Incidental Mutation 'IGL02672:Or5t17'
ID 302960
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5t17
Ensembl Gene ENSMUSG00000049843
Gene Name olfactory receptor family 5 subfamily T member 17
Synonyms MOR179-4, GA_x6K02T2Q125-48487992-48488966, Olfr1102
Accession Numbers
Essential gene? Probably non essential (E-score: 0.121) question?
Stock # IGL02672
Quality Score
Status
Chromosome 2
Chromosomal Location 86832276-86833338 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 86832417 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 35 (M35L)
Ref Sequence ENSEMBL: ENSMUSP00000149634 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055129] [ENSMUST00000214002]
AlphaFold Q8VES2
Predicted Effect probably benign
Transcript: ENSMUST00000055129
AA Change: M35L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000052861
Gene: ENSMUSG00000049843
AA Change: M35L

DomainStartEndE-ValueType
low complexity region 8 19 N/A INTRINSIC
Pfam:7tm_4 43 320 8.1e-52 PFAM
Pfam:7TM_GPCR_Srsx 47 322 8.7e-6 PFAM
Pfam:7tm_1 53 302 3.6e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214002
AA Change: M35L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agrn C T 4: 156,259,018 (GRCm39) probably benign Het
Alpi A G 1: 87,028,994 (GRCm39) L60P probably damaging Het
Arpc1a A C 5: 145,041,697 (GRCm39) I327L probably damaging Het
Col5a1 C T 2: 27,864,727 (GRCm39) A737V unknown Het
Dcaf7 T C 11: 105,945,684 (GRCm39) probably benign Het
Dnah9 T G 11: 65,818,427 (GRCm39) I3304L probably benign Het
Dpp10 T A 1: 123,304,376 (GRCm39) H508L probably benign Het
Dync1i1 A G 6: 5,767,034 (GRCm39) D86G probably benign Het
Enpp7 T C 11: 118,883,166 (GRCm39) probably null Het
Fbxw9 C A 8: 85,792,682 (GRCm39) probably null Het
Foxred2 A G 15: 77,829,777 (GRCm39) probably null Het
Gas2l2 C T 11: 83,315,957 (GRCm39) R254H probably damaging Het
Gatad2b C T 3: 90,249,198 (GRCm39) L79F possibly damaging Het
Igf1r A T 7: 67,839,781 (GRCm39) D696V probably benign Het
Kcnk5 A G 14: 20,196,580 (GRCm39) I96T probably damaging Het
Lrrc8c C T 5: 105,755,224 (GRCm39) T333M possibly damaging Het
Mcm10 T C 2: 5,006,092 (GRCm39) T417A probably benign Het
Mesp2 T C 7: 79,461,145 (GRCm39) S157P probably benign Het
Naca A G 10: 127,876,152 (GRCm39) probably benign Het
Osgepl1 A G 1: 53,359,270 (GRCm39) T260A probably benign Het
Otop1 T C 5: 38,435,170 (GRCm39) probably null Het
Pdk1 T C 2: 71,726,096 (GRCm39) S335P probably damaging Het
Phkb A G 8: 86,668,987 (GRCm39) N338S probably benign Het
Pogz G A 3: 94,763,410 (GRCm39) V61I probably benign Het
Ppp4r1 A G 17: 66,147,942 (GRCm39) Y928C probably damaging Het
Rab17 T C 1: 90,886,940 (GRCm39) E160G probably damaging Het
Rasgrp3 T A 17: 75,803,412 (GRCm39) F70Y probably benign Het
Rere T A 4: 150,594,483 (GRCm39) N364K unknown Het
Ryr1 A T 7: 28,703,944 (GRCm39) probably benign Het
Sae1 A G 7: 16,104,273 (GRCm39) V112A probably damaging Het
Serpinb6d C T 13: 33,855,372 (GRCm39) H349Y probably benign Het
Slc12a1 T C 2: 125,012,596 (GRCm39) V286A probably damaging Het
Smad3 A T 9: 63,575,009 (GRCm39) probably null Het
Sox8 T A 17: 25,787,963 (GRCm39) D162V probably damaging Het
Sptbn1 A G 11: 30,087,239 (GRCm39) F1067L probably damaging Het
Tmprss3 T C 17: 31,409,981 (GRCm39) Y211C probably damaging Het
Top2b T C 14: 16,409,166 (GRCm38) probably benign Het
Tpp1 A T 7: 105,396,168 (GRCm39) H510Q probably benign Het
Ugcg T A 4: 59,218,587 (GRCm39) probably benign Het
Vmn2r96 T A 17: 18,818,376 (GRCm39) I651N probably benign Het
Wdr25 A T 12: 108,864,007 (GRCm39) K51* probably null Het
Other mutations in Or5t17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01371:Or5t17 APN 2 86,833,267 (GRCm39) missense probably benign 0.31
IGL01584:Or5t17 APN 2 86,832,495 (GRCm39) missense probably benign 0.04
IGL01913:Or5t17 APN 2 86,833,164 (GRCm39) missense possibly damaging 0.68
R0003:Or5t17 UTSW 2 86,832,710 (GRCm39) nonsense probably null
R0003:Or5t17 UTSW 2 86,832,710 (GRCm39) nonsense probably null
R1674:Or5t17 UTSW 2 86,832,577 (GRCm39) missense probably benign 0.07
R1688:Or5t17 UTSW 2 86,832,730 (GRCm39) missense probably benign 0.01
R3826:Or5t17 UTSW 2 86,832,388 (GRCm39) missense probably damaging 0.97
R3925:Or5t17 UTSW 2 86,832,718 (GRCm39) missense possibly damaging 0.91
R4023:Or5t17 UTSW 2 86,833,266 (GRCm39) nonsense probably null
R4730:Or5t17 UTSW 2 86,832,510 (GRCm39) missense possibly damaging 0.48
R5154:Or5t17 UTSW 2 86,832,382 (GRCm39) missense probably benign 0.00
R5525:Or5t17 UTSW 2 86,832,683 (GRCm39) missense possibly damaging 0.95
R5685:Or5t17 UTSW 2 86,832,621 (GRCm39) missense probably benign 0.02
R5788:Or5t17 UTSW 2 86,832,645 (GRCm39) missense probably benign 0.01
R6280:Or5t17 UTSW 2 86,832,364 (GRCm39) missense probably damaging 0.99
R7178:Or5t17 UTSW 2 86,832,879 (GRCm39) missense probably benign 0.07
R9493:Or5t17 UTSW 2 86,833,140 (GRCm39) missense probably benign 0.45
R9745:Or5t17 UTSW 2 86,832,487 (GRCm39) missense probably benign 0.28
Z1176:Or5t17 UTSW 2 86,832,955 (GRCm39) missense probably benign 0.00
Z1176:Or5t17 UTSW 2 86,832,954 (GRCm39) missense probably benign 0.04
Posted On 2015-04-16