Incidental Mutation 'IGL02656:Dok3'
ID302329
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dok3
Ensembl Gene ENSMUSG00000035711
Gene Namedocking protein 3
Synonymsp62Dok-like protein
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.122) question?
Stock #IGL02656
Quality Score
Status
Chromosome13
Chromosomal Location55523231-55529296 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 55528480 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Asparagine at position 12 (I12N)
Ref Sequence ENSEMBL: ENSMUSP00000153308 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021956] [ENSMUST00000047877] [ENSMUST00000223563] [ENSMUST00000224765]
Predicted Effect probably benign
Transcript: ENSMUST00000021956
SMART Domains Protein: ENSMUSP00000021956
Gene: ENSMUSG00000021494

DomainStartEndE-ValueType
low complexity region 24 32 N/A INTRINSIC
low complexity region 39 56 N/A INTRINSIC
low complexity region 95 115 N/A INTRINSIC
DEXDc 200 411 8.56e-53 SMART
HELICc 446 527 5.99e-34 SMART
ZnF_C2HC 581 597 1.98e-2 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000047877
AA Change: I12N

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000046695
Gene: ENSMUSG00000035711
AA Change: I12N

DomainStartEndE-ValueType
PH 7 125 3.54e-5 SMART
IRS 157 256 1.61e-41 SMART
PTBI 158 256 2.59e-24 SMART
low complexity region 273 284 N/A INTRINSIC
low complexity region 304 315 N/A INTRINSIC
low complexity region 358 376 N/A INTRINSIC
low complexity region 410 421 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000223563
AA Change: I12N

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223944
Predicted Effect probably benign
Transcript: ENSMUST00000224765
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased incidence of lung adenocarcinomas. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd28 G T 14: 31,702,240 A981D possibly damaging Het
Ccdc69 G T 11: 55,052,437 Q114K possibly damaging Het
Cct5 A T 15: 31,597,430 D66E probably damaging Het
Ces2e G T 8: 104,927,056 R42I possibly damaging Het
Cib2 T G 9: 54,545,898 D178A probably damaging Het
Cldn7 G A 11: 69,967,008 V97I probably benign Het
Fndc5 T A 4: 129,139,446 V102E probably damaging Het
Gas2 T C 7: 51,943,744 S191P probably benign Het
Herc6 T A 6: 57,611,836 probably null Het
Krt18 A G 15: 102,030,922 T277A probably benign Het
Mpp3 A G 11: 102,008,601 S365P probably benign Het
Msmo1 T C 8: 64,727,872 T3A probably benign Het
Olfr1509 G T 14: 52,450,709 A99S possibly damaging Het
Olfr1537 T A 9: 39,238,160 E88V probably benign Het
Olfr394 A G 11: 73,888,039 F111S probably damaging Het
Pex19 C A 1: 172,130,685 A77E probably benign Het
Phf20l1 A G 15: 66,629,827 D620G probably damaging Het
Prr5 A G 15: 84,699,136 D105G probably damaging Het
Rab12 T A 17: 66,506,054 K88M probably damaging Het
Rictor T C 15: 6,776,920 V673A probably damaging Het
Rps26 A G 10: 128,625,257 S88P possibly damaging Het
Sema5a T A 15: 32,631,285 S605T possibly damaging Het
Slc35a4 T C 18: 36,682,447 M110T probably damaging Het
Sowahb T C 5: 93,043,247 S538G probably benign Het
Srrt T A 5: 137,299,676 probably benign Het
Ssbp2 G A 13: 91,669,752 probably benign Het
Supt20 C T 3: 54,708,395 R236W probably damaging Het
Tenm4 A G 7: 96,885,433 D1791G probably damaging Het
Tgm6 G A 2: 130,145,103 G497D probably damaging Het
Trim12c C T 7: 104,341,203 V356I probably damaging Het
Vwce T A 19: 10,664,352 I814K probably benign Het
Other mutations in Dok3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01837:Dok3 APN 13 55523570 missense probably damaging 1.00
IGL02088:Dok3 APN 13 55524370 missense probably damaging 1.00
IGL02218:Dok3 APN 13 55523786 missense probably damaging 1.00
IGL03410:Dok3 APN 13 55524231 nonsense probably null
R0601:Dok3 UTSW 13 55524263 missense probably benign 0.16
R1306:Dok3 UTSW 13 55527448 nonsense probably null
R1749:Dok3 UTSW 13 55524355 frame shift probably null
R3684:Dok3 UTSW 13 55524493 missense probably damaging 1.00
R4863:Dok3 UTSW 13 55523457 missense probably damaging 1.00
R6195:Dok3 UTSW 13 55523576 missense probably benign 0.00
R7021:Dok3 UTSW 13 55524284 missense probably benign 0.00
R7526:Dok3 UTSW 13 55527493 missense probably benign 0.03
R8379:Dok3 UTSW 13 55524020 missense probably benign
Posted On2015-04-16