Incidental Mutation 'IGL02657:Tekt4'
ID 302364
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tekt4
Ensembl Gene ENSMUSG00000024175
Gene Name tektin 4
Synonyms 1700010L19Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # IGL02657
Quality Score
Chromosome 17
Chromosomal Location 25673589-25695576 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 25692732 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 186 (I186T)
Ref Sequence ENSEMBL: ENSMUSP00000025002 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025002]
AlphaFold Q149S1
Predicted Effect possibly damaging
Transcript: ENSMUST00000025002
AA Change: I186T

PolyPhen 2 Score 0.929 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000025002
Gene: ENSMUSG00000024175
AA Change: I186T

Pfam:Tektin 56 438 6.2e-143 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele exhibit decreased male fertility due to abnormal flagellum function. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afmid G A 11: 117,725,648 (GRCm39) V120M possibly damaging Het
Aldh1l1 T C 6: 90,567,776 (GRCm39) L680P probably damaging Het
Alox12 A T 11: 70,138,104 (GRCm39) D410E probably benign Het
Amt T A 9: 108,178,579 (GRCm39) V365E probably damaging Het
Ano9 A G 7: 140,687,353 (GRCm39) S321P probably damaging Het
Atp2c2 A T 8: 120,479,771 (GRCm39) I767F probably damaging Het
Bag1 A T 4: 40,936,643 (GRCm39) Y338N probably benign Het
Bcr T A 10: 74,990,796 (GRCm39) D767E probably benign Het
Chfr A T 5: 110,302,705 (GRCm39) Q350L probably damaging Het
Cops3 A T 11: 59,721,043 (GRCm39) L124H probably damaging Het
Ddx60 T C 8: 62,437,149 (GRCm39) Y988H probably benign Het
Dnajc2 A T 5: 21,975,479 (GRCm39) probably benign Het
Dym C T 18: 75,215,527 (GRCm39) Q238* probably null Het
Fbn1 A T 2: 125,193,945 (GRCm39) C1341S possibly damaging Het
Fryl G T 5: 73,212,203 (GRCm39) N2308K probably benign Het
Gbp2b G T 3: 142,309,873 (GRCm39) R221L probably damaging Het
Gpat2 A G 2: 127,269,251 (GRCm39) N8S probably benign Het
Gvin2 T C 7: 105,545,972 (GRCm39) K2360R probably damaging Het
Hycc2 A T 1: 58,574,561 (GRCm39) W327R probably damaging Het
Ift52 A G 2: 162,887,135 (GRCm39) D379G probably damaging Het
Inhbe C A 10: 127,186,645 (GRCm39) L178F probably damaging Het
Ipo5 T C 14: 121,181,212 (GRCm39) Y913H possibly damaging Het
Kif21b T A 1: 136,099,968 (GRCm39) D1507E possibly damaging Het
Lnx2 A G 5: 146,964,984 (GRCm39) V413A probably damaging Het
Lrrc40 C A 3: 157,742,410 (GRCm39) F16L probably damaging Het
Magi2 A G 5: 19,432,581 (GRCm39) K99E probably damaging Het
Me3 A G 7: 89,495,461 (GRCm39) I357M probably benign Het
Med30 A G 15: 52,582,761 (GRCm39) Y66C probably benign Het
Mief2 A T 11: 60,621,783 (GRCm39) S118C probably damaging Het
Mylip A G 13: 45,544,722 (GRCm39) S49G probably benign Het
Ncoa7 T A 10: 30,528,972 (GRCm39) D107V probably damaging Het
Nvl C A 1: 180,934,541 (GRCm39) V655F probably damaging Het
Olfml2b C T 1: 170,508,645 (GRCm39) T501I probably benign Het
Ormdl2 T C 10: 128,656,186 (GRCm39) I40V probably benign Het
Pde6b G T 5: 108,568,142 (GRCm39) probably benign Het
Ralgapa1 A C 12: 55,720,292 (GRCm39) L1785W probably damaging Het
Rnf112 A T 11: 61,341,078 (GRCm39) probably null Het
Sema3c A T 5: 17,781,866 (GRCm39) M1L possibly damaging Het
Sema3c T A 5: 17,867,972 (GRCm39) Y128N probably damaging Het
Sema4b G A 7: 79,866,789 (GRCm39) G255D probably damaging Het
Setd1a C T 7: 127,394,997 (GRCm39) probably benign Het
Sirpb1a A C 3: 15,482,111 (GRCm39) S72R possibly damaging Het
Slu7 T A 11: 43,332,849 (GRCm39) probably null Het
Spata19 T C 9: 27,309,276 (GRCm39) V59A probably benign Het
Srrm1 G A 4: 135,052,415 (GRCm39) P658L unknown Het
Suclg1 T A 6: 73,237,504 (GRCm39) V83E probably damaging Het
Syncrip G T 9: 88,338,457 (GRCm39) R536S probably benign Het
Tap2 T C 17: 34,424,432 (GRCm39) V55A probably damaging Het
Trpc6 C A 9: 8,643,602 (GRCm39) D462E possibly damaging Het
Ubqln3 T G 7: 103,791,170 (GRCm39) T307P probably damaging Het
Vmn1r64 A T 7: 5,886,727 (GRCm39) I272K probably benign Het
Xpr1 T C 1: 155,166,026 (GRCm39) T574A probably benign Het
Zfc3h1 A G 10: 115,247,859 (GRCm39) T1021A possibly damaging Het
Zfp512 A T 5: 31,628,501 (GRCm39) H159L probably damaging Het
Other mutations in Tekt4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01571:Tekt4 APN 17 25,695,358 (GRCm39) missense probably benign 0.31
R0788:Tekt4 UTSW 17 25,691,021 (GRCm39) missense probably damaging 1.00
R1280:Tekt4 UTSW 17 25,690,861 (GRCm39) missense probably damaging 1.00
R1466:Tekt4 UTSW 17 25,691,048 (GRCm39) missense probably benign 0.29
R1466:Tekt4 UTSW 17 25,691,048 (GRCm39) missense probably benign 0.29
R1819:Tekt4 UTSW 17 25,692,785 (GRCm39) splice site probably null
R1902:Tekt4 UTSW 17 25,690,832 (GRCm39) missense possibly damaging 0.63
R2262:Tekt4 UTSW 17 25,695,485 (GRCm39) missense possibly damaging 0.76
R2263:Tekt4 UTSW 17 25,695,485 (GRCm39) missense possibly damaging 0.76
R4010:Tekt4 UTSW 17 25,695,460 (GRCm39) missense probably damaging 1.00
R4604:Tekt4 UTSW 17 25,690,749 (GRCm39) missense probably benign
R5085:Tekt4 UTSW 17 25,692,749 (GRCm39) missense probably damaging 0.99
R6187:Tekt4 UTSW 17 25,691,197 (GRCm39) missense probably damaging 1.00
R7102:Tekt4 UTSW 17 25,693,718 (GRCm39) missense probably damaging 0.99
R8726:Tekt4 UTSW 17 25,691,033 (GRCm39) missense probably damaging 1.00
R9178:Tekt4 UTSW 17 25,690,901 (GRCm39) missense possibly damaging 0.73
R9616:Tekt4 UTSW 17 25,692,782 (GRCm39) critical splice donor site probably null
Posted On 2015-04-16