Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02668:Vmn2r103'

302791

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r103

Ensembl Gene

ENSMUSG00000091771

Gene Name

vomeronasal 2, receptor 103

Synonyms

EG627636

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

IGL02668

Quality Score

Status

Chromosome

Chromosomal Location

19773363-19812536 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 19794127 bp

Zygosity

Heterozygous

Amino Acid Change

Alanine to Serine at position 394 (A394S)

Ref Sequence

ENSEMBL: ENSMUSP00000126756 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172203]

Predicted Effect

probably benign
Transcript: ENSMUST00000172203
AA Change: A394S

PolyPhen 2 Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: A394S

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	449	1.3e-37	PFAM
Pfam:NCD3G	509	562	3.5e-22	PFAM
Pfam:7tm_3	595	830	1.1e-51	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930596D02Rik	A	G	14: 35,810,117	M167T	probably benign	Het
Abcc4	G	T	14: 118,611,475	S488R	probably damaging	Het
Adprm	G	T	11: 67,040,247	D230E	possibly damaging	Het
Atp2a3	C	A	11: 72,975,339	H262N	probably benign	Het
Casc1	G	T	6: 145,205,257	R30S	unknown	Het
Ccdc66	T	C	14: 27,497,341	K309E	possibly damaging	Het
Cyb561d2	C	T	9: 107,540,172	A127T	probably benign	Het
Dctn1	T	A	6: 83,191,048	M357K	possibly damaging	Het
Diras2	T	C	13: 52,507,770	N167S	probably benign	Het
Dmgdh	T	G	13: 93,703,910	V283G	probably damaging	Het
Dmxl2	A	T	9: 54,416,945	W1052R	probably damaging	Het
Dnah6	A	T	6: 73,121,823	V2083D	possibly damaging	Het
Exoc4	T	G	6: 33,921,532	F895L	probably benign	Het
Fsip1	G	T	2: 118,251,725	A76E	probably benign	Het
Fsip2	A	G	2: 82,998,318	I6820V	probably benign	Het
Hdac10	G	A	15: 89,125,644	P395L	probably benign	Het
Ing3	A	G	6: 21,950,059	D17G	probably damaging	Het
Map3k4	A	T	17: 12,235,953	F1383L	possibly damaging	Het
Mpp6	C	T	6: 50,194,529	T386I	probably damaging	Het
Myct1	C	A	10: 5,604,513	P127T	probably damaging	Het
Olfr593	A	T	7: 103,212,735	I281F	possibly damaging	Het
Osbpl7	G	T	11: 97,067,205	A625S	possibly damaging	Het
Padi2	C	T	4: 140,949,880	R660C	probably benign	Het
Paip1	A	T	13: 119,438,071	I185F	probably damaging	Het
Phykpl	G	A	11: 51,593,687		probably null	Het
Plekhg6	G	A	6: 125,372,803		probably benign	Het
Plxna1	A	T	6: 89,357,269	L126*	probably null	Het
Rchy1	A	T	5: 91,962,718	M1K	probably null	Het
Rfx3	T	C	19: 27,815,614		probably benign	Het
Sdr9c7	T	C	10: 127,902,398	F182L	probably damaging	Het
Sgpl1	A	C	10: 61,105,450	V294G	probably damaging	Het
Sh2b1	A	G	7: 126,472,474	S180P	possibly damaging	Het
Sorbs1	T	C	19: 40,314,681	D488G	probably damaging	Het
Stab2	A	G	10: 86,846,163		probably benign	Het
Sycp1	A	C	3: 102,820,531		probably benign	Het
Tmem245	T	C	4: 56,925,081	K347E	possibly damaging	Het
Tnk1	A	G	11: 69,856,923	M51T	probably damaging	Het
Trpm2	C	T	10: 77,935,942	R621H	probably damaging	Het
Ubd	G	T	17: 37,195,529	R102L	probably benign	Het
Uhrf1bp1	A	C	17: 27,886,575	I692L	possibly damaging	Het
Zfp324	T	A	7: 12,970,846	C321S	probably damaging	Het
Zfp488	G	T	14: 33,970,820	Q129K	probably benign	Het
Zmpste24	T	A	4: 121,061,100	N442Y	probably damaging	Het

Other mutations in Vmn2r103

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00333:Vmn2r103	APN	17	19793102	missense	probably damaging	0.98
IGL00939:Vmn2r103	APN	17	19794965	missense	probably benign	0.00
IGL01120:Vmn2r103	APN	17	19792997	missense	probably benign	0.06
IGL01403:Vmn2r103	APN	17	19792967	missense	probably benign
IGL01404:Vmn2r103	APN	17	19812434	missense	probably damaging	1.00
IGL01713:Vmn2r103	APN	17	19794068	missense	probably damaging	1.00
IGL01802:Vmn2r103	APN	17	19799208	missense	probably benign
IGL02251:Vmn2r103	APN	17	19793969	missense	possibly damaging	0.84
IGL02466:Vmn2r103	APN	17	19773369	missense	probably benign
IGL02555:Vmn2r103	APN	17	19811611	missense	probably damaging	1.00
IGL02715:Vmn2r103	APN	17	19793956	missense	probably damaging	0.97
IGL02735:Vmn2r103	APN	17	19812248	missense	probably benign	0.27
IGL03101:Vmn2r103	APN	17	19773520	missense	probably damaging	0.98
R0003:Vmn2r103	UTSW	17	19811979	missense	probably damaging	0.99
R0052:Vmn2r103	UTSW	17	19811641	missense	probably benign	0.01
R0375:Vmn2r103	UTSW	17	19792859	missense	probably benign	0.06
R0375:Vmn2r103	UTSW	17	19793464	missense	probably benign	0.12
R0755:Vmn2r103	UTSW	17	19773568	missense	probably benign	0.01
R0837:Vmn2r103	UTSW	17	19793927	missense	probably damaging	0.99
R1345:Vmn2r103	UTSW	17	19794247	missense	probably damaging	1.00
R1396:Vmn2r103	UTSW	17	19792968	missense	probably benign
R1488:Vmn2r103	UTSW	17	19793660	missense	probably damaging	0.97
R1533:Vmn2r103	UTSW	17	19773400	missense	probably benign	0.01
R1590:Vmn2r103	UTSW	17	19794234	missense	probably benign
R1928:Vmn2r103	UTSW	17	19811767	missense	possibly damaging	0.95
R1942:Vmn2r103	UTSW	17	19812300	missense	probably benign	0.02
R2071:Vmn2r103	UTSW	17	19793794	missense	probably benign
R2219:Vmn2r103	UTSW	17	19793647	missense	probably damaging	1.00
R2442:Vmn2r103	UTSW	17	19773531	missense	probably benign	0.00
R2889:Vmn2r103	UTSW	17	19793600	missense	probably damaging	1.00
R3762:Vmn2r103	UTSW	17	19812149	missense	probably damaging	0.98
R4014:Vmn2r103	UTSW	17	19793604	missense	possibly damaging	0.67
R4331:Vmn2r103	UTSW	17	19794233	missense	probably benign	0.00
R4630:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4631:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4632:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4660:Vmn2r103	UTSW	17	19811815	missense	probably damaging	1.00
R4801:Vmn2r103	UTSW	17	19795076	missense	probably benign	0.06
R4802:Vmn2r103	UTSW	17	19795076	missense	probably benign	0.06
R4931:Vmn2r103	UTSW	17	19811769	missense	probably benign	0.01
R4995:Vmn2r103	UTSW	17	19773511	missense	probably benign	0.14
R5309:Vmn2r103	UTSW	17	19793034	missense	probably benign	0.01
R5312:Vmn2r103	UTSW	17	19793034	missense	probably benign	0.01
R5329:Vmn2r103	UTSW	17	19812171	missense	probably damaging	1.00
R5611:Vmn2r103	UTSW	17	19793642	missense	probably damaging	0.99
R5684:Vmn2r103	UTSW	17	19792989	missense	probably benign	0.02
R5715:Vmn2r103	UTSW	17	19794939	missense	probably benign	0.17
R5907:Vmn2r103	UTSW	17	19812453	missense	possibly damaging	0.67
R6029:Vmn2r103	UTSW	17	19794216	nonsense	probably null
R6114:Vmn2r103	UTSW	17	19812325	missense	probably damaging	0.99
R6285:Vmn2r103	UTSW	17	19812144	missense	probably benign
R6292:Vmn2r103	UTSW	17	19793604	missense	possibly damaging	0.67
R6334:Vmn2r103	UTSW	17	19794082	missense	probably damaging	0.97
R6501:Vmn2r103	UTSW	17	19811904	missense	probably benign	0.29
R6710:Vmn2r103	UTSW	17	19811977	missense	probably damaging	1.00
R6774:Vmn2r103	UTSW	17	19773511	missense	probably benign	0.14
R6981:Vmn2r103	UTSW	17	19793477	missense	probably benign	0.00
Z1088:Vmn2r103	UTSW	17	19795047	missense	probably benign	0.08

Posted On

2015-04-16