Incidental Mutation 'IGL02668:Zfp488'
ID302810
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp488
Ensembl Gene ENSMUSG00000044519
Gene Namezinc finger protein 488
SynonymsLOC382867
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02668
Quality Score
Status
Chromosome14
Chromosomal Location33967070-33978764 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 33970820 bp
ZygosityHeterozygous
Amino Acid Change Glutamine to Lysine at position 129 (Q129K)
Ref Sequence ENSEMBL: ENSMUSP00000132436 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000166737]
Predicted Effect probably benign
Transcript: ENSMUST00000166737
AA Change: Q129K

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000132436
Gene: ENSMUSG00000044519
AA Change: Q129K

DomainStartEndE-ValueType
low complexity region 161 175 N/A INTRINSIC
low complexity region 244 270 N/A INTRINSIC
ZnF_C2H2 272 294 2.89e1 SMART
ZnF_C2H2 314 336 5.06e-2 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930596D02Rik A G 14: 35,810,117 M167T probably benign Het
Abcc4 G T 14: 118,611,475 S488R probably damaging Het
Adprm G T 11: 67,040,247 D230E possibly damaging Het
Atp2a3 C A 11: 72,975,339 H262N probably benign Het
Casc1 G T 6: 145,205,257 R30S unknown Het
Ccdc66 T C 14: 27,497,341 K309E possibly damaging Het
Cyb561d2 C T 9: 107,540,172 A127T probably benign Het
Dctn1 T A 6: 83,191,048 M357K possibly damaging Het
Diras2 T C 13: 52,507,770 N167S probably benign Het
Dmgdh T G 13: 93,703,910 V283G probably damaging Het
Dmxl2 A T 9: 54,416,945 W1052R probably damaging Het
Dnah6 A T 6: 73,121,823 V2083D possibly damaging Het
Exoc4 T G 6: 33,921,532 F895L probably benign Het
Fsip1 G T 2: 118,251,725 A76E probably benign Het
Fsip2 A G 2: 82,998,318 I6820V probably benign Het
Hdac10 G A 15: 89,125,644 P395L probably benign Het
Ing3 A G 6: 21,950,059 D17G probably damaging Het
Map3k4 A T 17: 12,235,953 F1383L possibly damaging Het
Mpp6 C T 6: 50,194,529 T386I probably damaging Het
Myct1 C A 10: 5,604,513 P127T probably damaging Het
Olfr593 A T 7: 103,212,735 I281F possibly damaging Het
Osbpl7 G T 11: 97,067,205 A625S possibly damaging Het
Padi2 C T 4: 140,949,880 R660C probably benign Het
Paip1 A T 13: 119,438,071 I185F probably damaging Het
Phykpl G A 11: 51,593,687 probably null Het
Plekhg6 G A 6: 125,372,803 probably benign Het
Plxna1 A T 6: 89,357,269 L126* probably null Het
Rchy1 A T 5: 91,962,718 M1K probably null Het
Rfx3 T C 19: 27,815,614 probably benign Het
Sdr9c7 T C 10: 127,902,398 F182L probably damaging Het
Sgpl1 A C 10: 61,105,450 V294G probably damaging Het
Sh2b1 A G 7: 126,472,474 S180P possibly damaging Het
Sorbs1 T C 19: 40,314,681 D488G probably damaging Het
Stab2 A G 10: 86,846,163 probably benign Het
Sycp1 A C 3: 102,820,531 probably benign Het
Tmem245 T C 4: 56,925,081 K347E possibly damaging Het
Tnk1 A G 11: 69,856,923 M51T probably damaging Het
Trpm2 C T 10: 77,935,942 R621H probably damaging Het
Ubd G T 17: 37,195,529 R102L probably benign Het
Uhrf1bp1 A C 17: 27,886,575 I692L possibly damaging Het
Vmn2r103 G T 17: 19,794,127 A394S probably benign Het
Zfp324 T A 7: 12,970,846 C321S probably damaging Het
Zmpste24 T A 4: 121,061,100 N442Y probably damaging Het
Other mutations in Zfp488
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00160:Zfp488 APN 14 33971069 missense probably benign 0.00
IGL02156:Zfp488 APN 14 33970400 missense possibly damaging 0.83
R0504:Zfp488 UTSW 14 33970540 missense probably damaging 0.97
R4021:Zfp488 UTSW 14 33971153 missense probably benign 0.01
R4022:Zfp488 UTSW 14 33971153 missense probably benign 0.01
R4291:Zfp488 UTSW 14 33970894 missense possibly damaging 0.83
R6180:Zfp488 UTSW 14 33970794 missense possibly damaging 0.66
R6927:Zfp488 UTSW 14 33970798 missense probably benign
R7687:Zfp488 UTSW 14 33970400 missense possibly damaging 0.83
Posted On2015-04-16