Incidental Mutation 'IGL02676:Vmn2r98'
ID 303116
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r98
Ensembl Gene ENSMUSG00000096717
Gene Name vomeronasal 2, receptor 98
Synonyms EG224552
Accession Numbers
Essential gene? Probably non essential (E-score: 0.096) question?
Stock # IGL02676
Quality Score
Status
Chromosome 17
Chromosomal Location 19273755-19301573 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 19285521 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 114 (T114S)
Ref Sequence ENSEMBL: ENSMUSP00000131261 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170424]
AlphaFold E9PZ56
Predicted Effect probably benign
Transcript: ENSMUST00000170424
AA Change: T114S

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000131261
Gene: ENSMUSG00000096717
AA Change: T114S

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:ANF_receptor 82 460 2.6e-35 PFAM
Pfam:NCD3G 509 562 7.4e-22 PFAM
Pfam:7tm_3 594 830 1.4e-52 PFAM
low complexity region 844 856 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apc G A 18: 34,448,687 (GRCm39) S1827N probably damaging Het
Atrnl1 T A 19: 57,680,316 (GRCm39) C739S probably damaging Het
Cep350 T C 1: 155,737,977 (GRCm39) E2622G possibly damaging Het
Chd5 C T 4: 152,440,530 (GRCm39) probably benign Het
Chst11 T A 10: 83,027,563 (GRCm39) L330Q probably damaging Het
Clcnka A T 4: 141,120,094 (GRCm39) V275E probably damaging Het
Clip4 G A 17: 72,135,616 (GRCm39) S456N probably damaging Het
Cmya5 A T 13: 93,229,361 (GRCm39) I1909N probably damaging Het
Cyp26b1 A G 6: 84,553,626 (GRCm39) I176T probably damaging Het
Dst A G 1: 34,346,668 (GRCm39) R7717G probably damaging Het
Eml2 C T 7: 18,918,846 (GRCm39) R99* probably null Het
Fibin T C 2: 110,192,929 (GRCm39) Q71R probably benign Het
Fsip2 T G 2: 82,812,501 (GRCm39) I2940S possibly damaging Het
Gabrb3 G T 7: 57,241,112 (GRCm39) probably benign Het
Gfra1 G A 19: 58,441,787 (GRCm39) T48I probably damaging Het
Gm6483 C T 8: 19,743,675 (GRCm39) noncoding transcript Het
Hdgfl1 G A 13: 26,953,348 (GRCm39) R242C possibly damaging Het
Hmcn1 T C 1: 150,494,760 (GRCm39) T4110A probably benign Het
Lama2 T G 10: 26,994,489 (GRCm39) M1807L probably benign Het
Larp4 T C 15: 99,888,302 (GRCm39) V113A possibly damaging Het
Mkx T C 18: 7,000,640 (GRCm39) T101A probably benign Het
Nfe2l1 A G 11: 96,718,491 (GRCm39) F15L probably damaging Het
Nherf2 A T 17: 24,860,930 (GRCm39) V204E probably damaging Het
Nif3l1 G A 1: 58,494,895 (GRCm39) probably null Het
Nop14 A G 5: 34,796,565 (GRCm39) V764A probably damaging Het
Nosip C A 7: 44,726,752 (GRCm39) A259E probably damaging Het
Ntn5 T C 7: 45,341,300 (GRCm39) probably benign Het
Or9g20 T C 2: 85,629,934 (GRCm39) I227V possibly damaging Het
Phospho1 G A 11: 95,721,714 (GRCm39) G128D probably damaging Het
Ppp4r3a G A 12: 101,008,770 (GRCm39) T703M probably benign Het
Pramel21 T C 4: 143,342,667 (GRCm39) F258S possibly damaging Het
Pramel58 A G 5: 94,831,730 (GRCm39) T246A possibly damaging Het
Prdm8 G A 5: 98,334,418 (GRCm39) E662K probably damaging Het
Ralgapa1 A G 12: 55,723,202 (GRCm39) S1775P probably damaging Het
Rapgef6 T C 11: 54,540,172 (GRCm39) probably benign Het
Rasef T C 4: 73,677,966 (GRCm39) T87A possibly damaging Het
Scrn3 A G 2: 73,160,215 (GRCm39) Q286R probably benign Het
Sema3d A T 5: 12,620,945 (GRCm39) Q517L probably benign Het
Taf6l T C 19: 8,752,413 (GRCm39) Y425C probably damaging Het
Tbk1 T C 10: 121,403,985 (GRCm39) N254S possibly damaging Het
Tcf3 C T 10: 80,256,925 (GRCm39) G64R probably damaging Het
Tmco4 T C 4: 138,750,380 (GRCm39) probably null Het
Trappc11 A G 8: 47,946,448 (GRCm39) probably benign Het
Vmn1r19 A T 6: 57,382,025 (GRCm39) I193F possibly damaging Het
Vmn2r14 G A 5: 109,367,882 (GRCm39) T370I probably benign Het
Vmn2r65 T A 7: 84,589,381 (GRCm39) H845L possibly damaging Het
Zfp280d A T 9: 72,242,356 (GRCm39) R661S probably damaging Het
Zranb1 T C 7: 132,568,410 (GRCm39) I356T probably benign Het
Other mutations in Vmn2r98
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00897:Vmn2r98 APN 17 19,286,007 (GRCm39) splice site probably benign
IGL01296:Vmn2r98 APN 17 19,285,447 (GRCm39) missense probably damaging 1.00
IGL01363:Vmn2r98 APN 17 19,286,020 (GRCm39) missense probably benign 0.01
IGL01618:Vmn2r98 APN 17 19,285,521 (GRCm39) missense possibly damaging 0.93
IGL01746:Vmn2r98 APN 17 19,286,713 (GRCm39) missense probably damaging 1.00
IGL01747:Vmn2r98 APN 17 19,286,702 (GRCm39) missense probably damaging 1.00
IGL01770:Vmn2r98 APN 17 19,286,702 (GRCm39) missense probably damaging 1.00
IGL01868:Vmn2r98 APN 17 19,286,548 (GRCm39) missense probably benign
IGL02123:Vmn2r98 APN 17 19,300,941 (GRCm39) missense probably damaging 1.00
IGL02323:Vmn2r98 APN 17 19,286,113 (GRCm39) missense probably damaging 0.99
IGL02543:Vmn2r98 APN 17 19,286,083 (GRCm39) missense probably benign
IGL02650:Vmn2r98 APN 17 19,301,223 (GRCm39) missense probably benign 0.00
IGL02803:Vmn2r98 APN 17 19,286,275 (GRCm39) missense probably benign
IGL02807:Vmn2r98 APN 17 19,301,283 (GRCm39) missense probably damaging 1.00
IGL03307:Vmn2r98 APN 17 19,286,242 (GRCm39) missense possibly damaging 0.62
IGL03396:Vmn2r98 APN 17 19,290,107 (GRCm39) missense possibly damaging 0.92
PIT4131001:Vmn2r98 UTSW 17 19,301,223 (GRCm39) missense probably benign 0.00
R0122:Vmn2r98 UTSW 17 19,286,662 (GRCm39) missense probably benign 0.06
R0329:Vmn2r98 UTSW 17 19,286,609 (GRCm39) missense probably benign 0.21
R0330:Vmn2r98 UTSW 17 19,286,609 (GRCm39) missense probably benign 0.21
R0368:Vmn2r98 UTSW 17 19,286,089 (GRCm39) nonsense probably null
R0545:Vmn2r98 UTSW 17 19,273,875 (GRCm39) missense probably benign 0.15
R0635:Vmn2r98 UTSW 17 19,300,759 (GRCm39) missense probably benign 0.00
R0689:Vmn2r98 UTSW 17 19,300,782 (GRCm39) missense possibly damaging 0.83
R1035:Vmn2r98 UTSW 17 19,301,011 (GRCm39) missense possibly damaging 0.90
R1243:Vmn2r98 UTSW 17 19,286,210 (GRCm39) missense possibly damaging 0.52
R1421:Vmn2r98 UTSW 17 19,285,440 (GRCm39) missense probably damaging 1.00
R1629:Vmn2r98 UTSW 17 19,287,645 (GRCm39) missense possibly damaging 0.94
R1643:Vmn2r98 UTSW 17 19,301,170 (GRCm39) missense probably damaging 1.00
R1795:Vmn2r98 UTSW 17 19,286,702 (GRCm39) missense probably damaging 1.00
R1958:Vmn2r98 UTSW 17 19,286,680 (GRCm39) missense possibly damaging 0.70
R1962:Vmn2r98 UTSW 17 19,285,595 (GRCm39) nonsense probably null
R2165:Vmn2r98 UTSW 17 19,301,553 (GRCm39) missense unknown
R2238:Vmn2r98 UTSW 17 19,286,213 (GRCm39) missense probably damaging 1.00
R2252:Vmn2r98 UTSW 17 19,300,698 (GRCm39) missense probably benign 0.00
R2323:Vmn2r98 UTSW 17 19,286,081 (GRCm39) missense probably benign 0.18
R2887:Vmn2r98 UTSW 17 19,301,439 (GRCm39) missense possibly damaging 0.83
R2909:Vmn2r98 UTSW 17 19,287,664 (GRCm39) missense probably damaging 1.00
R3001:Vmn2r98 UTSW 17 19,286,125 (GRCm39) missense probably benign 0.01
R3002:Vmn2r98 UTSW 17 19,286,125 (GRCm39) missense probably benign 0.01
R3003:Vmn2r98 UTSW 17 19,286,125 (GRCm39) missense probably benign 0.01
R3788:Vmn2r98 UTSW 17 19,300,887 (GRCm39) missense probably benign 0.31
R4570:Vmn2r98 UTSW 17 19,286,354 (GRCm39) missense probably benign 0.11
R4706:Vmn2r98 UTSW 17 19,290,007 (GRCm39) missense probably damaging 1.00
R4723:Vmn2r98 UTSW 17 19,286,602 (GRCm39) missense probably benign 0.01
R5036:Vmn2r98 UTSW 17 19,286,419 (GRCm39) missense probably benign 0.00
R5072:Vmn2r98 UTSW 17 19,286,306 (GRCm39) missense probably benign 0.07
R5121:Vmn2r98 UTSW 17 19,273,815 (GRCm39) missense probably benign 0.13
R5283:Vmn2r98 UTSW 17 19,300,981 (GRCm39) missense probably benign 0.05
R5294:Vmn2r98 UTSW 17 19,290,016 (GRCm39) nonsense probably null
R5371:Vmn2r98 UTSW 17 19,290,015 (GRCm39) missense probably damaging 1.00
R5532:Vmn2r98 UTSW 17 19,287,645 (GRCm39) missense possibly damaging 0.94
R5598:Vmn2r98 UTSW 17 19,301,161 (GRCm39) missense probably benign 0.37
R5800:Vmn2r98 UTSW 17 19,286,260 (GRCm39) missense probably benign 0.17
R6089:Vmn2r98 UTSW 17 19,286,336 (GRCm39) missense probably benign 0.29
R6155:Vmn2r98 UTSW 17 19,286,143 (GRCm39) missense possibly damaging 0.87
R6853:Vmn2r98 UTSW 17 19,286,063 (GRCm39) missense probably benign 0.00
R6920:Vmn2r98 UTSW 17 19,285,510 (GRCm39) missense probably damaging 0.98
R7012:Vmn2r98 UTSW 17 19,286,530 (GRCm39) missense probably benign 0.06
R7042:Vmn2r98 UTSW 17 19,301,184 (GRCm39) missense probably benign
R7068:Vmn2r98 UTSW 17 19,285,575 (GRCm39) missense probably benign
R7607:Vmn2r98 UTSW 17 19,287,570 (GRCm39) missense possibly damaging 0.95
R7763:Vmn2r98 UTSW 17 19,300,797 (GRCm39) missense probably benign 0.00
R7771:Vmn2r98 UTSW 17 19,287,460 (GRCm39) splice site probably null
R7915:Vmn2r98 UTSW 17 19,287,493 (GRCm39) missense probably benign 0.10
R8028:Vmn2r98 UTSW 17 19,273,912 (GRCm39) missense probably benign 0.00
R8205:Vmn2r98 UTSW 17 19,301,425 (GRCm39) missense probably damaging 0.99
R8241:Vmn2r98 UTSW 17 19,301,031 (GRCm39) missense probably damaging 0.99
R8906:Vmn2r98 UTSW 17 19,286,532 (GRCm39) missense probably benign
R8952:Vmn2r98 UTSW 17 19,285,531 (GRCm39) missense possibly damaging 0.76
R9147:Vmn2r98 UTSW 17 19,286,383 (GRCm39) missense probably benign 0.04
R9148:Vmn2r98 UTSW 17 19,286,383 (GRCm39) missense probably benign 0.04
R9187:Vmn2r98 UTSW 17 19,301,481 (GRCm39) missense probably damaging 1.00
R9344:Vmn2r98 UTSW 17 19,286,777 (GRCm39) missense probably benign 0.14
R9467:Vmn2r98 UTSW 17 19,287,517 (GRCm39) missense probably benign 0.01
R9487:Vmn2r98 UTSW 17 19,301,496 (GRCm39) missense possibly damaging 0.78
R9753:Vmn2r98 UTSW 17 19,285,665 (GRCm39) missense probably benign 0.27
Z1177:Vmn2r98 UTSW 17 19,287,685 (GRCm39) nonsense probably null
Z1177:Vmn2r98 UTSW 17 19,285,398 (GRCm39) critical splice acceptor site probably null
Posted On 2015-04-16