Incidental Mutation 'IGL02666:Utp25'
ID 302732
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Utp25
Ensembl Gene ENSMUSG00000016181
Gene Name UTP25 small subunit processome component
Synonyms AA408296, mDef, Diexf
Accession Numbers
Essential gene? Probably essential (E-score: 0.970) question?
Stock # IGL02666
Quality Score
Status
Chromosome 1
Chromosomal Location 192786707-192812603 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 192789904 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Stop codon at position 752 (Q752*)
Ref Sequence ENSEMBL: ENSMUSP00000082691 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085555] [ENSMUST00000193460] [ENSMUST00000195291]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000085555
AA Change: Q752*
SMART Domains Protein: ENSMUSP00000082691
Gene: ENSMUSG00000016181
AA Change: Q752*

DomainStartEndE-ValueType
low complexity region 51 70 N/A INTRINSIC
coiled coil region 72 113 N/A INTRINSIC
low complexity region 123 139 N/A INTRINSIC
low complexity region 217 224 N/A INTRINSIC
Pfam:UTP25 288 763 6.1e-200 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000193070
Predicted Effect probably benign
Transcript: ENSMUST00000193460
SMART Domains Protein: ENSMUSP00000142059
Gene: ENSMUSG00000016181

DomainStartEndE-ValueType
Pfam:DUF1253 1 205 6.8e-78 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000194412
Predicted Effect probably benign
Transcript: ENSMUST00000195291
SMART Domains Protein: ENSMUSP00000141676
Gene: ENSMUSG00000016181

DomainStartEndE-ValueType
low complexity region 51 70 N/A INTRINSIC
coiled coil region 72 113 N/A INTRINSIC
low complexity region 123 139 N/A INTRINSIC
low complexity region 217 224 N/A INTRINSIC
Pfam:DUF1253 325 634 6.9e-100 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9230109A22Rik T C 15: 25,138,944 (GRCm39) noncoding transcript Het
Abca15 G A 7: 119,934,431 (GRCm39) V136M probably damaging Het
Abhd3 A G 18: 10,645,148 (GRCm39) I382T probably benign Het
Cux1 C A 5: 136,304,169 (GRCm39) E1336* probably null Het
Cyb5r3 T C 15: 83,044,554 (GRCm39) I155V probably damaging Het
Ddx24 T C 12: 103,390,314 (GRCm39) T226A possibly damaging Het
Dld T C 12: 31,382,408 (GRCm39) N465S probably null Het
Dnmbp A G 19: 43,842,566 (GRCm39) probably benign Het
Dock9 T C 14: 121,818,111 (GRCm39) H1580R probably benign Het
Drd3 C A 16: 43,637,319 (GRCm39) probably benign Het
Gabrb2 G T 11: 42,420,322 (GRCm39) probably null Het
Gbp9 T C 5: 105,242,141 (GRCm39) probably null Het
Inhba A T 13: 16,201,664 (GRCm39) I409F possibly damaging Het
Iqgap2 T C 13: 95,764,564 (GRCm39) N1560S probably damaging Het
Itsn1 A G 16: 91,617,606 (GRCm39) probably benign Het
Kat6b T C 14: 21,678,938 (GRCm39) F434L probably damaging Het
Klra1 A G 6: 130,341,278 (GRCm39) C232R probably damaging Het
Krt18 T A 15: 101,938,302 (GRCm39) I175N probably damaging Het
Lck A G 4: 129,450,212 (GRCm39) V178A probably damaging Het
Mroh4 C A 15: 74,481,624 (GRCm39) G737V probably benign Het
Mug2 A C 6: 122,058,285 (GRCm39) L1282F probably damaging Het
Myo9a A G 9: 59,832,187 (GRCm39) N2572S probably benign Het
Nup88 G T 11: 70,834,695 (GRCm39) probably benign Het
Nxph3 G T 11: 95,401,834 (GRCm39) H193Q possibly damaging Het
Or5b97 G T 19: 12,878,221 (GRCm39) H308N probably benign Het
Orm2 A G 4: 63,283,970 (GRCm39) T198A possibly damaging Het
Pom121 T C 5: 135,415,686 (GRCm39) I397V unknown Het
Prex1 C A 2: 166,414,909 (GRCm39) E1313D probably benign Het
Prkg2 T A 5: 99,145,378 (GRCm39) probably benign Het
Prl2a1 A T 13: 27,990,310 (GRCm39) K86N possibly damaging Het
Ptpro G A 6: 137,355,057 (GRCm39) S188N probably damaging Het
Ptprz1 A T 6: 23,001,209 (GRCm39) I1100F probably benign Het
Ryr1 C A 7: 28,719,188 (GRCm39) M4406I unknown Het
Sdf4 T A 4: 156,093,281 (GRCm39) Y204* probably null Het
Serinc1 A T 10: 57,400,089 (GRCm39) probably null Het
Slc39a5 C T 10: 128,234,324 (GRCm39) R193H probably damaging Het
Smad9 A G 3: 54,689,888 (GRCm39) K36R probably damaging Het
Spam1 T A 6: 24,796,123 (GRCm39) L25I possibly damaging Het
Stab2 A T 10: 86,686,766 (GRCm39) S809R possibly damaging Het
Szt2 G A 4: 118,231,252 (GRCm39) R35C probably damaging Het
Tcaf2 C A 6: 42,606,058 (GRCm39) probably benign Het
Tfap2d A C 1: 19,174,979 (GRCm39) D144A probably benign Het
Tmprss11d A T 5: 86,479,052 (GRCm39) V117D probably damaging Het
Tnxb A G 17: 34,903,913 (GRCm39) D1141G probably benign Het
Traf6 A T 2: 101,527,512 (GRCm39) T421S possibly damaging Het
Txndc16 G A 14: 45,448,607 (GRCm39) probably benign Het
Vmn1r73 C A 7: 11,490,865 (GRCm39) P228T probably damaging Het
Vmn2r4 A G 3: 64,296,433 (GRCm39) I784T probably benign Het
Zfp420 A G 7: 29,573,795 (GRCm39) D5G probably benign Het
Other mutations in Utp25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00754:Utp25 APN 1 192,797,309 (GRCm39) missense probably damaging 1.00
IGL01700:Utp25 APN 1 192,800,573 (GRCm39) missense probably damaging 1.00
IGL02076:Utp25 APN 1 192,812,367 (GRCm39) missense probably damaging 1.00
IGL02121:Utp25 APN 1 192,800,586 (GRCm39) missense probably benign 0.05
IGL02997:Utp25 APN 1 192,802,892 (GRCm39) missense probably benign 0.34
3-1:Utp25 UTSW 1 192,800,588 (GRCm39) missense probably benign 0.07
R0099:Utp25 UTSW 1 192,810,778 (GRCm39) missense probably damaging 1.00
R0395:Utp25 UTSW 1 192,805,984 (GRCm39) missense possibly damaging 0.69
R0502:Utp25 UTSW 1 192,797,136 (GRCm39) splice site probably benign
R0973:Utp25 UTSW 1 192,797,011 (GRCm39) missense probably damaging 0.98
R0973:Utp25 UTSW 1 192,797,011 (GRCm39) missense probably damaging 0.98
R0974:Utp25 UTSW 1 192,797,011 (GRCm39) missense probably damaging 0.98
R1815:Utp25 UTSW 1 192,800,591 (GRCm39) missense probably benign 0.26
R1930:Utp25 UTSW 1 192,800,617 (GRCm39) missense probably damaging 1.00
R1931:Utp25 UTSW 1 192,800,617 (GRCm39) missense probably damaging 1.00
R1937:Utp25 UTSW 1 192,804,401 (GRCm39) missense probably damaging 1.00
R2847:Utp25 UTSW 1 192,810,759 (GRCm39) missense probably benign 0.41
R2848:Utp25 UTSW 1 192,810,759 (GRCm39) missense probably benign 0.41
R3412:Utp25 UTSW 1 192,810,810 (GRCm39) missense possibly damaging 0.93
R3414:Utp25 UTSW 1 192,810,810 (GRCm39) missense possibly damaging 0.93
R4471:Utp25 UTSW 1 192,812,445 (GRCm39) missense possibly damaging 0.68
R4627:Utp25 UTSW 1 192,790,003 (GRCm39) missense probably benign 0.00
R4644:Utp25 UTSW 1 192,810,788 (GRCm39) missense probably damaging 1.00
R4761:Utp25 UTSW 1 192,796,230 (GRCm39) missense probably damaging 1.00
R4791:Utp25 UTSW 1 192,810,575 (GRCm39) missense probably benign
R4793:Utp25 UTSW 1 192,796,116 (GRCm39) missense probably null 0.56
R4858:Utp25 UTSW 1 192,796,072 (GRCm39) missense probably damaging 1.00
R4944:Utp25 UTSW 1 192,797,262 (GRCm39) missense probably damaging 1.00
R5162:Utp25 UTSW 1 192,796,089 (GRCm39) missense probably damaging 1.00
R5347:Utp25 UTSW 1 192,810,687 (GRCm39) missense probably benign
R5837:Utp25 UTSW 1 192,800,701 (GRCm39) missense probably damaging 1.00
R6113:Utp25 UTSW 1 192,811,810 (GRCm39) missense probably null 0.01
R6455:Utp25 UTSW 1 192,810,684 (GRCm39) missense probably benign 0.07
R6563:Utp25 UTSW 1 192,800,698 (GRCm39) missense probably damaging 1.00
R6636:Utp25 UTSW 1 192,796,075 (GRCm39) missense probably damaging 1.00
R7018:Utp25 UTSW 1 192,797,163 (GRCm39) missense probably benign 0.06
R7037:Utp25 UTSW 1 192,803,031 (GRCm39) splice site probably null
R8027:Utp25 UTSW 1 192,800,530 (GRCm39) missense probably benign
R8042:Utp25 UTSW 1 192,796,980 (GRCm39) missense
R8092:Utp25 UTSW 1 192,802,671 (GRCm39) missense probably benign 0.00
R8243:Utp25 UTSW 1 192,796,937 (GRCm39) missense probably benign
R8691:Utp25 UTSW 1 192,796,110 (GRCm39) missense probably benign 0.41
R9485:Utp25 UTSW 1 192,812,541 (GRCm39) unclassified probably benign
RF021:Utp25 UTSW 1 192,802,974 (GRCm39) missense probably benign
X0050:Utp25 UTSW 1 192,806,040 (GRCm39) missense probably benign 0.23
Z1177:Utp25 UTSW 1 192,796,983 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16