Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02651:Tmem210'

302169

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem210

Ensembl Gene

ENSMUSG00000026963

Gene Name

transmembrane protein 210

Synonyms

4930571C24Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.102) question?

Stock #

IGL02651

Quality Score

Status

Chromosome

Chromosomal Location

25178157-25179201 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 25179101 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 130 (T130A)

Ref Sequence

ENSEMBL: ENSMUSP00000028340 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000028335] [ENSMUST00000028337] [ENSMUST00000028340] [ENSMUST00000028341] [ENSMUST00000114307] [ENSMUST00000114308] [ENSMUST00000114310] [ENSMUST00000114318] [ENSMUST00000114312] [ENSMUST00000114314] [ENSMUST00000114317]

AlphaFold

Q9D2F0

Predicted Effect

probably benign
Transcript: ENSMUST00000028335

SMART Domains

Protein: ENSMUSP00000028335
Gene: ENSMUSG00000026959

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:ANF_receptor	38	357	6.6e-35	PFAM
PBPe	433	795	2.71e-97	SMART
Lig_chan-Glu_bd	439	507	2.99e-18	SMART
Pfam:CaM_bdg_C0	835	863	1.5e-18	PFAM
PDB:3BYA\|B	875	898	4e-6	PDB

Predicted Effect

probably benign
Transcript: ENSMUST00000028337

SMART Domains

Protein: ENSMUSP00000028337
Gene: ENSMUSG00000026961

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
LRRNT	42	75	1.86e0	SMART
LRR	72	93	7.57e0	SMART
LRR	95	117	6.96e0	SMART
LRR_TYP	118	141	1e-5	SMART
LRR	142	165	6.22e0	SMART
LRR	166	189	2.86e-1	SMART
LRRCT	201	254	3.01e-5	SMART
transmembrane domain	267	289	N/A	INTRINSIC
low complexity region	293	308	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000028340
AA Change: T130A

PolyPhen 2 Score 0.707 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000028340
Gene: ENSMUSG00000026963
AA Change: T130A

Domain	Start	End	E-Value	Type
signal peptide	1	30	N/A	INTRINSIC
Pfam:TMEM210	32	144	1.1e-65	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000028341

SMART Domains

Protein: ENSMUSP00000028341
Gene: ENSMUSG00000026965

Domain	Start	End	E-Value	Type
low complexity region	6	19	N/A	INTRINSIC
low complexity region	123	133	N/A	INTRINSIC
low complexity region	153	164	N/A	INTRINSIC
low complexity region	221	229	N/A	INTRINSIC
low complexity region	456	467	N/A	INTRINSIC
CULLIN	515	663	6.72e-9	SMART
APC2	772	832	3.67e-27	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000114307

SMART Domains

Protein: ENSMUSP00000109946
Gene: ENSMUSG00000026959

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:ANF_receptor	38	357	1e-34	PFAM
PBPe	433	795	2.71e-97	SMART
Lig_chan-Glu_bd	439	507	2.99e-18	SMART
Pfam:CaM_bdg_C0	835	863	3.2e-19	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000114308

SMART Domains

Protein: ENSMUSP00000109947
Gene: ENSMUSG00000026959

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:ANF_receptor	38	378	8e-31	PFAM
PBPe	454	816	2.71e-97	SMART
Lig_chan-Glu_bd	460	528	2.99e-18	SMART
Pfam:CaM_bdg_C0	856	884	3.3e-19	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000114310

SMART Domains

Protein: ENSMUSP00000109949
Gene: ENSMUSG00000026959

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:ANF_receptor	39	299	3.6e-24	PFAM
Blast:PBPe	352	420	9e-37	BLAST
PBPe	454	816	2.71e-97	SMART
Lig_chan-Glu_bd	460	528	2.99e-18	SMART
Pfam:CaM_bdg_C0	856	884	8.4e-17	PFAM
PDB:3BYA\|B	896	919	4e-6	PDB

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129723

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000135426

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000144102

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000127171

Predicted Effect

probably benign
Transcript: ENSMUST00000114318

SMART Domains

Protein: ENSMUSP00000109957
Gene: ENSMUSG00000026959

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:ANF_receptor	38	378	8.4e-31	PFAM
PBPe	454	816	2.71e-97	SMART
Lig_chan-Glu_bd	460	528	2.99e-18	SMART
Pfam:CaM_bdg_C0	856	884	3.4e-19	PFAM
PDB:3BYA\|B	896	919	4e-6	PDB

Predicted Effect

probably benign
Transcript: ENSMUST00000114312

SMART Domains

Protein: ENSMUSP00000109951
Gene: ENSMUSG00000026959

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:ANF_receptor	38	357	5.9e-35	PFAM
PBPe	433	795	2.71e-97	SMART
Lig_chan-Glu_bd	439	507	2.99e-18	SMART
Pfam:CaM_bdg_C0	835	863	1.4e-18	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000114314

SMART Domains

Protein: ENSMUSP00000109953
Gene: ENSMUSG00000026959

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:ANF_receptor	38	357	1.1e-34	PFAM
PBPe	433	795	2.71e-97	SMART
Lig_chan-Glu_bd	439	507	2.99e-18	SMART
Pfam:CaM_bdg_C0	835	863	3.3e-19	PFAM
PDB:3BYA\|B	875	898	4e-6	PDB

Predicted Effect

probably benign
Transcript: ENSMUST00000114317

SMART Domains

Protein: ENSMUSP00000109956
Gene: ENSMUSG00000026959

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:ANF_receptor	38	378	7.7e-31	PFAM
PBPe	454	816	2.71e-97	SMART
Lig_chan-Glu_bd	460	528	2.99e-18	SMART
Pfam:CaM_bdg_C0	856	884	3.3e-19	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A1cf	G	A	19: 31,909,906 (GRCm39)	G233S	probably benign	Het
Abcc1	T	A	16: 14,283,990 (GRCm39)	C1202S	probably benign	Het
Acaca	C	T	11: 84,136,030 (GRCm39)		probably benign	Het
Ap3b1	T	A	13: 94,613,529 (GRCm39)	F676Y	probably damaging	Het
Arhgef11	C	A	3: 87,606,171 (GRCm39)	Q309K	probably damaging	Het
Asgr1	T	C	11: 69,947,956 (GRCm39)	Y80H	possibly damaging	Het
Atp13a5	A	T	16: 29,152,909 (GRCm39)		probably benign	Het
Atp2a3	C	A	11: 72,866,165 (GRCm39)	H262N	probably benign	Het
Atp8b2	A	C	3: 89,861,896 (GRCm39)		probably null	Het
Btnl2	A	G	17: 34,575,196 (GRCm39)	M1V	probably null	Het
Cpsf3	T	A	12: 21,343,298 (GRCm39)	M121K	probably damaging	Het
Creb3l3	A	G	10: 80,920,668 (GRCm39)	I454T	probably benign	Het
Cyp2d12	A	G	15: 82,440,941 (GRCm39)	E153G	probably damaging	Het
Dnah5	A	G	15: 28,350,768 (GRCm39)	I2597V	probably benign	Het
Ercc5	C	A	1: 44,196,104 (GRCm39)	S32R	probably damaging	Het
Fchsd2	T	A	7: 100,926,807 (GRCm39)	N656K	possibly damaging	Het
Fga	G	A	3: 82,935,841 (GRCm39)	E23K	probably benign	Het
Fn1	T	C	1: 71,636,835 (GRCm39)	T1925A	possibly damaging	Het
Fstl5	A	T	3: 76,500,841 (GRCm39)	E423D	probably damaging	Het
Glg1	C	T	8: 111,887,359 (GRCm39)	M465I	possibly damaging	Het
H2-M10.4	C	A	17: 36,771,548 (GRCm39)	R210L	probably benign	Het
Hbb-y	T	G	7: 103,501,957 (GRCm39)	K105Q	probably benign	Het
Hspg2	A	T	4: 137,284,756 (GRCm39)		probably benign	Het
Ipo11	T	C	13: 107,012,114 (GRCm39)	Y556C	probably damaging	Het
Itpr3	A	G	17: 27,325,372 (GRCm39)	M1322V	probably damaging	Het
Jhy	A	G	9: 40,828,631 (GRCm39)	L425P	probably damaging	Het
Krt26	C	T	11: 99,224,471 (GRCm39)	R349Q	probably benign	Het
Ms4a6c	A	T	19: 11,455,669 (GRCm39)	E159D	possibly damaging	Het
Msh6	A	T	17: 88,296,943 (GRCm39)	L1213F	probably damaging	Het
Npy1r	A	C	8: 67,157,675 (GRCm39)	R328S	possibly damaging	Het
Or4a74	A	T	2: 89,439,842 (GRCm39)	N201K	possibly damaging	Het
Or5ak20	A	C	2: 85,183,394 (GRCm39)	L292R	probably damaging	Het
Pcdhb18	T	G	18: 37,624,234 (GRCm39)	Y521*	probably null	Het
Pkhd1l1	A	T	15: 44,347,210 (GRCm39)	Y192F	probably damaging	Het
Rdh12	T	A	12: 79,268,826 (GRCm39)	I301N	probably damaging	Het
Rptor	T	C	11: 119,783,438 (GRCm39)	V1144A	possibly damaging	Het
Sap25	T	C	5: 137,640,632 (GRCm39)	F171L	possibly damaging	Het
Senp5	A	G	16: 31,808,897 (GRCm39)	L92P	probably benign	Het
Sfmbt1	T	C	14: 30,537,494 (GRCm39)	S736P	probably damaging	Het
Tacr1	T	C	6: 82,469,622 (GRCm39)	S169P	probably damaging	Het
Tbc1d21	A	T	9: 58,270,384 (GRCm39)	Y130*	probably null	Het
Tle2	G	A	10: 81,422,723 (GRCm39)	G428D	probably damaging	Het
Tmem117	T	A	15: 94,992,442 (GRCm39)	N367K	probably damaging	Het
Ttn	T	G	2: 76,680,368 (GRCm39)		probably benign	Het
Ttyh1	T	C	7: 4,127,678 (GRCm39)	L122P	probably damaging	Het
Vmn2r60	T	C	7: 41,845,010 (GRCm39)	F791S	probably damaging	Het
Vps13d	A	T	4: 144,891,129 (GRCm39)	N575K	probably benign	Het
Vps8	T	C	16: 21,336,086 (GRCm39)	V746A	probably damaging	Het
Wdfy3	A	T	5: 102,044,341 (GRCm39)	M1888K	probably benign	Het
Zfp595	T	C	13: 67,469,017 (GRCm39)	D3G	probably benign	Het

Other mutations in Tmem210

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0135:Tmem210	UTSW	2	25,178,480 (GRCm39)	missense	probably damaging	0.99
R1758:Tmem210	UTSW	2	25,178,435 (GRCm39)	missense	probably damaging	0.96
R3837:Tmem210	UTSW	2	25,178,444 (GRCm39)	missense	possibly damaging	0.60
R3838:Tmem210	UTSW	2	25,178,444 (GRCm39)	missense	possibly damaging	0.60
R6170:Tmem210	UTSW	2	25,178,776 (GRCm39)	critical splice acceptor site	probably null
R6348:Tmem210	UTSW	2	25,178,796 (GRCm39)	missense	probably benign	0.27
R6349:Tmem210	UTSW	2	25,179,048 (GRCm39)	missense	possibly damaging	0.85

Posted On

2015-04-16