Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02668:Dmxl2'

302811

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dmxl2

Ensembl Gene

ENSMUSG00000041268

Gene Name

Dmx-like 2

Synonyms

E130119P06Rik, 6430411K14Rik

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL02668

Quality Score

Status

Chromosome

Chromosomal Location

54272442-54408910 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 54324229 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tryptophan to Arginine at position 1052 (W1052R)

Ref Sequence

ENSEMBL: ENSMUSP00000113705 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000118163] [ENSMUST00000118600] [ENSMUST00000127880]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000118163
AA Change: W1052R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000113705
Gene: ENSMUSG00000041268
AA Change: W1052R

Domain	Start	End	E-Value	Type
WD40	43	84	4.58e1	SMART
WD40	100	136	2.28e2	SMART
WD40	159	198	2.57e-2	SMART
WD40	221	269	1.03e-1	SMART
low complexity region	420	440	N/A	INTRINSIC
WD40	741	793	1.42e2	SMART
low complexity region	861	875	N/A	INTRINSIC
low complexity region	945	961	N/A	INTRINSIC
WD40	985	1029	1.15e1	SMART
WD40	1236	1273	2.84e2	SMART
Pfam:Rav1p_C	1430	1903	1.5e-71	PFAM
low complexity region	1978	1993	N/A	INTRINSIC
coiled coil region	2118	2146	N/A	INTRINSIC
low complexity region	2189	2204	N/A	INTRINSIC
low complexity region	2251	2266	N/A	INTRINSIC
low complexity region	2472	2490	N/A	INTRINSIC
low complexity region	2635	2649	N/A	INTRINSIC
low complexity region	2744	2766	N/A	INTRINSIC
WD40	2774	2809	5.73e0	SMART
WD40	2813	2852	8.88e0	SMART
WD40	2859	2901	2.67e-1	SMART
WD40	2907	2946	2.57e-2	SMART
WD40	2949	2988	3.61e-6	SMART
WD40	3001	3039	8.25e0	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000118600
AA Change: W1052R

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000113693
Gene: ENSMUSG00000041268
AA Change: W1052R

Domain	Start	End	E-Value	Type
WD40	43	84	4.58e1	SMART
WD40	100	136	2.28e2	SMART
WD40	159	198	2.57e-2	SMART
WD40	221	269	1.03e-1	SMART
low complexity region	420	440	N/A	INTRINSIC
WD40	741	793	1.42e2	SMART
low complexity region	861	875	N/A	INTRINSIC
low complexity region	945	961	N/A	INTRINSIC
WD40	985	1029	1.15e1	SMART
WD40	1236	1273	2.84e2	SMART
low complexity region	1426	1436	N/A	INTRINSIC
Pfam:Rav1p_C	1447	1903	4.2e-68	PFAM
low complexity region	1978	1993	N/A	INTRINSIC
coiled coil region	2118	2146	N/A	INTRINSIC
low complexity region	2189	2204	N/A	INTRINSIC
low complexity region	2251	2266	N/A	INTRINSIC
low complexity region	2471	2489	N/A	INTRINSIC
low complexity region	2722	2744	N/A	INTRINSIC
WD40	2752	2787	5.73e0	SMART
WD40	2791	2830	8.88e0	SMART
WD40	2837	2879	2.67e-1	SMART
WD40	2885	2924	2.57e-2	SMART
WD40	2927	2966	3.61e-6	SMART
WD40	2979	3017	8.25e0	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000123709
AA Change: W253R

PolyPhen 2 Score 0.842 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000119959
Gene: ENSMUSG00000041268
AA Change: W253R

Domain	Start	End	E-Value	Type
low complexity region	63	77	N/A	INTRINSIC
low complexity region	147	163	N/A	INTRINSIC
WD40	187	231	1.15e1	SMART
WD40	438	475	2.84e2	SMART
Pfam:Rav1p_C	632	1105	9.1e-72	PFAM
low complexity region	1180	1195	N/A	INTRINSIC
coiled coil region	1319	1347	N/A	INTRINSIC
low complexity region	1391	1406	N/A	INTRINSIC
low complexity region	1453	1468	N/A	INTRINSIC
low complexity region	1674	1692	N/A	INTRINSIC
low complexity region	1925	1947	N/A	INTRINSIC
WD40	1955	1990	5.73e0	SMART
WD40	1994	2033	8.88e0	SMART
WD40	2040	2082	2.67e-1	SMART
WD40	2088	2127	2.57e-2	SMART
WD40	2130	2169	3.61e-6	SMART
WD40	2182	2220	8.25e0	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000127880
AA Change: W878R

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000122293
Gene: ENSMUSG00000041268
AA Change: W878R

Domain	Start	End	E-Value	Type
Pfam:WD40	1	24	7.9e-4	PFAM
WD40	47	95	1.03e-1	SMART
low complexity region	246	266	N/A	INTRINSIC
WD40	567	619	1.42e2	SMART
low complexity region	687	701	N/A	INTRINSIC
low complexity region	771	787	N/A	INTRINSIC
WD40	811	855	1.15e1	SMART
WD40	1062	1099	2.84e2	SMART
low complexity region	1252	1262	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein with 12 WD domains. Proteins with WD domains are involved in many functions including participation in signal transduction pathways. Participation of the encoded protein in regulation of the Notch signaling pathway has been demonstrated in vitro using several human cell lines (PMID:20810660). A gene encoding a similar protein is located on chromosome 5. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit complete prenatal lethality. [provided by MGI curators]

Allele List at MGI

All alleles(4) : Targeted(2) Gene trapped(2)

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930596D02Rik	A	G	14: 35,532,074 (GRCm39)	M167T	probably benign	Het
Abcc4	G	T	14: 118,848,887 (GRCm39)	S488R	probably damaging	Het
Adprm	G	T	11: 66,931,073 (GRCm39)	D230E	possibly damaging	Het
Atp2a3	C	A	11: 72,866,165 (GRCm39)	H262N	probably benign	Het
Bltp3a	A	C	17: 28,105,549 (GRCm39)	I692L	possibly damaging	Het
Ccdc66	T	C	14: 27,219,298 (GRCm39)	K309E	possibly damaging	Het
Cyb561d2	C	T	9: 107,417,371 (GRCm39)	A127T	probably benign	Het
Dctn1	T	A	6: 83,168,030 (GRCm39)	M357K	possibly damaging	Het
Diras2	T	C	13: 52,661,806 (GRCm39)	N167S	probably benign	Het
Dmgdh	T	G	13: 93,840,418 (GRCm39)	V283G	probably damaging	Het
Dnah6	A	T	6: 73,098,806 (GRCm39)	V2083D	possibly damaging	Het
Dnai7	G	T	6: 145,150,983 (GRCm39)	R30S	unknown	Het
Exoc4	T	G	6: 33,898,467 (GRCm39)	F895L	probably benign	Het
Fsip1	G	T	2: 118,082,206 (GRCm39)	A76E	probably benign	Het
Fsip2	A	G	2: 82,828,662 (GRCm39)	I6820V	probably benign	Het
Hdac10	G	A	15: 89,009,847 (GRCm39)	P395L	probably benign	Het
Ing3	A	G	6: 21,950,058 (GRCm39)	D17G	probably damaging	Het
Map3k4	A	T	17: 12,454,840 (GRCm39)	F1383L	possibly damaging	Het
Myct1	C	A	10: 5,554,513 (GRCm39)	P127T	probably damaging	Het
Or52s1	A	T	7: 102,861,942 (GRCm39)	I281F	possibly damaging	Het
Osbpl7	G	T	11: 96,958,031 (GRCm39)	A625S	possibly damaging	Het
Padi2	C	T	4: 140,677,191 (GRCm39)	R660C	probably benign	Het
Paip1	A	T	13: 119,574,607 (GRCm39)	I185F	probably damaging	Het
Pals2	C	T	6: 50,171,509 (GRCm39)	T386I	probably damaging	Het
Phykpl	G	A	11: 51,484,514 (GRCm39)		probably null	Het
Plekhg6	G	A	6: 125,349,766 (GRCm39)		probably benign	Het
Plxna1	A	T	6: 89,334,251 (GRCm39)	L126*	probably null	Het
Rchy1	A	T	5: 92,110,577 (GRCm39)	M1K	probably null	Het
Rfx3	T	C	19: 27,793,014 (GRCm39)		probably benign	Het
Sdr9c7	T	C	10: 127,738,267 (GRCm39)	F182L	probably damaging	Het
Sgpl1	A	C	10: 60,941,229 (GRCm39)	V294G	probably damaging	Het
Sh2b1	A	G	7: 126,071,646 (GRCm39)	S180P	possibly damaging	Het
Sorbs1	T	C	19: 40,303,125 (GRCm39)	D488G	probably damaging	Het
Stab2	A	G	10: 86,682,027 (GRCm39)		probably benign	Het
Sycp1	A	C	3: 102,727,847 (GRCm39)		probably benign	Het
Tmem245	T	C	4: 56,925,081 (GRCm39)	K347E	possibly damaging	Het
Tnk1	A	G	11: 69,747,749 (GRCm39)	M51T	probably damaging	Het
Trpm2	C	T	10: 77,771,776 (GRCm39)	R621H	probably damaging	Het
Ubd	G	T	17: 37,506,420 (GRCm39)	R102L	probably benign	Het
Vmn2r103	G	T	17: 20,014,389 (GRCm39)	A394S	probably benign	Het
Zfp324	T	A	7: 12,704,773 (GRCm39)	C321S	probably damaging	Het
Zfp488	G	T	14: 33,692,777 (GRCm39)	Q129K	probably benign	Het
Zmpste24	T	A	4: 120,918,297 (GRCm39)	N442Y	probably damaging	Het

Other mutations in Dmxl2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00088:Dmxl2	APN	9	54,308,988 (GRCm39)	missense	probably benign
IGL00226:Dmxl2	APN	9	54,323,277 (GRCm39)	missense	probably damaging	1.00
IGL00419:Dmxl2	APN	9	54,313,951 (GRCm39)	missense	probably damaging	0.96
IGL00551:Dmxl2	APN	9	54,358,122 (GRCm39)	missense	probably damaging	1.00
IGL00765:Dmxl2	APN	9	54,322,706 (GRCm39)	unclassified	probably benign
IGL00852:Dmxl2	APN	9	54,330,597 (GRCm39)	nonsense	probably null
IGL00857:Dmxl2	APN	9	54,283,604 (GRCm39)	missense	probably benign	0.32
IGL00952:Dmxl2	APN	9	54,324,166 (GRCm39)	missense	probably damaging	0.99
IGL01139:Dmxl2	APN	9	54,366,248 (GRCm39)	missense	probably damaging	1.00
IGL01346:Dmxl2	APN	9	54,322,759 (GRCm39)	missense	probably damaging	1.00
IGL01538:Dmxl2	APN	9	54,352,660 (GRCm39)	splice site	probably benign
IGL01645:Dmxl2	APN	9	54,286,017 (GRCm39)	missense	possibly damaging	0.93
IGL02096:Dmxl2	APN	9	54,308,349 (GRCm39)	missense	possibly damaging	0.89
IGL02104:Dmxl2	APN	9	54,311,299 (GRCm39)	nonsense	probably null
IGL02145:Dmxl2	APN	9	54,281,981 (GRCm39)	missense	probably benign	0.29
IGL02210:Dmxl2	APN	9	54,311,333 (GRCm39)	missense	probably damaging	1.00
IGL02238:Dmxl2	APN	9	54,352,717 (GRCm39)	missense	probably damaging	1.00
IGL02255:Dmxl2	APN	9	54,301,052 (GRCm39)	missense	probably benign	0.06
IGL02364:Dmxl2	APN	9	54,301,127 (GRCm39)	missense	probably benign	0.02
IGL02423:Dmxl2	APN	9	54,301,032 (GRCm39)	missense	possibly damaging	0.89
IGL02440:Dmxl2	APN	9	54,313,899 (GRCm39)	missense	probably damaging	0.98
IGL02546:Dmxl2	APN	9	54,273,698 (GRCm39)	utr 3 prime	probably benign
IGL03229:Dmxl2	APN	9	54,311,456 (GRCm39)	missense	probably damaging	1.00
IGL03244:Dmxl2	APN	9	54,323,655 (GRCm39)	missense	probably damaging	1.00
IGL03277:Dmxl2	APN	9	54,311,504 (GRCm39)	missense	probably damaging	1.00
IGL03399:Dmxl2	APN	9	54,353,956 (GRCm39)	missense	probably damaging	1.00
BB003:Dmxl2	UTSW	9	54,335,326 (GRCm39)	missense	probably benign	0.01
BB013:Dmxl2	UTSW	9	54,335,326 (GRCm39)	missense	probably benign	0.01
I2288:Dmxl2	UTSW	9	54,309,077 (GRCm39)	missense	probably damaging	1.00
P0014:Dmxl2	UTSW	9	54,309,048 (GRCm39)	missense	probably damaging	1.00
R0411:Dmxl2	UTSW	9	54,286,223 (GRCm39)	missense	probably damaging	1.00
R0422:Dmxl2	UTSW	9	54,307,224 (GRCm39)	critical splice donor site	probably null
R0432:Dmxl2	UTSW	9	54,324,235 (GRCm39)	missense	probably benign	0.01
R0436:Dmxl2	UTSW	9	54,291,034 (GRCm39)	missense	probably damaging	1.00
R0538:Dmxl2	UTSW	9	54,301,120 (GRCm39)	missense	probably benign	0.06
R0603:Dmxl2	UTSW	9	54,313,190 (GRCm39)	missense	possibly damaging	0.95
R0605:Dmxl2	UTSW	9	54,327,229 (GRCm39)	missense	probably benign	0.01
R0625:Dmxl2	UTSW	9	54,289,986 (GRCm39)	missense	probably benign
R0626:Dmxl2	UTSW	9	54,323,838 (GRCm39)	missense	probably damaging	1.00
R0736:Dmxl2	UTSW	9	54,286,101 (GRCm39)	missense	probably damaging	0.99
R0847:Dmxl2	UTSW	9	54,313,112 (GRCm39)	missense	probably damaging	1.00
R0855:Dmxl2	UTSW	9	54,273,724 (GRCm39)	missense	probably benign	0.03
R0962:Dmxl2	UTSW	9	54,353,696 (GRCm39)	missense	probably damaging	0.99
R1015:Dmxl2	UTSW	9	54,275,049 (GRCm39)	missense	probably benign	0.32
R1084:Dmxl2	UTSW	9	54,323,717 (GRCm39)	missense	probably damaging	1.00
R1328:Dmxl2	UTSW	9	54,303,533 (GRCm39)	missense	probably benign	0.12
R1401:Dmxl2	UTSW	9	54,322,712 (GRCm39)	critical splice donor site	probably null
R1503:Dmxl2	UTSW	9	54,354,272 (GRCm39)	nonsense	probably null
R1609:Dmxl2	UTSW	9	54,316,547 (GRCm39)	missense	possibly damaging	0.90
R1613:Dmxl2	UTSW	9	54,289,311 (GRCm39)	missense	probably benign
R1660:Dmxl2	UTSW	9	54,358,314 (GRCm39)	missense	possibly damaging	0.68
R1712:Dmxl2	UTSW	9	54,308,769 (GRCm39)	missense	probably benign	0.00
R1772:Dmxl2	UTSW	9	54,330,508 (GRCm39)	splice site	probably benign
R1832:Dmxl2	UTSW	9	54,368,233 (GRCm39)	missense	probably damaging	0.97
R1922:Dmxl2	UTSW	9	54,308,807 (GRCm39)	missense	probably benign
R2104:Dmxl2	UTSW	9	54,322,848 (GRCm39)	missense	probably damaging	1.00
R2109:Dmxl2	UTSW	9	54,301,097 (GRCm39)	missense	probably benign	0.06
R2145:Dmxl2	UTSW	9	54,323,194 (GRCm39)	missense	probably damaging	1.00
R2199:Dmxl2	UTSW	9	54,283,527 (GRCm39)	missense	probably benign	0.35
R2352:Dmxl2	UTSW	9	54,301,146 (GRCm39)	missense	probably damaging	1.00
R2516:Dmxl2	UTSW	9	54,307,378 (GRCm39)	missense	probably damaging	1.00
R2981:Dmxl2	UTSW	9	54,300,986 (GRCm39)	missense	probably damaging	1.00
R3430:Dmxl2	UTSW	9	54,384,745 (GRCm39)	missense	possibly damaging	0.94
R3625:Dmxl2	UTSW	9	54,300,927 (GRCm39)	missense	probably benign	0.23
R3725:Dmxl2	UTSW	9	54,301,053 (GRCm39)	missense	probably damaging	1.00
R3787:Dmxl2	UTSW	9	54,277,162 (GRCm39)	missense	probably damaging	1.00
R4002:Dmxl2	UTSW	9	54,381,116 (GRCm39)	splice site	probably benign
R4004:Dmxl2	UTSW	9	54,353,674 (GRCm39)	missense	probably benign	0.04
R4005:Dmxl2	UTSW	9	54,353,674 (GRCm39)	missense	probably benign	0.04
R4012:Dmxl2	UTSW	9	54,286,297 (GRCm39)	splice site	probably null
R4014:Dmxl2	UTSW	9	54,285,993 (GRCm39)	splice site	probably null
R4115:Dmxl2	UTSW	9	54,354,272 (GRCm39)	nonsense	probably null
R4232:Dmxl2	UTSW	9	54,327,193 (GRCm39)	missense	possibly damaging	0.89
R4388:Dmxl2	UTSW	9	54,303,551 (GRCm39)	missense	probably damaging	1.00
R4513:Dmxl2	UTSW	9	54,327,168 (GRCm39)	missense	probably null	0.17
R4552:Dmxl2	UTSW	9	54,359,047 (GRCm39)	missense	probably damaging	1.00
R4609:Dmxl2	UTSW	9	54,353,796 (GRCm39)	missense	probably damaging	1.00
R4625:Dmxl2	UTSW	9	54,311,404 (GRCm39)	missense	possibly damaging	0.55
R4694:Dmxl2	UTSW	9	54,354,189 (GRCm39)	missense	probably benign	0.04
R4711:Dmxl2	UTSW	9	54,358,208 (GRCm39)	missense	probably benign	0.37
R4715:Dmxl2	UTSW	9	54,353,689 (GRCm39)	splice site	probably null
R4746:Dmxl2	UTSW	9	54,359,080 (GRCm39)	missense	probably benign	0.04
R4789:Dmxl2	UTSW	9	54,287,099 (GRCm39)	missense	probably benign	0.30
R4825:Dmxl2	UTSW	9	54,311,325 (GRCm39)	missense	probably benign	0.01
R4911:Dmxl2	UTSW	9	54,318,937 (GRCm39)	missense	probably damaging	1.00
R4995:Dmxl2	UTSW	9	54,408,725 (GRCm39)	utr 5 prime	probably benign
R5026:Dmxl2	UTSW	9	54,323,960 (GRCm39)	missense	probably damaging	1.00
R5118:Dmxl2	UTSW	9	54,368,271 (GRCm39)	missense	probably damaging	1.00
R5174:Dmxl2	UTSW	9	54,352,768 (GRCm39)	splice site	probably null
R5288:Dmxl2	UTSW	9	54,286,041 (GRCm39)	missense	probably benign
R5373:Dmxl2	UTSW	9	54,276,473 (GRCm39)	intron	probably benign
R5374:Dmxl2	UTSW	9	54,276,473 (GRCm39)	intron	probably benign
R5385:Dmxl2	UTSW	9	54,286,041 (GRCm39)	missense	probably benign
R5386:Dmxl2	UTSW	9	54,286,041 (GRCm39)	missense	probably benign
R5418:Dmxl2	UTSW	9	54,281,935 (GRCm39)	critical splice donor site	probably null
R5540:Dmxl2	UTSW	9	54,301,141 (GRCm39)	missense	probably benign	0.21
R5568:Dmxl2	UTSW	9	54,330,643 (GRCm39)	splice site	probably null
R5733:Dmxl2	UTSW	9	54,283,550 (GRCm39)	missense	possibly damaging	0.64
R5758:Dmxl2	UTSW	9	54,380,248 (GRCm39)	missense	probably benign	0.28
R5759:Dmxl2	UTSW	9	54,282,792 (GRCm39)	missense	probably damaging	1.00
R5893:Dmxl2	UTSW	9	54,294,704 (GRCm39)	missense	possibly damaging	0.64
R6030:Dmxl2	UTSW	9	54,300,957 (GRCm39)	missense	probably benign	0.18
R6030:Dmxl2	UTSW	9	54,300,957 (GRCm39)	missense	probably benign	0.18
R6041:Dmxl2	UTSW	9	54,324,037 (GRCm39)	missense	probably damaging	1.00
R6174:Dmxl2	UTSW	9	54,301,011 (GRCm39)	missense	probably damaging	1.00
R6278:Dmxl2	UTSW	9	54,323,046 (GRCm39)	missense	probably damaging	1.00
R6307:Dmxl2	UTSW	9	54,289,990 (GRCm39)	missense	possibly damaging	0.68
R6349:Dmxl2	UTSW	9	54,327,193 (GRCm39)	missense	possibly damaging	0.89
R6404:Dmxl2	UTSW	9	54,282,820 (GRCm39)	missense	probably damaging	1.00
R6516:Dmxl2	UTSW	9	54,323,960 (GRCm39)	missense	probably damaging	1.00
R6712:Dmxl2	UTSW	9	54,318,908 (GRCm39)	missense	probably damaging	1.00
R6747:Dmxl2	UTSW	9	54,323,372 (GRCm39)	missense	probably damaging	1.00
R6769:Dmxl2	UTSW	9	54,323,808 (GRCm39)	missense	probably damaging	1.00
R6771:Dmxl2	UTSW	9	54,323,808 (GRCm39)	missense	probably damaging	1.00
R6800:Dmxl2	UTSW	9	54,316,467 (GRCm39)	missense	probably damaging	1.00
R6891:Dmxl2	UTSW	9	54,387,664 (GRCm39)	missense	probably damaging	0.99
R6920:Dmxl2	UTSW	9	54,379,496 (GRCm39)	missense	probably damaging	1.00
R6979:Dmxl2	UTSW	9	54,358,163 (GRCm39)	missense	possibly damaging	0.49
R7147:Dmxl2	UTSW	9	54,324,013 (GRCm39)	missense	probably benign	0.06
R7327:Dmxl2	UTSW	9	54,308,869 (GRCm39)	missense	probably damaging	1.00
R7462:Dmxl2	UTSW	9	54,273,916 (GRCm39)	splice site	probably null
R7526:Dmxl2	UTSW	9	54,308,241 (GRCm39)	missense	possibly damaging	0.47
R7569:Dmxl2	UTSW	9	54,323,271 (GRCm39)	missense	possibly damaging	0.51
R7622:Dmxl2	UTSW	9	54,379,502 (GRCm39)	missense	probably damaging	0.99
R7638:Dmxl2	UTSW	9	54,365,078 (GRCm39)	missense	unknown
R7703:Dmxl2	UTSW	9	54,368,370 (GRCm39)	missense	probably benign	0.01
R7768:Dmxl2	UTSW	9	54,288,223 (GRCm39)	missense	probably damaging	1.00
R7926:Dmxl2	UTSW	9	54,335,326 (GRCm39)	missense	probably benign	0.01
R7969:Dmxl2	UTSW	9	54,354,165 (GRCm39)	missense	possibly damaging	0.85
R8007:Dmxl2	UTSW	9	54,290,975 (GRCm39)	nonsense	probably null
R8200:Dmxl2	UTSW	9	54,387,630 (GRCm39)	missense	probably benign
R8311:Dmxl2	UTSW	9	54,354,217 (GRCm39)	missense	probably benign	0.00
R8320:Dmxl2	UTSW	9	54,291,043 (GRCm39)	missense	probably benign
R8377:Dmxl2	UTSW	9	54,286,032 (GRCm39)	missense	probably damaging	1.00
R8400:Dmxl2	UTSW	9	54,291,037 (GRCm39)	missense	probably benign	0.03
R8509:Dmxl2	UTSW	9	54,335,341 (GRCm39)	nonsense	probably null
R8698:Dmxl2	UTSW	9	54,281,953 (GRCm39)	missense	probably benign	0.10
R8768:Dmxl2	UTSW	9	54,301,105 (GRCm39)	missense	possibly damaging	0.83
R8770:Dmxl2	UTSW	9	54,311,298 (GRCm39)	missense	probably benign	0.01
R8799:Dmxl2	UTSW	9	54,327,027 (GRCm39)	critical splice donor site	probably null
R8840:Dmxl2	UTSW	9	54,309,139 (GRCm39)	missense	possibly damaging	0.58
R8898:Dmxl2	UTSW	9	54,308,941 (GRCm39)	missense	probably benign	0.01
R8954:Dmxl2	UTSW	9	54,381,156 (GRCm39)	missense	probably benign	0.04
R9083:Dmxl2	UTSW	9	54,316,548 (GRCm39)	missense	probably benign	0.29
R9114:Dmxl2	UTSW	9	54,307,321 (GRCm39)	missense
R9115:Dmxl2	UTSW	9	54,309,011 (GRCm39)	missense	probably benign
R9263:Dmxl2	UTSW	9	54,358,945 (GRCm39)	missense	probably benign	0.01
R9272:Dmxl2	UTSW	9	54,311,404 (GRCm39)	missense	possibly damaging	0.55
R9577:Dmxl2	UTSW	9	54,323,664 (GRCm39)	missense	unknown
R9673:Dmxl2	UTSW	9	54,294,840 (GRCm39)	missense	probably damaging	1.00
R9722:Dmxl2	UTSW	9	54,323,892 (GRCm39)	missense	probably benign	0.00
R9726:Dmxl2	UTSW	9	54,322,996 (GRCm39)	missense	probably benign	0.09
R9797:Dmxl2	UTSW	9	54,358,187 (GRCm39)	missense	probably benign	0.00
X0064:Dmxl2	UTSW	9	54,308,997 (GRCm39)	missense	probably benign
Z1177:Dmxl2	UTSW	9	54,289,318 (GRCm39)	frame shift	probably null

Posted On

2015-04-16