Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02664:Ppp1r32'

302682

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ppp1r32

Ensembl Gene

ENSMUSG00000035179

Gene Name

protein phosphatase 1, regulatory subunit 32

Synonyms

IIIG9L, 4930579J09Rik, IIIG9S, IIIG9

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02664

Quality Score

Status

Chromosome

Chromosomal Location

10474257-10482897 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 10482291 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Arginine at position 17 (S17R)

Ref Sequence

ENSEMBL: ENSMUSP00000035684 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038842]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000038842
AA Change: S17R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ablim2	A	T	5: 35,849,516	D425V	probably damaging	Het
Afdn	G	T	17: 13,852,466		probably benign	Het
Ap2a2	C	T	7: 141,629,223	T776I	probably benign	Het
Apcdd1	T	C	18: 62,951,820		probably benign	Het
Bdp1	A	T	13: 100,051,539	Y1513N	probably benign	Het
Btaf1	T	C	19: 36,978,428		probably benign	Het
C2cd3	A	T	7: 100,419,715	M917L	possibly damaging	Het
Cmtm6	T	C	9: 114,746,545	V174A	probably benign	Het
Cyp2d12	T	A	15: 82,559,334	I448K	probably benign	Het
Ddb1	A	G	19: 10,607,883	I101V	probably benign	Het
Dicer1	A	G	12: 104,705,129	Y961H	probably damaging	Het
Dnaaf1	T	G	8: 119,582,521	I116S	probably damaging	Het
Ecscr	T	A	18: 35,721,398	I5F	possibly damaging	Het
Eftud2	T	C	11: 102,841,712	E691G	probably damaging	Het
Fat2	A	G	11: 55,311,096	V384A	probably damaging	Het
Ftcd	T	C	10: 76,584,605	M391T	probably damaging	Het
Gab2	T	G	7: 97,304,182	S587R	probably damaging	Het
Gm18856	G	A	13: 13,965,224		probably benign	Het
Herc2	A	T	7: 56,135,678	R1559*	probably null	Het
Inpp5f	G	A	7: 128,664,014	R161H	probably damaging	Het
Iws1	A	T	18: 32,070,164	D31V	possibly damaging	Het
Klhl2	A	T	8: 64,752,767	Y373*	probably null	Het
Lce6a	A	T	3: 92,620,300	C67S	possibly damaging	Het
Lrba	A	G	3: 86,325,731	I800V	possibly damaging	Het
Mis18bp1	A	C	12: 65,153,880	Y407*	probably null	Het
Mllt3	A	C	4: 88,031,623	W29G	probably damaging	Het
Mon2	A	G	10: 123,009,496		probably benign	Het
Mtbp	C	T	15: 55,619,643	T372M	probably benign	Het
Nefm	A	T	14: 68,120,215		probably benign	Het
Nf1	A	T	11: 79,444,598		probably null	Het
Nf1	G	A	11: 79,444,599		probably null	Het
Ntn1	T	A	11: 68,385,469	I218F	probably benign	Het
Numa1	T	G	7: 101,998,902	S613R	possibly damaging	Het
Olfr305	C	T	7: 86,363,603	V245I	possibly damaging	Het
Pcsk5	A	T	19: 17,456,770	D1411E	probably damaging	Het
Prl2b1	G	T	13: 27,385,242	N124K	possibly damaging	Het
Rab15	T	C	12: 76,804,451	I30M	possibly damaging	Het
Rnf215	G	T	11: 4,140,307	V342L	probably damaging	Het
Spata5	A	G	3: 37,436,665	D453G	probably damaging	Het
Togaram2	T	A	17: 71,729,239	I908N	probably damaging	Het
Trim54	A	G	5: 31,136,047	N205S	probably damaging	Het
Ttn	G	A	2: 76,867,451	T80I	possibly damaging	Het
Vmn2r106	G	A	17: 20,268,082	T685I	possibly damaging	Het
Vwa5b2	T	C	16: 20,595,313		probably benign	Het
Zfat	A	T	15: 68,180,721	I401N	probably damaging	Het
Zfp40	G	A	17: 23,176,986	S209F	probably benign	Het

Other mutations in Ppp1r32

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00959:Ppp1r32	APN	19	10477523	critical splice donor site	probably null
IGL00979:Ppp1r32	APN	19	10474499	makesense	probably null
IGL02405:Ppp1r32	APN	19	10474566	missense	probably damaging	1.00
IGL03105:Ppp1r32	APN	19	10477020	splice site	probably benign
R0255:Ppp1r32	UTSW	19	10475054	missense	probably damaging	1.00
R0268:Ppp1r32	UTSW	19	10477085	missense	possibly damaging	0.88
R1018:Ppp1r32	UTSW	19	10479460	splice site	probably benign
R1559:Ppp1r32	UTSW	19	10481406	missense	probably benign	0.01
R2384:Ppp1r32	UTSW	19	10481282	critical splice donor site	probably null
R4362:Ppp1r32	UTSW	19	10475021	missense	probably damaging	1.00
R4884:Ppp1r32	UTSW	19	10474501	makesense	probably null
R5998:Ppp1r32	UTSW	19	10481352	missense	possibly damaging	0.50
R6130:Ppp1r32	UTSW	19	10477764	missense	probably benign	0.16
R6360:Ppp1r32	UTSW	19	10479481	missense	probably damaging	1.00
R6388:Ppp1r32	UTSW	19	10482301	missense	probably damaging	1.00
R6625:Ppp1r32	UTSW	19	10481736	missense	probably damaging	0.97
R6754:Ppp1r32	UTSW	19	10477089	missense	probably damaging	1.00
R7188:Ppp1r32	UTSW	19	10482338	missense	probably benign	0.15
R7361:Ppp1r32	UTSW	19	10479579	missense	probably damaging	1.00
R7679:Ppp1r32	UTSW	19	10482254	missense	probably damaging	1.00
R8157:Ppp1r32	UTSW	19	10478265	missense	probably damaging	1.00
R8797:Ppp1r32	UTSW	19	10478238	missense	probably benign	0.43
R8859:Ppp1r32	UTSW	19	10482235	missense	probably damaging	1.00
R9315:Ppp1r32	UTSW	19	10481403	missense	probably damaging	1.00

Posted On

2015-04-16