Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02670:Sstr4'

302886

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Sstr4

Ensembl Gene

ENSMUSG00000037014

Gene Name

somatostatin receptor 4

Synonyms

Smstr4, sst4

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.333) question?

Stock #

IGL02670

Quality Score

Status

Chromosome

Chromosomal Location

148395344-148396767 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to T at 148396533 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Stop codon at position 355 (G355*)

Ref Sequence

ENSEMBL: ENSMUSP00000105588 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000109962]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000109962
AA Change: G355*

SMART Domains

Protein: ENSMUSP00000105588
Gene: ENSMUSG00000037014
AA Change: G355*

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	55	323	4.7e-16	PFAM
Pfam:7tm_1	61	308	2.2e-61	PFAM
Pfam:7TM_GPCR_Srv	117	325	1.8e-10	PFAM
Pfam:7TM_GPCR_Srw	203	326	8.1e-9	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygote null mice have increased susceptibility to inflammation, delayed type hypersensitivity, hyperalgesia and airway hypersensitivity. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438A13Rik	C	T	3: 36,967,305	Q2193*	probably null	Het
Asb1	T	C	1: 91,546,918		probably benign	Het
Cnot6	G	A	11: 49,685,114	Q178*	probably null	Het
Col5a1	C	T	2: 27,974,715	A737V	unknown	Het
Cyp27b1	T	C	10: 127,050,358	S303P	probably benign	Het
Dnah5	T	C	15: 28,409,296	L3620P	probably damaging	Het
Dock7	A	T	4: 98,966,286		probably null	Het
Fam161b	T	C	12: 84,357,594	D104G	probably benign	Het
Fam8a1	A	G	13: 46,673,604	M284V	possibly damaging	Het
Fkbp3	T	A	12: 65,069,103	K65*	probably null	Het
Gatb	A	G	3: 85,613,551		probably null	Het
Gm572	A	T	4: 148,651,228	H38L	probably benign	Het
Gm6576	A	C	15: 27,025,512		noncoding transcript	Het
L2hgdh	G	A	12: 69,692,480	R406W	possibly damaging	Het
Lmo7	A	T	14: 101,880,980	T214S	probably damaging	Het
Map3k12	T	C	15: 102,503,546	H361R	probably benign	Het
Mios	T	C	6: 8,235,378		probably benign	Het
Mta1	T	C	12: 113,130,121	L315P	probably damaging	Het
Pask	A	C	1: 93,310,818	V1315G	probably damaging	Het
Pias4	A	T	10: 81,164,070	C50S	probably damaging	Het
Rgs11	G	A	17: 26,207,631	V279I	probably benign	Het
Sgk1	T	A	10: 21,928,546	C92S	probably benign	Het
Slc2a13	C	T	15: 91,497,509	G259E	probably damaging	Het
Slc5a4b	A	G	10: 76,075,100	C301R	probably damaging	Het
Tnrc6a	T	A	7: 123,171,312	L775Q	possibly damaging	Het
Vmn1r218	A	G	13: 23,137,004	I94V	probably benign	Het
Xpa	A	G	4: 46,185,682	F99L	probably benign	Het

Other mutations in Sstr4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01325:Sstr4	APN	2	148395552	missense	probably benign	0.00
IGL01536:Sstr4	APN	2	148395880	missense	probably damaging	1.00
IGL02210:Sstr4	APN	2	148396309	missense	probably damaging	1.00
R0396:Sstr4	UTSW	2	148396261	missense	probably damaging	1.00
R1428:Sstr4	UTSW	2	148396359	missense	probably benign	0.01
R1839:Sstr4	UTSW	2	148395533	missense	probably benign	0.21
R2332:Sstr4	UTSW	2	148396410	missense	probably damaging	1.00
R2943:Sstr4	UTSW	2	148396165	missense	probably damaging	0.96
R3700:Sstr4	UTSW	2	148396353	missense	possibly damaging	0.57
R5502:Sstr4	UTSW	2	148395551	small insertion	probably benign
R5503:Sstr4	UTSW	2	148395551	small insertion	probably benign
R5596:Sstr4	UTSW	2	148395732	missense	possibly damaging	0.65
R5726:Sstr4	UTSW	2	148396083	missense	probably damaging	1.00
R6985:Sstr4	UTSW	2	148396249	missense	probably damaging	0.97
R8939:Sstr4	UTSW	2	148396308	missense	probably damaging	1.00
R8943:Sstr4	UTSW	2	148395862	missense	possibly damaging	0.94
X0022:Sstr4	UTSW	2	148395532	missense	probably benign	0.00

Posted On

2015-04-16