Incidental Mutation 'IGL02652:Olfr1298'
ID 302179
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1298
Ensembl Gene ENSMUSG00000109487
Gene Name olfactory receptor 1298
Synonyms GA_x6K02T2Q125-72697413-72696475, MOR248-6
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.135) question?
Stock # IGL02652
Quality Score
Status
Chromosome 2
Chromosomal Location 111644498-111649201 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 111645494 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 168 (F168L)
Ref Sequence ENSEMBL: ENSMUSP00000146343 (fasta)
AlphaFold Q8VGE6
Predicted Effect probably benign
Transcript: ENSMUST00000119566
AA Change: F168L

PolyPhen 2 Score 0.164 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect probably benign
Transcript: ENSMUST00000208284
AA Change: F168L

PolyPhen 2 Score 0.164 (Sensitivity: 0.92; Specificity: 0.87)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap28 A T 17: 67,884,800 D139E probably benign Het
Asph C T 4: 9,529,984 V347I probably benign Het
Ccdc138 A T 10: 58,513,079 D149V probably benign Het
Cep192 A G 18: 67,858,850 probably benign Het
Cnnm2 G A 19: 46,763,211 R480Q probably damaging Het
Col24a1 C A 3: 145,492,301 S1321* probably null Het
Cops6 T G 5: 138,161,438 probably null Het
Crim1 G A 17: 78,315,677 A435T probably damaging Het
Cttn G T 7: 144,441,731 Q382K probably benign Het
Dhx38 A G 8: 109,556,129 L635P probably damaging Het
Dmtf1 T A 5: 9,121,853 T458S probably benign Het
Dnah5 T C 15: 28,366,187 F2682S probably damaging Het
Dnah6 T A 6: 73,095,104 Q2413L probably damaging Het
Dock10 T C 1: 80,592,844 probably null Het
Engase C T 11: 118,478,950 P63S probably damaging Het
Grik4 A G 9: 42,675,277 V94A possibly damaging Het
Heatr6 T C 11: 83,769,732 V566A probably damaging Het
Hydin A C 8: 110,589,522 T4349P possibly damaging Het
Inpp4b G A 8: 81,770,800 probably benign Het
Mertk A G 2: 128,801,270 E863G probably benign Het
Muc19 T A 15: 91,877,815 noncoding transcript Het
Myo9a T A 9: 59,863,928 F928I probably damaging Het
Nyap2 T C 1: 81,241,720 Y486H probably damaging Het
Oas1e T C 5: 120,795,405 R32G probably damaging Het
Olfr113 A T 17: 37,574,945 Y159* probably null Het
Osbpl6 G A 2: 76,593,454 R848Q probably damaging Het
Piezo2 G A 18: 63,024,475 T2388I probably damaging Het
Prkdc A G 16: 15,783,087 T2871A probably benign Het
Ptpn12 T C 5: 21,002,437 K308E probably benign Het
Rgsl1 A G 1: 153,825,490 L441P probably damaging Het
Rictor T C 15: 6,776,187 probably null Het
Scn2a T A 2: 65,702,038 S665T possibly damaging Het
Scn8a A G 15: 101,013,476 I926V probably damaging Het
Snrpg T C 6: 86,376,528 I30T probably damaging Het
Spryd3 A T 15: 102,118,990 probably null Het
Svil A G 18: 5,114,531 D2036G probably damaging Het
Synj2 A T 17: 6,017,593 I551F probably damaging Het
Tiam2 A T 17: 3,439,696 probably benign Het
Tmem132b T C 5: 125,787,575 F915S probably damaging Het
Try5 C A 6: 41,311,408 V204L probably benign Het
Vmn2r6 T C 3: 64,556,328 T362A probably benign Het
Other mutations in Olfr1298
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01393:Olfr1298 APN 2 111645256 missense probably damaging 1.00
IGL01571:Olfr1298 APN 2 111645380 missense probably benign 0.00
IGL02605:Olfr1298 APN 2 111645505 missense probably benign 0.00
IGL02669:Olfr1298 APN 2 111645891 nonsense probably null
R0197:Olfr1298 UTSW 2 111645791 missense probably benign 0.00
R0701:Olfr1298 UTSW 2 111645791 missense probably benign 0.00
R0883:Olfr1298 UTSW 2 111645791 missense probably benign 0.00
R1563:Olfr1298 UTSW 2 111645682 missense probably damaging 1.00
R1567:Olfr1298 UTSW 2 111645926 missense possibly damaging 0.92
R1740:Olfr1298 UTSW 2 111645869 missense probably damaging 0.97
R2142:Olfr1298 UTSW 2 111645221 missense probably benign 0.04
R3949:Olfr1298 UTSW 2 111645526 missense possibly damaging 0.67
R4766:Olfr1298 UTSW 2 111645881 missense probably benign
R4924:Olfr1298 UTSW 2 111645776 missense possibly damaging 0.87
R7320:Olfr1298 UTSW 2 111645952 missense probably benign 0.03
R7695:Olfr1298 UTSW 2 111645625 missense probably damaging 1.00
R7961:Olfr1298 UTSW 2 111645937 missense probably damaging 0.97
R8549:Olfr1298 UTSW 2 111649167 start gained probably benign
R8958:Olfr1298 UTSW 2 111645725 missense possibly damaging 0.93
R9444:Olfr1298 UTSW 2 111645787 missense probably damaging 1.00
R9744:Olfr1298 UTSW 2 111645319 missense probably benign 0.00
Posted On 2015-04-16