Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02666:Vmn2r4'

302720

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r4

Ensembl Gene

ENSMUSG00000092049

Gene Name

vomeronasal 2, receptor 4

Synonyms

EG637053

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

IGL02666

Quality Score

Status

Chromosome

Chromosomal Location

64388621-64415296 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 64389012 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 784 (I784T)

Ref Sequence

ENSEMBL: ENSMUSP00000135228 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170280] [ENSMUST00000175724]

AlphaFold

K7N784

Predicted Effect

probably benign
Transcript: ENSMUST00000170280
AA Change: I695T

PolyPhen 2 Score 0.103 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000127513
Gene: ENSMUSG00000092049
AA Change: I695T

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	1	416	2.7e-72	PFAM
Pfam:Peripla_BP_6	61	240	1.9e-9	PFAM
Pfam:NCD3G	458	511	1.1e-17	PFAM
Pfam:7tm_3	542	779	1.8e-75	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000175724
AA Change: I784T

PolyPhen 2 Score 0.103 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000135228
Gene: ENSMUSG00000092049
AA Change: I784T

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	88	505	2.3e-75	PFAM
Pfam:NCD3G	547	600	4.7e-17	PFAM
Pfam:7tm_3	633	867	8.2e-47	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9230109A22Rik	T	C	15: 25,138,858		noncoding transcript	Het
Abca15	G	A	7: 120,335,208	V136M	probably damaging	Het
Abhd3	A	G	18: 10,645,148	I382T	probably benign	Het
Cux1	C	A	5: 136,275,315	E1336*	probably null	Het
Cyb5r3	T	C	15: 83,160,353	I155V	probably damaging	Het
Ddx24	T	C	12: 103,424,055	T226A	possibly damaging	Het
Diexf	G	A	1: 193,107,596	Q752*	probably null	Het
Dld	T	C	12: 31,332,409	N465S	probably null	Het
Dnmbp	A	G	19: 43,854,127		probably benign	Het
Dock9	T	C	14: 121,580,699	H1580R	probably benign	Het
Drd3	C	A	16: 43,816,956		probably benign	Het
Gabrb2	G	T	11: 42,529,495		probably null	Het
Gbp9	T	C	5: 105,094,275		probably null	Het
Inhba	A	T	13: 16,027,079	I409F	possibly damaging	Het
Iqgap2	T	C	13: 95,628,056	N1560S	probably damaging	Het
Itsn1	A	G	16: 91,820,718		probably benign	Het
Kat6b	T	C	14: 21,628,870	F434L	probably damaging	Het
Klra1	A	G	6: 130,364,315	C232R	probably damaging	Het
Krt18	T	A	15: 102,029,867	I175N	probably damaging	Het
Lck	A	G	4: 129,556,419	V178A	probably damaging	Het
Mroh4	C	A	15: 74,609,775	G737V	probably benign	Het
Mug2	A	C	6: 122,081,326	L1282F	probably damaging	Het
Myo9a	A	G	9: 59,924,904	N2572S	probably benign	Het
Nup88	G	T	11: 70,943,869		probably benign	Het
Nxph3	G	T	11: 95,511,008	H193Q	possibly damaging	Het
Olfr1447	G	T	19: 12,900,857	H308N	probably benign	Het
Orm2	A	G	4: 63,365,733	T198A	possibly damaging	Het
Pom121	T	C	5: 135,386,832	I397V	unknown	Het
Prex1	C	A	2: 166,572,989	E1313D	probably benign	Het
Prkg2	T	A	5: 98,997,519		probably benign	Het
Prl2a1	A	T	13: 27,806,327	K86N	possibly damaging	Het
Ptpro	G	A	6: 137,378,059	S188N	probably damaging	Het
Ptprz1	A	T	6: 23,001,210	I1100F	probably benign	Het
Ryr1	C	A	7: 29,019,763	M4406I	unknown	Het
Sdf4	T	A	4: 156,008,824	Y204*	probably null	Het
Serinc1	A	T	10: 57,523,993		probably null	Het
Slc39a5	C	T	10: 128,398,455	R193H	probably damaging	Het
Smad9	A	G	3: 54,782,467	K36R	probably damaging	Het
Spam1	T	A	6: 24,796,124	L25I	possibly damaging	Het
Stab2	A	T	10: 86,850,902	S809R	possibly damaging	Het
Szt2	G	A	4: 118,374,055	R35C	probably damaging	Het
Tcaf2	C	A	6: 42,629,124		probably benign	Het
Tfap2d	A	C	1: 19,104,755	D144A	probably benign	Het
Tmprss11d	A	T	5: 86,331,193	V117D	probably damaging	Het
Tnxb	A	G	17: 34,684,939	D1141G	probably benign	Het
Traf6	A	T	2: 101,697,167	T421S	possibly damaging	Het
Txndc16	G	A	14: 45,211,150		probably benign	Het
Vmn1r73	C	A	7: 11,756,938	P228T	probably damaging	Het
Zfp420	A	G	7: 29,874,370	D5G	probably benign	Het

Other mutations in Vmn2r4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01310:Vmn2r4	APN	3	64409779	splice site	probably null
IGL01448:Vmn2r4	APN	3	64406395	missense	probably damaging	0.99
IGL01452:Vmn2r4	APN	3	64406395	missense	probably damaging	0.99
IGL01454:Vmn2r4	APN	3	64406395	missense	probably damaging	0.99
IGL01456:Vmn2r4	APN	3	64406395	missense	probably damaging	0.99
IGL01463:Vmn2r4	APN	3	64406395	missense	probably damaging	0.99
IGL01467:Vmn2r4	APN	3	64406395	missense	probably damaging	0.99
IGL01468:Vmn2r4	APN	3	64406395	missense	probably damaging	0.99
IGL01470:Vmn2r4	APN	3	64406395	missense	probably damaging	0.99
IGL01476:Vmn2r4	APN	3	64406395	missense	probably damaging	0.99
IGL01481:Vmn2r4	APN	3	64406395	missense	probably damaging	0.99
IGL01534:Vmn2r4	APN	3	64406423	missense	probably damaging	1.00
IGL01636:Vmn2r4	APN	3	64406236	missense	probably benign	0.21
IGL01879:Vmn2r4	APN	3	64391010	missense	probably damaging	1.00
IGL02147:Vmn2r4	APN	3	64398361	splice site	probably benign
IGL02276:Vmn2r4	APN	3	64406456	missense	possibly damaging	0.95
IGL02432:Vmn2r4	APN	3	64406400	missense	probably benign	0.38
IGL02533:Vmn2r4	APN	3	64398419	nonsense	probably null
IGL02655:Vmn2r4	APN	3	64398465	missense	probably damaging	0.97
IGL02902:Vmn2r4	APN	3	64406916	missense	probably benign	0.22
IGL03189:Vmn2r4	APN	3	64389168	missense	possibly damaging	0.89
IGL03250:Vmn2r4	APN	3	64406642	missense	probably damaging	1.00
IGL03271:Vmn2r4	APN	3	64398429	missense	probably benign	0.01
R0310:Vmn2r4	UTSW	3	64389434	nonsense	probably null
R0504:Vmn2r4	UTSW	3	64389363	missense	probably damaging	1.00
R1546:Vmn2r4	UTSW	3	64406888	missense	probably damaging	1.00
R1562:Vmn2r4	UTSW	3	64389444	missense	probably damaging	0.98
R1863:Vmn2r4	UTSW	3	64406989	missense	probably benign	0.33
R1873:Vmn2r4	UTSW	3	64391058	missense	possibly damaging	0.93
R1939:Vmn2r4	UTSW	3	64398555	missense	probably benign	0.00
R2103:Vmn2r4	UTSW	3	64415283	missense	possibly damaging	0.48
R3083:Vmn2r4	UTSW	3	64389367	missense	probably damaging	1.00
R3687:Vmn2r4	UTSW	3	64389475	missense	possibly damaging	0.93
R3707:Vmn2r4	UTSW	3	64389474	missense	probably damaging	0.99
R3963:Vmn2r4	UTSW	3	64415151	missense	probably damaging	0.99
R4428:Vmn2r4	UTSW	3	64415169	missense	probably damaging	1.00
R4710:Vmn2r4	UTSW	3	64409780	critical splice donor site	probably null
R4737:Vmn2r4	UTSW	3	64409963	missense	probably damaging	1.00
R4767:Vmn2r4	UTSW	3	64390976	missense	probably damaging	0.99
R4776:Vmn2r4	UTSW	3	64388661	missense	probably damaging	0.96
R4834:Vmn2r4	UTSW	3	64410063	missense	probably benign	0.40
R4893:Vmn2r4	UTSW	3	64406255	missense	probably damaging	0.96
R4908:Vmn2r4	UTSW	3	64389055	missense	possibly damaging	0.59
R5049:Vmn2r4	UTSW	3	64398598	splice site	probably null
R5092:Vmn2r4	UTSW	3	64390952	missense	probably benign	0.01
R5234:Vmn2r4	UTSW	3	64398457	missense	possibly damaging	0.88
R5240:Vmn2r4	UTSW	3	64406937	missense	possibly damaging	0.53
R5704:Vmn2r4	UTSW	3	64409949	missense	probably benign	0.03
R5897:Vmn2r4	UTSW	3	64415266	nonsense	probably null
R5907:Vmn2r4	UTSW	3	64391066	missense	probably damaging	0.99
R5924:Vmn2r4	UTSW	3	64389264	missense	probably damaging	1.00
R6145:Vmn2r4	UTSW	3	64406943	missense	probably benign	0.00
R6191:Vmn2r4	UTSW	3	64415281	missense	probably benign	0.34
R6192:Vmn2r4	UTSW	3	64415278	missense	probably benign	0.00
R6207:Vmn2r4	UTSW	3	64406505	missense	probably damaging	1.00
R6457:Vmn2r4	UTSW	3	64409957	missense	probably damaging	1.00
R6533:Vmn2r4	UTSW	3	64415098	missense	probably benign
R6545:Vmn2r4	UTSW	3	64406356	missense	possibly damaging	0.50
R6594:Vmn2r4	UTSW	3	64389310	missense	probably damaging	1.00
R7049:Vmn2r4	UTSW	3	64389129	missense	probably benign	0.14
R7150:Vmn2r4	UTSW	3	64398477	missense	probably benign	0.01
R7187:Vmn2r4	UTSW	3	64415260	missense	probably benign	0.00
R7363:Vmn2r4	UTSW	3	64407011	missense	probably damaging	1.00
R7477:Vmn2r4	UTSW	3	64398429	missense	probably benign	0.01
R7675:Vmn2r4	UTSW	3	64415236	missense	probably benign	0.01
R7858:Vmn2r4	UTSW	3	64409805	missense	probably benign	0.00
R7888:Vmn2r4	UTSW	3	64406522	missense	probably damaging	0.99
R8678:Vmn2r4	UTSW	3	64406970	missense	probably benign
R8743:Vmn2r4	UTSW	3	64409826	missense	possibly damaging	0.95
R8841:Vmn2r4	UTSW	3	64406637	missense	probably damaging	0.97
R9671:Vmn2r4	UTSW	3	64409850	missense	probably benign	0.00
R9778:Vmn2r4	UTSW	3	64415076	missense	probably benign	0.15
X0019:Vmn2r4	UTSW	3	64406636	missense	probably damaging	0.99

Posted On

2015-04-16