Incidental Mutation 'IGL02653:Vmn2r20'
ID302232
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r20
Ensembl Gene ENSMUSG00000094145
Gene Namevomeronasal 2, receptor 20
SynonymsEG667180
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.563) question?
Stock #IGL02653
Quality Score
Status
Chromosome6
Chromosomal Location123385262-123418061 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 123385365 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Asparagine at position 820 (I820N)
Ref Sequence ENSEMBL: ENSMUSP00000129145 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000172199]
Predicted Effect probably damaging
Transcript: ENSMUST00000172199
AA Change: I820N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000129145
Gene: ENSMUSG00000094145
AA Change: I820N

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:ANF_receptor 81 473 5e-33 PFAM
Pfam:NCD3G 517 570 9.6e-24 PFAM
Pfam:7tm_3 601 838 1.4e-54 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc8 T C 7: 46,115,767 probably benign Het
Alox5 T A 6: 116,415,477 H361L probably benign Het
Arid2 A G 15: 96,287,702 N3S probably damaging Het
Atp1a4 T A 1: 172,251,406 I182F possibly damaging Het
Ctnna2 A T 6: 76,980,777 D496E probably benign Het
Cyp3a25 G T 5: 146,003,110 S29Y possibly damaging Het
Dglucy G A 12: 100,871,431 G611D probably benign Het
Efcab5 T C 11: 77,132,022 K622E probably damaging Het
Esyt1 T A 10: 128,511,008 I1071L probably benign Het
Fbn2 T C 18: 58,076,705 K1035E probably benign Het
Frem1 T G 4: 82,959,334 E1335D probably benign Het
Gm5900 A G 7: 104,950,133 noncoding transcript Het
Ikbke T A 1: 131,271,835 Q283L possibly damaging Het
Lepr A T 4: 101,764,944 I358F probably benign Het
Lnpk A G 2: 74,548,048 V123A probably damaging Het
Mis12 A G 11: 71,025,531 K130R probably damaging Het
Ncapg2 T A 12: 116,425,906 probably null Het
Npy6r T C 18: 44,276,627 *372Q probably null Het
Polr3d T C 14: 70,440,117 D273G probably damaging Het
Ppp2r3a A G 9: 101,211,693 V477A probably benign Het
Prpf19 T A 19: 10,902,964 probably benign Het
Pwwp2a A G 11: 43,706,035 T676A possibly damaging Het
Ralgapb T A 2: 158,443,309 I242N probably damaging Het
Scn3a A T 2: 65,461,187 S1738R probably damaging Het
Snapc1 C A 12: 73,982,487 P348Q probably benign Het
Spert T C 14: 75,583,157 D385G probably damaging Het
Tbc1d7 T C 13: 43,165,398 I88V probably benign Het
Tnks2 T C 19: 36,872,451 S220P probably damaging Het
Trim56 A T 5: 137,112,906 S585R probably damaging Het
Trpm2 T G 10: 77,912,669 E1389A probably benign Het
Tspear T A 10: 77,706,965 probably benign Het
Vmn1r180 T C 7: 23,953,075 I221T probably damaging Het
Vmn1r204 A C 13: 22,556,630 I144L probably benign Het
Vwa3b T A 1: 37,175,565 probably benign Het
Wnt1 G A 15: 98,792,455 G222R probably damaging Het
Zadh2 T C 18: 84,095,318 V373A possibly damaging Het
Other mutations in Vmn2r20
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01915:Vmn2r20 APN 6 123393965 missense possibly damaging 0.89
IGL02686:Vmn2r20 APN 6 123385626 missense probably benign 0.00
R0309:Vmn2r20 UTSW 6 123386104 missense probably benign 0.18
R3724:Vmn2r20 UTSW 6 123385747 missense probably benign 0.00
R6502:Vmn2r20 UTSW 6 123396383 missense possibly damaging 0.51
R7039:Vmn2r20 UTSW 6 123386123 missense probably damaging 0.98
R7218:Vmn2r20 UTSW 6 123386115 missense probably damaging 1.00
R7372:Vmn2r20 UTSW 6 123385509 missense probably damaging 1.00
R7509:Vmn2r20 UTSW 6 123385423 missense probably benign 0.00
R7832:Vmn2r20 UTSW 6 123385923 missense probably damaging 1.00
R7915:Vmn2r20 UTSW 6 123385923 missense probably damaging 1.00
R8011:Vmn2r20 UTSW 6 123396410 missense possibly damaging 0.71
R8118:Vmn2r20 UTSW 6 123396470 missense probably damaging 1.00
Posted On2015-04-16