Incidental Mutation 'IGL02658:Zfp691'
ID 302449
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp691
Ensembl Gene ENSMUSG00000045268
Gene Name zinc finger protein 691
Synonyms 6430544H17Rik
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.364) question?
Stock # IGL02658
Quality Score
Status
Chromosome 4
Chromosomal Location 119026710-119031392 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 119027704 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 176 (F176S)
Ref Sequence ENSEMBL: ENSMUSP00000136119 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052715] [ENSMUST00000106355] [ENSMUST00000138395] [ENSMUST00000154226] [ENSMUST00000179290]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000052715
AA Change: F176S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000053013
Gene: ENSMUSG00000045268
AA Change: F176S

DomainStartEndE-ValueType
ZnF_C2H2 83 105 4.54e-4 SMART
ZnF_C2H2 111 133 5.99e-4 SMART
ZnF_C2H2 139 161 3.89e-3 SMART
ZnF_C2H2 167 189 3.95e-4 SMART
ZnF_C2H2 195 217 4.72e-2 SMART
ZnF_C2H2 223 245 2.4e-3 SMART
ZnF_C2H2 251 273 1.6e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000106355
AA Change: F176S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000101962
Gene: ENSMUSG00000045268
AA Change: F176S

DomainStartEndE-ValueType
ZnF_C2H2 83 105 4.54e-4 SMART
ZnF_C2H2 111 133 5.99e-4 SMART
ZnF_C2H2 139 161 3.89e-3 SMART
ZnF_C2H2 167 189 3.95e-4 SMART
ZnF_C2H2 195 217 4.72e-2 SMART
ZnF_C2H2 223 245 2.4e-3 SMART
ZnF_C2H2 251 273 1.6e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000138395
SMART Domains Protein: ENSMUSP00000123426
Gene: ENSMUSG00000028644

DomainStartEndE-ValueType
IGv 68 151 9.26e-8 SMART
transmembrane domain 272 294 N/A INTRINSIC
coiled coil region 304 342 N/A INTRINSIC
PRY 354 406 1.15e-27 SMART
SPRY 407 532 3.25e-28 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000154226
Predicted Effect probably damaging
Transcript: ENSMUST00000179290
AA Change: F176S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000136119
Gene: ENSMUSG00000045268
AA Change: F176S

DomainStartEndE-ValueType
ZnF_C2H2 83 105 4.54e-4 SMART
ZnF_C2H2 111 133 5.99e-4 SMART
ZnF_C2H2 139 161 3.89e-3 SMART
ZnF_C2H2 167 189 3.95e-4 SMART
ZnF_C2H2 195 217 4.72e-2 SMART
ZnF_C2H2 223 245 2.4e-3 SMART
ZnF_C2H2 251 273 1.6e-4 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b T A 11: 109,843,386 (GRCm39) Y946F probably benign Het
Abcb4 T G 5: 8,984,240 (GRCm39) W657G probably benign Het
Adcy1 T C 11: 7,088,279 (GRCm39) probably benign Het
Arap3 A G 18: 38,124,047 (GRCm39) V351A probably benign Het
Bpifb9b A C 2: 154,153,201 (GRCm39) Y89S probably benign Het
Carns1 C T 19: 4,223,083 (GRCm39) C47Y probably benign Het
Chd5 C T 4: 152,445,050 (GRCm39) H344Y probably damaging Het
Ctnna2 T C 6: 76,957,807 (GRCm39) T481A probably benign Het
Cyth1 T A 11: 118,073,072 (GRCm39) D264V probably damaging Het
Dph1 C A 11: 75,071,461 (GRCm39) L311F probably benign Het
Eif3l A G 15: 78,961,142 (GRCm39) D65G probably damaging Het
Gtf2a1l T A 17: 88,976,146 (GRCm39) F3Y probably benign Het
Hcn4 A T 9: 58,766,748 (GRCm39) T770S unknown Het
Hydin A T 8: 111,139,908 (GRCm39) I726F possibly damaging Het
Klf2 A G 8: 73,072,940 (GRCm39) I7V probably benign Het
Ltn1 A T 16: 87,212,662 (GRCm39) L633H probably damaging Het
Ncoa3 A G 2: 165,893,313 (GRCm39) D206G probably benign Het
Nlrp4a T G 7: 26,149,138 (GRCm39) D248E probably benign Het
Nyap1 A G 5: 137,733,746 (GRCm39) I429T probably damaging Het
Or1j10 T A 2: 36,267,072 (GRCm39) C95S probably damaging Het
Or2p2 G A 13: 21,256,982 (GRCm39) T163I probably damaging Het
Or2t6 T A 14: 14,175,732 (GRCm38) M117L possibly damaging Het
Or51g1 A G 7: 102,633,537 (GRCm39) M278T probably benign Het
Or8s16 A G 15: 98,211,237 (GRCm39) S65P probably damaging Het
Pcf11 T C 7: 92,296,254 (GRCm39) E1322G probably damaging Het
Plcxd2 A T 16: 45,792,689 (GRCm39) F217I probably benign Het
Plxna4 A T 6: 32,162,346 (GRCm39) I1389N probably damaging Het
Ppp1r15a T C 7: 45,174,091 (GRCm39) Y239C probably benign Het
Psma6 A G 12: 55,458,996 (GRCm39) E126G probably benign Het
R3hcc1l T A 19: 42,551,141 (GRCm39) V46E probably damaging Het
Rap1gds1 G T 3: 138,663,240 (GRCm39) H320N probably damaging Het
Sdhaf3 A G 6: 7,038,992 (GRCm39) M105V probably damaging Het
Slc22a26 T A 19: 7,765,613 (GRCm39) N345I probably benign Het
Sncaip T C 18: 53,028,027 (GRCm39) I412T possibly damaging Het
Sorcs1 A T 19: 50,178,530 (GRCm39) I864N probably damaging Het
Spag5 C T 11: 78,212,157 (GRCm39) Q1062* probably null Het
Srrm1 G A 4: 135,052,415 (GRCm39) P658L unknown Het
Szrd1 A G 4: 140,867,057 (GRCm39) probably benign Het
Tns2 C A 15: 102,016,231 (GRCm39) probably benign Het
Trcg1 C A 9: 57,149,511 (GRCm39) S361* probably null Het
Tshz3 T C 7: 36,468,583 (GRCm39) F191L probably damaging Het
Ttc39a T C 4: 109,280,090 (GRCm39) V124A probably damaging Het
Ttf1 T C 2: 28,964,023 (GRCm39) I633T probably damaging Het
Other mutations in Zfp691
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02440:Zfp691 APN 4 119,027,493 (GRCm39) missense probably damaging 0.96
IGL02850:Zfp691 APN 4 119,027,389 (GRCm39) missense probably damaging 0.96
R0417:Zfp691 UTSW 4 119,027,693 (GRCm39) missense possibly damaging 0.67
R4822:Zfp691 UTSW 4 119,027,764 (GRCm39) missense probably damaging 1.00
R4923:Zfp691 UTSW 4 119,027,999 (GRCm39) missense probably benign
R7619:Zfp691 UTSW 4 119,028,181 (GRCm39) missense probably damaging 0.98
R8738:Zfp691 UTSW 4 119,027,861 (GRCm39) missense probably damaging 1.00
R8841:Zfp691 UTSW 4 119,027,861 (GRCm39) missense probably damaging 0.99
R9574:Zfp691 UTSW 4 119,028,230 (GRCm39) start codon destroyed possibly damaging 0.85
RF007:Zfp691 UTSW 4 119,027,932 (GRCm39) missense probably benign 0.08
Posted On 2015-04-16