Incidental Mutation 'IGL02675:Suds3'
ID303110
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Suds3
Ensembl Gene ENSMUSG00000066900
Gene Namesuppressor of defective silencing 3 homolog (S. cerevisiae)
Synonyms
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL02675
Quality Score
Status
Chromosome5
Chromosomal Location117091680-117116113 bp(-) (GRCm38)
Type of Mutationsplice site (5 bp from exon)
DNA Base Change (assembly) C to T at 117094905 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000130535 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086471] [ENSMUST00000166397]
Predicted Effect probably null
Transcript: ENSMUST00000086471
SMART Domains Protein: ENSMUSP00000083662
Gene: ENSMUSG00000066900

DomainStartEndE-ValueType
low complexity region 2 37 N/A INTRINSIC
Pfam:Sds3 52 223 3.6e-30 PFAM
low complexity region 225 238 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000166397
SMART Domains Protein: ENSMUSP00000130535
Gene: ENSMUSG00000066900

DomainStartEndE-ValueType
low complexity region 2 37 N/A INTRINSIC
low complexity region 44 56 N/A INTRINSIC
Pfam:Sds3 61 296 4.7e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202684
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202713
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a knock-out allele display early embryonic lethality in the peri-implantation period. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ano8 A G 8: 71,483,540 I204T probably damaging Het
Anxa8 A G 14: 34,093,414 D150G probably damaging Het
Arel1 T C 12: 84,930,228 T438A probably damaging Het
Asphd1 T C 7: 126,946,834 probably benign Het
Bcl2l12 A T 7: 44,991,400 probably benign Het
Cand1 A G 10: 119,219,697 I87T probably damaging Het
Ccdc80 A C 16: 45,116,332 T707P probably damaging Het
Cdh9 T A 15: 16,849,076 probably null Het
Chrd T C 16: 20,739,949 probably benign Het
Cpn1 T C 19: 43,980,930 Q98R probably benign Het
D630045J12Rik A G 6: 38,195,485 S583P possibly damaging Het
Dnah7a A G 1: 53,504,024 I2329T possibly damaging Het
Egln3 A G 12: 54,203,210 S118P probably benign Het
Gfra1 G A 19: 58,453,355 T48I probably damaging Het
Hapln3 C T 7: 79,117,848 probably null Het
Heatr3 T C 8: 88,144,557 F180L possibly damaging Het
Herc2 T A 7: 56,164,101 S2661T probably damaging Het
Hook3 A T 8: 26,061,434 L126Q possibly damaging Het
Hoxd8 T G 2: 74,706,586 L214R probably damaging Het
Ifna1 T G 4: 88,850,433 L116R probably damaging Het
Il31ra T A 13: 112,524,352 T487S probably benign Het
Kifc2 C T 15: 76,662,979 R252W probably damaging Het
Meox2 A G 12: 37,178,334 D290G probably damaging Het
Micu2 A G 14: 57,945,377 probably benign Het
Myh9 T C 15: 77,788,930 T406A possibly damaging Het
Naip1 T A 13: 100,409,118 M1301L probably benign Het
Pbrm1 T C 14: 31,106,287 L1341P possibly damaging Het
Pcna-ps2 C A 19: 9,283,959 A194E probably benign Het
Pdcd10 G A 3: 75,527,594 T130I probably damaging Het
Pprc1 G A 19: 46,063,507 G491D probably damaging Het
Prss57 A G 10: 79,787,475 V46A probably benign Het
Ptcd3 A G 6: 71,883,442 probably null Het
Riok1 C T 13: 38,050,243 P262S probably damaging Het
Rnf13 A G 3: 57,779,396 N70S probably benign Het
Skint7 T A 4: 111,981,981 D157E probably benign Het
Sri T C 5: 8,067,534 F191S probably damaging Het
Stat5b T C 11: 100,787,374 R638G probably benign Het
Tmem19 A G 10: 115,342,573 L281P probably damaging Het
Tmf1 A G 6: 97,164,042 probably benign Het
Trio A G 15: 27,768,039 probably benign Het
Usp28 T C 9: 49,039,091 I940T possibly damaging Het
Wisp3 A G 10: 39,151,240 V332A possibly damaging Het
Zfp280d T A 9: 72,312,222 I227K probably benign Het
Zfp335 A G 2: 164,910,689 V45A probably benign Het
Other mutations in Suds3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02713:Suds3 APN 5 117094905 splice site probably null
R1779:Suds3 UTSW 5 117105244 missense probably benign 0.02
R1986:Suds3 UTSW 5 117108352 missense probably damaging 0.98
R2519:Suds3 UTSW 5 117094953 missense probably damaging 1.00
R5189:Suds3 UTSW 5 117100599 critical splice donor site probably benign
R6213:Suds3 UTSW 5 117106662 missense probably damaging 0.99
R7756:Suds3 UTSW 5 117115737 missense unknown
R7758:Suds3 UTSW 5 117115737 missense unknown
R7818:Suds3 UTSW 5 117115749 unclassified probably benign
R7879:Suds3 UTSW 5 117098270 critical splice donor site probably null
R7962:Suds3 UTSW 5 117098270 critical splice donor site probably null
Posted On2015-04-16