Incidental Mutation 'IGL02677:Zc2hc1c'
ID 303178
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zc2hc1c
Ensembl Gene ENSMUSG00000045064
Gene Name zinc finger, C2HC-type containing 1C
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.128) question?
Stock # IGL02677
Quality Score
Status
Chromosome 12
Chromosomal Location 85288591-85299358 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to C at 85290076 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Alanine at position 169 (D169A)
Ref Sequence ENSEMBL: ENSMUSP00000051664 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059341] [ENSMUST00000121930]
AlphaFold Q8CCG1
Predicted Effect probably benign
Transcript: ENSMUST00000059341
AA Change: D169A

PolyPhen 2 Score 0.312 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000051664
Gene: ENSMUSG00000045064
AA Change: D169A

DomainStartEndE-ValueType
low complexity region 93 106 N/A INTRINSIC
coiled coil region 207 254 N/A INTRINSIC
Pfam:zf-C2HC_2 378 402 3.6e-10 PFAM
low complexity region 433 444 N/A INTRINSIC
Pfam:zf-C2HC_2 489 513 3.1e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000121930
SMART Domains Protein: ENSMUSP00000112609
Gene: ENSMUSG00000008822

DomainStartEndE-ValueType
Pfam:Acylphosphatase 64 156 4.5e-25 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931406B18Rik G T 7: 43,501,095 Y84* probably null Het
4931406P16Rik T A 7: 34,242,409 probably benign Het
Adam5 A G 8: 24,812,379 probably benign Het
Aipl1 T C 11: 72,029,396 E282G possibly damaging Het
Akp3 A G 1: 87,125,272 D61G probably damaging Het
Anpep A G 7: 79,838,730 S451P probably damaging Het
Csnka2ip A G 16: 64,478,312 L119P probably damaging Het
Ddx19a T C 8: 110,989,609 E53G probably benign Het
Ddx50 C T 10: 62,616,293 R116Q unknown Het
Ddx60 A T 8: 61,988,132 E1078D probably damaging Het
Dpy19l1 T C 9: 24,485,072 D116G probably damaging Het
Dsg4 A G 18: 20,464,876 T668A possibly damaging Het
Dspp A G 5: 104,175,977 T329A possibly damaging Het
Eftud2 T C 11: 102,846,614 T554A probably damaging Het
Enpp1 T C 10: 24,679,185 probably benign Het
Ext2 A T 2: 93,707,245 F599I probably damaging Het
Fahd1 A T 17: 24,849,530 I191N probably damaging Het
Fcrls A T 3: 87,259,387 S100T probably benign Het
Fras1 T A 5: 96,545,024 C181S probably damaging Het
Gcnt4 A G 13: 96,947,233 I346V probably benign Het
Gfra1 G A 19: 58,453,355 T48I probably damaging Het
Kcnma1 A G 14: 23,463,156 Y392H probably damaging Het
Klc2 T C 19: 5,111,668 Y298C probably damaging Het
Lamb3 G A 1: 193,339,522 V1011I probably benign Het
Ldb1 T C 19: 46,036,155 probably benign Het
Mcph1 A G 8: 18,625,593 K11E probably damaging Het
Myc A G 15: 61,989,664 H374R probably damaging Het
Myom1 A G 17: 71,084,349 Y853C probably damaging Het
Olfr1282 A T 2: 111,335,802 I92N probably damaging Het
Pakap C T 4: 57,856,263 P572S probably benign Het
Pclo A G 5: 14,676,929 probably benign Het
Pde3a G A 6: 141,405,172 probably benign Het
Per1 T C 11: 69,106,660 V887A probably benign Het
Prokr1 G A 6: 87,588,368 probably benign Het
Rb1cc1 A G 1: 6,249,419 I1021V probably benign Het
Ryr1 T C 7: 29,110,608 E344G probably benign Het
Sec24c A T 14: 20,689,642 D529V probably damaging Het
Slc1a6 T C 10: 78,789,064 V101A probably damaging Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Tap2 G A 17: 34,212,047 V374M probably benign Het
Tex15 T A 8: 33,571,080 D179E probably benign Het
Tmem8b T C 4: 43,686,092 L241P probably damaging Het
Tmprss11g T C 5: 86,492,290 D160G probably benign Het
Trim30a C T 7: 104,435,913 C30Y probably damaging Het
Ttn A G 2: 76,771,496 probably benign Het
Ush2a A G 1: 188,734,685 R2849G probably damaging Het
Usp5 A G 6: 124,819,426 V570A probably damaging Het
Vipr1 T C 9: 121,660,283 probably benign Het
Other mutations in Zc2hc1c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01763:Zc2hc1c APN 12 85289676 missense probably benign 0.03
R1053:Zc2hc1c UTSW 12 85296556 missense probably damaging 1.00
R1696:Zc2hc1c UTSW 12 85290781 missense possibly damaging 0.86
R1724:Zc2hc1c UTSW 12 85289812 missense probably benign 0.00
R1905:Zc2hc1c UTSW 12 85290514 missense probably benign 0.03
R1996:Zc2hc1c UTSW 12 85296660 missense probably benign 0.31
R4463:Zc2hc1c UTSW 12 85290297 missense probably damaging 0.97
R4834:Zc2hc1c UTSW 12 85290208 missense probably damaging 1.00
R5070:Zc2hc1c UTSW 12 85290514 missense probably benign 0.03
R5943:Zc2hc1c UTSW 12 85289709 missense probably damaging 1.00
R6184:Zc2hc1c UTSW 12 85296444 missense probably damaging 0.96
R6701:Zc2hc1c UTSW 12 85289672 splice site probably null
R6704:Zc2hc1c UTSW 12 85290484 missense possibly damaging 0.84
R6719:Zc2hc1c UTSW 12 85290672 missense probably damaging 1.00
R7665:Zc2hc1c UTSW 12 85296562 missense possibly damaging 0.69
R8125:Zc2hc1c UTSW 12 85296612 missense probably damaging 1.00
R8154:Zc2hc1c UTSW 12 85290172 missense probably benign 0.00
R8268:Zc2hc1c UTSW 12 85289821 missense probably benign 0.02
R8356:Zc2hc1c UTSW 12 85290697 missense probably damaging 0.97
R8678:Zc2hc1c UTSW 12 85290310 missense probably benign 0.07
R8875:Zc2hc1c UTSW 12 85289775 missense possibly damaging 0.87
R9056:Zc2hc1c UTSW 12 85296456 small deletion probably benign
Posted On 2015-04-16