Incidental Mutation 'IGL02675:Pcna-ps2'
ID303084
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pcna-ps2
Ensembl Gene ENSMUSG00000067608
Gene Nameproliferating cell nuclear antigen pseudogene 2
Synonyms
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.925) question?
Stock #IGL02675
Quality Score
Status
Chromosome19
Chromosomal Location9283238-9284494 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 9283959 bp
ZygosityHeterozygous
Amino Acid Change Alanine to Glutamic Acid at position 194 (A194E)
Ref Sequence ENSEMBL: ENSMUSP00000137596 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088040]
Predicted Effect probably benign
Transcript: ENSMUST00000088040
AA Change: A194E

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000137596
Gene: ENSMUSG00000067608
AA Change: A194E

DomainStartEndE-ValueType
Pfam:PCNA_N 1 125 1.4e-62 PFAM
Pfam:Rad1 1 236 1.2e-11 PFAM
Pfam:Rad9 12 245 1.7e-10 PFAM
Pfam:PCNA_C 127 254 4.7e-67 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142025
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ano8 A G 8: 71,483,540 I204T probably damaging Het
Anxa8 A G 14: 34,093,414 D150G probably damaging Het
Arel1 T C 12: 84,930,228 T438A probably damaging Het
Asphd1 T C 7: 126,946,834 probably benign Het
Bcl2l12 A T 7: 44,991,400 probably benign Het
Cand1 A G 10: 119,219,697 I87T probably damaging Het
Ccdc80 A C 16: 45,116,332 T707P probably damaging Het
Cdh9 T A 15: 16,849,076 probably null Het
Chrd T C 16: 20,739,949 probably benign Het
Cpn1 T C 19: 43,980,930 Q98R probably benign Het
D630045J12Rik A G 6: 38,195,485 S583P possibly damaging Het
Dnah7a A G 1: 53,504,024 I2329T possibly damaging Het
Egln3 A G 12: 54,203,210 S118P probably benign Het
Gfra1 G A 19: 58,453,355 T48I probably damaging Het
Hapln3 C T 7: 79,117,848 probably null Het
Heatr3 T C 8: 88,144,557 F180L possibly damaging Het
Herc2 T A 7: 56,164,101 S2661T probably damaging Het
Hook3 A T 8: 26,061,434 L126Q possibly damaging Het
Hoxd8 T G 2: 74,706,586 L214R probably damaging Het
Ifna1 T G 4: 88,850,433 L116R probably damaging Het
Il31ra T A 13: 112,524,352 T487S probably benign Het
Kifc2 C T 15: 76,662,979 R252W probably damaging Het
Meox2 A G 12: 37,178,334 D290G probably damaging Het
Micu2 A G 14: 57,945,377 probably benign Het
Myh9 T C 15: 77,788,930 T406A possibly damaging Het
Naip1 T A 13: 100,409,118 M1301L probably benign Het
Pbrm1 T C 14: 31,106,287 L1341P possibly damaging Het
Pdcd10 G A 3: 75,527,594 T130I probably damaging Het
Pprc1 G A 19: 46,063,507 G491D probably damaging Het
Prss57 A G 10: 79,787,475 V46A probably benign Het
Ptcd3 A G 6: 71,883,442 probably null Het
Riok1 C T 13: 38,050,243 P262S probably damaging Het
Rnf13 A G 3: 57,779,396 N70S probably benign Het
Skint7 T A 4: 111,981,981 D157E probably benign Het
Sri T C 5: 8,067,534 F191S probably damaging Het
Stat5b T C 11: 100,787,374 R638G probably benign Het
Suds3 C T 5: 117,094,905 probably null Het
Tmem19 A G 10: 115,342,573 L281P probably damaging Het
Tmf1 A G 6: 97,164,042 probably benign Het
Trio A G 15: 27,768,039 probably benign Het
Usp28 T C 9: 49,039,091 I940T possibly damaging Het
Wisp3 A G 10: 39,151,240 V332A possibly damaging Het
Zfp280d T A 9: 72,312,222 I227K probably benign Het
Zfp335 A G 2: 164,910,689 V45A probably benign Het
Other mutations in Pcna-ps2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00568:Pcna-ps2 APN 19 9283926 nonsense probably null
IGL02528:Pcna-ps2 APN 19 9283967 missense probably benign 0.09
R0900:Pcna-ps2 UTSW 19 9284123 missense probably damaging 1.00
R1982:Pcna-ps2 UTSW 19 9283683 missense possibly damaging 0.61
R4704:Pcna-ps2 UTSW 19 9283422 missense possibly damaging 0.87
R5179:Pcna-ps2 UTSW 19 9283527 missense probably damaging 1.00
R5877:Pcna-ps2 UTSW 19 9284099 missense probably benign 0.34
R6129:Pcna-ps2 UTSW 19 9284015 missense possibly damaging 0.63
R6817:Pcna-ps2 UTSW 19 9283497 missense probably damaging 1.00
R7710:Pcna-ps2 UTSW 19 9284125 nonsense probably null
Z1176:Pcna-ps2 UTSW 19 9284112 missense probably damaging 1.00
Posted On2015-04-16