Incidental Mutation 'IGL02655:Cpm'
ID 302309
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cpm
Ensembl Gene ENSMUSG00000020183
Gene Name carboxypeptidase M
Synonyms 1110060I01Rik, 5730456K23Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.094) question?
Stock # IGL02655
Quality Score
Status
Chromosome 10
Chromosomal Location 117465405-117523257 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 117519186 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 365 (T365A)
Ref Sequence ENSEMBL: ENSMUSP00000020399 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020399]
AlphaFold Q80V42
Predicted Effect probably benign
Transcript: ENSMUST00000020399
AA Change: T365A

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000020399
Gene: ENSMUSG00000020183
AA Change: T365A

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Zn_pept 22 406 2.03e-45 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141991
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930402F06Rik A T 2: 35,270,498 (GRCm39) S68T possibly damaging Het
4930544G11Rik T G 6: 65,930,074 (GRCm39) V103G probably damaging Het
Adam7 A T 14: 68,754,060 (GRCm39) D346E probably damaging Het
Adamts1 A G 16: 85,599,505 (GRCm39) S32P probably benign Het
Adamtsl2 T C 2: 26,972,542 (GRCm39) probably benign Het
Adgrb2 C A 4: 129,885,972 (GRCm39) Y37* probably null Het
Apba3 A G 10: 81,108,788 (GRCm39) R547G probably benign Het
Ccnd2 C T 6: 127,125,733 (GRCm39) G101D probably damaging Het
Cpt2 A G 4: 107,764,624 (GRCm39) V380A probably damaging Het
Dnah7b A T 1: 46,155,461 (GRCm39) probably benign Het
Enpp1 A C 10: 24,553,872 (GRCm39) D105E probably damaging Het
Ermp1 C A 19: 29,623,610 (GRCm39) E127* probably null Het
Evi5 T C 5: 107,961,446 (GRCm39) K375R probably benign Het
Gm11564 A T 11: 99,705,982 (GRCm39) C149* probably null Het
Golgb1 A T 16: 36,738,442 (GRCm39) E2260D probably damaging Het
Gpc2 T C 5: 138,277,187 (GRCm39) D80G possibly damaging Het
Hsd11b2 A G 8: 106,248,960 (GRCm39) I151V probably benign Het
Knl1 T C 2: 118,901,473 (GRCm39) I1058T possibly damaging Het
Krtap4-8 A T 11: 99,671,454 (GRCm39) probably benign Het
Me1 A G 9: 86,536,780 (GRCm39) probably benign Het
Mki67 C T 7: 135,315,748 (GRCm39) R38H probably damaging Het
Nsmaf A G 4: 6,424,933 (GRCm39) F272L possibly damaging Het
Pcyox1 A T 6: 86,366,326 (GRCm39) V78E probably damaging Het
Pkp1 G T 1: 135,817,511 (GRCm39) T208N probably benign Het
Plagl2 T C 2: 153,074,337 (GRCm39) E188G probably damaging Het
Pramel15 A G 4: 144,099,416 (GRCm39) F450L probably benign Het
Relch G A 1: 105,605,971 (GRCm39) V204M probably damaging Het
Ric1 T A 19: 29,572,851 (GRCm39) S764T probably damaging Het
Sec24a G A 11: 51,625,482 (GRCm39) T247M probably benign Het
Slc25a17 C T 15: 81,207,844 (GRCm39) R248Q probably benign Het
Stk36 C T 1: 74,673,694 (GRCm39) P1068S probably damaging Het
Tcn2 C A 11: 3,876,158 (GRCm39) S90I possibly damaging Het
Tfec C T 6: 16,834,308 (GRCm39) A200T possibly damaging Het
Vmn2r4 A G 3: 64,305,886 (GRCm39) I512T probably damaging Het
Other mutations in Cpm
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00924:Cpm APN 10 117,511,971 (GRCm39) missense probably damaging 1.00
IGL01400:Cpm APN 10 117,495,680 (GRCm39) missense probably benign 0.25
IGL02724:Cpm APN 10 117,465,756 (GRCm39) missense probably damaging 1.00
IGL03144:Cpm APN 10 117,519,319 (GRCm39) missense probably benign 0.03
R0898:Cpm UTSW 10 117,512,011 (GRCm39) splice site probably benign
R2179:Cpm UTSW 10 117,519,266 (GRCm39) missense probably benign 0.24
R2213:Cpm UTSW 10 117,495,744 (GRCm39) missense probably damaging 1.00
R4622:Cpm UTSW 10 117,506,202 (GRCm39) missense possibly damaging 0.91
R4623:Cpm UTSW 10 117,506,202 (GRCm39) missense possibly damaging 0.91
R4658:Cpm UTSW 10 117,503,956 (GRCm39) missense probably benign 0.43
R4714:Cpm UTSW 10 117,511,890 (GRCm39) missense probably damaging 0.97
R4991:Cpm UTSW 10 117,504,008 (GRCm39) missense probably damaging 1.00
R5430:Cpm UTSW 10 117,511,986 (GRCm39) missense possibly damaging 0.92
R5765:Cpm UTSW 10 117,507,638 (GRCm39) missense probably benign 0.09
R6757:Cpm UTSW 10 117,507,543 (GRCm39) missense probably damaging 1.00
R6803:Cpm UTSW 10 117,512,002 (GRCm39) splice site probably null
R7509:Cpm UTSW 10 117,495,745 (GRCm39) missense probably damaging 1.00
R7761:Cpm UTSW 10 117,519,340 (GRCm39) missense possibly damaging 0.64
R8171:Cpm UTSW 10 117,519,220 (GRCm39) missense probably damaging 0.96
R8472:Cpm UTSW 10 117,515,883 (GRCm39) missense probably damaging 1.00
R8951:Cpm UTSW 10 117,511,938 (GRCm39) missense probably damaging 0.96
R9028:Cpm UTSW 10 117,519,414 (GRCm39) missense probably benign 0.00
R9601:Cpm UTSW 10 117,511,999 (GRCm39) critical splice donor site probably null
Posted On 2015-04-16