Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02668:Vmn2r103'

302791

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r103

Ensembl Gene

ENSMUSG00000091771

Gene Name

vomeronasal 2, receptor 103

Synonyms

EG627636

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

IGL02668

Quality Score

Status

Chromosome

Chromosomal Location

19773363-19812536 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 19794127 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Serine at position 394 (A394S)

Ref Sequence

ENSEMBL: ENSMUSP00000126756 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172203]

AlphaFold

E9PWW0

Predicted Effect

probably benign
Transcript: ENSMUST00000172203
AA Change: A394S

PolyPhen 2 Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: A394S

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	449	1.3e-37	PFAM
Pfam:NCD3G	509	562	3.5e-22	PFAM
Pfam:7tm_3	595	830	1.1e-51	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930596D02Rik	A	G	14: 35,810,117 (GRCm38)	M167T	probably benign	Het
Abcc4	G	T	14: 118,611,475 (GRCm38)	S488R	probably damaging	Het
Adprm	G	T	11: 67,040,247 (GRCm38)	D230E	possibly damaging	Het
Atp2a3	C	A	11: 72,975,339 (GRCm38)	H262N	probably benign	Het
Casc1	G	T	6: 145,205,257 (GRCm38)	R30S	unknown	Het
Ccdc66	T	C	14: 27,497,341 (GRCm38)	K309E	possibly damaging	Het
Cyb561d2	C	T	9: 107,540,172 (GRCm38)	A127T	probably benign	Het
Dctn1	T	A	6: 83,191,048 (GRCm38)	M357K	possibly damaging	Het
Diras2	T	C	13: 52,507,770 (GRCm38)	N167S	probably benign	Het
Dmgdh	T	G	13: 93,703,910 (GRCm38)	V283G	probably damaging	Het
Dmxl2	A	T	9: 54,416,945 (GRCm38)	W1052R	probably damaging	Het
Dnah6	A	T	6: 73,121,823 (GRCm38)	V2083D	possibly damaging	Het
Exoc4	T	G	6: 33,921,532 (GRCm38)	F895L	probably benign	Het
Fsip1	G	T	2: 118,251,725 (GRCm38)	A76E	probably benign	Het
Fsip2	A	G	2: 82,998,318 (GRCm38)	I6820V	probably benign	Het
Hdac10	G	A	15: 89,125,644 (GRCm38)	P395L	probably benign	Het
Ing3	A	G	6: 21,950,059 (GRCm38)	D17G	probably damaging	Het
Map3k4	A	T	17: 12,235,953 (GRCm38)	F1383L	possibly damaging	Het
Mpp6	C	T	6: 50,194,529 (GRCm38)	T386I	probably damaging	Het
Myct1	C	A	10: 5,604,513 (GRCm38)	P127T	probably damaging	Het
Olfr593	A	T	7: 103,212,735 (GRCm38)	I281F	possibly damaging	Het
Osbpl7	G	T	11: 97,067,205 (GRCm38)	A625S	possibly damaging	Het
Padi2	C	T	4: 140,949,880 (GRCm38)	R660C	probably benign	Het
Paip1	A	T	13: 119,438,071 (GRCm38)	I185F	probably damaging	Het
Phykpl	G	A	11: 51,593,687 (GRCm38)		probably null	Het
Plekhg6	G	A	6: 125,372,803 (GRCm38)		probably benign	Het
Plxna1	A	T	6: 89,357,269 (GRCm38)	L126*	probably null	Het
Rchy1	A	T	5: 91,962,718 (GRCm38)	M1K	probably null	Het
Rfx3	T	C	19: 27,815,614 (GRCm38)		probably benign	Het
Sdr9c7	T	C	10: 127,902,398 (GRCm38)	F182L	probably damaging	Het
Sgpl1	A	C	10: 61,105,450 (GRCm38)	V294G	probably damaging	Het
Sh2b1	A	G	7: 126,472,474 (GRCm38)	S180P	possibly damaging	Het
Sorbs1	T	C	19: 40,314,681 (GRCm38)	D488G	probably damaging	Het
Stab2	A	G	10: 86,846,163 (GRCm38)		probably benign	Het
Sycp1	A	C	3: 102,820,531 (GRCm38)		probably benign	Het
Tmem245	T	C	4: 56,925,081 (GRCm38)	K347E	possibly damaging	Het
Tnk1	A	G	11: 69,856,923 (GRCm38)	M51T	probably damaging	Het
Trpm2	C	T	10: 77,935,942 (GRCm38)	R621H	probably damaging	Het
Ubd	G	T	17: 37,195,529 (GRCm38)	R102L	probably benign	Het
Uhrf1bp1	A	C	17: 27,886,575 (GRCm38)	I692L	possibly damaging	Het
Zfp324	T	A	7: 12,970,846 (GRCm38)	C321S	probably damaging	Het
Zfp488	G	T	14: 33,970,820 (GRCm38)	Q129K	probably benign	Het
Zmpste24	T	A	4: 121,061,100 (GRCm38)	N442Y	probably damaging	Het

Other mutations in Vmn2r103

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00333:Vmn2r103	APN	17	19,793,102 (GRCm38)	missense	probably damaging	0.98
IGL00939:Vmn2r103	APN	17	19,794,965 (GRCm38)	missense	probably benign	0.00
IGL01120:Vmn2r103	APN	17	19,792,997 (GRCm38)	missense	probably benign	0.06
IGL01403:Vmn2r103	APN	17	19,792,967 (GRCm38)	missense	probably benign
IGL01404:Vmn2r103	APN	17	19,812,434 (GRCm38)	missense	probably damaging	1.00
IGL01713:Vmn2r103	APN	17	19,794,068 (GRCm38)	missense	probably damaging	1.00
IGL01802:Vmn2r103	APN	17	19,799,208 (GRCm38)	missense	probably benign
IGL02251:Vmn2r103	APN	17	19,793,969 (GRCm38)	missense	possibly damaging	0.84
IGL02466:Vmn2r103	APN	17	19,773,369 (GRCm38)	missense	probably benign
IGL02555:Vmn2r103	APN	17	19,811,611 (GRCm38)	missense	probably damaging	1.00
IGL02715:Vmn2r103	APN	17	19,793,956 (GRCm38)	missense	probably damaging	0.97
IGL02735:Vmn2r103	APN	17	19,812,248 (GRCm38)	missense	probably benign	0.27
IGL03101:Vmn2r103	APN	17	19,773,520 (GRCm38)	missense	probably damaging	0.98
R0003:Vmn2r103	UTSW	17	19,811,979 (GRCm38)	missense	probably damaging	0.99
R0052:Vmn2r103	UTSW	17	19,811,641 (GRCm38)	missense	probably benign	0.01
R0375:Vmn2r103	UTSW	17	19,793,464 (GRCm38)	missense	probably benign	0.12
R0375:Vmn2r103	UTSW	17	19,792,859 (GRCm38)	missense	probably benign	0.06
R0755:Vmn2r103	UTSW	17	19,773,568 (GRCm38)	missense	probably benign	0.01
R0837:Vmn2r103	UTSW	17	19,793,927 (GRCm38)	missense	probably damaging	0.99
R1345:Vmn2r103	UTSW	17	19,794,247 (GRCm38)	missense	probably damaging	1.00
R1396:Vmn2r103	UTSW	17	19,792,968 (GRCm38)	missense	probably benign
R1488:Vmn2r103	UTSW	17	19,793,660 (GRCm38)	missense	probably damaging	0.97
R1533:Vmn2r103	UTSW	17	19,773,400 (GRCm38)	missense	probably benign	0.01
R1590:Vmn2r103	UTSW	17	19,794,234 (GRCm38)	missense	probably benign
R1928:Vmn2r103	UTSW	17	19,811,767 (GRCm38)	missense	possibly damaging	0.95
R1942:Vmn2r103	UTSW	17	19,812,300 (GRCm38)	missense	probably benign	0.02
R2071:Vmn2r103	UTSW	17	19,793,794 (GRCm38)	missense	probably benign
R2219:Vmn2r103	UTSW	17	19,793,647 (GRCm38)	missense	probably damaging	1.00
R2442:Vmn2r103	UTSW	17	19,773,531 (GRCm38)	missense	probably benign	0.00
R2889:Vmn2r103	UTSW	17	19,793,600 (GRCm38)	missense	probably damaging	1.00
R3762:Vmn2r103	UTSW	17	19,812,149 (GRCm38)	missense	probably damaging	0.98
R4014:Vmn2r103	UTSW	17	19,793,604 (GRCm38)	missense	possibly damaging	0.67
R4331:Vmn2r103	UTSW	17	19,794,233 (GRCm38)	missense	probably benign	0.00
R4630:Vmn2r103	UTSW	17	19,793,696 (GRCm38)	missense	probably benign	0.04
R4631:Vmn2r103	UTSW	17	19,793,696 (GRCm38)	missense	probably benign	0.04
R4632:Vmn2r103	UTSW	17	19,793,696 (GRCm38)	missense	probably benign	0.04
R4660:Vmn2r103	UTSW	17	19,811,815 (GRCm38)	missense	probably damaging	1.00
R4801:Vmn2r103	UTSW	17	19,795,076 (GRCm38)	missense	probably benign	0.06
R4802:Vmn2r103	UTSW	17	19,795,076 (GRCm38)	missense	probably benign	0.06
R4931:Vmn2r103	UTSW	17	19,811,769 (GRCm38)	missense	probably benign	0.01
R4995:Vmn2r103	UTSW	17	19,773,511 (GRCm38)	missense	probably benign	0.14
R5309:Vmn2r103	UTSW	17	19,793,034 (GRCm38)	missense	probably benign	0.01
R5312:Vmn2r103	UTSW	17	19,793,034 (GRCm38)	missense	probably benign	0.01
R5329:Vmn2r103	UTSW	17	19,812,171 (GRCm38)	missense	probably damaging	1.00
R5611:Vmn2r103	UTSW	17	19,793,642 (GRCm38)	missense	probably damaging	0.99
R5684:Vmn2r103	UTSW	17	19,792,989 (GRCm38)	missense	probably benign	0.02
R5715:Vmn2r103	UTSW	17	19,794,939 (GRCm38)	missense	probably benign	0.17
R5907:Vmn2r103	UTSW	17	19,812,453 (GRCm38)	missense	possibly damaging	0.67
R6029:Vmn2r103	UTSW	17	19,794,216 (GRCm38)	nonsense	probably null
R6114:Vmn2r103	UTSW	17	19,812,325 (GRCm38)	missense	probably damaging	0.99
R6285:Vmn2r103	UTSW	17	19,812,144 (GRCm38)	missense	probably benign
R6292:Vmn2r103	UTSW	17	19,793,604 (GRCm38)	missense	possibly damaging	0.67
R6334:Vmn2r103	UTSW	17	19,794,082 (GRCm38)	missense	probably damaging	0.97
R6501:Vmn2r103	UTSW	17	19,811,904 (GRCm38)	missense	probably benign	0.29
R6710:Vmn2r103	UTSW	17	19,811,977 (GRCm38)	missense	probably damaging	1.00
R6774:Vmn2r103	UTSW	17	19,773,511 (GRCm38)	missense	probably benign	0.14
R6981:Vmn2r103	UTSW	17	19,793,477 (GRCm38)	missense	probably benign	0.00
R7768:Vmn2r103	UTSW	17	19,812,052 (GRCm38)	missense	probably damaging	0.99
R7816:Vmn2r103	UTSW	17	19,794,214 (GRCm38)	missense	probably benign	0.06
R7885:Vmn2r103	UTSW	17	19,793,123 (GRCm38)	missense	probably benign	0.25
R8002:Vmn2r103	UTSW	17	19,799,249 (GRCm38)	missense	probably damaging	1.00
R8031:Vmn2r103	UTSW	17	19,793,497 (GRCm38)	missense	probably benign	0.00
R8140:Vmn2r103	UTSW	17	19,811,796 (GRCm38)	missense	probably damaging	1.00
R8186:Vmn2r103	UTSW	17	19,811,943 (GRCm38)	missense	probably damaging	1.00
R8559:Vmn2r103	UTSW	17	19,812,384 (GRCm38)	missense	probably benign	0.01
R9413:Vmn2r103	UTSW	17	19,811,896 (GRCm38)	missense	possibly damaging	0.54
R9591:Vmn2r103	UTSW	17	19,811,659 (GRCm38)	missense	possibly damaging	0.70
R9652:Vmn2r103	UTSW	17	19,793,765 (GRCm38)	missense	probably benign	0.01
R9680:Vmn2r103	UTSW	17	19,799,263 (GRCm38)	nonsense	probably null
R9743:Vmn2r103	UTSW	17	19,812,213 (GRCm38)	missense	probably damaging	1.00
Z1088:Vmn2r103	UTSW	17	19,795,047 (GRCm38)	missense	probably benign	0.08

Posted On

2015-04-16