Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02652:Try5'

302189

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Try5

Ensembl Gene

ENSMUSG00000036938

Gene Name

trypsin 5

Synonyms

Tc, 1810049H19Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.072) question?

Stock #

IGL02652

Quality Score

Status

Chromosome

Chromosomal Location

41288166-41291644 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 41288342 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Leucine at position 204 (V204L)

Ref Sequence

ENSEMBL: ENSMUSP00000064498 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064324] [ENSMUST00000173916]

AlphaFold

Q9QUK9

Predicted Effect

probably benign
Transcript: ENSMUST00000064324
AA Change: V204L

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000064498
Gene: ENSMUSG00000036938
AA Change: V204L

Domain	Start	End	E-Value	Type
low complexity region	4	16	N/A	INTRINSIC
Tryp_SPc	23	239	1.47e-104	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000173916
AA Change: V96L

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)

SMART Domains

Protein: ENSMUSP00000133640
Gene: ENSMUSG00000036938
AA Change: V96L

Domain	Start	End	E-Value	Type
Tryp_SPc	1	131	1.21e-27	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000193013

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arhgap28	A	T	17: 68,191,795 (GRCm39)	D139E	probably benign	Het
Asph	C	T	4: 9,529,984 (GRCm39)	V347I	probably benign	Het
Ccdc138	A	T	10: 58,348,901 (GRCm39)	D149V	probably benign	Het
Cep192	A	G	18: 67,991,921 (GRCm39)		probably benign	Het
Cnnm2	G	A	19: 46,751,650 (GRCm39)	R480Q	probably damaging	Het
Col24a1	C	A	3: 145,198,056 (GRCm39)	S1321*	probably null	Het
Cops6	T	G	5: 138,159,700 (GRCm39)		probably null	Het
Crim1	G	A	17: 78,623,106 (GRCm39)	A435T	probably damaging	Het
Cttn	G	T	7: 143,995,468 (GRCm39)	Q382K	probably benign	Het
Dhx38	A	G	8: 110,282,761 (GRCm39)	L635P	probably damaging	Het
Dmtf1	T	A	5: 9,171,853 (GRCm39)	T458S	probably benign	Het
Dnah5	T	C	15: 28,366,333 (GRCm39)	F2682S	probably damaging	Het
Dnah6	T	A	6: 73,072,087 (GRCm39)	Q2413L	probably damaging	Het
Dock10	T	C	1: 80,570,561 (GRCm39)		probably null	Het
Engase	C	T	11: 118,369,776 (GRCm39)	P63S	probably damaging	Het
Grik4	A	G	9: 42,586,573 (GRCm39)	V94A	possibly damaging	Het
Heatr6	T	C	11: 83,660,558 (GRCm39)	V566A	probably damaging	Het
Hydin	A	C	8: 111,316,154 (GRCm39)	T4349P	possibly damaging	Het
Inpp4b	G	A	8: 82,497,429 (GRCm39)		probably benign	Het
Mertk	A	G	2: 128,643,190 (GRCm39)	E863G	probably benign	Het
Muc19	T	A	15: 91,762,009 (GRCm39)		noncoding transcript	Het
Myo9a	T	A	9: 59,771,211 (GRCm39)	F928I	probably damaging	Het
Nyap2	T	C	1: 81,219,435 (GRCm39)	Y486H	probably damaging	Het
Oas1e	T	C	5: 120,933,470 (GRCm39)	R32G	probably damaging	Het
Or14j2	A	T	17: 37,885,836 (GRCm39)	Y159*	probably null	Het
Or4k48	A	G	2: 111,475,839 (GRCm39)	F168L	probably benign	Het
Osbpl6	G	A	2: 76,423,798 (GRCm39)	R848Q	probably damaging	Het
Piezo2	G	A	18: 63,157,546 (GRCm39)	T2388I	probably damaging	Het
Prkdc	A	G	16: 15,600,951 (GRCm39)	T2871A	probably benign	Het
Ptpn12	T	C	5: 21,207,435 (GRCm39)	K308E	probably benign	Het
Rgsl1	A	G	1: 153,701,236 (GRCm39)	L441P	probably damaging	Het
Rictor	T	C	15: 6,805,668 (GRCm39)		probably null	Het
Scn2a	T	A	2: 65,532,382 (GRCm39)	S665T	possibly damaging	Het
Scn8a	A	G	15: 100,911,357 (GRCm39)	I926V	probably damaging	Het
Snrpg	T	C	6: 86,353,510 (GRCm39)	I30T	probably damaging	Het
Spryd3	A	T	15: 102,027,425 (GRCm39)		probably null	Het
Svil	A	G	18: 5,114,531 (GRCm39)	D2036G	probably damaging	Het
Synj2	A	T	17: 6,067,868 (GRCm39)	I551F	probably damaging	Het
Tiam2	A	T	17: 3,489,971 (GRCm39)		probably benign	Het
Tmem132b	T	C	5: 125,864,639 (GRCm39)	F915S	probably damaging	Het
Vmn2r6	T	C	3: 64,463,749 (GRCm39)	T362A	probably benign	Het

Other mutations in Try5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01837:Try5	APN	6	41,290,358 (GRCm39)	missense	probably benign	0.31
IGL01885:Try5	APN	6	41,288,672 (GRCm39)	missense	possibly damaging	0.93
R1955:Try5	UTSW	6	41,288,703 (GRCm39)	missense	probably benign	0.17
R2014:Try5	UTSW	6	41,291,585 (GRCm39)	splice site	probably null
R2015:Try5	UTSW	6	41,291,585 (GRCm39)	splice site	probably null
R2848:Try5	UTSW	6	41,290,410 (GRCm39)	missense	probably benign	0.01
R4227:Try5	UTSW	6	41,290,401 (GRCm39)	missense	possibly damaging	0.65
R4685:Try5	UTSW	6	41,288,233 (GRCm39)	missense	possibly damaging	0.59
R4816:Try5	UTSW	6	41,290,349 (GRCm39)	missense	probably benign	0.18
R5230:Try5	UTSW	6	41,289,312 (GRCm39)	missense	probably benign	0.19
R5658:Try5	UTSW	6	41,289,361 (GRCm39)	missense	probably damaging	1.00
R6518:Try5	UTSW	6	41,291,613 (GRCm39)	missense	probably benign
R6910:Try5	UTSW	6	41,288,733 (GRCm39)	missense	possibly damaging	0.62
R6913:Try5	UTSW	6	41,288,266 (GRCm39)	missense	probably damaging	1.00
R7219:Try5	UTSW	6	41,288,637 (GRCm39)	missense	probably damaging	1.00
R7242:Try5	UTSW	6	41,290,388 (GRCm39)	missense	probably benign	0.09
R7444:Try5	UTSW	6	41,288,299 (GRCm39)	missense	probably benign	0.00
R7575:Try5	UTSW	6	41,288,748 (GRCm39)	missense	probably benign	0.05
R7585:Try5	UTSW	6	41,288,748 (GRCm39)	missense	probably benign	0.14
R8011:Try5	UTSW	6	41,290,421 (GRCm39)	missense	probably benign	0.12
R8739:Try5	UTSW	6	41,288,637 (GRCm39)	missense	probably damaging	1.00
R8991:Try5	UTSW	6	41,289,295 (GRCm39)	missense	probably benign	0.18
R9397:Try5	UTSW	6	41,289,314 (GRCm39)	missense	probably benign	0.00

Posted On

2015-04-16