Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02671:Tmem132b'

302935

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem132b

Ensembl Gene

ENSMUSG00000070498

Gene Name

transmembrane protein 132B

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

IGL02671

Quality Score

Status

Chromosome

Chromosomal Location

125531774-125792583 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 125778727 bp

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 508 (T508A)

Ref Sequence

ENSEMBL: ENSMUSP00000031446 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000031446]

Predicted Effect

probably damaging
Transcript: ENSMUST00000031446
AA Change: T508A

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000031446
Gene: ENSMUSG00000070498
AA Change: T508A

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:TMEM132D_N	44	173	2.9e-53	PFAM
Pfam:TMEM132	432	774	5.9e-145	PFAM
Pfam:TMEM132D_C	870	953	1.3e-36	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1810043G02Rik	A	T	10: 77,980,550		probably benign	Het
9030612E09Rik	T	A	10: 43,174,891	H60Q	probably benign	Het
Agrn	C	T	4: 156,174,561		probably benign	Het
Angpt1	C	T	15: 42,676,394	R23H	possibly damaging	Het
Cadps	T	A	14: 12,491,824	E775D	probably damaging	Het
Cdc42bpa	T	A	1: 180,061,822	M211K	probably benign	Het
Clec16a	A	G	16: 10,627,381	M77V	probably benign	Het
Csgalnact1	C	A	8: 68,401,492	G219V	probably damaging	Het
Cyp27b1	G	T	10: 127,051,043		probably null	Het
Eef1d	A	G	15: 75,895,805	I240T	probably damaging	Het
Fras1	T	A	5: 96,728,616	F2403I	possibly damaging	Het
Ighv1-47	C	T	12: 114,991,398	V21I	possibly damaging	Het
Kank1	T	C	19: 25,428,095	L1159P	probably damaging	Het
Kif12	T	C	4: 63,170,457	E202G	probably benign	Het
Kif17	A	G	4: 138,288,061	D315G	possibly damaging	Het
Mcam	T	C	9: 44,137,034		probably benign	Het
Mpdz	A	T	4: 81,290,273	D1778E	probably damaging	Het
Numbl	C	T	7: 27,264,902	R46W	probably damaging	Het
Olfr213	C	T	6: 116,541,143	T230I	possibly damaging	Het
Olfr366	A	T	2: 37,220,245	Y252F	probably damaging	Het
Pde3b	T	C	7: 114,523,345	V716A	possibly damaging	Het
Plcg1	T	A	2: 160,755,752	Y771*	probably null	Het
Pramel5	A	G	4: 144,273,112	V135A	probably benign	Het
Slu7	A	G	11: 43,445,475		probably null	Het
Taf2	C	T	15: 55,034,176	V919I	probably benign	Het
Tcf12	G	A	9: 72,109,717	T36M	probably damaging	Het
Tlr11	A	T	14: 50,360,692	D45V	probably damaging	Het
Trf	C	T	9: 103,211,982	E569K	probably benign	Het
Trim24	T	C	6: 37,960,784	C875R	probably damaging	Het
Usf3	A	G	16: 44,221,781	N2208S	probably damaging	Het
Usp14	A	G	18: 9,997,196	V436A	probably damaging	Het
Vwa5b1	G	A	4: 138,569,126	R1197*	probably null	Het

Other mutations in Tmem132b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01397:Tmem132b	APN	5	125698728	missense	probably benign
IGL01518:Tmem132b	APN	5	125778791	missense	probably damaging	1.00
IGL02542:Tmem132b	APN	5	125622494	missense	probably damaging	1.00
IGL02652:Tmem132b	APN	5	125787575	missense	probably damaging	1.00
IGL02951:Tmem132b	APN	5	125787547	missense	probably damaging	0.99
R0456:Tmem132b	UTSW	5	125787724	missense	probably damaging	0.99
R0462:Tmem132b	UTSW	5	125785926	missense	probably damaging	1.00
R0724:Tmem132b	UTSW	5	125783421	missense	possibly damaging	0.95
R1137:Tmem132b	UTSW	5	125783542	missense	possibly damaging	0.94
R1168:Tmem132b	UTSW	5	125787019	missense	probably damaging	0.99
R1418:Tmem132b	UTSW	5	125638249	missense	probably benign	0.01
R1689:Tmem132b	UTSW	5	125787614	missense	possibly damaging	0.95
R1744:Tmem132b	UTSW	5	125778844	critical splice donor site	probably null
R1835:Tmem132b	UTSW	5	125785899	missense	probably damaging	1.00
R2016:Tmem132b	UTSW	5	125623016	missense	probably benign
R2033:Tmem132b	UTSW	5	125749289	missense	probably damaging	0.98
R2097:Tmem132b	UTSW	5	125638208	missense	probably damaging	0.99
R2114:Tmem132b	UTSW	5	125622551	missense	probably damaging	1.00
R2116:Tmem132b	UTSW	5	125622551	missense	probably damaging	1.00
R2117:Tmem132b	UTSW	5	125622551	missense	probably damaging	1.00
R2870:Tmem132b	UTSW	5	125638268	missense	probably benign
R2870:Tmem132b	UTSW	5	125638268	missense	probably benign
R3807:Tmem132b	UTSW	5	125787580	missense	probably damaging	1.00
R4825:Tmem132b	UTSW	5	125783433	missense	probably benign
R5149:Tmem132b	UTSW	5	125622925	missense	probably damaging	0.99
R5484:Tmem132b	UTSW	5	125787733	missense	probably damaging	1.00
R5623:Tmem132b	UTSW	5	125623352	missense	probably damaging	0.99
R5624:Tmem132b	UTSW	5	125622646	missense	probably benign	0.04
R5775:Tmem132b	UTSW	5	125638330	critical splice donor site	probably null
R7012:Tmem132b	UTSW	5	125698590	missense	probably damaging	1.00
R7142:Tmem132b	UTSW	5	125622673	missense	probably damaging	1.00
R7308:Tmem132b	UTSW	5	125787646	missense	possibly damaging	0.88
R7414:Tmem132b	UTSW	5	125787491	missense	probably damaging	1.00
R7452:Tmem132b	UTSW	5	125638268	missense	probably benign
R7650:Tmem132b	UTSW	5	125787010	missense	probably benign	0.04
Z1176:Tmem132b	UTSW	5	125787886	missense	not run

Posted On

2015-04-16