Incidental Mutation 'IGL02652:Muc19'
ID 302215
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Muc19
Ensembl Gene ENSMUSG00000044021
Gene Name mucin 19
Synonyms sld, apomucin
Accession Numbers
Essential gene? Probably non essential (E-score: 0.182) question?
Stock # IGL02652
Quality Score
Status
Chromosome 15
Chromosomal Location 91722531-91832440 bp(+) (GRCm39)
Type of Mutation critical splice donor site
DNA Base Change (assembly) T to A at 91762009 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s):
AlphaFold no structure available at present
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160242
SMART Domains Protein: ENSMUSP00000125205
Gene: ENSMUSG00000044021

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
low complexity region 21 34 N/A INTRINSIC
VWD 47 198 1.31e-13 SMART
Pfam:C8 221 293 1.1e-8 PFAM
Pfam:TIL 298 353 1.6e-11 PFAM
VWD 383 545 1.58e-25 SMART
C8 577 651 8.71e-20 SMART
Pfam:TIL 654 711 2.1e-7 PFAM
Pfam:TIL 753 813 5.2e-8 PFAM
VWD 842 1005 2.36e-47 SMART
C8 1041 1115 1.84e-27 SMART
low complexity region 1220 1254 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000178108
SMART Domains Protein: ENSMUSP00000136475
Gene: ENSMUSG00000044021

DomainStartEndE-ValueType
low complexity region 4 17 N/A INTRINSIC
VWD 30 181 1.31e-13 SMART
Pfam:C8 200 277 2.5e-8 PFAM
Pfam:TIL 281 336 7.5e-12 PFAM
Pfam:VWD 377 477 4.1e-8 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180042
SMART Domains Protein: ENSMUSP00000136207
Gene: ENSMUSG00000044021

DomainStartEndE-ValueType
C8 17 91 8.71e-20 SMART
Pfam:TIL 94 151 1.2e-7 PFAM
Pfam:TIL 193 253 6.6e-8 PFAM
VWD 282 445 2.36e-47 SMART
C8 481 555 1.84e-27 SMART
low complexity region 660 701 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for this spontaneous mutation show a partially arrested mucous cell differentiation of the sublingual glands. Severe inflammatory lesions resembling Sjogren's syndrome develop spontaneously in salivary and lacrimal glands of neonatally thymectomized mutants without any immunization. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap28 A T 17: 68,191,795 (GRCm39) D139E probably benign Het
Asph C T 4: 9,529,984 (GRCm39) V347I probably benign Het
Ccdc138 A T 10: 58,348,901 (GRCm39) D149V probably benign Het
Cep192 A G 18: 67,991,921 (GRCm39) probably benign Het
Cnnm2 G A 19: 46,751,650 (GRCm39) R480Q probably damaging Het
Col24a1 C A 3: 145,198,056 (GRCm39) S1321* probably null Het
Cops6 T G 5: 138,159,700 (GRCm39) probably null Het
Crim1 G A 17: 78,623,106 (GRCm39) A435T probably damaging Het
Cttn G T 7: 143,995,468 (GRCm39) Q382K probably benign Het
Dhx38 A G 8: 110,282,761 (GRCm39) L635P probably damaging Het
Dmtf1 T A 5: 9,171,853 (GRCm39) T458S probably benign Het
Dnah5 T C 15: 28,366,333 (GRCm39) F2682S probably damaging Het
Dnah6 T A 6: 73,072,087 (GRCm39) Q2413L probably damaging Het
Dock10 T C 1: 80,570,561 (GRCm39) probably null Het
Engase C T 11: 118,369,776 (GRCm39) P63S probably damaging Het
Grik4 A G 9: 42,586,573 (GRCm39) V94A possibly damaging Het
Heatr6 T C 11: 83,660,558 (GRCm39) V566A probably damaging Het
Hydin A C 8: 111,316,154 (GRCm39) T4349P possibly damaging Het
Inpp4b G A 8: 82,497,429 (GRCm39) probably benign Het
Mertk A G 2: 128,643,190 (GRCm39) E863G probably benign Het
Myo9a T A 9: 59,771,211 (GRCm39) F928I probably damaging Het
Nyap2 T C 1: 81,219,435 (GRCm39) Y486H probably damaging Het
Oas1e T C 5: 120,933,470 (GRCm39) R32G probably damaging Het
Or14j2 A T 17: 37,885,836 (GRCm39) Y159* probably null Het
Or4k48 A G 2: 111,475,839 (GRCm39) F168L probably benign Het
Osbpl6 G A 2: 76,423,798 (GRCm39) R848Q probably damaging Het
Piezo2 G A 18: 63,157,546 (GRCm39) T2388I probably damaging Het
Prkdc A G 16: 15,600,951 (GRCm39) T2871A probably benign Het
Ptpn12 T C 5: 21,207,435 (GRCm39) K308E probably benign Het
Rgsl1 A G 1: 153,701,236 (GRCm39) L441P probably damaging Het
Rictor T C 15: 6,805,668 (GRCm39) probably null Het
Scn2a T A 2: 65,532,382 (GRCm39) S665T possibly damaging Het
Scn8a A G 15: 100,911,357 (GRCm39) I926V probably damaging Het
Snrpg T C 6: 86,353,510 (GRCm39) I30T probably damaging Het
Spryd3 A T 15: 102,027,425 (GRCm39) probably null Het
Svil A G 18: 5,114,531 (GRCm39) D2036G probably damaging Het
Synj2 A T 17: 6,067,868 (GRCm39) I551F probably damaging Het
Tiam2 A T 17: 3,489,971 (GRCm39) probably benign Het
Tmem132b T C 5: 125,864,639 (GRCm39) F915S probably damaging Het
Try5 C A 6: 41,288,342 (GRCm39) V204L probably benign Het
Vmn2r6 T C 3: 64,463,749 (GRCm39) T362A probably benign Het
Other mutations in Muc19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00985:Muc19 APN 15 91,770,943 (GRCm39) exon noncoding transcript
IGL01017:Muc19 APN 15 91,764,901 (GRCm39) exon noncoding transcript
IGL01140:Muc19 APN 15 91,783,593 (GRCm39) exon noncoding transcript
IGL01292:Muc19 APN 15 91,778,470 (GRCm39) exon noncoding transcript
IGL01397:Muc19 APN 15 91,778,498 (GRCm39) exon noncoding transcript
IGL01525:Muc19 APN 15 91,770,877 (GRCm39) exon noncoding transcript
IGL01589:Muc19 APN 15 91,754,699 (GRCm39) exon noncoding transcript
IGL02023:Muc19 APN 15 91,772,453 (GRCm39) exon noncoding transcript
IGL02088:Muc19 APN 15 91,775,362 (GRCm39) splice site noncoding transcript
IGL02168:Muc19 APN 15 91,778,292 (GRCm39) exon noncoding transcript
IGL02343:Muc19 APN 15 91,778,428 (GRCm39) exon noncoding transcript
IGL02402:Muc19 APN 15 91,778,192 (GRCm39) splice site noncoding transcript
IGL02433:Muc19 APN 15 91,756,694 (GRCm39) exon noncoding transcript
IGL02533:Muc19 APN 15 91,782,241 (GRCm39) exon noncoding transcript
IGL02558:Muc19 APN 15 91,781,816 (GRCm39) exon noncoding transcript
IGL03032:Muc19 APN 15 91,808,424 (GRCm39) unclassified noncoding transcript
IGL02837:Muc19 UTSW 15 91,766,850 (GRCm39) exon noncoding transcript
R0098:Muc19 UTSW 15 91,777,101 (GRCm39) exon noncoding transcript
R0098:Muc19 UTSW 15 91,777,101 (GRCm39) exon noncoding transcript
R0208:Muc19 UTSW 15 91,777,218 (GRCm39) splice site noncoding transcript
R0597:Muc19 UTSW 15 91,784,696 (GRCm39) splice site noncoding transcript
R1185:Muc19 UTSW 15 91,762,743 (GRCm39) exon noncoding transcript
R1185:Muc19 UTSW 15 91,762,743 (GRCm39) exon noncoding transcript
R1469:Muc19 UTSW 15 91,758,498 (GRCm39) unclassified noncoding transcript
R1942:Muc19 UTSW 15 91,776,666 (GRCm39) exon noncoding transcript
R2035:Muc19 UTSW 15 91,776,599 (GRCm39) splice site noncoding transcript
R2208:Muc19 UTSW 15 91,755,747 (GRCm39) exon noncoding transcript
R2877:Muc19 UTSW 15 91,777,200 (GRCm39) exon noncoding transcript
R2897:Muc19 UTSW 15 91,822,550 (GRCm39) critical splice donor site noncoding transcript
R4110:Muc19 UTSW 15 91,781,816 (GRCm39) exon noncoding transcript
R4403:Muc19 UTSW 15 91,755,768 (GRCm39) exon noncoding transcript
R4606:Muc19 UTSW 15 91,832,268 (GRCm39) exon noncoding transcript
R4677:Muc19 UTSW 15 91,772,411 (GRCm39) exon noncoding transcript
R4753:Muc19 UTSW 15 91,761,955 (GRCm39) unclassified noncoding transcript
R4781:Muc19 UTSW 15 91,787,360 (GRCm39) critical splice donor site noncoding transcript
R4869:Muc19 UTSW 15 91,781,910 (GRCm39) exon noncoding transcript
R5000:Muc19 UTSW 15 91,757,429 (GRCm39) unclassified noncoding transcript
R5044:Muc19 UTSW 15 91,772,332 (GRCm39) exon noncoding transcript
R5156:Muc19 UTSW 15 91,784,614 (GRCm39) exon noncoding transcript
R5176:Muc19 UTSW 15 91,776,374 (GRCm39) exon noncoding transcript
R5224:Muc19 UTSW 15 91,825,910 (GRCm39) exon noncoding transcript
R5524:Muc19 UTSW 15 91,778,587 (GRCm39) exon noncoding transcript
R5568:Muc19 UTSW 15 91,768,468 (GRCm39) splice site noncoding transcript
R5592:Muc19 UTSW 15 91,828,199 (GRCm39) exon noncoding transcript
Posted On 2015-04-16