Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02671:Tmem132b'

302935

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem132b

Ensembl Gene

ENSMUSG00000070498

Gene Name

transmembrane protein 132B

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.092) question?

Stock #

IGL02671

Quality Score

Status

Chromosome

Chromosomal Location

125609449-125869647 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 125855791 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 508 (T508A)

Ref Sequence

ENSEMBL: ENSMUSP00000031446 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000031446]

AlphaFold

F7BAB2

Predicted Effect

probably damaging
Transcript: ENSMUST00000031446
AA Change: T508A

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000031446
Gene: ENSMUSG00000070498
AA Change: T508A

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:TMEM132D_N	44	173	2.9e-53	PFAM
Pfam:TMEM132	432	774	5.9e-145	PFAM
Pfam:TMEM132D_C	870	953	1.3e-36	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9030612E09Rik	T	A	10: 43,050,887 (GRCm39)	H60Q	probably benign	Het
Agrn	C	T	4: 156,259,018 (GRCm39)		probably benign	Het
Angpt1	C	T	15: 42,539,790 (GRCm39)	R23H	possibly damaging	Het
Cadps	T	A	14: 12,491,824 (GRCm38)	E775D	probably damaging	Het
Cdc42bpa	T	A	1: 179,889,387 (GRCm39)	M211K	probably benign	Het
Cfap410	A	T	10: 77,816,384 (GRCm39)		probably benign	Het
Clec16a	A	G	16: 10,445,245 (GRCm39)	M77V	probably benign	Het
Csgalnact1	C	A	8: 68,854,144 (GRCm39)	G219V	probably damaging	Het
Cyp27b1	G	T	10: 126,886,912 (GRCm39)		probably null	Het
Eef1d	A	G	15: 75,767,654 (GRCm39)	I240T	probably damaging	Het
Fras1	T	A	5: 96,876,475 (GRCm39)	F2403I	possibly damaging	Het
Ighv1-47	C	T	12: 114,955,018 (GRCm39)	V21I	possibly damaging	Het
Kank1	T	C	19: 25,405,459 (GRCm39)	L1159P	probably damaging	Het
Kif12	T	C	4: 63,088,694 (GRCm39)	E202G	probably benign	Het
Kif17	A	G	4: 138,015,372 (GRCm39)	D315G	possibly damaging	Het
Mcam	T	C	9: 44,048,331 (GRCm39)		probably benign	Het
Mpdz	A	T	4: 81,208,510 (GRCm39)	D1778E	probably damaging	Het
Numbl	C	T	7: 26,964,327 (GRCm39)	R46W	probably damaging	Het
Or1af1	A	T	2: 37,110,257 (GRCm39)	Y252F	probably damaging	Het
Or6d13	C	T	6: 116,518,104 (GRCm39)	T230I	possibly damaging	Het
Pde3b	T	C	7: 114,122,580 (GRCm39)	V716A	possibly damaging	Het
Plcg1	T	A	2: 160,597,672 (GRCm39)	Y771*	probably null	Het
Pramel5	A	G	4: 143,999,682 (GRCm39)	V135A	probably benign	Het
Slu7	A	G	11: 43,336,302 (GRCm39)		probably null	Het
Taf2	C	T	15: 54,897,572 (GRCm39)	V919I	probably benign	Het
Tcf12	G	A	9: 72,016,999 (GRCm39)	T36M	probably damaging	Het
Tlr11	A	T	14: 50,598,149 (GRCm39)	D45V	probably damaging	Het
Trf	C	T	9: 103,089,181 (GRCm39)	E569K	probably benign	Het
Trim24	T	C	6: 37,937,719 (GRCm39)	C875R	probably damaging	Het
Usf3	A	G	16: 44,042,144 (GRCm39)	N2208S	probably damaging	Het
Usp14	A	G	18: 9,997,196 (GRCm39)	V436A	probably damaging	Het
Vwa5b1	G	A	4: 138,296,437 (GRCm39)	R1197*	probably null	Het

Other mutations in Tmem132b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01397:Tmem132b	APN	5	125,775,792 (GRCm39)	missense	probably benign
IGL01518:Tmem132b	APN	5	125,855,855 (GRCm39)	missense	probably damaging	1.00
IGL02542:Tmem132b	APN	5	125,699,558 (GRCm39)	missense	probably damaging	1.00
IGL02652:Tmem132b	APN	5	125,864,639 (GRCm39)	missense	probably damaging	1.00
IGL02951:Tmem132b	APN	5	125,864,611 (GRCm39)	missense	probably damaging	0.99
R0456:Tmem132b	UTSW	5	125,864,788 (GRCm39)	missense	probably damaging	0.99
R0462:Tmem132b	UTSW	5	125,862,990 (GRCm39)	missense	probably damaging	1.00
R0724:Tmem132b	UTSW	5	125,860,485 (GRCm39)	missense	possibly damaging	0.95
R1137:Tmem132b	UTSW	5	125,860,606 (GRCm39)	missense	possibly damaging	0.94
R1168:Tmem132b	UTSW	5	125,864,083 (GRCm39)	missense	probably damaging	0.99
R1418:Tmem132b	UTSW	5	125,715,313 (GRCm39)	missense	probably benign	0.01
R1689:Tmem132b	UTSW	5	125,864,678 (GRCm39)	missense	possibly damaging	0.95
R1744:Tmem132b	UTSW	5	125,855,908 (GRCm39)	critical splice donor site	probably null
R1835:Tmem132b	UTSW	5	125,862,963 (GRCm39)	missense	probably damaging	1.00
R2016:Tmem132b	UTSW	5	125,700,080 (GRCm39)	missense	probably benign
R2033:Tmem132b	UTSW	5	125,826,353 (GRCm39)	missense	probably damaging	0.98
R2097:Tmem132b	UTSW	5	125,715,272 (GRCm39)	missense	probably damaging	0.99
R2114:Tmem132b	UTSW	5	125,699,615 (GRCm39)	missense	probably damaging	1.00
R2116:Tmem132b	UTSW	5	125,699,615 (GRCm39)	missense	probably damaging	1.00
R2117:Tmem132b	UTSW	5	125,699,615 (GRCm39)	missense	probably damaging	1.00
R2870:Tmem132b	UTSW	5	125,715,332 (GRCm39)	missense	probably benign
R2870:Tmem132b	UTSW	5	125,715,332 (GRCm39)	missense	probably benign
R3807:Tmem132b	UTSW	5	125,864,644 (GRCm39)	missense	probably damaging	1.00
R4825:Tmem132b	UTSW	5	125,860,497 (GRCm39)	missense	probably benign
R5149:Tmem132b	UTSW	5	125,699,989 (GRCm39)	missense	probably damaging	0.99
R5484:Tmem132b	UTSW	5	125,864,797 (GRCm39)	missense	probably damaging	1.00
R5623:Tmem132b	UTSW	5	125,700,416 (GRCm39)	missense	probably damaging	0.99
R5624:Tmem132b	UTSW	5	125,699,710 (GRCm39)	missense	probably benign	0.04
R5775:Tmem132b	UTSW	5	125,715,394 (GRCm39)	critical splice donor site	probably null
R7012:Tmem132b	UTSW	5	125,775,654 (GRCm39)	missense	probably damaging	1.00
R7142:Tmem132b	UTSW	5	125,699,737 (GRCm39)	missense	probably damaging	1.00
R7308:Tmem132b	UTSW	5	125,864,710 (GRCm39)	missense	possibly damaging	0.88
R7414:Tmem132b	UTSW	5	125,864,555 (GRCm39)	missense	probably damaging	1.00
R7452:Tmem132b	UTSW	5	125,715,332 (GRCm39)	missense	probably benign
R7650:Tmem132b	UTSW	5	125,864,074 (GRCm39)	missense	probably benign	0.04
R8111:Tmem132b	UTSW	5	125,699,857 (GRCm39)	missense	probably benign	0.00
R8326:Tmem132b	UTSW	5	125,864,618 (GRCm39)	missense	probably damaging	1.00
R8525:Tmem132b	UTSW	5	125,715,380 (GRCm39)	missense	probably benign	0.01
R8900:Tmem132b	UTSW	5	125,855,884 (GRCm39)	missense	probably damaging	0.96
R9147:Tmem132b	UTSW	5	125,864,167 (GRCm39)	missense	probably damaging	1.00
R9148:Tmem132b	UTSW	5	125,864,167 (GRCm39)	missense	probably damaging	1.00
R9179:Tmem132b	UTSW	5	125,700,115 (GRCm39)	missense	probably benign	0.02
R9215:Tmem132b	UTSW	5	125,864,180 (GRCm39)	missense	probably damaging	0.99
R9231:Tmem132b	UTSW	5	125,860,531 (GRCm39)	missense	probably damaging	1.00
R9284:Tmem132b	UTSW	5	125,864,711 (GRCm39)	missense	possibly damaging	0.67
R9311:Tmem132b	UTSW	5	125,863,029 (GRCm39)	missense	possibly damaging	0.56
R9436:Tmem132b	UTSW	5	125,775,633 (GRCm39)	missense	possibly damaging	0.53
R9484:Tmem132b	UTSW	5	125,860,420 (GRCm39)	missense	probably damaging	0.98
R9775:Tmem132b	UTSW	5	125,864,566 (GRCm39)	missense	probably benign	0.07
Z1176:Tmem132b	UTSW	5	125,864,950 (GRCm39)	missense	possibly damaging	0.51

Posted On

2015-04-16