Incidental Mutation 'IGL02676:Tmco4'
ID 303157
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmco4
Ensembl Gene ENSMUSG00000041143
Gene Name transmembrane and coiled-coil domains 4
Synonyms 4632413C14Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # IGL02676
Quality Score
Status
Chromosome 4
Chromosomal Location 138700199-138786482 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to C at 138750380 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000059320 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043042] [ENSMUST00000050949]
AlphaFold Q91WU4
Predicted Effect probably null
Transcript: ENSMUST00000043042
SMART Domains Protein: ENSMUSP00000041388
Gene: ENSMUSG00000041143

DomainStartEndE-ValueType
Pfam:DUF726 182 518 1.1e-138 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000050949
SMART Domains Protein: ENSMUSP00000059320
Gene: ENSMUSG00000041143

DomainStartEndE-ValueType
Pfam:DUF726 182 518 5.3e-145 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124835
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apc G A 18: 34,448,687 (GRCm39) S1827N probably damaging Het
Atrnl1 T A 19: 57,680,316 (GRCm39) C739S probably damaging Het
Cep350 T C 1: 155,737,977 (GRCm39) E2622G possibly damaging Het
Chd5 C T 4: 152,440,530 (GRCm39) probably benign Het
Chst11 T A 10: 83,027,563 (GRCm39) L330Q probably damaging Het
Clcnka A T 4: 141,120,094 (GRCm39) V275E probably damaging Het
Clip4 G A 17: 72,135,616 (GRCm39) S456N probably damaging Het
Cmya5 A T 13: 93,229,361 (GRCm39) I1909N probably damaging Het
Cyp26b1 A G 6: 84,553,626 (GRCm39) I176T probably damaging Het
Dst A G 1: 34,346,668 (GRCm39) R7717G probably damaging Het
Eml2 C T 7: 18,918,846 (GRCm39) R99* probably null Het
Fibin T C 2: 110,192,929 (GRCm39) Q71R probably benign Het
Fsip2 T G 2: 82,812,501 (GRCm39) I2940S possibly damaging Het
Gabrb3 G T 7: 57,241,112 (GRCm39) probably benign Het
Gfra1 G A 19: 58,441,787 (GRCm39) T48I probably damaging Het
Gm6483 C T 8: 19,743,675 (GRCm39) noncoding transcript Het
Hdgfl1 G A 13: 26,953,348 (GRCm39) R242C possibly damaging Het
Hmcn1 T C 1: 150,494,760 (GRCm39) T4110A probably benign Het
Lama2 T G 10: 26,994,489 (GRCm39) M1807L probably benign Het
Larp4 T C 15: 99,888,302 (GRCm39) V113A possibly damaging Het
Mkx T C 18: 7,000,640 (GRCm39) T101A probably benign Het
Nfe2l1 A G 11: 96,718,491 (GRCm39) F15L probably damaging Het
Nherf2 A T 17: 24,860,930 (GRCm39) V204E probably damaging Het
Nif3l1 G A 1: 58,494,895 (GRCm39) probably null Het
Nop14 A G 5: 34,796,565 (GRCm39) V764A probably damaging Het
Nosip C A 7: 44,726,752 (GRCm39) A259E probably damaging Het
Ntn5 T C 7: 45,341,300 (GRCm39) probably benign Het
Or9g20 T C 2: 85,629,934 (GRCm39) I227V possibly damaging Het
Phospho1 G A 11: 95,721,714 (GRCm39) G128D probably damaging Het
Ppp4r3a G A 12: 101,008,770 (GRCm39) T703M probably benign Het
Pramel21 T C 4: 143,342,667 (GRCm39) F258S possibly damaging Het
Pramel58 A G 5: 94,831,730 (GRCm39) T246A possibly damaging Het
Prdm8 G A 5: 98,334,418 (GRCm39) E662K probably damaging Het
Ralgapa1 A G 12: 55,723,202 (GRCm39) S1775P probably damaging Het
Rapgef6 T C 11: 54,540,172 (GRCm39) probably benign Het
Rasef T C 4: 73,677,966 (GRCm39) T87A possibly damaging Het
Scrn3 A G 2: 73,160,215 (GRCm39) Q286R probably benign Het
Sema3d A T 5: 12,620,945 (GRCm39) Q517L probably benign Het
Taf6l T C 19: 8,752,413 (GRCm39) Y425C probably damaging Het
Tbk1 T C 10: 121,403,985 (GRCm39) N254S possibly damaging Het
Tcf3 C T 10: 80,256,925 (GRCm39) G64R probably damaging Het
Trappc11 A G 8: 47,946,448 (GRCm39) probably benign Het
Vmn1r19 A T 6: 57,382,025 (GRCm39) I193F possibly damaging Het
Vmn2r14 G A 5: 109,367,882 (GRCm39) T370I probably benign Het
Vmn2r65 T A 7: 84,589,381 (GRCm39) H845L possibly damaging Het
Vmn2r98 A T 17: 19,285,521 (GRCm39) T114S probably benign Het
Zfp280d A T 9: 72,242,356 (GRCm39) R661S probably damaging Het
Zranb1 T C 7: 132,568,410 (GRCm39) I356T probably benign Het
Other mutations in Tmco4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00741:Tmco4 APN 4 138,723,885 (GRCm39) critical splice donor site probably null
IGL01346:Tmco4 APN 4 138,748,260 (GRCm39) missense probably damaging 0.97
IGL02552:Tmco4 APN 4 138,785,690 (GRCm39) missense probably benign 0.00
IGL02644:Tmco4 APN 4 138,737,920 (GRCm39) splice site probably benign
IGL02741:Tmco4 APN 4 138,757,188 (GRCm39) missense probably damaging 1.00
R0116:Tmco4 UTSW 4 138,781,231 (GRCm39) missense probably damaging 1.00
R0611:Tmco4 UTSW 4 138,747,383 (GRCm39) missense probably damaging 1.00
R4034:Tmco4 UTSW 4 138,748,172 (GRCm39) missense probably damaging 1.00
R4612:Tmco4 UTSW 4 138,717,871 (GRCm39) missense probably benign
R4785:Tmco4 UTSW 4 138,725,350 (GRCm39) missense probably damaging 0.97
R4981:Tmco4 UTSW 4 138,718,012 (GRCm39) missense possibly damaging 0.63
R5040:Tmco4 UTSW 4 138,747,477 (GRCm39) missense probably damaging 1.00
R5052:Tmco4 UTSW 4 138,785,817 (GRCm39) missense probably benign
R5074:Tmco4 UTSW 4 138,785,433 (GRCm39) missense probably damaging 0.98
R5364:Tmco4 UTSW 4 138,779,815 (GRCm39) missense probably damaging 0.99
R5445:Tmco4 UTSW 4 138,748,178 (GRCm39) missense probably damaging 1.00
R5598:Tmco4 UTSW 4 138,781,216 (GRCm39) missense probably damaging 1.00
R6959:Tmco4 UTSW 4 138,737,810 (GRCm39) missense probably damaging 0.99
R7539:Tmco4 UTSW 4 138,749,010 (GRCm39) missense probably benign 0.33
R7662:Tmco4 UTSW 4 138,737,872 (GRCm39) missense probably benign 0.00
R7981:Tmco4 UTSW 4 138,785,772 (GRCm39) missense probably damaging 1.00
R7996:Tmco4 UTSW 4 138,748,172 (GRCm39) missense probably damaging 1.00
R8543:Tmco4 UTSW 4 138,781,251 (GRCm39) missense probably benign 0.01
R9460:Tmco4 UTSW 4 138,747,387 (GRCm39) missense probably damaging 1.00
R9551:Tmco4 UTSW 4 138,779,895 (GRCm39) missense probably damaging 1.00
R9552:Tmco4 UTSW 4 138,779,895 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16