Incidental Mutation 'IGL02653:Vmn1r180'
ID302220
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r180
Ensembl Gene ENSMUSG00000092473
Gene Namevomeronasal 1 receptor 180
SynonymsLOC232962, V1rd16
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.063) question?
Stock #IGL02653
Quality Score
Status
Chromosome7
Chromosomal Location23950632-23955691 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 23953075 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Threonine at position 221 (I221T)
Ref Sequence ENSEMBL: ENSMUSP00000134362 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000173816]
Predicted Effect probably damaging
Transcript: ENSMUST00000173816
AA Change: I221T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000134362
Gene: ENSMUSG00000092473
AA Change: I221T

DomainStartEndE-ValueType
Pfam:TAS2R 8 298 2.9e-15 PFAM
Pfam:7tm_1 31 286 6.7e-9 PFAM
Pfam:V1R 41 297 1.4e-17 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc8 T C 7: 46,115,767 probably benign Het
Alox5 T A 6: 116,415,477 H361L probably benign Het
Arid2 A G 15: 96,287,702 N3S probably damaging Het
Atp1a4 T A 1: 172,251,406 I182F possibly damaging Het
Ctnna2 A T 6: 76,980,777 D496E probably benign Het
Cyp3a25 G T 5: 146,003,110 S29Y possibly damaging Het
Dglucy G A 12: 100,871,431 G611D probably benign Het
Efcab5 T C 11: 77,132,022 K622E probably damaging Het
Esyt1 T A 10: 128,511,008 I1071L probably benign Het
Fbn2 T C 18: 58,076,705 K1035E probably benign Het
Frem1 T G 4: 82,959,334 E1335D probably benign Het
Gm5900 A G 7: 104,950,133 noncoding transcript Het
Ikbke T A 1: 131,271,835 Q283L possibly damaging Het
Lepr A T 4: 101,764,944 I358F probably benign Het
Lnpk A G 2: 74,548,048 V123A probably damaging Het
Mis12 A G 11: 71,025,531 K130R probably damaging Het
Ncapg2 T A 12: 116,425,906 probably null Het
Npy6r T C 18: 44,276,627 *372Q probably null Het
Polr3d T C 14: 70,440,117 D273G probably damaging Het
Ppp2r3a A G 9: 101,211,693 V477A probably benign Het
Prpf19 T A 19: 10,902,964 probably benign Het
Pwwp2a A G 11: 43,706,035 T676A possibly damaging Het
Ralgapb T A 2: 158,443,309 I242N probably damaging Het
Scn3a A T 2: 65,461,187 S1738R probably damaging Het
Snapc1 C A 12: 73,982,487 P348Q probably benign Het
Spert T C 14: 75,583,157 D385G probably damaging Het
Tbc1d7 T C 13: 43,165,398 I88V probably benign Het
Tnks2 T C 19: 36,872,451 S220P probably damaging Het
Trim56 A T 5: 137,112,906 S585R probably damaging Het
Trpm2 T G 10: 77,912,669 E1389A probably benign Het
Tspear T A 10: 77,706,965 probably benign Het
Vmn1r204 A C 13: 22,556,630 I144L probably benign Het
Vmn2r20 A T 6: 123,385,365 I820N probably damaging Het
Vwa3b T A 1: 37,175,565 probably benign Het
Wnt1 G A 15: 98,792,455 G222R probably damaging Het
Zadh2 T C 18: 84,095,318 V373A possibly damaging Het
Other mutations in Vmn1r180
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00487:Vmn1r180 APN 7 23952523 missense probably benign 0.36
IGL01309:Vmn1r180 APN 7 23952999 missense probably damaging 1.00
IGL01793:Vmn1r180 APN 7 23953243 missense probably benign 0.00
IGL03277:Vmn1r180 APN 7 23953285 missense probably damaging 0.99
IGL03352:Vmn1r180 APN 7 23952652 nonsense probably null
R1298:Vmn1r180 UTSW 7 23953147 missense possibly damaging 0.84
R1701:Vmn1r180 UTSW 7 23952970 missense possibly damaging 0.84
R1702:Vmn1r180 UTSW 7 23952969 missense possibly damaging 0.52
R2122:Vmn1r180 UTSW 7 23953141 missense probably damaging 1.00
R4241:Vmn1r180 UTSW 7 23952873 missense probably damaging 1.00
R5683:Vmn1r180 UTSW 7 23953210 missense possibly damaging 0.58
R7241:Vmn1r180 UTSW 7 23952466 missense probably damaging 0.96
R7522:Vmn1r180 UTSW 7 23953260 missense probably damaging 1.00
Posted On2015-04-16