Incidental Mutation 'IGL02666:Zfp420'
ID302731
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp420
Ensembl Gene ENSMUSG00000058402
Gene Namezinc finger protein 420
SynonymsB230312I18Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02666
Quality Score
Status
Chromosome7
Chromosomal Location29859979-29877292 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 29874370 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 5 (D5G)
Ref Sequence ENSEMBL: ENSMUSP00000074417 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057652] [ENSMUST00000074876]
Predicted Effect probably benign
Transcript: ENSMUST00000057652
AA Change: D5G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000056077
Gene: ENSMUSG00000058402
AA Change: D5G

DomainStartEndE-ValueType
ZnF_C2H2 29 51 4.87e-4 SMART
ZnF_C2H2 57 79 2.24e-3 SMART
ZnF_C2H2 85 107 6.88e-4 SMART
ZnF_C2H2 113 135 5.99e-4 SMART
ZnF_C2H2 141 163 1.04e-3 SMART
ZnF_C2H2 169 191 4.17e-3 SMART
ZnF_C2H2 197 219 2.53e-2 SMART
ZnF_C2H2 225 247 4.47e-3 SMART
ZnF_C2H2 253 275 3.95e-4 SMART
ZnF_C2H2 281 303 2.27e-4 SMART
ZnF_C2H2 309 331 3.44e-4 SMART
ZnF_C2H2 337 359 9.73e-4 SMART
ZnF_C2H2 365 387 3.95e-4 SMART
ZnF_C2H2 393 415 2.2e-2 SMART
ZnF_C2H2 421 443 2.95e-3 SMART
ZnF_C2H2 449 471 2.61e-4 SMART
ZnF_C2H2 477 499 2.24e-3 SMART
ZnF_C2H2 505 527 2.57e-3 SMART
ZnF_C2H2 533 555 1.22e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000074876
AA Change: D5G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000074417
Gene: ENSMUSG00000058402
AA Change: D5G

DomainStartEndE-ValueType
ZnF_C2H2 29 51 4.87e-4 SMART
ZnF_C2H2 57 79 2.24e-3 SMART
ZnF_C2H2 85 107 6.88e-4 SMART
ZnF_C2H2 113 135 5.99e-4 SMART
ZnF_C2H2 141 163 1.04e-3 SMART
ZnF_C2H2 169 191 4.17e-3 SMART
ZnF_C2H2 197 219 2.53e-2 SMART
ZnF_C2H2 225 247 4.47e-3 SMART
ZnF_C2H2 253 275 3.95e-4 SMART
ZnF_C2H2 281 303 2.27e-4 SMART
ZnF_C2H2 309 331 3.44e-4 SMART
ZnF_C2H2 337 359 9.73e-4 SMART
ZnF_C2H2 365 387 3.95e-4 SMART
ZnF_C2H2 393 415 2.2e-2 SMART
ZnF_C2H2 421 443 2.95e-3 SMART
ZnF_C2H2 449 471 2.61e-4 SMART
ZnF_C2H2 477 499 2.24e-3 SMART
ZnF_C2H2 505 527 2.57e-3 SMART
ZnF_C2H2 533 555 1.22e-4 SMART
Pfam:zf-C2H2_6 561 578 1.6e0 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130272
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145952
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a KRAB-type zinc finger protein that negatively-regulates p53-mediated apoptosis. Under stress conditions, the encoded protein is phosphorylated by ATM and dissociates from p53, which activates p53 and initiates apoptosis. [provided by RefSeq, Jul 2016]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9230109A22Rik T C 15: 25,138,858 noncoding transcript Het
Abca15 G A 7: 120,335,208 V136M probably damaging Het
Abhd3 A G 18: 10,645,148 I382T probably benign Het
Cux1 C A 5: 136,275,315 E1336* probably null Het
Cyb5r3 T C 15: 83,160,353 I155V probably damaging Het
Ddx24 T C 12: 103,424,055 T226A possibly damaging Het
Diexf G A 1: 193,107,596 Q752* probably null Het
Dld T C 12: 31,332,409 N465S probably null Het
Dnmbp A G 19: 43,854,127 probably benign Het
Dock9 T C 14: 121,580,699 H1580R probably benign Het
Drd3 C A 16: 43,816,956 probably benign Het
Gabrb2 G T 11: 42,529,495 probably null Het
Gbp9 T C 5: 105,094,275 probably null Het
Inhba A T 13: 16,027,079 I409F possibly damaging Het
Iqgap2 T C 13: 95,628,056 N1560S probably damaging Het
Itsn1 A G 16: 91,820,718 probably benign Het
Kat6b T C 14: 21,628,870 F434L probably damaging Het
Klra1 A G 6: 130,364,315 C232R probably damaging Het
Krt18 T A 15: 102,029,867 I175N probably damaging Het
Lck A G 4: 129,556,419 V178A probably damaging Het
Mroh4 C A 15: 74,609,775 G737V probably benign Het
Mug2 A C 6: 122,081,326 L1282F probably damaging Het
Myo9a A G 9: 59,924,904 N2572S probably benign Het
Nup88 G T 11: 70,943,869 probably benign Het
Nxph3 G T 11: 95,511,008 H193Q possibly damaging Het
Olfr1447 G T 19: 12,900,857 H308N probably benign Het
Orm2 A G 4: 63,365,733 T198A possibly damaging Het
Pom121 T C 5: 135,386,832 I397V unknown Het
Prex1 C A 2: 166,572,989 E1313D probably benign Het
Prkg2 T A 5: 98,997,519 probably benign Het
Prl2a1 A T 13: 27,806,327 K86N possibly damaging Het
Ptpro G A 6: 137,378,059 S188N probably damaging Het
Ptprz1 A T 6: 23,001,210 I1100F probably benign Het
Ryr1 C A 7: 29,019,763 M4406I unknown Het
Sdf4 T A 4: 156,008,824 Y204* probably null Het
Serinc1 A T 10: 57,523,993 probably null Het
Slc39a5 C T 10: 128,398,455 R193H probably damaging Het
Smad9 A G 3: 54,782,467 K36R probably damaging Het
Spam1 T A 6: 24,796,124 L25I possibly damaging Het
Stab2 A T 10: 86,850,902 S809R possibly damaging Het
Szt2 G A 4: 118,374,055 R35C probably damaging Het
Tcaf2 C A 6: 42,629,124 probably benign Het
Tfap2d A C 1: 19,104,755 D144A probably benign Het
Tmprss11d A T 5: 86,331,193 V117D probably damaging Het
Tnxb A G 17: 34,684,939 D1141G probably benign Het
Traf6 A T 2: 101,697,167 T421S possibly damaging Het
Txndc16 G A 14: 45,211,150 probably benign Het
Vmn1r73 C A 7: 11,756,938 P228T probably damaging Het
Vmn2r4 A G 3: 64,389,012 I784T probably benign Het
Other mutations in Zfp420
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00582:Zfp420 APN 7 29875093 missense probably damaging 1.00
IGL00963:Zfp420 APN 7 29875093 missense probably damaging 1.00
IGL03267:Zfp420 APN 7 29875483 missense probably damaging 0.97
PIT4585001:Zfp420 UTSW 7 29876005 missense probably benign
R0033:Zfp420 UTSW 7 29874562 missense probably benign 0.00
R0282:Zfp420 UTSW 7 29875680 missense probably benign 0.14
R0659:Zfp420 UTSW 7 29875539 missense probably damaging 1.00
R1888:Zfp420 UTSW 7 29874508 missense probably damaging 1.00
R1888:Zfp420 UTSW 7 29874508 missense probably damaging 1.00
R1894:Zfp420 UTSW 7 29874508 missense probably damaging 1.00
R4041:Zfp420 UTSW 7 29876002 missense probably benign
R4834:Zfp420 UTSW 7 29874334 start gained probably benign
R6979:Zfp420 UTSW 7 29876021 missense probably damaging 1.00
R7168:Zfp420 UTSW 7 29875366 missense probably damaging 1.00
Posted On2015-04-16