Incidental Mutation 'IGL02681:Tas2r113'
ID303366
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas2r113
Ensembl Gene ENSMUSG00000056926
Gene Nametaste receptor, type 2, member 113
SynonymsT2R13, mGR13, mt2r58, Tas2r13
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.061) question?
Stock #IGL02681
Quality Score
Status
Chromosome6
Chromosomal Location132893011-132893940 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to G at 132893367 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Leucine at position 119 (F119L)
Ref Sequence ENSEMBL: ENSMUSP00000078044 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079035]
Predicted Effect probably damaging
Transcript: ENSMUST00000079035
AA Change: F119L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000078044
Gene: ENSMUSG00000056926
AA Change: F119L

DomainStartEndE-ValueType
Pfam:TAS2R 1 301 9.4e-78 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bcar3 C T 3: 122,512,768 probably null Het
Cyp3a59 T C 5: 146,090,746 probably benign Het
Dnah2 G A 11: 69,452,933 T2844M probably benign Het
Ehbp1l1 T C 19: 5,720,825 I241M probably damaging Het
Fam129b A G 2: 32,911,390 Y122C probably benign Het
Fancl G A 11: 26,468,722 probably null Het
Filip1l A G 16: 57,571,779 Q910R probably benign Het
Fn1 A T 1: 71,619,482 V1139E probably damaging Het
Gm4787 A G 12: 81,378,769 V205A possibly damaging Het
Gpr158 T A 2: 21,815,630 L646Q probably damaging Het
Ifna1 A G 4: 88,850,286 D67G probably benign Het
Il11ra1 T A 4: 41,768,552 M412K possibly damaging Het
Klra10 T A 6: 130,279,419 M91L probably damaging Het
Krba1 T A 6: 48,404,118 D129E probably damaging Het
Mat1a T C 14: 41,122,496 probably benign Het
Med24 T A 11: 98,709,739 K627* probably null Het
Mpl A T 4: 118,448,871 probably benign Het
Mynn T A 3: 30,616,642 D554E probably benign Het
Olfr382 T C 11: 73,516,530 Y223C probably benign Het
Prkcd T C 14: 30,601,233 probably null Het
Prrc2c T C 1: 162,705,612 probably benign Het
Scp2d1 T C 2: 144,823,884 F48L probably benign Het
Slc12a2 A G 18: 57,879,399 H198R probably benign Het
Sulf2 A G 2: 166,116,985 V101A probably benign Het
Synj2 T A 17: 5,990,336 V144E probably damaging Het
Tspan17 A G 13: 54,789,629 E12G probably damaging Het
Other mutations in Tas2r113
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00858:Tas2r113 APN 6 132893152 missense probably benign 0.01
IGL01118:Tas2r113 APN 6 132893315 missense probably benign 0.00
IGL01366:Tas2r113 APN 6 132893797 missense probably benign 0.06
IGL01955:Tas2r113 APN 6 132893854 missense probably benign
IGL02629:Tas2r113 APN 6 132893336 missense probably damaging 1.00
IGL02883:Tas2r113 APN 6 132893419 missense probably damaging 1.00
R0002:Tas2r113 UTSW 6 132893779 missense probably benign 0.21
R0309:Tas2r113 UTSW 6 132893378 missense probably damaging 1.00
R1700:Tas2r113 UTSW 6 132893792 missense possibly damaging 0.92
R1748:Tas2r113 UTSW 6 132893732 missense probably damaging 0.98
R1854:Tas2r113 UTSW 6 132893329 missense probably damaging 1.00
R1974:Tas2r113 UTSW 6 132893833 missense probably benign 0.00
R4697:Tas2r113 UTSW 6 132893516 missense probably benign 0.04
R4798:Tas2r113 UTSW 6 132893707 missense possibly damaging 0.69
R4816:Tas2r113 UTSW 6 132893782 missense probably benign 0.09
R4906:Tas2r113 UTSW 6 132893558 missense possibly damaging 0.69
R6005:Tas2r113 UTSW 6 132893696 missense probably benign 0.02
R6012:Tas2r113 UTSW 6 132893681 missense probably damaging 1.00
R6107:Tas2r113 UTSW 6 132893014 missense probably damaging 1.00
R6603:Tas2r113 UTSW 6 132893458 missense probably benign 0.01
R7263:Tas2r113 UTSW 6 132893576 missense possibly damaging 0.90
R7434:Tas2r113 UTSW 6 132893309 missense probably benign 0.03
R7759:Tas2r113 UTSW 6 132893927 missense possibly damaging 0.85
X0022:Tas2r113 UTSW 6 132893296 missense probably damaging 0.98
Posted On2015-04-16