Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02666:Zfp420'

302731

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp420

Ensembl Gene

ENSMUSG00000058402

Gene Name

zinc finger protein 420

Synonyms

B230312I18Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02666

Quality Score

Status

Chromosome

Chromosomal Location

29559404-29576717 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 29573795 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 5 (D5G)

Ref Sequence

ENSEMBL: ENSMUSP00000074417 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057652] [ENSMUST00000074876]

AlphaFold

Q7TMN8

Predicted Effect

probably benign
Transcript: ENSMUST00000057652
AA Change: D5G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000056077
Gene: ENSMUSG00000058402
AA Change: D5G

Domain	Start	End	E-Value	Type
ZnF_C2H2	29	51	4.87e-4	SMART
ZnF_C2H2	57	79	2.24e-3	SMART
ZnF_C2H2	85	107	6.88e-4	SMART
ZnF_C2H2	113	135	5.99e-4	SMART
ZnF_C2H2	141	163	1.04e-3	SMART
ZnF_C2H2	169	191	4.17e-3	SMART
ZnF_C2H2	197	219	2.53e-2	SMART
ZnF_C2H2	225	247	4.47e-3	SMART
ZnF_C2H2	253	275	3.95e-4	SMART
ZnF_C2H2	281	303	2.27e-4	SMART
ZnF_C2H2	309	331	3.44e-4	SMART
ZnF_C2H2	337	359	9.73e-4	SMART
ZnF_C2H2	365	387	3.95e-4	SMART
ZnF_C2H2	393	415	2.2e-2	SMART
ZnF_C2H2	421	443	2.95e-3	SMART
ZnF_C2H2	449	471	2.61e-4	SMART
ZnF_C2H2	477	499	2.24e-3	SMART
ZnF_C2H2	505	527	2.57e-3	SMART
ZnF_C2H2	533	555	1.22e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000074876
AA Change: D5G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000074417
Gene: ENSMUSG00000058402
AA Change: D5G

Domain	Start	End	E-Value	Type
ZnF_C2H2	29	51	4.87e-4	SMART
ZnF_C2H2	57	79	2.24e-3	SMART
ZnF_C2H2	85	107	6.88e-4	SMART
ZnF_C2H2	113	135	5.99e-4	SMART
ZnF_C2H2	141	163	1.04e-3	SMART
ZnF_C2H2	169	191	4.17e-3	SMART
ZnF_C2H2	197	219	2.53e-2	SMART
ZnF_C2H2	225	247	4.47e-3	SMART
ZnF_C2H2	253	275	3.95e-4	SMART
ZnF_C2H2	281	303	2.27e-4	SMART
ZnF_C2H2	309	331	3.44e-4	SMART
ZnF_C2H2	337	359	9.73e-4	SMART
ZnF_C2H2	365	387	3.95e-4	SMART
ZnF_C2H2	393	415	2.2e-2	SMART
ZnF_C2H2	421	443	2.95e-3	SMART
ZnF_C2H2	449	471	2.61e-4	SMART
ZnF_C2H2	477	499	2.24e-3	SMART
ZnF_C2H2	505	527	2.57e-3	SMART
ZnF_C2H2	533	555	1.22e-4	SMART
Pfam:zf-C2H2_6	561	578	1.6e0	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000130272

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000145952

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a KRAB-type zinc finger protein that negatively-regulates p53-mediated apoptosis. Under stress conditions, the encoded protein is phosphorylated by ATM and dissociates from p53, which activates p53 and initiates apoptosis. [provided by RefSeq, Jul 2016]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9230109A22Rik	T	C	15: 25,138,944 (GRCm39)		noncoding transcript	Het
Abca15	G	A	7: 119,934,431 (GRCm39)	V136M	probably damaging	Het
Abhd3	A	G	18: 10,645,148 (GRCm39)	I382T	probably benign	Het
Cux1	C	A	5: 136,304,169 (GRCm39)	E1336*	probably null	Het
Cyb5r3	T	C	15: 83,044,554 (GRCm39)	I155V	probably damaging	Het
Ddx24	T	C	12: 103,390,314 (GRCm39)	T226A	possibly damaging	Het
Dld	T	C	12: 31,382,408 (GRCm39)	N465S	probably null	Het
Dnmbp	A	G	19: 43,842,566 (GRCm39)		probably benign	Het
Dock9	T	C	14: 121,818,111 (GRCm39)	H1580R	probably benign	Het
Drd3	C	A	16: 43,637,319 (GRCm39)		probably benign	Het
Gabrb2	G	T	11: 42,420,322 (GRCm39)		probably null	Het
Gbp9	T	C	5: 105,242,141 (GRCm39)		probably null	Het
Inhba	A	T	13: 16,201,664 (GRCm39)	I409F	possibly damaging	Het
Iqgap2	T	C	13: 95,764,564 (GRCm39)	N1560S	probably damaging	Het
Itsn1	A	G	16: 91,617,606 (GRCm39)		probably benign	Het
Kat6b	T	C	14: 21,678,938 (GRCm39)	F434L	probably damaging	Het
Klra1	A	G	6: 130,341,278 (GRCm39)	C232R	probably damaging	Het
Krt18	T	A	15: 101,938,302 (GRCm39)	I175N	probably damaging	Het
Lck	A	G	4: 129,450,212 (GRCm39)	V178A	probably damaging	Het
Mroh4	C	A	15: 74,481,624 (GRCm39)	G737V	probably benign	Het
Mug2	A	C	6: 122,058,285 (GRCm39)	L1282F	probably damaging	Het
Myo9a	A	G	9: 59,832,187 (GRCm39)	N2572S	probably benign	Het
Nup88	G	T	11: 70,834,695 (GRCm39)		probably benign	Het
Nxph3	G	T	11: 95,401,834 (GRCm39)	H193Q	possibly damaging	Het
Or5b97	G	T	19: 12,878,221 (GRCm39)	H308N	probably benign	Het
Orm2	A	G	4: 63,283,970 (GRCm39)	T198A	possibly damaging	Het
Pom121	T	C	5: 135,415,686 (GRCm39)	I397V	unknown	Het
Prex1	C	A	2: 166,414,909 (GRCm39)	E1313D	probably benign	Het
Prkg2	T	A	5: 99,145,378 (GRCm39)		probably benign	Het
Prl2a1	A	T	13: 27,990,310 (GRCm39)	K86N	possibly damaging	Het
Ptpro	G	A	6: 137,355,057 (GRCm39)	S188N	probably damaging	Het
Ptprz1	A	T	6: 23,001,209 (GRCm39)	I1100F	probably benign	Het
Ryr1	C	A	7: 28,719,188 (GRCm39)	M4406I	unknown	Het
Sdf4	T	A	4: 156,093,281 (GRCm39)	Y204*	probably null	Het
Serinc1	A	T	10: 57,400,089 (GRCm39)		probably null	Het
Slc39a5	C	T	10: 128,234,324 (GRCm39)	R193H	probably damaging	Het
Smad9	A	G	3: 54,689,888 (GRCm39)	K36R	probably damaging	Het
Spam1	T	A	6: 24,796,123 (GRCm39)	L25I	possibly damaging	Het
Stab2	A	T	10: 86,686,766 (GRCm39)	S809R	possibly damaging	Het
Szt2	G	A	4: 118,231,252 (GRCm39)	R35C	probably damaging	Het
Tcaf2	C	A	6: 42,606,058 (GRCm39)		probably benign	Het
Tfap2d	A	C	1: 19,174,979 (GRCm39)	D144A	probably benign	Het
Tmprss11d	A	T	5: 86,479,052 (GRCm39)	V117D	probably damaging	Het
Tnxb	A	G	17: 34,903,913 (GRCm39)	D1141G	probably benign	Het
Traf6	A	T	2: 101,527,512 (GRCm39)	T421S	possibly damaging	Het
Txndc16	G	A	14: 45,448,607 (GRCm39)		probably benign	Het
Utp25	G	A	1: 192,789,904 (GRCm39)	Q752*	probably null	Het
Vmn1r73	C	A	7: 11,490,865 (GRCm39)	P228T	probably damaging	Het
Vmn2r4	A	G	3: 64,296,433 (GRCm39)	I784T	probably benign	Het

Other mutations in Zfp420

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00582:Zfp420	APN	7	29,574,518 (GRCm39)	missense	probably damaging	1.00
IGL00963:Zfp420	APN	7	29,574,518 (GRCm39)	missense	probably damaging	1.00
IGL03267:Zfp420	APN	7	29,574,908 (GRCm39)	missense	probably damaging	0.97
PIT4585001:Zfp420	UTSW	7	29,575,430 (GRCm39)	missense	probably benign
R0033:Zfp420	UTSW	7	29,573,987 (GRCm39)	missense	probably benign	0.00
R0282:Zfp420	UTSW	7	29,575,105 (GRCm39)	missense	probably benign	0.14
R0659:Zfp420	UTSW	7	29,574,964 (GRCm39)	missense	probably damaging	1.00
R1888:Zfp420	UTSW	7	29,573,933 (GRCm39)	missense	probably damaging	1.00
R1888:Zfp420	UTSW	7	29,573,933 (GRCm39)	missense	probably damaging	1.00
R1894:Zfp420	UTSW	7	29,573,933 (GRCm39)	missense	probably damaging	1.00
R4041:Zfp420	UTSW	7	29,575,427 (GRCm39)	missense	probably benign
R4834:Zfp420	UTSW	7	29,573,759 (GRCm39)	start gained	probably benign
R6979:Zfp420	UTSW	7	29,575,446 (GRCm39)	missense	probably damaging	1.00
R7168:Zfp420	UTSW	7	29,574,791 (GRCm39)	missense	probably damaging	1.00
R8386:Zfp420	UTSW	7	29,575,043 (GRCm39)	missense	probably benign	0.34
R9480:Zfp420	UTSW	7	29,575,497 (GRCm39)	missense	probably benign
R9574:Zfp420	UTSW	7	29,575,480 (GRCm39)	nonsense	probably null
Z1176:Zfp420	UTSW	7	29,574,911 (GRCm39)	missense	possibly damaging	0.51
Z1186:Zfp420	UTSW	7	29,574,949 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16