Incidental Mutation 'IGL02682:Gm4846'
ID303401
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm4846
Ensembl Gene ENSMUSG00000086056
Gene Namepredicted gene 4846
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.093) question?
Stock #IGL02682
Quality Score
Status
Chromosome1
Chromosomal Location166483613-166497588 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 166494626 bp
ZygosityHeterozygous
Amino Acid Change Glycine to Valine at position 124 (G124V)
Ref Sequence ENSEMBL: ENSMUSP00000123476 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000143922]
Predicted Effect probably damaging
Transcript: ENSMUST00000143922
AA Change: G124V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000123476
Gene: ENSMUSG00000086056
AA Change: G124V

DomainStartEndE-ValueType
Pfam:FMO-like 3 534 9.2e-239 PFAM
Pfam:Pyr_redox_2 4 227 1.1e-10 PFAM
Pfam:Pyr_redox_3 7 221 1.9e-12 PFAM
Pfam:NAD_binding_8 8 92 4.2e-7 PFAM
Pfam:K_oxygenase 77 333 3.4e-9 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acvr1 A G 2: 58,477,811 S113P probably benign Het
Arhgdib A T 6: 136,924,168 W188R probably damaging Het
Bcr T A 10: 75,166,046 N927K possibly damaging Het
Cd209c A G 8: 3,940,324 Y165H probably damaging Het
Cnnm2 A G 19: 46,762,076 K102E probably benign Het
Col12a1 T C 9: 79,699,341 E600G probably damaging Het
Ddx4 A T 13: 112,622,186 H280Q probably benign Het
Eya4 T C 10: 23,116,600 Y462C probably damaging Het
Fibcd1 T A 2: 31,838,564 I94F probably damaging Het
Gm5624 A G 14: 44,560,012 I108T possibly damaging Het
Gpr179 A T 11: 97,351,865 M51K probably benign Het
Hck A G 2: 153,134,134 I198V probably damaging Het
Kcnd2 T A 6: 21,216,925 C209* probably null Het
Klhl1 T A 14: 96,201,342 I507F possibly damaging Het
Knl1 A T 2: 119,077,969 K1693N possibly damaging Het
Mcam T C 9: 44,140,417 V490A possibly damaging Het
Mrgprx1 A T 7: 48,021,992 D2E probably damaging Het
Mtg1 T C 7: 140,144,729 probably benign Het
Myof C A 19: 37,921,481 R1512L probably benign Het
Nrp2 C T 1: 62,771,837 T679I probably benign Het
Nwd2 T A 5: 63,804,678 L535H probably damaging Het
Nwd2 C A 5: 63,804,677 L535I probably benign Het
Olfr1307 T A 2: 111,944,940 N172I probably damaging Het
Olfr1442 T C 19: 12,674,669 S155P probably damaging Het
Olfr592 A T 7: 103,187,014 I138F probably damaging Het
Phkb A G 8: 85,875,646 *41W probably null Het
Prl5a1 T A 13: 28,145,420 N27K probably benign Het
Rims1 T C 1: 22,288,484 T1292A probably damaging Het
Rnf38 G A 4: 44,133,745 A376V probably damaging Het
Slc34a2 T C 5: 53,059,238 V117A possibly damaging Het
Slfn8 A T 11: 83,003,691 F707L probably damaging Het
Snx16 G A 3: 10,438,175 P4L probably damaging Het
Snx6 T C 12: 54,754,345 D289G probably damaging Het
St8sia3 G T 18: 64,269,679 V130F probably damaging Het
U2surp A G 9: 95,481,651 probably null Het
Ubqln3 A G 7: 104,142,065 F273L probably benign Het
Vmn2r101 A T 17: 19,612,245 R834S possibly damaging Het
Vmn2r18 G T 5: 151,584,637 H341N probably damaging Het
Vrk3 A G 7: 44,753,820 I2V probably benign Het
Zglp1 A G 9: 21,066,238 S94P probably benign Het
Other mutations in Gm4846
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02975:Gm4846 APN 1 166483880 missense possibly damaging 0.46
R0504:Gm4846 UTSW 1 166491545 missense probably benign 0.04
R0989:Gm4846 UTSW 1 166487120 missense possibly damaging 0.81
R1836:Gm4846 UTSW 1 166483923 missense probably benign 0.17
R1965:Gm4846 UTSW 1 166486964 missense possibly damaging 0.93
R3120:Gm4846 UTSW 1 166491548 missense probably benign 0.11
R4013:Gm4846 UTSW 1 166494680 splice site probably null
R4617:Gm4846 UTSW 1 166495981 missense probably damaging 1.00
R4641:Gm4846 UTSW 1 166483893 missense probably damaging 0.99
R4825:Gm4846 UTSW 1 166491668 missense probably damaging 1.00
R4952:Gm4846 UTSW 1 166483934 missense probably damaging 0.97
R5135:Gm4846 UTSW 1 166483982 missense probably damaging 1.00
R5230:Gm4846 UTSW 1 166490179 missense probably benign 0.26
R5335:Gm4846 UTSW 1 166497453 nonsense probably null
R5711:Gm4846 UTSW 1 166484025 missense probably benign 0.12
R5957:Gm4846 UTSW 1 166486953 missense probably benign
R6024:Gm4846 UTSW 1 166490127 missense probably benign 0.00
R6460:Gm4846 UTSW 1 166497513 missense probably benign 0.00
R6764:Gm4846 UTSW 1 166491552 missense probably benign
R6833:Gm4846 UTSW 1 166494578 missense possibly damaging 0.63
R6834:Gm4846 UTSW 1 166494578 missense possibly damaging 0.63
R7161:Gm4846 UTSW 1 166487010 missense probably damaging 1.00
R7275:Gm4846 UTSW 1 166487079 missense probably benign 0.01
R7622:Gm4846 UTSW 1 166495872 missense possibly damaging 0.64
R7890:Gm4846 UTSW 1 166494659 missense probably benign
R7973:Gm4846 UTSW 1 166494659 missense probably benign
R8072:Gm4846 UTSW 1 166494672 missense probably benign 0.06
Posted On2015-04-16