam:TLD	26	147	2.8e-7	PFAM
low complexity region	193	208	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000127733

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000133888

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000149919

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932414N04Rik	A	G	2: 68,741,537	T586A	probably benign	Het
Acads	G	T	5: 115,112,815	T141N	probably benign	Het
Ankmy1	C	T	1: 92,881,023	R721H	probably damaging	Het
Appl1	A	G	14: 26,950,708	V236A	possibly damaging	Het
Arhgef5	C	T	6: 43,272,935	Q207*	probably null	Het
Atp2a3	C	A	11: 72,975,339	H262N	probably benign	Het
Atp6v0a2	G	T	5: 124,712,362		probably benign	Het
Cenpf	T	C	1: 189,652,473	K2537E	possibly damaging	Het
Cox7a1	A	T	7: 30,185,137	E32V	possibly damaging	Het
Dis3	A	T	14: 99,098,785	M95K	probably benign	Het
Dnah5	A	T	15: 28,289,047		probably benign	Het
Dock10	T	A	1: 80,574,123	Y665F	probably damaging	Het
Ghsr	A	T	3: 27,374,855	Q343L	probably benign	Het
Gm3252	T	A	14: 4,746,353	V215E	probably damaging	Het
Gm9979	A	G	13: 40,705,749		noncoding transcript	Het
Grik2	A	T	10: 49,101,235	M867K	probably benign	Het
Grm7	A	G	6: 111,358,958	T777A	probably damaging	Het
Hc	T	A	2: 35,000,874	Q1310L	possibly damaging	Het
Igkv4-86	T	C	6: 68,910,633	I40V	probably benign	Het
Jag1	T	C	2: 137,115,585	D69G	possibly damaging	Het
Lrch1	T	C	14: 74,813,698	D333G	probably damaging	Het
Mapre3	T	A	5: 30,864,709	I187N	probably damaging	Het
Myo15b	T	C	11: 115,886,511		probably null	Het
Nanos2	C	T	7: 18,987,869	P89S	probably damaging	Het
Olfr1214	T	A	2: 88,988,080	M41L	probably benign	Het
Parp16	G	A	9: 65,233,816	V223I	probably damaging	Het
Rnf123	A	G	9: 108,069,748	M231T	probably benign	Het
Suco	C	A	1: 161,848,753		probably benign	Het
Synj1	G	T	16: 90,976,696	T459N	probably benign	Het
Taf4b	C	T	18: 14,841,983	Q732*	probably null	Het
Tas2r102	A	G	6: 132,762,210	N27S	probably null	Het
Tctex1d1	C	A	4: 102,988,606	Q12K	probably benign	Het
Tll1	C	T	8: 64,046,997		probably benign	Het
Vmn1r168	A	G	7: 23,541,491	I258V	probably benign	Het
Vmn2r71	T	A	7: 85,624,327	M783K	probably damaging	Het
Vmn2r98	G	A	17: 19,080,961	V742I	probably benign	Het

Other mutations in Ifi44

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00858:Ifi44	APN	3	151749580	missense	probably benign	0.03
IGL01477:Ifi44	APN	3	151745998	splice site	probably benign
IGL01571:Ifi44	APN	3	151745537	missense	probably damaging	0.97
IGL02165:Ifi44	APN	3	151749430	missense	probably damaging	1.00
IGL02238:Ifi44	APN	3	151732382	makesense	probably null
IGL02609:Ifi44	APN	3	151732497	missense	probably damaging	1.00
IGL02726:Ifi44	APN	3	151749596	start gained	probably benign
IGL02977:Ifi44	APN	3	151739379	missense	probably benign	0.00
R0201:Ifi44	UTSW	3	151745636	missense	probably damaging	1.00
R0454:Ifi44	UTSW	3	151745497	missense	possibly damaging	0.78
R0763:Ifi44	UTSW	3	151749498	missense	probably damaging	1.00
R1640:Ifi44	UTSW	3	151732534	missense	probably benign	0.00
R1747:Ifi44	UTSW	3	151749285	missense	probably benign	0.00
R2278:Ifi44	UTSW	3	151732388	missense	probably benign
R3816:Ifi44	UTSW	3	151749257	missense	possibly damaging	0.92
R4075:Ifi44	UTSW	3	151745976	missense	probably benign	0.00
R4084:Ifi44	UTSW	3	151745489	critical splice donor site	probably null
R4782:Ifi44	UTSW	3	151745592	missense	probably damaging	0.99
R5071:Ifi44	UTSW	3	151749632	start gained	probably benign
R5074:Ifi44	UTSW	3	151749632	start gained	probably benign
R6030:Ifi44	UTSW	3	151749558	missense	probably benign	0.00
R6030:Ifi44	UTSW	3	151749558	missense	probably benign	0.00
R6128:Ifi44	UTSW	3	151749186	missense	probably benign	0.00
R6192:Ifi44	UTSW	3	151745639	critical splice acceptor site	probably null
R6434:Ifi44	UTSW	3	151749189	missense	probably benign	0.02
R6536:Ifi44	UTSW	3	151732489	missense	probably benign	0.03
R6902:Ifi44	UTSW	3	151745899	missense	possibly damaging	0.92
R6946:Ifi44	UTSW	3	151745899	missense	possibly damaging	0.92
R7346:Ifi44	UTSW	3	151732457	missense	probably benign
R7608:Ifi44	UTSW	3	151732408	missense	probably damaging	0.97
R7704:Ifi44	UTSW	3	151732424	missense	probably benign	0.44
Z1176:Ifi44	UTSW	3	151732453	missense	probably damaging	1.00
Z1177:Ifi44	UTSW	3	151749438	missense	probably damaging	1.00

Posted On

2015-04-16