Incidental Mutation 'IGL02672:Dpp10'
ID 302953
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dpp10
Ensembl Gene ENSMUSG00000036815
Gene Name dipeptidylpeptidase 10
Synonyms 6430601K09Rik, DPRP3
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02672
Quality Score
Status
Chromosome 1
Chromosomal Location 123259871-124773774 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 123304376 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 508 (H508L)
Ref Sequence ENSEMBL: ENSMUSP00000108225 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000112603] [ENSMUST00000112606]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000112603
AA Change: H497L

PolyPhen 2 Score 0.066 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000108222
Gene: ENSMUSG00000036815
AA Change: H497L

DomainStartEndE-ValueType
low complexity region 10 25 N/A INTRINSIC
Pfam:DPPIV_N 83 450 4.9e-118 PFAM
Pfam:Peptidase_S9 530 734 6.4e-47 PFAM
Pfam:DLH 556 711 1.4e-6 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000112606
AA Change: H508L

PolyPhen 2 Score 0.446 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000108225
Gene: ENSMUSG00000036815
AA Change: H508L

DomainStartEndE-ValueType
transmembrane domain 38 60 N/A INTRINSIC
low complexity region 64 79 N/A INTRINSIC
Pfam:DPPIV_N 137 504 4.4e-115 PFAM
Pfam:Peptidase_S9 584 788 8.6e-48 PFAM
Pfam:DLH 604 774 1.1e-7 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000194472
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agrn C T 4: 156,259,018 (GRCm39) probably benign Het
Alpi A G 1: 87,028,994 (GRCm39) L60P probably damaging Het
Arpc1a A C 5: 145,041,697 (GRCm39) I327L probably damaging Het
Col5a1 C T 2: 27,864,727 (GRCm39) A737V unknown Het
Dcaf7 T C 11: 105,945,684 (GRCm39) probably benign Het
Dnah9 T G 11: 65,818,427 (GRCm39) I3304L probably benign Het
Dync1i1 A G 6: 5,767,034 (GRCm39) D86G probably benign Het
Enpp7 T C 11: 118,883,166 (GRCm39) probably null Het
Fbxw9 C A 8: 85,792,682 (GRCm39) probably null Het
Foxred2 A G 15: 77,829,777 (GRCm39) probably null Het
Gas2l2 C T 11: 83,315,957 (GRCm39) R254H probably damaging Het
Gatad2b C T 3: 90,249,198 (GRCm39) L79F possibly damaging Het
Igf1r A T 7: 67,839,781 (GRCm39) D696V probably benign Het
Kcnk5 A G 14: 20,196,580 (GRCm39) I96T probably damaging Het
Lrrc8c C T 5: 105,755,224 (GRCm39) T333M possibly damaging Het
Mcm10 T C 2: 5,006,092 (GRCm39) T417A probably benign Het
Mesp2 T C 7: 79,461,145 (GRCm39) S157P probably benign Het
Naca A G 10: 127,876,152 (GRCm39) probably benign Het
Or5t17 A T 2: 86,832,417 (GRCm39) M35L probably benign Het
Osgepl1 A G 1: 53,359,270 (GRCm39) T260A probably benign Het
Otop1 T C 5: 38,435,170 (GRCm39) probably null Het
Pdk1 T C 2: 71,726,096 (GRCm39) S335P probably damaging Het
Phkb A G 8: 86,668,987 (GRCm39) N338S probably benign Het
Pogz G A 3: 94,763,410 (GRCm39) V61I probably benign Het
Ppp4r1 A G 17: 66,147,942 (GRCm39) Y928C probably damaging Het
Rab17 T C 1: 90,886,940 (GRCm39) E160G probably damaging Het
Rasgrp3 T A 17: 75,803,412 (GRCm39) F70Y probably benign Het
Rere T A 4: 150,594,483 (GRCm39) N364K unknown Het
Ryr1 A T 7: 28,703,944 (GRCm39) probably benign Het
Sae1 A G 7: 16,104,273 (GRCm39) V112A probably damaging Het
Serpinb6d C T 13: 33,855,372 (GRCm39) H349Y probably benign Het
Slc12a1 T C 2: 125,012,596 (GRCm39) V286A probably damaging Het
Smad3 A T 9: 63,575,009 (GRCm39) probably null Het
Sox8 T A 17: 25,787,963 (GRCm39) D162V probably damaging Het
Sptbn1 A G 11: 30,087,239 (GRCm39) F1067L probably damaging Het
Tmprss3 T C 17: 31,409,981 (GRCm39) Y211C probably damaging Het
Top2b T C 14: 16,409,166 (GRCm38) probably benign Het
Tpp1 A T 7: 105,396,168 (GRCm39) H510Q probably benign Het
Ugcg T A 4: 59,218,587 (GRCm39) probably benign Het
Vmn2r96 T A 17: 18,818,376 (GRCm39) I651N probably benign Het
Wdr25 A T 12: 108,864,007 (GRCm39) K51* probably null Het
Other mutations in Dpp10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01592:Dpp10 APN 1 123,262,099 (GRCm39) missense probably damaging 1.00
IGL01618:Dpp10 APN 1 123,295,596 (GRCm39) missense probably benign
IGL02101:Dpp10 APN 1 123,339,555 (GRCm39) missense probably damaging 1.00
IGL02284:Dpp10 APN 1 123,973,103 (GRCm39) splice site probably benign
IGL02324:Dpp10 APN 1 123,295,531 (GRCm39) missense probably benign 0.02
IGL02391:Dpp10 APN 1 123,578,087 (GRCm39) missense probably damaging 0.98
IGL02458:Dpp10 APN 1 123,269,418 (GRCm39) missense probably benign 0.01
IGL02469:Dpp10 APN 1 123,339,532 (GRCm39) missense probably benign 0.01
IGL02501:Dpp10 APN 1 123,613,999 (GRCm39) missense possibly damaging 0.93
IGL02522:Dpp10 APN 1 123,351,381 (GRCm39) missense probably benign 0.24
IGL03034:Dpp10 APN 1 123,269,348 (GRCm39) missense probably damaging 1.00
PIT1430001:Dpp10 UTSW 1 123,268,911 (GRCm39) splice site probably benign
R0104:Dpp10 UTSW 1 123,295,572 (GRCm39) missense probably benign 0.00
R0114:Dpp10 UTSW 1 123,413,821 (GRCm39) missense probably benign 0.07
R0242:Dpp10 UTSW 1 123,326,275 (GRCm39) missense possibly damaging 0.56
R0242:Dpp10 UTSW 1 123,326,275 (GRCm39) missense possibly damaging 0.56
R0682:Dpp10 UTSW 1 123,832,852 (GRCm39) missense probably damaging 0.98
R0815:Dpp10 UTSW 1 123,360,658 (GRCm39) critical splice donor site probably null
R1549:Dpp10 UTSW 1 123,269,109 (GRCm39) critical splice acceptor site probably null
R1742:Dpp10 UTSW 1 123,372,935 (GRCm39) missense probably damaging 1.00
R1859:Dpp10 UTSW 1 123,281,333 (GRCm39) missense possibly damaging 0.47
R1991:Dpp10 UTSW 1 123,832,833 (GRCm39) missense probably null 1.00
R1992:Dpp10 UTSW 1 123,832,833 (GRCm39) missense probably null 1.00
R2079:Dpp10 UTSW 1 123,360,721 (GRCm39) missense probably damaging 1.00
R2882:Dpp10 UTSW 1 123,372,932 (GRCm39) missense probably damaging 1.00
R2974:Dpp10 UTSW 1 123,339,434 (GRCm39) splice site probably benign
R3827:Dpp10 UTSW 1 123,339,519 (GRCm39) missense possibly damaging 0.56
R3852:Dpp10 UTSW 1 123,413,653 (GRCm39) nonsense probably null
R3876:Dpp10 UTSW 1 123,281,216 (GRCm39) missense probably damaging 0.98
R3899:Dpp10 UTSW 1 123,281,286 (GRCm39) missense probably damaging 1.00
R4735:Dpp10 UTSW 1 123,326,356 (GRCm39) missense probably benign 0.15
R4922:Dpp10 UTSW 1 123,305,882 (GRCm39) missense probably benign 0.44
R5457:Dpp10 UTSW 1 123,339,539 (GRCm39) missense possibly damaging 0.51
R5599:Dpp10 UTSW 1 123,832,803 (GRCm39) missense probably damaging 0.99
R5913:Dpp10 UTSW 1 123,312,018 (GRCm39) missense probably damaging 1.00
R5979:Dpp10 UTSW 1 123,312,012 (GRCm39) critical splice donor site probably null
R6378:Dpp10 UTSW 1 123,339,468 (GRCm39) missense probably damaging 1.00
R6429:Dpp10 UTSW 1 123,295,330 (GRCm39) missense possibly damaging 0.72
R6505:Dpp10 UTSW 1 123,264,580 (GRCm39) missense probably damaging 0.99
R6776:Dpp10 UTSW 1 123,295,385 (GRCm39) nonsense probably null
R6894:Dpp10 UTSW 1 123,264,593 (GRCm39) missense probably damaging 1.00
R6951:Dpp10 UTSW 1 123,269,379 (GRCm39) missense possibly damaging 0.93
R7182:Dpp10 UTSW 1 123,268,880 (GRCm39) missense probably benign 0.15
R7246:Dpp10 UTSW 1 123,262,106 (GRCm39) missense probably damaging 1.00
R7297:Dpp10 UTSW 1 123,281,157 (GRCm39) nonsense probably null
R7375:Dpp10 UTSW 1 123,295,524 (GRCm39) missense probably benign
R7387:Dpp10 UTSW 1 123,268,869 (GRCm39) missense probably benign 0.01
R7661:Dpp10 UTSW 1 123,312,681 (GRCm39) missense probably damaging 1.00
R8065:Dpp10 UTSW 1 123,280,389 (GRCm39) missense probably benign
R8067:Dpp10 UTSW 1 123,280,389 (GRCm39) missense probably benign
R8260:Dpp10 UTSW 1 123,614,024 (GRCm39) missense probably benign
R8324:Dpp10 UTSW 1 123,781,901 (GRCm39) missense probably benign 0.02
R8373:Dpp10 UTSW 1 123,781,958 (GRCm39) missense possibly damaging 0.94
R8434:Dpp10 UTSW 1 123,360,739 (GRCm39) missense probably damaging 1.00
R9068:Dpp10 UTSW 1 123,360,667 (GRCm39) missense probably damaging 1.00
R9104:Dpp10 UTSW 1 123,339,484 (GRCm39) missense probably damaging 1.00
R9477:Dpp10 UTSW 1 123,304,370 (GRCm39) missense possibly damaging 0.46
R9492:Dpp10 UTSW 1 123,281,159 (GRCm39) missense probably damaging 1.00
R9524:Dpp10 UTSW 1 123,264,611 (GRCm39) missense probably damaging 1.00
R9576:Dpp10 UTSW 1 123,269,409 (GRCm39) missense probably damaging 1.00
R9631:Dpp10 UTSW 1 123,269,432 (GRCm39) missense probably damaging 1.00
R9736:Dpp10 UTSW 1 123,262,088 (GRCm39) missense possibly damaging 0.64
X0019:Dpp10 UTSW 1 123,326,314 (GRCm39) missense possibly damaging 0.88
X0020:Dpp10 UTSW 1 123,326,311 (GRCm39) missense probably benign 0.36
X0021:Dpp10 UTSW 1 123,360,721 (GRCm39) missense probably damaging 1.00
X0024:Dpp10 UTSW 1 123,312,015 (GRCm39) missense probably damaging 1.00
Z1176:Dpp10 UTSW 1 123,281,169 (GRCm39) nonsense probably null
Posted On 2015-04-16