Incidental Mutation 'IGL02660:Dcaf10'
ID302505
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dcaf10
Ensembl Gene ENSMUSG00000035572
Gene NameDDB1 and CUL4 associated factor 10
SynonymsWdr32
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02660
Quality Score
Status
Chromosome4
Chromosomal Location45342101-45379759 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 45372769 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Glutamine at position 394 (R394Q)
Ref Sequence ENSEMBL: ENSMUSP00000117082 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000153803] [ENSMUST00000155551]
Predicted Effect noncoding transcript
Transcript: ENSMUST00000107798
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130821
Predicted Effect probably benign
Transcript: ENSMUST00000153803
SMART Domains Protein: ENSMUSP00000121616
Gene: ENSMUSG00000035572

DomainStartEndE-ValueType
Blast:WD40 1 30 3e-11 BLAST
Blast:WD40 127 165 2e-10 BLAST
WD40 183 222 1.31e-3 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000155551
AA Change: R394Q

PolyPhen 2 Score 0.919 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000117082
Gene: ENSMUSG00000035572
AA Change: R394Q

DomainStartEndE-ValueType
low complexity region 15 46 N/A INTRINSIC
low complexity region 80 107 N/A INTRINSIC
low complexity region 110 132 N/A INTRINSIC
WD40 166 203 1.71e1 SMART
WD40 206 245 7.85e-7 SMART
WD40 249 288 2.59e-7 SMART
WD40 295 334 2.05e1 SMART
low complexity region 352 374 N/A INTRINSIC
Blast:WD40 468 506 3e-10 BLAST
WD40 524 563 1.31e-3 SMART
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6030458C11Rik A G 15: 12,810,767 L341P probably damaging Het
Abcd3 A C 3: 121,784,020 N206K probably damaging Het
Adamtsl1 A G 4: 86,232,610 D335G probably damaging Het
Ankmy1 A T 1: 92,896,094 M150K probably damaging Het
Ap3b2 T C 7: 81,465,698 D680G probably benign Het
Asxl3 T A 18: 22,524,345 V1804D probably damaging Het
Bace2 T C 16: 97,415,140 V311A probably damaging Het
C2cd4c T A 10: 79,613,302 T4S probably benign Het
C2cd6 T C 1: 59,051,230 Y456C probably damaging Het
Cbr1 A G 16: 93,609,824 S143G probably benign Het
Ccdc191 A G 16: 43,960,099 T815A probably benign Het
Cenpf T A 1: 189,654,782 Q1767L probably damaging Het
Col6a5 A C 9: 105,936,886 N642K unknown Het
Ephb1 A T 9: 102,041,092 I406N possibly damaging Het
F13a1 A G 13: 36,943,894 V370A possibly damaging Het
Gm14403 A T 2: 177,509,464 H401L probably damaging Het
Gp6 T G 7: 4,384,998 R157S probably benign Het
Gucy2e G A 11: 69,232,007 T514I probably benign Het
Hist1h2aa T C 13: 23,934,625 V55A probably damaging Het
Mok A G 12: 110,828,065 I63T probably damaging Het
Otop1 T C 5: 38,288,005 V169A probably damaging Het
Pdzph1 T A 17: 58,880,647 T1193S probably damaging Het
Plekha7 A G 7: 116,157,574 probably benign Het
Plekhm1 A T 11: 103,374,094 probably benign Het
Prex1 A G 2: 166,593,867 Y587H probably damaging Het
Scaf1 C A 7: 45,012,118 probably benign Het
Sema3f A T 9: 107,683,984 F601Y probably benign Het
Shoc2 T C 19: 53,988,021 I114T probably benign Het
Skint10 T A 4: 112,765,030 probably benign Het
Slc18b1 T C 10: 23,810,952 probably benign Het
Slco5a1 A G 1: 12,989,636 L287P probably damaging Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Syncrip G T 9: 88,456,404 R536S probably benign Het
Trim5 C A 7: 104,266,218 R296L probably damaging Het
Vmn2r60 G T 7: 42,142,296 E548* probably null Het
Wdr26 A T 1: 181,198,898 W251R probably damaging Het
Other mutations in Dcaf10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02431:Dcaf10 APN 4 45342630 missense probably benign 0.01
R0048:Dcaf10 UTSW 4 45374262 nonsense probably null
R0550:Dcaf10 UTSW 4 45372753 missense probably benign
R0611:Dcaf10 UTSW 4 45373011 missense probably damaging 1.00
R2289:Dcaf10 UTSW 4 45359816 missense probably damaging 1.00
R2973:Dcaf10 UTSW 4 45373957 missense probably benign 0.04
R3610:Dcaf10 UTSW 4 45372962 nonsense probably null
R3735:Dcaf10 UTSW 4 45348117 missense probably benign 0.01
R4655:Dcaf10 UTSW 4 45372769 missense possibly damaging 0.92
R4665:Dcaf10 UTSW 4 45372769 missense possibly damaging 0.92
R4690:Dcaf10 UTSW 4 45372769 missense possibly damaging 0.92
R4724:Dcaf10 UTSW 4 45372769 missense possibly damaging 0.92
R4725:Dcaf10 UTSW 4 45372769 missense possibly damaging 0.92
R4735:Dcaf10 UTSW 4 45372769 missense possibly damaging 0.92
R4743:Dcaf10 UTSW 4 45370409 missense probably damaging 0.98
R5220:Dcaf10 UTSW 4 45373909 missense possibly damaging 0.94
R5254:Dcaf10 UTSW 4 45370415 missense possibly damaging 0.94
R5855:Dcaf10 UTSW 4 45342558 missense probably benign 0.18
R6833:Dcaf10 UTSW 4 45373043 missense probably damaging 1.00
R7132:Dcaf10 UTSW 4 45342391 missense probably benign
R7345:Dcaf10 UTSW 4 45342583 missense probably damaging 0.98
R7366:Dcaf10 UTSW 4 45373919 missense probably damaging 1.00
R7832:Dcaf10 UTSW 4 45348196 missense probably damaging 1.00
R7915:Dcaf10 UTSW 4 45348196 missense probably damaging 1.00
Posted On2015-04-16