Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02653:Vmn1r180'

302220

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r180

Ensembl Gene

ENSMUSG00000092473

Gene Name

vomeronasal 1 receptor 180

Synonyms

LOC232962, V1rd16

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

IGL02653

Quality Score

Status

Chromosome

Chromosomal Location

23950632-23955691 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 23953075 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 221 (I221T)

Ref Sequence

ENSEMBL: ENSMUSP00000134362 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000173816]

AlphaFold

B9EK86

Predicted Effect

probably damaging
Transcript: ENSMUST00000173816
AA Change: I221T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000134362
Gene: ENSMUSG00000092473
AA Change: I221T

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	298	2.9e-15	PFAM
Pfam:7tm_1	31	286	6.7e-9	PFAM
Pfam:V1R	41	297	1.4e-17	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc8	T	C	7: 46,115,767		probably benign	Het
Alox5	T	A	6: 116,415,477	H361L	probably benign	Het
Arid2	A	G	15: 96,287,702	N3S	probably damaging	Het
Atp1a4	T	A	1: 172,251,406	I182F	possibly damaging	Het
Ctnna2	A	T	6: 76,980,777	D496E	probably benign	Het
Cyp3a25	G	T	5: 146,003,110	S29Y	possibly damaging	Het
Dglucy	G	A	12: 100,871,431	G611D	probably benign	Het
Efcab5	T	C	11: 77,132,022	K622E	probably damaging	Het
Esyt1	T	A	10: 128,511,008	I1071L	probably benign	Het
Fbn2	T	C	18: 58,076,705	K1035E	probably benign	Het
Frem1	T	G	4: 82,959,334	E1335D	probably benign	Het
Gm5900	A	G	7: 104,950,133		noncoding transcript	Het
Ikbke	T	A	1: 131,271,835	Q283L	possibly damaging	Het
Lepr	A	T	4: 101,764,944	I358F	probably benign	Het
Lnpk	A	G	2: 74,548,048	V123A	probably damaging	Het
Mis12	A	G	11: 71,025,531	K130R	probably damaging	Het
Ncapg2	T	A	12: 116,425,906		probably null	Het
Npy6r	T	C	18: 44,276,627	*372Q	probably null	Het
Polr3d	T	C	14: 70,440,117	D273G	probably damaging	Het
Ppp2r3a	A	G	9: 101,211,693	V477A	probably benign	Het
Prpf19	T	A	19: 10,902,964		probably benign	Het
Pwwp2a	A	G	11: 43,706,035	T676A	possibly damaging	Het
Ralgapb	T	A	2: 158,443,309	I242N	probably damaging	Het
Scn3a	A	T	2: 65,461,187	S1738R	probably damaging	Het
Snapc1	C	A	12: 73,982,487	P348Q	probably benign	Het
Spert	T	C	14: 75,583,157	D385G	probably damaging	Het
Tbc1d7	T	C	13: 43,165,398	I88V	probably benign	Het
Tnks2	T	C	19: 36,872,451	S220P	probably damaging	Het
Trim56	A	T	5: 137,112,906	S585R	probably damaging	Het
Trpm2	T	G	10: 77,912,669	E1389A	probably benign	Het
Tspear	T	A	10: 77,706,965		probably benign	Het
Vmn1r204	A	C	13: 22,556,630	I144L	probably benign	Het
Vmn2r20	A	T	6: 123,385,365	I820N	probably damaging	Het
Vwa3b	T	A	1: 37,175,565		probably benign	Het
Wnt1	G	A	15: 98,792,455	G222R	probably damaging	Het
Zadh2	T	C	18: 84,095,318	V373A	possibly damaging	Het

Other mutations in Vmn1r180

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00487:Vmn1r180	APN	7	23952523	missense	probably benign	0.36
IGL01309:Vmn1r180	APN	7	23952999	missense	probably damaging	1.00
IGL01793:Vmn1r180	APN	7	23953243	missense	probably benign	0.00
IGL03277:Vmn1r180	APN	7	23953285	missense	probably damaging	0.99
IGL03352:Vmn1r180	APN	7	23952652	nonsense	probably null
R1298:Vmn1r180	UTSW	7	23953147	missense	possibly damaging	0.84
R1701:Vmn1r180	UTSW	7	23952970	missense	possibly damaging	0.84
R1702:Vmn1r180	UTSW	7	23952969	missense	possibly damaging	0.52
R2122:Vmn1r180	UTSW	7	23953141	missense	probably damaging	1.00
R4241:Vmn1r180	UTSW	7	23952873	missense	probably damaging	1.00
R5683:Vmn1r180	UTSW	7	23953210	missense	possibly damaging	0.58
R7241:Vmn1r180	UTSW	7	23952466	missense	probably damaging	0.96
R7522:Vmn1r180	UTSW	7	23953260	missense	probably damaging	1.00
R8749:Vmn1r180	UTSW	7	23952990	missense	probably damaging	1.00
R8991:Vmn1r180	UTSW	7	23952651	missense	probably benign	0.06
R9442:Vmn1r180	UTSW	7	23952195	start gained	probably benign

Posted On

2015-04-16