Incidental Mutation 'R0364:Arhgef12'
| ID |
30236 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arhgef12
|
| Ensembl Gene |
ENSMUSG00000059495 |
| Gene Name |
Rho guanine nucleotide exchange factor 12 |
| Synonyms |
2310014B11Rik, LARG |
| MMRRC Submission |
038570-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.936)
|
| Stock # |
R0364 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
42875138-43017069 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 42929697 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Lysine
at position 199
(N199K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126598
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000072767]
[ENSMUST00000165665]
|
| AlphaFold |
Q8R4H2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000072767
AA Change: N199K
PolyPhen 2
Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000072547
Gene: ENSMUSG00000059495
AA Change: N199K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
49 |
64 |
N/A |
INTRINSIC |
|
PDZ
|
80 |
148 |
1.64e-19 |
SMART |
|
coiled coil region
|
196 |
259 |
N/A |
INTRINSIC |
|
low complexity region
|
293 |
313 |
N/A |
INTRINSIC |
|
Pfam:RGS-like
|
368 |
558 |
8.6e-87 |
PFAM |
|
low complexity region
|
583 |
596 |
N/A |
INTRINSIC |
|
low complexity region
|
663 |
676 |
N/A |
INTRINSIC |
|
low complexity region
|
721 |
733 |
N/A |
INTRINSIC |
|
RhoGEF
|
791 |
976 |
6.35e-66 |
SMART |
|
PH
|
1020 |
1134 |
6.26e-6 |
SMART |
|
low complexity region
|
1256 |
1269 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000165665
AA Change: N199K
PolyPhen 2
Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000126598
Gene: ENSMUSG00000059495
AA Change: N199K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
49 |
64 |
N/A |
INTRINSIC |
|
PDZ
|
80 |
148 |
1.64e-19 |
SMART |
|
coiled coil region
|
196 |
259 |
N/A |
INTRINSIC |
|
low complexity region
|
293 |
313 |
N/A |
INTRINSIC |
|
Pfam:RGS-like
|
369 |
559 |
1.6e-88 |
PFAM |
|
low complexity region
|
584 |
597 |
N/A |
INTRINSIC |
|
low complexity region
|
664 |
677 |
N/A |
INTRINSIC |
|
low complexity region
|
722 |
734 |
N/A |
INTRINSIC |
|
RhoGEF
|
792 |
977 |
6.35e-66 |
SMART |
|
PH
|
1021 |
1135 |
6.26e-6 |
SMART |
|
low complexity region
|
1257 |
1270 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000213566
|
| Meta Mutation Damage Score |
0.0651 |
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.0%
- 10x: 95.3%
- 20x: 89.3%
|
| Validation Efficiency |
99% (86/87) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
PHENOTYPE: Mice homozygous for a null allele exhibit decreased sensitivity to certain vasoconstrictors and resistance to salt-induced hypertension. Mice homozygous for a different knock-out allele exhibit partial prenatal lethality. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 87 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acp7 |
G |
A |
7: 28,310,553 (GRCm39) |
|
probably benign |
Het |
| Ano7 |
A |
G |
1: 93,316,380 (GRCm39) |
D221G |
probably benign |
Het |
| Arpc2 |
A |
G |
1: 74,276,046 (GRCm39) |
N26S |
probably null |
Het |
| Camta2 |
G |
A |
11: 70,574,136 (GRCm39) |
T127I |
probably damaging |
Het |
| Ccdc13 |
T |
A |
9: 121,627,282 (GRCm39) |
N665I |
probably damaging |
Het |
| Ccdc178 |
C |
T |
18: 22,048,119 (GRCm39) |
R757H |
probably damaging |
Het |
| Cfap52 |
A |
C |
11: 67,844,436 (GRCm39) |
I93S |
possibly damaging |
Het |
| Cmklr1 |
A |
T |
5: 113,752,578 (GRCm39) |
L141H |
probably damaging |
Het |
| Crybb3 |
T |
A |
5: 113,223,819 (GRCm39) |
I197F |
probably damaging |
Het |
| Cryzl1 |
G |
A |
16: 91,504,155 (GRCm39) |
P97S |
probably benign |
Het |
| Cubn |
T |
C |
2: 13,315,318 (GRCm39) |
|
probably benign |
Het |
| Cyp2d37-ps |
T |
C |
15: 82,574,253 (GRCm39) |
|
noncoding transcript |
Het |
| Cyp4a12b |
C |
A |
4: 115,290,117 (GRCm39) |
N223K |
probably benign |
Het |
| Dennd2a |
T |
C |
6: 39,485,233 (GRCm39) |
T349A |
probably benign |
Het |
| Dnah12 |
A |
G |
14: 26,445,628 (GRCm39) |
T730A |
probably benign |
Het |
| Dock5 |
G |
A |
14: 68,060,129 (GRCm39) |
|
probably benign |
Het |
| Dync2i1 |
A |
G |
12: 116,221,097 (GRCm39) |
|
probably benign |
Het |
| Elac2 |
A |
G |
11: 64,870,136 (GRCm39) |
Y67C |
probably damaging |
Het |
| Elmo1 |
A |
T |
13: 20,748,663 (GRCm39) |
K503* |
probably null |
Het |
| Endou |
A |
T |
15: 97,616,854 (GRCm39) |
|
probably benign |
Het |
| Eng |
T |
C |
2: 32,569,149 (GRCm39) |
S559P |
probably benign |
Het |
| Epc2 |
T |
A |
2: 49,427,145 (GRCm39) |
V563E |
possibly damaging |
Het |
| Fbxw17 |
T |
C |
13: 50,586,477 (GRCm39) |
S40P |
possibly damaging |
Het |
| Flt4 |
A |
T |
11: 49,527,818 (GRCm39) |
M924L |
probably benign |
Het |
| Fyb1 |
A |
G |
15: 6,610,272 (GRCm39) |
K282E |
probably damaging |
Het |
| Gabpa |
T |
A |
16: 84,654,275 (GRCm39) |
N317K |
possibly damaging |
Het |
| Gli3 |
G |
T |
13: 15,899,349 (GRCm39) |
G912V |
probably benign |
Het |
| Gm10295 |
C |
A |
7: 71,000,361 (GRCm39) |
C73F |
unknown |
Het |
| Gm10382 |
G |
T |
5: 125,466,728 (GRCm39) |
|
probably benign |
Het |
| Gp1ba |
T |
C |
11: 70,531,284 (GRCm39) |
|
probably benign |
Het |
| Gpr146 |
G |
A |
5: 139,364,933 (GRCm39) |
|
probably benign |
Het |
| Grm5 |
A |
G |
7: 87,723,594 (GRCm39) |
Y628C |
probably damaging |
Het |
| Hexa |
A |
G |
9: 59,471,218 (GRCm39) |
N491D |
probably benign |
Het |
| Hexd |
T |
A |
11: 121,102,969 (GRCm39) |
H62Q |
probably benign |
Het |
| Hpx |
G |
T |
7: 105,245,471 (GRCm39) |
Q101K |
probably benign |
Het |
| Ino80 |
G |
A |
2: 119,213,441 (GRCm39) |
R1249C |
probably damaging |
Het |
| Inpp4b |
A |
T |
8: 82,723,943 (GRCm39) |
T492S |
probably benign |
Het |
| Iqgap2 |
A |
C |
13: 95,867,783 (GRCm39) |
|
probably benign |
Het |
| Islr2 |
T |
C |
9: 58,107,027 (GRCm39) |
T78A |
possibly damaging |
Het |
| Itga9 |
A |
G |
9: 118,670,210 (GRCm39) |
T177A |
probably benign |
Het |
| Itpkc |
A |
C |
7: 26,927,174 (GRCm39) |
S247A |
possibly damaging |
Het |
| Kirrel1 |
T |
C |
3: 86,997,106 (GRCm39) |
Y287C |
probably damaging |
Het |
| Kiz |
T |
G |
2: 146,784,076 (GRCm39) |
S536R |
probably benign |
Het |
| Klhl9 |
T |
G |
4: 88,638,527 (GRCm39) |
K571N |
probably benign |
Het |
| Kprp |
A |
T |
3: 92,731,642 (GRCm39) |
Y469* |
probably null |
Het |
| Ksr1 |
A |
T |
11: 78,919,851 (GRCm39) |
|
probably benign |
Het |
| Lrrc37a |
C |
T |
11: 103,391,466 (GRCm39) |
V1320I |
possibly damaging |
Het |
| Ltf |
A |
T |
9: 110,854,235 (GRCm39) |
N350I |
probably benign |
Het |
| Msl3l2 |
G |
A |
10: 55,991,947 (GRCm39) |
R224Q |
possibly damaging |
Het |
| Myh6 |
A |
T |
14: 55,185,804 (GRCm39) |
Y1490* |
probably null |
Het |
| Necap1 |
A |
G |
6: 122,857,728 (GRCm39) |
|
probably benign |
Het |
| Nf1 |
A |
T |
11: 79,332,783 (GRCm39) |
K810* |
probably null |
Het |
| Nkx6-3 |
A |
G |
8: 23,647,722 (GRCm39) |
E227G |
possibly damaging |
Het |
| Nlrp1a |
T |
A |
11: 71,004,830 (GRCm39) |
|
probably benign |
Het |
| Obscn |
G |
A |
11: 59,019,107 (GRCm39) |
A969V |
probably benign |
Het |
| Or11a4 |
T |
C |
17: 37,536,934 (GRCm39) |
L306P |
possibly damaging |
Het |
| Or7g32 |
G |
A |
9: 19,389,268 (GRCm39) |
Q90* |
probably null |
Het |
| Or8b40 |
A |
G |
9: 38,027,325 (GRCm39) |
T78A |
probably benign |
Het |
| Or8k33 |
A |
T |
2: 86,384,123 (GRCm39) |
L115Q |
probably damaging |
Het |
| Pcdhb17 |
C |
A |
18: 37,618,888 (GRCm39) |
A226E |
possibly damaging |
Het |
| Phldb1 |
A |
T |
9: 44,610,632 (GRCm39) |
|
probably benign |
Het |
| Plekha5 |
G |
A |
6: 140,537,473 (GRCm39) |
R646K |
possibly damaging |
Het |
| Pon2 |
G |
A |
6: 5,266,156 (GRCm39) |
Q288* |
probably null |
Het |
| Prr14 |
G |
A |
7: 127,073,751 (GRCm39) |
R205H |
probably benign |
Het |
| Ptpn13 |
C |
A |
5: 103,681,214 (GRCm39) |
R805S |
probably damaging |
Het |
| Pyroxd2 |
A |
T |
19: 42,735,992 (GRCm39) |
V62D |
probably damaging |
Het |
| Rab37 |
G |
T |
11: 115,047,790 (GRCm39) |
C44F |
probably damaging |
Het |
| Rbm44 |
T |
C |
1: 91,080,069 (GRCm39) |
S52P |
probably benign |
Het |
| Rusf1 |
C |
T |
7: 127,889,786 (GRCm39) |
R1H |
probably damaging |
Het |
| Scn5a |
T |
C |
9: 119,351,665 (GRCm39) |
D772G |
probably damaging |
Het |
| Slc7a5 |
A |
G |
8: 122,611,754 (GRCm39) |
F425L |
probably benign |
Het |
| Slk |
T |
A |
19: 47,608,628 (GRCm39) |
L527* |
probably null |
Het |
| Stpg4 |
T |
A |
17: 87,697,142 (GRCm39) |
|
probably null |
Het |
| Taar6 |
C |
A |
10: 23,861,046 (GRCm39) |
V167L |
probably benign |
Het |
| Tas2r123 |
T |
A |
6: 132,824,644 (GRCm39) |
S180R |
probably benign |
Het |
| Tmc2 |
C |
T |
2: 130,044,023 (GRCm39) |
R86W |
probably benign |
Het |
| Tmem200c |
T |
A |
17: 69,147,543 (GRCm39) |
V42E |
probably damaging |
Het |
| Trhde |
T |
C |
10: 114,338,887 (GRCm39) |
|
probably benign |
Het |
| Tshz1 |
A |
T |
18: 84,034,249 (GRCm39) |
I53N |
probably benign |
Het |
| Tshz3 |
A |
G |
7: 36,469,958 (GRCm39) |
E649G |
probably benign |
Het |
| Ttll7 |
C |
A |
3: 146,650,936 (GRCm39) |
R719S |
possibly damaging |
Het |
| Utp4 |
T |
C |
8: 107,625,169 (GRCm39) |
|
probably benign |
Het |
| Vmn1r35 |
A |
G |
6: 66,655,827 (GRCm39) |
I281T |
probably damaging |
Het |
| Vps39 |
T |
G |
2: 120,176,119 (GRCm39) |
K76T |
probably damaging |
Het |
| Whamm |
A |
G |
7: 81,243,799 (GRCm39) |
T674A |
probably benign |
Het |
| Zbtb16 |
A |
G |
9: 48,654,876 (GRCm39) |
|
probably benign |
Het |
| Zfp623 |
T |
C |
15: 75,820,510 (GRCm39) |
S489P |
probably benign |
Het |
|
| Other mutations in Arhgef12 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00923:Arhgef12
|
APN |
9 |
42,931,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00942:Arhgef12
|
APN |
9 |
42,893,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01529:Arhgef12
|
APN |
9 |
42,901,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01845:Arhgef12
|
APN |
9 |
42,934,137 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL02039:Arhgef12
|
APN |
9 |
42,883,563 (GRCm39) |
missense |
probably benign |
|
|
IGL02135:Arhgef12
|
APN |
9 |
42,883,461 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02272:Arhgef12
|
APN |
9 |
42,912,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02498:Arhgef12
|
APN |
9 |
42,893,339 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02507:Arhgef12
|
APN |
9 |
42,903,859 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02574:Arhgef12
|
APN |
9 |
42,916,919 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02586:Arhgef12
|
APN |
9 |
42,917,200 (GRCm39) |
nonsense |
probably null |
|
|
IGL02803:Arhgef12
|
APN |
9 |
42,883,324 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02892:Arhgef12
|
APN |
9 |
42,912,268 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL02937:Arhgef12
|
APN |
9 |
42,927,216 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02992:Arhgef12
|
APN |
9 |
42,910,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03028:Arhgef12
|
APN |
9 |
42,937,524 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL03146:Arhgef12
|
APN |
9 |
42,885,866 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03193:Arhgef12
|
APN |
9 |
42,903,829 (GRCm39) |
splice site |
probably benign |
|
|
IGL03398:Arhgef12
|
APN |
9 |
42,889,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0019:Arhgef12
|
UTSW |
9 |
42,889,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0143:Arhgef12
|
UTSW |
9 |
42,916,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0211:Arhgef12
|
UTSW |
9 |
42,883,300 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0330:Arhgef12
|
UTSW |
9 |
42,931,982 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0426:Arhgef12
|
UTSW |
9 |
42,882,286 (GRCm39) |
splice site |
probably null |
|
|
R0658:Arhgef12
|
UTSW |
9 |
42,893,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0686:Arhgef12
|
UTSW |
9 |
42,904,324 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0693:Arhgef12
|
UTSW |
9 |
42,929,697 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0990:Arhgef12
|
UTSW |
9 |
42,883,677 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1147:Arhgef12
|
UTSW |
9 |
42,955,552 (GRCm39) |
unclassified |
probably benign |
|
|
R1395:Arhgef12
|
UTSW |
9 |
42,917,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1419:Arhgef12
|
UTSW |
9 |
42,938,516 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1451:Arhgef12
|
UTSW |
9 |
42,903,874 (GRCm39) |
splice site |
probably benign |
|
|
R1458:Arhgef12
|
UTSW |
9 |
42,900,294 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1654:Arhgef12
|
UTSW |
9 |
42,908,956 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1722:Arhgef12
|
UTSW |
9 |
42,932,013 (GRCm39) |
makesense |
probably null |
|
|
R1773:Arhgef12
|
UTSW |
9 |
42,916,838 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1895:Arhgef12
|
UTSW |
9 |
42,917,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2109:Arhgef12
|
UTSW |
9 |
42,890,768 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R2215:Arhgef12
|
UTSW |
9 |
42,917,167 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2421:Arhgef12
|
UTSW |
9 |
42,912,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3967:Arhgef12
|
UTSW |
9 |
42,916,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3968:Arhgef12
|
UTSW |
9 |
42,916,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3969:Arhgef12
|
UTSW |
9 |
42,916,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4077:Arhgef12
|
UTSW |
9 |
42,886,588 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4079:Arhgef12
|
UTSW |
9 |
42,886,588 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4111:Arhgef12
|
UTSW |
9 |
42,883,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4302:Arhgef12
|
UTSW |
9 |
42,929,645 (GRCm39) |
nonsense |
probably null |
|
|
R4327:Arhgef12
|
UTSW |
9 |
42,886,525 (GRCm39) |
nonsense |
probably null |
|
|
R4462:Arhgef12
|
UTSW |
9 |
42,893,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4583:Arhgef12
|
UTSW |
9 |
42,888,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4603:Arhgef12
|
UTSW |
9 |
42,921,489 (GRCm39) |
missense |
probably benign |
0.27 |
|
R4650:Arhgef12
|
UTSW |
9 |
42,893,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4741:Arhgef12
|
UTSW |
9 |
42,883,449 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R4823:Arhgef12
|
UTSW |
9 |
42,931,992 (GRCm39) |
missense |
probably benign |
|
|
R4840:Arhgef12
|
UTSW |
9 |
42,886,364 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4912:Arhgef12
|
UTSW |
9 |
42,904,361 (GRCm39) |
nonsense |
probably null |
|
|
R5176:Arhgef12
|
UTSW |
9 |
42,931,982 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5426:Arhgef12
|
UTSW |
9 |
42,897,880 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5579:Arhgef12
|
UTSW |
9 |
42,921,489 (GRCm39) |
missense |
probably benign |
0.27 |
|
R5838:Arhgef12
|
UTSW |
9 |
42,916,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6230:Arhgef12
|
UTSW |
9 |
42,900,261 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6741:Arhgef12
|
UTSW |
9 |
42,883,503 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6959:Arhgef12
|
UTSW |
9 |
42,927,249 (GRCm39) |
missense |
probably benign |
|
|
R7252:Arhgef12
|
UTSW |
9 |
42,927,205 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7470:Arhgef12
|
UTSW |
9 |
42,951,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7658:Arhgef12
|
UTSW |
9 |
42,903,832 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7724:Arhgef12
|
UTSW |
9 |
42,938,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7980:Arhgef12
|
UTSW |
9 |
42,882,595 (GRCm39) |
nonsense |
probably null |
|
|
R8074:Arhgef12
|
UTSW |
9 |
42,882,399 (GRCm39) |
nonsense |
probably null |
|
|
R8155:Arhgef12
|
UTSW |
9 |
42,953,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8270:Arhgef12
|
UTSW |
9 |
42,882,354 (GRCm39) |
missense |
probably benign |
|
|
R8407:Arhgef12
|
UTSW |
9 |
42,937,475 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8527:Arhgef12
|
UTSW |
9 |
42,908,944 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9116:Arhgef12
|
UTSW |
9 |
42,893,241 (GRCm39) |
splice site |
probably benign |
|
|
R9127:Arhgef12
|
UTSW |
9 |
42,885,870 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9602:Arhgef12
|
UTSW |
9 |
42,895,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9665:Arhgef12
|
UTSW |
9 |
42,929,650 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9733:Arhgef12
|
UTSW |
9 |
42,901,294 (GRCm39) |
nonsense |
probably null |
|
|
R9735:Arhgef12
|
UTSW |
9 |
42,882,399 (GRCm39) |
nonsense |
probably null |
|
|
R9760:Arhgef12
|
UTSW |
9 |
42,903,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF020:Arhgef12
|
UTSW |
9 |
42,901,285 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
Z1176:Arhgef12
|
UTSW |
9 |
42,882,368 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1186:Arhgef12
|
UTSW |
9 |
42,911,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGCAATCTTTGGGTAGCCGTTCG -3'
(R):5'- GGCAAAACTGTTCCTGCCTTCCTG -3'
Sequencing Primer
(F):5'- ACTAATTATCCATGTCAGGTGGAG -3'
(R):5'- CTGTTTTCTTAATGAAATGAGCCACC -3'
|
| Posted On |
2013-04-24 |
Incidental Mutation