Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02676:Scrn3'

303118

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Scrn3

Ensembl Gene

ENSMUSG00000008226

Gene Name

secernin 3

Synonyms

4833415E20Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02676

Quality Score

Status

Chromosome

Chromosomal Location

73312601-73337818 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 73329871 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Arginine at position 286 (Q286R)

Ref Sequence

ENSEMBL: ENSMUSP00000088320 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000090811]

AlphaFold

Q3TMH2

Predicted Effect

probably benign
Transcript: ENSMUST00000090811
AA Change: Q286R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000088320
Gene: ENSMUSG00000008226
AA Change: Q286R

Domain	Start	End	E-Value	Type
Pfam:Peptidase_C69	50	268	4.7e-13	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000123621

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000154158

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Apc	G	A	18: 34,315,634	S1827N	probably damaging	Het
Atrnl1	T	A	19: 57,691,884	C739S	probably damaging	Het
Cep350	T	C	1: 155,862,231	E2622G	possibly damaging	Het
Chd5	C	T	4: 152,356,073		probably benign	Het
Chst11	T	A	10: 83,191,729	L330Q	probably damaging	Het
Clcnka	A	T	4: 141,392,783	V275E	probably damaging	Het
Clip4	G	A	17: 71,828,621	S456N	probably damaging	Het
Cmya5	A	T	13: 93,092,853	I1909N	probably damaging	Het
Cyp26b1	A	G	6: 84,576,644	I176T	probably damaging	Het
Dst	A	G	1: 34,307,587	R7717G	probably damaging	Het
Eml2	C	T	7: 19,184,921	R99*	probably null	Het
Fibin	T	C	2: 110,362,584	Q71R	probably benign	Het
Fsip2	T	G	2: 82,982,157	I2940S	possibly damaging	Het
Gabrb3	G	T	7: 57,591,364		probably benign	Het
Gfra1	G	A	19: 58,453,355	T48I	probably damaging	Het
Gm13083	T	C	4: 143,616,097	F258S	possibly damaging	Het
Gm6205	A	G	5: 94,683,871	T246A	possibly damaging	Het
Gm6483	C	T	8: 19,693,659		noncoding transcript	Het
Hdgfl1	G	A	13: 26,769,365	R242C	possibly damaging	Het
Hmcn1	T	C	1: 150,619,009	T4110A	probably benign	Het
Lama2	T	G	10: 27,118,493	M1807L	probably benign	Het
Larp4	T	C	15: 99,990,421	V113A	possibly damaging	Het
Mkx	T	C	18: 7,000,640	T101A	probably benign	Het
Nfe2l1	A	G	11: 96,827,665	F15L	probably damaging	Het
Nif3l1	G	A	1: 58,455,736		probably null	Het
Nop14	A	G	5: 34,639,221	V764A	probably damaging	Het
Nosip	C	A	7: 45,077,328	A259E	probably damaging	Het
Ntn5	T	C	7: 45,691,876		probably benign	Het
Olfr1016	T	C	2: 85,799,590	I227V	possibly damaging	Het
Phospho1	G	A	11: 95,830,888	G128D	probably damaging	Het
Ppp4r3a	G	A	12: 101,042,511	T703M	probably benign	Het
Prdm8	G	A	5: 98,186,559	E662K	probably damaging	Het
Ralgapa1	A	G	12: 55,676,417	S1775P	probably damaging	Het
Rapgef6	T	C	11: 54,649,346		probably benign	Het
Rasef	T	C	4: 73,759,729	T87A	possibly damaging	Het
Sema3d	A	T	5: 12,570,978	Q517L	probably benign	Het
Slc9a3r2	A	T	17: 24,641,956	V204E	probably damaging	Het
Taf6l	T	C	19: 8,775,049	Y425C	probably damaging	Het
Tbk1	T	C	10: 121,568,080	N254S	possibly damaging	Het
Tcf3	C	T	10: 80,421,091	G64R	probably damaging	Het
Tmco4	T	C	4: 139,023,069		probably null	Het
Trappc11	A	G	8: 47,493,413		probably benign	Het
Vmn1r19	A	T	6: 57,405,040	I193F	possibly damaging	Het
Vmn2r14	G	A	5: 109,220,016	T370I	probably benign	Het
Vmn2r65	T	A	7: 84,940,173	H845L	possibly damaging	Het
Vmn2r98	A	T	17: 19,065,259	T114S	probably benign	Het
Zfp280d	A	T	9: 72,335,074	R661S	probably damaging	Het
Zranb1	T	C	7: 132,966,681	I356T	probably benign	Het

Other mutations in Scrn3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02012:Scrn3	APN	2	73318429	critical splice donor site	probably null
PIT4445001:Scrn3	UTSW	2	73318329	missense	possibly damaging	0.90
PIT4519001:Scrn3	UTSW	2	73318424	missense	possibly damaging	0.78
PIT4519001:Scrn3	UTSW	2	73331003	missense	possibly damaging	0.95
R2105:Scrn3	UTSW	2	73329852	missense	probably damaging	0.96
R3973:Scrn3	UTSW	2	73335777	missense	possibly damaging	0.66
R3974:Scrn3	UTSW	2	73335777	missense	possibly damaging	0.66
R3975:Scrn3	UTSW	2	73335777	missense	possibly damaging	0.66
R4206:Scrn3	UTSW	2	73319501	critical splice donor site	probably null
R5340:Scrn3	UTSW	2	73335810	nonsense	probably null
R5545:Scrn3	UTSW	2	73335781	missense	possibly damaging	0.64
R5852:Scrn3	UTSW	2	73331005	missense	probably damaging	1.00
R6819:Scrn3	UTSW	2	73319482	missense	probably damaging	0.98
R7664:Scrn3	UTSW	2	73319370	missense	possibly damaging	0.90
R8260:Scrn3	UTSW	2	73335858	missense	probably damaging	1.00
R8350:Scrn3	UTSW	2	73329769	missense	possibly damaging	0.95
R8450:Scrn3	UTSW	2	73329769	missense	possibly damaging	0.95
R8906:Scrn3	UTSW	2	73331008	missense	probably benign	0.34
R8906:Scrn3	UTSW	2	73331011	missense	possibly damaging	0.75
R8915:Scrn3	UTSW	2	73318292	missense	probably damaging	0.99
R9355:Scrn3	UTSW	2	73335733	missense	probably benign	0.00

Posted On

2015-04-16