Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02650:Dynlt5'

302120

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dynlt5

Ensembl Gene

ENSMUSG00000028523

Gene Name

dynein light chain Tctex-type 5

Synonyms

1700055O19Rik, Tctex1d1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.109) question?

Stock #

IGL02650

Quality Score

Status

Chromosome

Chromosomal Location

102835900-102862419 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 102845803 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Lysine at position 12 (Q12K)

Ref Sequence

ENSEMBL: ENSMUSP00000128228 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030248] [ENSMUST00000116317] [ENSMUST00000125417] [ENSMUST00000140654] [ENSMUST00000169211] [ENSMUST00000223169] [ENSMUST00000220547]

AlphaFold

Q9D5I4

Predicted Effect

probably benign
Transcript: ENSMUST00000030248
AA Change: Q12K

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000030248
Gene: ENSMUSG00000028523
AA Change: Q12K

Domain	Start	End	E-Value	Type
Pfam:Tctex-1	74	171	9.8e-28	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000116317
AA Change: Q12K

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000112019
Gene: ENSMUSG00000028523
AA Change: Q12K

Domain	Start	End	E-Value	Type
Pfam:Tctex-1	72	172	7.7e-29	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000125417

SMART Domains

Protein: ENSMUSP00000117319
Gene: ENSMUSG00000028523

Domain	Start	End	E-Value	Type
Pfam:Tctex-1	17	114	4.5e-28	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000139883

Predicted Effect

probably benign
Transcript: ENSMUST00000140654

SMART Domains

Protein: ENSMUSP00000116692
Gene: ENSMUSG00000028523

Domain	Start	End	E-Value	Type
Pfam:Tctex-1	15	99	4.6e-24	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000149348

Predicted Effect

probably benign
Transcript: ENSMUST00000169211
AA Change: Q12K

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000128228
Gene: ENSMUSG00000028523
AA Change: Q12K

Domain	Start	End	E-Value	Type
Pfam:Tctex-1	15	115	3.3e-29	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000223169

Predicted Effect

probably benign
Transcript: ENSMUST00000220547

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932414N04Rik	A	G	2: 68,571,881 (GRCm39)	T586A	probably benign	Het
Acads	G	T	5: 115,250,874 (GRCm39)	T141N	probably benign	Het
Ankmy1	C	T	1: 92,808,745 (GRCm39)	R721H	probably damaging	Het
Appl1	A	G	14: 26,672,665 (GRCm39)	V236A	possibly damaging	Het
Arhgef5	C	T	6: 43,249,869 (GRCm39)	Q207*	probably null	Het
Atp2a3	C	A	11: 72,866,165 (GRCm39)	H262N	probably benign	Het
Atp6v0a2	G	T	5: 124,789,426 (GRCm39)		probably benign	Het
Cenpf	T	C	1: 189,384,670 (GRCm39)	K2537E	possibly damaging	Het
Cox7a1	A	T	7: 29,884,562 (GRCm39)	E32V	possibly damaging	Het
Dis3	A	T	14: 99,336,221 (GRCm39)	M95K	probably benign	Het
Dnah5	A	T	15: 28,289,193 (GRCm39)		probably benign	Het
Dock10	T	A	1: 80,551,840 (GRCm39)	Y665F	probably damaging	Het
Ghsr	A	T	3: 27,429,004 (GRCm39)	Q343L	probably benign	Het
Gm3252	T	A	14: 4,746,353 (GRCm38)	V215E	probably damaging	Het
Gm9979	A	G	13: 40,859,225 (GRCm39)		noncoding transcript	Het
Grik2	A	T	10: 48,977,331 (GRCm39)	M867K	probably benign	Het
Grm7	A	G	6: 111,335,919 (GRCm39)	T777A	probably damaging	Het
Hc	T	A	2: 34,890,886 (GRCm39)	Q1310L	possibly damaging	Het
Ifi44	A	G	3: 151,451,492 (GRCm39)	F205L	probably damaging	Het
Igkv4-86	T	C	6: 68,887,617 (GRCm39)	I40V	probably benign	Het
Jag1	T	C	2: 136,957,505 (GRCm39)	D69G	possibly damaging	Het
Lrch1	T	C	14: 75,051,138 (GRCm39)	D333G	probably damaging	Het
Mapre3	T	A	5: 31,022,053 (GRCm39)	I187N	probably damaging	Het
Myo15b	T	C	11: 115,777,337 (GRCm39)		probably null	Het
Nanos2	C	T	7: 18,721,794 (GRCm39)	P89S	probably damaging	Het
Or4c109	T	A	2: 88,818,424 (GRCm39)	M41L	probably benign	Het
Parp16	G	A	9: 65,141,098 (GRCm39)	V223I	probably damaging	Het
Rnf123	A	G	9: 107,946,947 (GRCm39)	M231T	probably benign	Het
Suco	C	A	1: 161,676,322 (GRCm39)		probably benign	Het
Synj1	G	T	16: 90,773,584 (GRCm39)	T459N	probably benign	Het
Taf4b	C	T	18: 14,975,040 (GRCm39)	Q732*	probably null	Het
Tas2r102	A	G	6: 132,739,173 (GRCm39)	N27S	probably null	Het
Tll1	C	T	8: 64,500,031 (GRCm39)		probably benign	Het
Vmn1r168	A	G	7: 23,240,916 (GRCm39)	I258V	probably benign	Het
Vmn2r71	T	A	7: 85,273,535 (GRCm39)	M783K	probably damaging	Het
Vmn2r98	G	A	17: 19,301,223 (GRCm39)	V742I	probably benign	Het

Other mutations in Dynlt5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02813:Dynlt5	APN	4	102,849,769 (GRCm39)	missense	probably damaging	1.00
IGL03022:Dynlt5	APN	4	102,859,714 (GRCm39)	missense	probably benign	0.00
R0127:Dynlt5	UTSW	4	102,859,649 (GRCm39)	splice site	probably benign
R0685:Dynlt5	UTSW	4	102,859,735 (GRCm39)	missense	probably damaging	1.00
R4695:Dynlt5	UTSW	4	102,861,426 (GRCm39)	missense	probably damaging	0.98
R5274:Dynlt5	UTSW	4	102,859,768 (GRCm39)	missense	possibly damaging	0.85
R5433:Dynlt5	UTSW	4	102,859,700 (GRCm39)	missense	possibly damaging	0.75
R5950:Dynlt5	UTSW	4	102,861,447 (GRCm39)	missense	probably damaging	1.00
R6196:Dynlt5	UTSW	4	102,849,766 (GRCm39)	missense	possibly damaging	0.89
R6245:Dynlt5	UTSW	4	102,845,864 (GRCm39)	missense	probably benign	0.02
R9270:Dynlt5	UTSW	4	102,845,955 (GRCm39)	splice site	probably null

Posted On

2015-04-16