Incidental Mutation 'IGL02652:Try5'
ID 302189
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Try5
Ensembl Gene ENSMUSG00000036938
Gene Name trypsin 5
Synonyms 1810049H19Rik, Tc
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.074) question?
Stock # IGL02652
Quality Score
Status
Chromosome 6
Chromosomal Location 41311233-41316841 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to A at 41311408 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Leucine at position 204 (V204L)
Ref Sequence ENSEMBL: ENSMUSP00000064498 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064324] [ENSMUST00000173916]
AlphaFold Q9QUK9
Predicted Effect probably benign
Transcript: ENSMUST00000064324
AA Change: V204L

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000064498
Gene: ENSMUSG00000036938
AA Change: V204L

DomainStartEndE-ValueType
low complexity region 4 16 N/A INTRINSIC
Tryp_SPc 23 239 1.47e-104 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000173916
AA Change: V96L

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000133640
Gene: ENSMUSG00000036938
AA Change: V96L

DomainStartEndE-ValueType
Tryp_SPc 1 131 1.21e-27 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000193013
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap28 A T 17: 67,884,800 D139E probably benign Het
Asph C T 4: 9,529,984 V347I probably benign Het
Ccdc138 A T 10: 58,513,079 D149V probably benign Het
Cep192 A G 18: 67,858,850 probably benign Het
Cnnm2 G A 19: 46,763,211 R480Q probably damaging Het
Col24a1 C A 3: 145,492,301 S1321* probably null Het
Cops6 T G 5: 138,161,438 probably null Het
Crim1 G A 17: 78,315,677 A435T probably damaging Het
Cttn G T 7: 144,441,731 Q382K probably benign Het
Dhx38 A G 8: 109,556,129 L635P probably damaging Het
Dmtf1 T A 5: 9,121,853 T458S probably benign Het
Dnah5 T C 15: 28,366,187 F2682S probably damaging Het
Dnah6 T A 6: 73,095,104 Q2413L probably damaging Het
Dock10 T C 1: 80,592,844 probably null Het
Engase C T 11: 118,478,950 P63S probably damaging Het
Grik4 A G 9: 42,675,277 V94A possibly damaging Het
Heatr6 T C 11: 83,769,732 V566A probably damaging Het
Hydin A C 8: 110,589,522 T4349P possibly damaging Het
Inpp4b G A 8: 81,770,800 probably benign Het
Mertk A G 2: 128,801,270 E863G probably benign Het
Muc19 T A 15: 91,877,815 noncoding transcript Het
Myo9a T A 9: 59,863,928 F928I probably damaging Het
Nyap2 T C 1: 81,241,720 Y486H probably damaging Het
Oas1e T C 5: 120,795,405 R32G probably damaging Het
Olfr113 A T 17: 37,574,945 Y159* probably null Het
Olfr1298 A G 2: 111,645,494 F168L probably benign Het
Osbpl6 G A 2: 76,593,454 R848Q probably damaging Het
Piezo2 G A 18: 63,024,475 T2388I probably damaging Het
Prkdc A G 16: 15,783,087 T2871A probably benign Het
Ptpn12 T C 5: 21,002,437 K308E probably benign Het
Rgsl1 A G 1: 153,825,490 L441P probably damaging Het
Rictor T C 15: 6,776,187 probably null Het
Scn2a T A 2: 65,702,038 S665T possibly damaging Het
Scn8a A G 15: 101,013,476 I926V probably damaging Het
Snrpg T C 6: 86,376,528 I30T probably damaging Het
Spryd3 A T 15: 102,118,990 probably null Het
Svil A G 18: 5,114,531 D2036G probably damaging Het
Synj2 A T 17: 6,017,593 I551F probably damaging Het
Tiam2 A T 17: 3,439,696 probably benign Het
Tmem132b T C 5: 125,787,575 F915S probably damaging Het
Vmn2r6 T C 3: 64,556,328 T362A probably benign Het
Other mutations in Try5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01837:Try5 APN 6 41313424 missense probably benign 0.31
IGL01885:Try5 APN 6 41311738 missense possibly damaging 0.93
R1955:Try5 UTSW 6 41311769 missense probably benign 0.17
R2014:Try5 UTSW 6 41314651 splice site probably null
R2015:Try5 UTSW 6 41314651 splice site probably null
R2848:Try5 UTSW 6 41313476 missense probably benign 0.01
R4227:Try5 UTSW 6 41313467 missense possibly damaging 0.65
R4685:Try5 UTSW 6 41311299 missense possibly damaging 0.59
R4816:Try5 UTSW 6 41313415 missense probably benign 0.18
R5230:Try5 UTSW 6 41312378 missense probably benign 0.19
R5658:Try5 UTSW 6 41312427 missense probably damaging 1.00
R6518:Try5 UTSW 6 41314679 missense probably benign
R6910:Try5 UTSW 6 41311799 missense possibly damaging 0.62
R6913:Try5 UTSW 6 41311332 missense probably damaging 1.00
R7219:Try5 UTSW 6 41311703 missense probably damaging 1.00
R7242:Try5 UTSW 6 41313454 missense probably benign 0.09
R7444:Try5 UTSW 6 41311365 missense probably benign 0.00
R7575:Try5 UTSW 6 41311814 missense probably benign 0.05
R7585:Try5 UTSW 6 41311814 missense probably benign 0.14
R8011:Try5 UTSW 6 41313487 missense probably benign 0.12
R8739:Try5 UTSW 6 41311703 missense probably damaging 1.00
R8991:Try5 UTSW 6 41312361 missense probably benign 0.18
R9397:Try5 UTSW 6 41312380 missense probably benign 0.00
Posted On 2015-04-16