Incidental Mutation 'IGL02671:Olfr213'
ID302913
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr213
Ensembl Gene ENSMUSG00000081649
Gene Nameolfactory receptor 213
SynonymsGA_x54KRFPKN04-58174409-58175392, MOR119-3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.066) question?
Stock #IGL02671
Quality Score
Status
Chromosome6
Chromosomal Location116538456-116544292 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 116541143 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Isoleucine at position 230 (T230I)
Ref Sequence ENSEMBL: ENSMUSP00000151916 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000121958] [ENSMUST00000220008]
Predicted Effect possibly damaging
Transcript: ENSMUST00000121958
AA Change: T230I

PolyPhen 2 Score 0.502 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000112931
Gene: ENSMUSG00000081649
AA Change: T230I

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 4e-45 PFAM
Pfam:7tm_1 47 296 5.4e-15 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000220008
AA Change: T230I

PolyPhen 2 Score 0.502 (Sensitivity: 0.88; Specificity: 0.90)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810043G02Rik A T 10: 77,980,550 probably benign Het
9030612E09Rik T A 10: 43,174,891 H60Q probably benign Het
Agrn C T 4: 156,174,561 probably benign Het
Angpt1 C T 15: 42,676,394 R23H possibly damaging Het
Cadps T A 14: 12,491,824 E775D probably damaging Het
Cdc42bpa T A 1: 180,061,822 M211K probably benign Het
Clec16a A G 16: 10,627,381 M77V probably benign Het
Csgalnact1 C A 8: 68,401,492 G219V probably damaging Het
Cyp27b1 G T 10: 127,051,043 probably null Het
Eef1d A G 15: 75,895,805 I240T probably damaging Het
Fras1 T A 5: 96,728,616 F2403I possibly damaging Het
Ighv1-47 C T 12: 114,991,398 V21I possibly damaging Het
Kank1 T C 19: 25,428,095 L1159P probably damaging Het
Kif12 T C 4: 63,170,457 E202G probably benign Het
Kif17 A G 4: 138,288,061 D315G possibly damaging Het
Mcam T C 9: 44,137,034 probably benign Het
Mpdz A T 4: 81,290,273 D1778E probably damaging Het
Numbl C T 7: 27,264,902 R46W probably damaging Het
Olfr366 A T 2: 37,220,245 Y252F probably damaging Het
Pde3b T C 7: 114,523,345 V716A possibly damaging Het
Plcg1 T A 2: 160,755,752 Y771* probably null Het
Pramel5 A G 4: 144,273,112 V135A probably benign Het
Slu7 A G 11: 43,445,475 probably null Het
Taf2 C T 15: 55,034,176 V919I probably benign Het
Tcf12 G A 9: 72,109,717 T36M probably damaging Het
Tlr11 A T 14: 50,360,692 D45V probably damaging Het
Tmem132b A G 5: 125,778,727 T508A probably damaging Het
Trf C T 9: 103,211,982 E569K probably benign Het
Trim24 T C 6: 37,960,784 C875R probably damaging Het
Usf3 A G 16: 44,221,781 N2208S probably damaging Het
Usp14 A G 18: 9,997,196 V436A probably damaging Het
Vwa5b1 G A 4: 138,569,126 R1197* probably null Het
Other mutations in Olfr213
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01063:Olfr213 APN 6 116541007 missense probably damaging 1.00
IGL03107:Olfr213 APN 6 116540939 missense possibly damaging 0.82
R0041:Olfr213 UTSW 6 116541334 missense possibly damaging 0.55
R0426:Olfr213 UTSW 6 116540485 missense probably damaging 1.00
R0627:Olfr213 UTSW 6 116540988 missense possibly damaging 0.56
R0829:Olfr213 UTSW 6 116541265 missense probably benign 0.01
R2111:Olfr213 UTSW 6 116540650 missense possibly damaging 0.95
R2112:Olfr213 UTSW 6 116540650 missense possibly damaging 0.95
R2120:Olfr213 UTSW 6 116540455 start codon destroyed probably null 0.04
R3161:Olfr213 UTSW 6 116540846 missense probably damaging 1.00
R3700:Olfr213 UTSW 6 116540528 missense probably benign 0.10
R4710:Olfr213 UTSW 6 116540650 missense possibly damaging 0.95
R5244:Olfr213 UTSW 6 116541226 missense probably damaging 1.00
R5859:Olfr213 UTSW 6 116540900 missense probably damaging 1.00
R6273:Olfr213 UTSW 6 116541316 missense possibly damaging 0.74
R6505:Olfr213 UTSW 6 116540600 missense probably benign 0.01
R7350:Olfr213 UTSW 6 116540534 missense probably benign 0.28
R7380:Olfr213 UTSW 6 116540933 missense probably benign 0.03
R7474:Olfr213 UTSW 6 116541038 missense probably damaging 0.99
R8054:Olfr213 UTSW 6 116540999 missense probably damaging 1.00
Posted On2015-04-16