Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02669:Zfp142'

302850

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp142

Ensembl Gene

ENSMUSG00000026135

Gene Name

zinc finger protein 142

Synonyms

9330177B18Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02669

Quality Score

Status

Chromosome

Chromosomal Location

74605490-74627308 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 74610432 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Arginine at position 1121 (Q1121R)

Ref Sequence

ENSEMBL: ENSMUSP00000027315 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027315] [ENSMUST00000066986] [ENSMUST00000067916] [ENSMUST00000113737] [ENSMUST00000113749] [ENSMUST00000127921] [ENSMUST00000141412] [ENSMUST00000156613]

AlphaFold

G5E869

Predicted Effect

probably benign
Transcript: ENSMUST00000027315
AA Change: Q1121R

PolyPhen 2 Score 0.183 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000027315
Gene: ENSMUSG00000026135
AA Change: Q1121R

Domain	Start	End	E-Value	Type
ZnF_C2H2	103	127	1.16e1	SMART
ZnF_C2H2	164	186	1.26e-2	SMART
ZnF_C2H2	193	218	7.78e-3	SMART
ZnF_C2H2	223	247	2.29e0	SMART
ZnF_C2H2	250	272	9.96e-1	SMART
low complexity region	317	329	N/A	INTRINSIC
ZnF_C2H2	363	385	9.96e-1	SMART
ZnF_C2H2	391	411	1.26e1	SMART
ZnF_C2H2	419	442	1.47e-3	SMART
ZnF_C2H2	453	475	2.75e-3	SMART
ZnF_C2H2	486	511	3.34e-2	SMART
ZnF_C2H2	516	540	4.81e0	SMART
ZnF_C2H2	543	566	7.05e-1	SMART
ZnF_C2H2	572	595	2.17e-1	SMART
ZnF_C2H2	601	623	1.56e-2	SMART
ZnF_C2H2	629	651	8.94e-3	SMART
ZnF_C2H2	657	679	1.38e-3	SMART
ZnF_C2H2	685	707	9.44e-2	SMART
ZnF_C2H2	712	735	1.26e-2	SMART
ZnF_C2H2	744	767	1.31e0	SMART
ZnF_C2H2	773	796	2.63e0	SMART
low complexity region	903	919	N/A	INTRINSIC
low complexity region	953	969	N/A	INTRINSIC
low complexity region	996	1007	N/A	INTRINSIC
ZnF_C2H2	1039	1059	2.01e1	SMART
ZnF_C2H2	1069	1089	1.91e1	SMART
low complexity region	1147	1160	N/A	INTRINSIC
ZnF_C2H2	1187	1207	2.7e2	SMART
low complexity region	1209	1222	N/A	INTRINSIC
ZnF_C2H2	1265	1285	3.56e1	SMART
ZnF_C2H2	1295	1318	4.98e-1	SMART
ZnF_C2H2	1331	1354	2.49e-1	SMART
ZnF_C2H2	1360	1382	1.03e-2	SMART
ZnF_C2H2	1388	1411	5.72e-1	SMART
ZnF_C2H2	1417	1440	6.75e0	SMART
ZnF_C2H2	1446	1469	9.58e-3	SMART
ZnF_C2H2	1488	1511	1.64e-1	SMART
ZnF_C2H2	1514	1536	1.1e-2	SMART
ZnF_C2H2	1540	1563	4.05e-1	SMART
ZnF_C2H2	1580	1602	4.45e0	SMART
ZnF_C2H2	1608	1630	8.81e-2	SMART
ZnF_C2H2	1636	1658	1.18e-2	SMART
ZnF_C2H2	1664	1686	1.2e-3	SMART
ZnF_C2H2	1692	1715	3.89e-3	SMART
ZnF_C2H2	1721	1743	4.54e-4	SMART
ZnF_C2H2	1749	1771	1.18e-2	SMART
ZnF_C2H2	1777	1799	3.52e-1	SMART
low complexity region	1829	1838	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000066986
AA Change: Q920R

PolyPhen 2 Score 0.112 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000065149
Gene: ENSMUSG00000026135
AA Change: Q920R

Domain	Start	End	E-Value	Type
low complexity region	116	128	N/A	INTRINSIC
ZnF_C2H2	162	184	9.96e-1	SMART
ZnF_C2H2	190	210	1.26e1	SMART
ZnF_C2H2	218	241	1.47e-3	SMART
ZnF_C2H2	252	274	2.75e-3	SMART
ZnF_C2H2	285	310	3.34e-2	SMART
ZnF_C2H2	315	339	4.81e0	SMART
ZnF_C2H2	342	365	7.05e-1	SMART
ZnF_C2H2	371	394	2.17e-1	SMART
ZnF_C2H2	400	422	1.56e-2	SMART
ZnF_C2H2	428	450	8.94e-3	SMART
ZnF_C2H2	456	478	1.38e-3	SMART
ZnF_C2H2	484	506	9.44e-2	SMART
ZnF_C2H2	511	534	1.26e-2	SMART
ZnF_C2H2	543	566	1.31e0	SMART
ZnF_C2H2	572	595	2.63e0	SMART
low complexity region	702	718	N/A	INTRINSIC
low complexity region	752	768	N/A	INTRINSIC
low complexity region	795	806	N/A	INTRINSIC
ZnF_C2H2	838	858	2.01e1	SMART
ZnF_C2H2	868	888	1.91e1	SMART
low complexity region	946	959	N/A	INTRINSIC
ZnF_C2H2	986	1006	2.7e2	SMART
low complexity region	1008	1021	N/A	INTRINSIC
ZnF_C2H2	1064	1084	3.56e1	SMART
ZnF_C2H2	1094	1117	4.98e-1	SMART
ZnF_C2H2	1130	1153	2.49e-1	SMART
ZnF_C2H2	1159	1181	1.03e-2	SMART
ZnF_C2H2	1187	1210	5.72e-1	SMART
ZnF_C2H2	1216	1239	6.75e0	SMART
ZnF_C2H2	1245	1268	9.58e-3	SMART
ZnF_C2H2	1287	1310	1.64e-1	SMART
ZnF_C2H2	1313	1335	1.1e-2	SMART
ZnF_C2H2	1339	1362	4.05e-1	SMART
ZnF_C2H2	1379	1401	4.45e0	SMART
ZnF_C2H2	1407	1429	8.81e-2	SMART
ZnF_C2H2	1435	1457	1.18e-2	SMART
ZnF_C2H2	1463	1485	1.2e-3	SMART
ZnF_C2H2	1491	1514	3.89e-3	SMART
ZnF_C2H2	1520	1542	4.54e-4	SMART
ZnF_C2H2	1548	1570	1.18e-2	SMART
ZnF_C2H2	1576	1598	3.52e-1	SMART
low complexity region	1628	1637	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000067916

SMART Domains

Protein: ENSMUSP00000064413
Gene: ENSMUSG00000026173

Domain	Start	End	E-Value	Type
PH	17	126	2.6e-12	SMART
EFh	138	166	9.97e-1	SMART
EFh	174	202	1.83e1	SMART
EFh	207	234	4.45e1	SMART
PLCXc	290	435	2.03e-79	SMART
low complexity region	441	459	N/A	INTRINSIC
PLCYc	506	622	1.26e-75	SMART
C2	641	747	5.68e-20	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000113737
AA Change: Q1018R

PolyPhen 2 Score 0.052 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000109366
Gene: ENSMUSG00000026135
AA Change: Q1018R

Domain	Start	End	E-Value	Type
ZnF_C2H2	93	115	9.81e1	SMART
ZnF_C2H2	120	144	2.29e0	SMART
ZnF_C2H2	147	169	9.96e-1	SMART
low complexity region	214	226	N/A	INTRINSIC
ZnF_C2H2	260	282	9.96e-1	SMART
ZnF_C2H2	288	308	1.26e1	SMART
ZnF_C2H2	316	339	1.47e-3	SMART
ZnF_C2H2	350	372	2.75e-3	SMART
ZnF_C2H2	383	408	3.34e-2	SMART
ZnF_C2H2	413	437	4.81e0	SMART
ZnF_C2H2	440	463	7.05e-1	SMART
ZnF_C2H2	469	492	2.17e-1	SMART
ZnF_C2H2	498	520	1.56e-2	SMART
ZnF_C2H2	526	548	8.94e-3	SMART
ZnF_C2H2	554	576	1.38e-3	SMART
ZnF_C2H2	582	604	9.44e-2	SMART
ZnF_C2H2	609	632	1.26e-2	SMART
ZnF_C2H2	641	664	1.31e0	SMART
ZnF_C2H2	670	693	2.63e0	SMART
low complexity region	800	816	N/A	INTRINSIC
low complexity region	850	866	N/A	INTRINSIC
low complexity region	893	904	N/A	INTRINSIC
ZnF_C2H2	936	956	2.01e1	SMART
ZnF_C2H2	966	986	1.91e1	SMART
low complexity region	1044	1057	N/A	INTRINSIC
ZnF_C2H2	1084	1104	2.7e2	SMART
low complexity region	1106	1119	N/A	INTRINSIC
ZnF_C2H2	1162	1182	3.56e1	SMART
ZnF_C2H2	1192	1215	4.98e-1	SMART
ZnF_C2H2	1228	1251	2.49e-1	SMART
ZnF_C2H2	1257	1279	1.03e-2	SMART
ZnF_C2H2	1285	1308	5.72e-1	SMART
ZnF_C2H2	1314	1337	6.75e0	SMART
ZnF_C2H2	1343	1366	9.58e-3	SMART
ZnF_C2H2	1385	1408	1.64e-1	SMART
ZnF_C2H2	1411	1433	1.1e-2	SMART
ZnF_C2H2	1437	1460	4.05e-1	SMART
ZnF_C2H2	1477	1499	4.45e0	SMART
ZnF_C2H2	1505	1527	8.81e-2	SMART
ZnF_C2H2	1533	1555	1.18e-2	SMART
ZnF_C2H2	1561	1583	1.2e-3	SMART
ZnF_C2H2	1589	1612	3.89e-3	SMART
ZnF_C2H2	1618	1640	4.54e-4	SMART
ZnF_C2H2	1646	1668	1.18e-2	SMART
ZnF_C2H2	1674	1696	3.52e-1	SMART
low complexity region	1726	1735	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000113749

SMART Domains

Protein: ENSMUSP00000109378
Gene: ENSMUSG00000026173

Domain	Start	End	E-Value	Type
PH	17	126	2.6e-12	SMART
EFh	138	166	9.97e-1	SMART
EFh	174	202	1.83e1	SMART
EFh	207	234	4.45e1	SMART
PLCXc	290	435	2.03e-79	SMART
low complexity region	441	459	N/A	INTRINSIC
PLCYc	538	654	1.26e-75	SMART
C2	673	779	5.68e-20	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000127921

Predicted Effect

probably benign
Transcript: ENSMUST00000141412

SMART Domains

Protein: ENSMUSP00000115322
Gene: ENSMUSG00000026173

Domain	Start	End	E-Value	Type
PH	17	126	2.6e-12	SMART
EFh	138	166	9.97e-1	SMART
EFh	174	202	1.83e1	SMART
EFh	207	234	4.45e1	SMART
PLCXc	290	435	2.03e-79	SMART
low complexity region	441	459	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000156613

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the Kruppel family of C2H2-type zinc finger proteins. It contains 31 C2H2-type zinc fingers and may be involved in transcriptional regulation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A930003A15Rik	T	A	16: 19,702,505 (GRCm39)		noncoding transcript	Het
Acap1	G	A	11: 69,785,421 (GRCm39)		probably benign	Het
Adam7	T	C	14: 68,745,343 (GRCm39)	Y627C	probably damaging	Het
Agrn	C	T	4: 156,259,018 (GRCm39)		probably benign	Het
Aoc1l2	A	G	6: 48,908,407 (GRCm39)	Y469C	probably damaging	Het
Bace2	T	C	16: 97,238,093 (GRCm39)	*515R	probably null	Het
Baiap3	C	T	17: 25,463,322 (GRCm39)	V958M	probably damaging	Het
Brms1l	A	T	12: 55,888,401 (GRCm39)	D63V	probably damaging	Het
Cnksr1	A	T	4: 133,957,774 (GRCm39)	I435N	probably damaging	Het
Col14a1	G	A	15: 55,282,178 (GRCm39)	G813E	unknown	Het
Cpne6	A	G	14: 55,751,283 (GRCm39)	N201S	probably benign	Het
Dnajc12	A	G	10: 63,233,071 (GRCm39)	S71G	probably damaging	Het
Dpp3	A	T	19: 4,973,710 (GRCm39)		probably null	Het
E2f3	A	G	13: 30,100,974 (GRCm39)	S239P	probably benign	Het
Eif3e	T	A	15: 43,146,088 (GRCm39)	M1L	probably benign	Het
Erap1	A	G	13: 74,823,987 (GRCm39)	T867A	probably benign	Het
Erlin1	G	T	19: 44,027,658 (GRCm39)	A260E	probably damaging	Het
Esrp1	A	G	4: 11,386,324 (GRCm39)	V38A	possibly damaging	Het
Foxn1	T	C	11: 78,261,986 (GRCm39)	R128G	probably damaging	Het
Gnb3	A	G	6: 124,814,688 (GRCm39)	L70P	probably benign	Het
Gon4l	T	C	3: 88,802,806 (GRCm39)	V1139A	probably damaging	Het
Gpt2	G	T	8: 86,249,908 (GRCm39)	M463I	probably benign	Het
Gtpbp3	C	A	8: 71,943,546 (GRCm39)	A201D	probably damaging	Het
Jaml	A	C	9: 45,015,489 (GRCm39)	K331T	possibly damaging	Het
Kntc1	G	A	5: 123,893,727 (GRCm39)		probably benign	Het
Ksr2	A	G	5: 117,693,446 (GRCm39)	K298R	probably damaging	Het
Mfge8	T	C	7: 78,795,429 (GRCm39)	D46G	probably benign	Het
Ncam2	T	A	16: 81,314,429 (GRCm39)	N468K	probably benign	Het
Nup88	A	G	11: 70,847,110 (GRCm39)	M300T	probably damaging	Het
Or4c118	T	A	2: 88,974,564 (GRCm39)	K268*	probably null	Het
Or4k48	A	T	2: 111,476,236 (GRCm39)	Y35*	probably null	Het
Or52b4	A	G	7: 102,184,868 (GRCm39)	M305V	probably benign	Het
Prdm1	A	T	10: 44,315,880 (GRCm39)	M752K	probably benign	Het
Prl3b1	A	T	13: 27,429,795 (GRCm39)	M78L	probably benign	Het
Ralgps2	T	C	1: 156,660,268 (GRCm39)	E268G	probably damaging	Het
Rgs11	G	A	17: 26,426,605 (GRCm39)	V279I	probably benign	Het
Slc4a5	A	G	6: 83,240,525 (GRCm39)	D279G	possibly damaging	Het
Tanc1	T	A	2: 59,630,330 (GRCm39)	I770K	probably damaging	Het
Tbl2	G	A	5: 135,181,852 (GRCm39)	R64H	probably damaging	Het
Tg	T	A	15: 66,620,575 (GRCm39)		probably benign	Het
Tmprss13	A	T	9: 45,243,824 (GRCm39)	I187F	probably benign	Het
Tubb3	T	C	8: 124,147,856 (GRCm39)	L263P	probably damaging	Het
Vmn2r109	T	G	17: 20,774,518 (GRCm39)	D279A	possibly damaging	Het
Vps33b	A	G	7: 79,925,786 (GRCm39)		probably benign	Het
Yeats2	A	G	16: 20,005,033 (GRCm39)	S338G	probably benign	Het
Zic1	G	T	9: 91,246,486 (GRCm39)	H195Q	possibly damaging	Het

Other mutations in Zfp142

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00581:Zfp142	APN	1	74,606,131 (GRCm39)	missense	probably damaging	1.00
IGL00711:Zfp142	APN	1	74,611,593 (GRCm39)	missense	probably damaging	1.00
IGL01391:Zfp142	APN	1	74,618,699 (GRCm39)	missense	probably damaging	1.00
IGL01808:Zfp142	APN	1	74,615,184 (GRCm39)	missense	probably damaging	1.00
IGL02074:Zfp142	APN	1	74,609,022 (GRCm39)	missense	probably damaging	0.97
IGL02134:Zfp142	APN	1	74,609,022 (GRCm39)	missense	probably damaging	0.97
IGL02567:Zfp142	APN	1	74,617,309 (GRCm39)	missense	possibly damaging	0.92
IGL02567:Zfp142	APN	1	74,617,306 (GRCm39)	missense	possibly damaging	0.84
IGL02567:Zfp142	APN	1	74,617,308 (GRCm39)	missense	possibly damaging	0.92
IGL02694:Zfp142	APN	1	74,609,307 (GRCm39)	missense	probably damaging	0.98
IGL02884:Zfp142	APN	1	74,611,142 (GRCm39)	missense	probably damaging	0.99
IGL03000:Zfp142	APN	1	74,612,777 (GRCm39)	missense	probably benign	0.01
IGL03080:Zfp142	APN	1	74,610,368 (GRCm39)	missense	probably benign	0.18
IGL03238:Zfp142	APN	1	74,615,437 (GRCm39)	missense	probably benign	0.37
IGL03277:Zfp142	APN	1	74,610,193 (GRCm39)	missense	probably damaging	1.00
PIT4402001:Zfp142	UTSW	1	74,618,687 (GRCm39)	missense	probably damaging	1.00
R0124:Zfp142	UTSW	1	74,607,782 (GRCm39)	missense	probably damaging	1.00
R0256:Zfp142	UTSW	1	74,617,317 (GRCm39)	missense	probably benign
R0267:Zfp142	UTSW	1	74,615,223 (GRCm39)	missense	probably benign	0.05
R0306:Zfp142	UTSW	1	74,609,341 (GRCm39)	missense	probably damaging	1.00
R0321:Zfp142	UTSW	1	74,608,873 (GRCm39)	missense	probably damaging	1.00
R0466:Zfp142	UTSW	1	74,624,570 (GRCm39)	missense	possibly damaging	0.95
R0513:Zfp142	UTSW	1	74,610,714 (GRCm39)	missense	probably damaging	1.00
R1084:Zfp142	UTSW	1	74,610,985 (GRCm39)	missense	probably benign
R1534:Zfp142	UTSW	1	74,611,247 (GRCm39)	missense	probably benign	0.00
R1548:Zfp142	UTSW	1	74,609,263 (GRCm39)	missense	probably damaging	1.00
R1623:Zfp142	UTSW	1	74,610,934 (GRCm39)	missense	possibly damaging	0.56
R1628:Zfp142	UTSW	1	74,611,047 (GRCm39)	missense	possibly damaging	0.94
R1710:Zfp142	UTSW	1	74,611,389 (GRCm39)	missense	probably damaging	1.00
R1722:Zfp142	UTSW	1	74,608,935 (GRCm39)	missense	probably damaging	1.00
R1770:Zfp142	UTSW	1	74,618,790 (GRCm39)	missense	probably damaging	0.99
R2042:Zfp142	UTSW	1	74,609,778 (GRCm39)	missense	probably benign	0.10
R2112:Zfp142	UTSW	1	74,612,795 (GRCm39)	missense	probably damaging	1.00
R2249:Zfp142	UTSW	1	74,606,191 (GRCm39)	missense	probably damaging	1.00
R4393:Zfp142	UTSW	1	74,611,219 (GRCm39)	missense	probably benign	0.00
R4700:Zfp142	UTSW	1	74,609,431 (GRCm39)	missense	probably damaging	1.00
R4750:Zfp142	UTSW	1	74,611,617 (GRCm39)	missense	probably damaging	1.00
R4763:Zfp142	UTSW	1	74,615,671 (GRCm39)	missense	probably damaging	1.00
R5208:Zfp142	UTSW	1	74,610,027 (GRCm39)	missense	probably benign	0.18
R5233:Zfp142	UTSW	1	74,624,608 (GRCm39)	missense	probably damaging	1.00
R5585:Zfp142	UTSW	1	74,617,404 (GRCm39)	nonsense	probably null
R6192:Zfp142	UTSW	1	74,609,667 (GRCm39)	missense	probably damaging	1.00
R6461:Zfp142	UTSW	1	74,606,344 (GRCm39)	missense	probably damaging	1.00
R6482:Zfp142	UTSW	1	74,609,376 (GRCm39)	splice site	probably null
R7320:Zfp142	UTSW	1	74,609,167 (GRCm39)	nonsense	probably null
R7438:Zfp142	UTSW	1	74,624,679 (GRCm39)	missense	probably benign
R7528:Zfp142	UTSW	1	74,610,061 (GRCm39)	missense	probably benign	0.00
R7600:Zfp142	UTSW	1	74,612,827 (GRCm39)	missense	probably damaging	1.00
R8007:Zfp142	UTSW	1	74,610,655 (GRCm39)	missense	probably benign	0.01
R8681:Zfp142	UTSW	1	74,610,747 (GRCm39)	missense	probably damaging	1.00
R8772:Zfp142	UTSW	1	74,610,825 (GRCm39)	missense	possibly damaging	0.87
R9058:Zfp142	UTSW	1	74,608,955 (GRCm39)	nonsense	probably null
R9233:Zfp142	UTSW	1	74,610,288 (GRCm39)	missense	probably benign
R9281:Zfp142	UTSW	1	74,607,731 (GRCm39)	missense	probably damaging	1.00
R9302:Zfp142	UTSW	1	74,606,302 (GRCm39)	missense	probably damaging	0.98
R9454:Zfp142	UTSW	1	74,609,016 (GRCm39)	missense	probably damaging	1.00
R9569:Zfp142	UTSW	1	74,615,386 (GRCm39)	missense	probably damaging	1.00
R9595:Zfp142	UTSW	1	74,611,462 (GRCm39)	missense	probably damaging	1.00
R9680:Zfp142	UTSW	1	74,610,933 (GRCm39)	missense	probably benign	0.16
Z1177:Zfp142	UTSW	1	74,609,325 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16