Incidental Mutation 'IGL02658:Bpifb9b'
ID 302421
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Bpifb9b
Ensembl Gene ENSMUSG00000067996
Gene Name BPI fold containing family B, member 9B
Synonyms 5430413K10Rik, OTTMUSG00000015915
Accession Numbers
Essential gene? Probably non essential (E-score: 0.142) question?
Stock # IGL02658
Quality Score
Status
Chromosome 2
Chromosomal Location 154149164-154162564 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 154153201 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Serine at position 89 (Y89S)
Ref Sequence ENSEMBL: ENSMUSP00000086311 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088921]
AlphaFold A2AJD1
Predicted Effect probably benign
Transcript: ENSMUST00000088921
AA Change: Y89S

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000086311
Gene: ENSMUSG00000067996
AA Change: Y89S

DomainStartEndE-ValueType
low complexity region 29 42 N/A INTRINSIC
low complexity region 60 77 N/A INTRINSIC
low complexity region 122 157 N/A INTRINSIC
low complexity region 167 181 N/A INTRINSIC
low complexity region 184 203 N/A INTRINSIC
Pfam:LBP_BPI_CETP 216 377 1.7e-11 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b T A 11: 109,843,386 (GRCm39) Y946F probably benign Het
Abcb4 T G 5: 8,984,240 (GRCm39) W657G probably benign Het
Adcy1 T C 11: 7,088,279 (GRCm39) probably benign Het
Arap3 A G 18: 38,124,047 (GRCm39) V351A probably benign Het
Carns1 C T 19: 4,223,083 (GRCm39) C47Y probably benign Het
Chd5 C T 4: 152,445,050 (GRCm39) H344Y probably damaging Het
Ctnna2 T C 6: 76,957,807 (GRCm39) T481A probably benign Het
Cyth1 T A 11: 118,073,072 (GRCm39) D264V probably damaging Het
Dph1 C A 11: 75,071,461 (GRCm39) L311F probably benign Het
Eif3l A G 15: 78,961,142 (GRCm39) D65G probably damaging Het
Gtf2a1l T A 17: 88,976,146 (GRCm39) F3Y probably benign Het
Hcn4 A T 9: 58,766,748 (GRCm39) T770S unknown Het
Hydin A T 8: 111,139,908 (GRCm39) I726F possibly damaging Het
Klf2 A G 8: 73,072,940 (GRCm39) I7V probably benign Het
Ltn1 A T 16: 87,212,662 (GRCm39) L633H probably damaging Het
Ncoa3 A G 2: 165,893,313 (GRCm39) D206G probably benign Het
Nlrp4a T G 7: 26,149,138 (GRCm39) D248E probably benign Het
Nyap1 A G 5: 137,733,746 (GRCm39) I429T probably damaging Het
Or1j10 T A 2: 36,267,072 (GRCm39) C95S probably damaging Het
Or2p2 G A 13: 21,256,982 (GRCm39) T163I probably damaging Het
Or2t6 T A 14: 14,175,732 (GRCm38) M117L possibly damaging Het
Or51g1 A G 7: 102,633,537 (GRCm39) M278T probably benign Het
Or8s16 A G 15: 98,211,237 (GRCm39) S65P probably damaging Het
Pcf11 T C 7: 92,296,254 (GRCm39) E1322G probably damaging Het
Plcxd2 A T 16: 45,792,689 (GRCm39) F217I probably benign Het
Plxna4 A T 6: 32,162,346 (GRCm39) I1389N probably damaging Het
Ppp1r15a T C 7: 45,174,091 (GRCm39) Y239C probably benign Het
Psma6 A G 12: 55,458,996 (GRCm39) E126G probably benign Het
R3hcc1l T A 19: 42,551,141 (GRCm39) V46E probably damaging Het
Rap1gds1 G T 3: 138,663,240 (GRCm39) H320N probably damaging Het
Sdhaf3 A G 6: 7,038,992 (GRCm39) M105V probably damaging Het
Slc22a26 T A 19: 7,765,613 (GRCm39) N345I probably benign Het
Sncaip T C 18: 53,028,027 (GRCm39) I412T possibly damaging Het
Sorcs1 A T 19: 50,178,530 (GRCm39) I864N probably damaging Het
Spag5 C T 11: 78,212,157 (GRCm39) Q1062* probably null Het
Srrm1 G A 4: 135,052,415 (GRCm39) P658L unknown Het
Szrd1 A G 4: 140,867,057 (GRCm39) probably benign Het
Tns2 C A 15: 102,016,231 (GRCm39) probably benign Het
Trcg1 C A 9: 57,149,511 (GRCm39) S361* probably null Het
Tshz3 T C 7: 36,468,583 (GRCm39) F191L probably damaging Het
Ttc39a T C 4: 109,280,090 (GRCm39) V124A probably damaging Het
Ttf1 T C 2: 28,964,023 (GRCm39) I633T probably damaging Het
Zfp691 A G 4: 119,027,704 (GRCm39) F176S probably damaging Het
Other mutations in Bpifb9b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01621:Bpifb9b APN 2 154,158,871 (GRCm39) splice site probably null
IGL02119:Bpifb9b APN 2 154,155,544 (GRCm39) missense possibly damaging 0.84
R0230:Bpifb9b UTSW 2 154,158,995 (GRCm39) missense probably damaging 1.00
R0269:Bpifb9b UTSW 2 154,161,545 (GRCm39) missense probably benign 0.00
R0617:Bpifb9b UTSW 2 154,161,545 (GRCm39) missense probably benign 0.00
R1953:Bpifb9b UTSW 2 154,153,234 (GRCm39) missense probably damaging 0.99
R2050:Bpifb9b UTSW 2 154,151,524 (GRCm39) missense possibly damaging 0.93
R2160:Bpifb9b UTSW 2 154,161,595 (GRCm39) missense possibly damaging 0.53
R2200:Bpifb9b UTSW 2 154,155,574 (GRCm39) missense probably benign 0.00
R2354:Bpifb9b UTSW 2 154,153,662 (GRCm39) missense probably benign
R4755:Bpifb9b UTSW 2 154,161,614 (GRCm39) missense probably benign 0.01
R4872:Bpifb9b UTSW 2 154,155,551 (GRCm39) missense probably damaging 0.99
R4914:Bpifb9b UTSW 2 154,156,026 (GRCm39) splice site probably null
R4915:Bpifb9b UTSW 2 154,156,026 (GRCm39) splice site probably null
R4917:Bpifb9b UTSW 2 154,156,026 (GRCm39) splice site probably null
R4918:Bpifb9b UTSW 2 154,156,026 (GRCm39) splice site probably null
R4950:Bpifb9b UTSW 2 154,153,579 (GRCm39) missense probably damaging 1.00
R5438:Bpifb9b UTSW 2 154,151,288 (GRCm39) missense possibly damaging 0.65
R5507:Bpifb9b UTSW 2 154,158,947 (GRCm39) missense possibly damaging 0.91
R6255:Bpifb9b UTSW 2 154,151,284 (GRCm39) missense probably damaging 0.98
R7130:Bpifb9b UTSW 2 154,153,592 (GRCm39) missense probably damaging 0.98
R7161:Bpifb9b UTSW 2 154,155,535 (GRCm39) missense possibly damaging 0.95
R7736:Bpifb9b UTSW 2 154,154,025 (GRCm39) missense probably benign 0.00
R8536:Bpifb9b UTSW 2 154,158,197 (GRCm39) missense probably benign 0.00
R9134:Bpifb9b UTSW 2 154,151,441 (GRCm39) missense probably benign
R9348:Bpifb9b UTSW 2 154,160,766 (GRCm39) missense probably benign 0.28
R9528:Bpifb9b UTSW 2 154,153,297 (GRCm39) missense probably benign 0.02
Posted On 2015-04-16