Incidental Mutation 'IGL02670:Sstr4'
ID 302886
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sstr4
Ensembl Gene ENSMUSG00000037014
Gene Name somatostatin receptor 4
Synonyms Smstr4, sst4
Accession Numbers
Essential gene? Probably non essential (E-score: 0.192) question?
Stock # IGL02670
Quality Score
Chromosome 2
Chromosomal Location 148237297-148238684 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 148238453 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Stop codon at position 355 (G355*)
Ref Sequence ENSEMBL: ENSMUSP00000105588 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109962]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000109962
AA Change: G355*
SMART Domains Protein: ENSMUSP00000105588
Gene: ENSMUSG00000037014
AA Change: G355*

Pfam:7TM_GPCR_Srsx 55 323 4.7e-16 PFAM
Pfam:7tm_1 61 308 2.2e-61 PFAM
Pfam:7TM_GPCR_Srv 117 325 1.8e-10 PFAM
Pfam:7TM_GPCR_Srw 203 326 8.1e-9 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygote null mice have increased susceptibility to inflammation, delayed type hypersensitivity, hyperalgesia and airway hypersensitivity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Asb1 T C 1: 91,474,640 (GRCm39) probably benign Het
Bltp1 C T 3: 37,021,454 (GRCm39) Q2193* probably null Het
Cnot6 G A 11: 49,575,941 (GRCm39) Q178* probably null Het
Col5a1 C T 2: 27,864,727 (GRCm39) A737V unknown Het
Cyp27b1 T C 10: 126,886,227 (GRCm39) S303P probably benign Het
Dnah5 T C 15: 28,409,442 (GRCm39) L3620P probably damaging Het
Dock7 A T 4: 98,854,523 (GRCm39) probably null Het
Fam161b T C 12: 84,404,368 (GRCm39) D104G probably benign Het
Fam8a1 A G 13: 46,827,080 (GRCm39) M284V possibly damaging Het
Fkbp3 T A 12: 65,115,877 (GRCm39) K65* probably null Het
Gatb A G 3: 85,520,858 (GRCm39) probably null Het
Gm572 A T 4: 148,735,685 (GRCm39) H38L probably benign Het
Gm6576 A C 15: 27,025,598 (GRCm39) noncoding transcript Het
L2hgdh G A 12: 69,739,254 (GRCm39) R406W possibly damaging Het
Lmo7 A T 14: 102,118,416 (GRCm39) T214S probably damaging Het
Map3k12 T C 15: 102,411,981 (GRCm39) H361R probably benign Het
Mios T C 6: 8,235,378 (GRCm39) probably benign Het
Mta1 T C 12: 113,093,741 (GRCm39) L315P probably damaging Het
Pask A C 1: 93,238,540 (GRCm39) V1315G probably damaging Het
Pias4 A T 10: 80,999,904 (GRCm39) C50S probably damaging Het
Rgs11 G A 17: 26,426,605 (GRCm39) V279I probably benign Het
Sgk1 T A 10: 21,804,445 (GRCm39) C92S probably benign Het
Slc2a13 C T 15: 91,381,712 (GRCm39) G259E probably damaging Het
Slc5a4b A G 10: 75,910,934 (GRCm39) C301R probably damaging Het
Tnrc6a T A 7: 122,770,535 (GRCm39) L775Q possibly damaging Het
Vmn1r218 A G 13: 23,321,174 (GRCm39) I94V probably benign Het
Xpa A G 4: 46,185,682 (GRCm39) F99L probably benign Het
Other mutations in Sstr4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01325:Sstr4 APN 2 148,237,472 (GRCm39) missense probably benign 0.00
IGL01536:Sstr4 APN 2 148,237,800 (GRCm39) missense probably damaging 1.00
IGL02210:Sstr4 APN 2 148,238,229 (GRCm39) missense probably damaging 1.00
R0396:Sstr4 UTSW 2 148,238,181 (GRCm39) missense probably damaging 1.00
R1428:Sstr4 UTSW 2 148,238,279 (GRCm39) missense probably benign 0.01
R1839:Sstr4 UTSW 2 148,237,453 (GRCm39) missense probably benign 0.21
R2332:Sstr4 UTSW 2 148,238,330 (GRCm39) missense probably damaging 1.00
R2943:Sstr4 UTSW 2 148,238,085 (GRCm39) missense probably damaging 0.96
R3700:Sstr4 UTSW 2 148,238,273 (GRCm39) missense possibly damaging 0.57
R5502:Sstr4 UTSW 2 148,237,471 (GRCm39) small insertion probably benign
R5503:Sstr4 UTSW 2 148,237,471 (GRCm39) small insertion probably benign
R5596:Sstr4 UTSW 2 148,237,652 (GRCm39) missense possibly damaging 0.65
R5726:Sstr4 UTSW 2 148,238,003 (GRCm39) missense probably damaging 1.00
R6985:Sstr4 UTSW 2 148,238,169 (GRCm39) missense probably damaging 0.97
R8939:Sstr4 UTSW 2 148,238,228 (GRCm39) missense probably damaging 1.00
R8943:Sstr4 UTSW 2 148,237,782 (GRCm39) missense possibly damaging 0.94
X0022:Sstr4 UTSW 2 148,237,452 (GRCm39) missense probably benign 0.00
Posted On 2015-04-16