Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02682:Prl5a1'

303407

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Prl5a1

Ensembl Gene

ENSMUSG00000017064

Gene Name

prolactin family 5, subfamily a, member 1

Synonyms

1600013P04Rik, D13Wsu14e, Prlpl, PLP-L

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

IGL02682

Quality Score

Status

Chromosome

Chromosomal Location

28326467-28335578 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 28329403 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 27 (N27K)

Ref Sequence

ENSEMBL: ENSMUSP00000017208 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000017208]

AlphaFold

Q9JII2

Predicted Effect

probably benign
Transcript: ENSMUST00000017208
AA Change: N27K

PolyPhen 2 Score 0.319 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000017208
Gene: ENSMUSG00000017064
AA Change: N27K

Domain	Start	End	E-Value	Type
Pfam:Hormone_1	17	230	4.8e-50	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acvr1	A	G	2: 58,367,823 (GRCm39)	S113P	probably benign	Het
Arhgdib	A	T	6: 136,901,166 (GRCm39)	W188R	probably damaging	Het
Bcr	T	A	10: 75,001,878 (GRCm39)	N927K	possibly damaging	Het
Cd209c	A	G	8: 3,990,324 (GRCm39)	Y165H	probably damaging	Het
Cnnm2	A	G	19: 46,750,515 (GRCm39)	K102E	probably benign	Het
Col12a1	T	C	9: 79,606,623 (GRCm39)	E600G	probably damaging	Het
Ddx4	A	T	13: 112,758,720 (GRCm39)	H280Q	probably benign	Het
Eya4	T	C	10: 22,992,498 (GRCm39)	Y462C	probably damaging	Het
Fibcd1	T	A	2: 31,728,576 (GRCm39)	I94F	probably damaging	Het
Gm4846	C	A	1: 166,322,195 (GRCm39)	G124V	probably damaging	Het
Gm5624	A	G	14: 44,797,469 (GRCm39)	I108T	possibly damaging	Het
Gpr179	A	T	11: 97,242,691 (GRCm39)	M51K	probably benign	Het
Hck	A	G	2: 152,976,054 (GRCm39)	I198V	probably damaging	Het
Kcnd2	T	A	6: 21,216,924 (GRCm39)	C209*	probably null	Het
Klhl1	T	A	14: 96,438,778 (GRCm39)	I507F	possibly damaging	Het
Knl1	A	T	2: 118,908,450 (GRCm39)	K1693N	possibly damaging	Het
Mcam	T	C	9: 44,051,714 (GRCm39)	V490A	possibly damaging	Het
Mrgprx1	A	T	7: 47,671,740 (GRCm39)	D2E	probably damaging	Het
Mtg1	T	C	7: 139,724,642 (GRCm39)		probably benign	Het
Myof	C	A	19: 37,909,929 (GRCm39)	R1512L	probably benign	Het
Nrp2	C	T	1: 62,810,996 (GRCm39)	T679I	probably benign	Het
Nwd2	C	A	5: 63,962,020 (GRCm39)	L535I	probably benign	Het
Nwd2	T	A	5: 63,962,021 (GRCm39)	L535H	probably damaging	Het
Or4f14b	T	A	2: 111,775,285 (GRCm39)	N172I	probably damaging	Het
Or52j3	A	T	7: 102,836,221 (GRCm39)	I138F	probably damaging	Het
Or5b94	T	C	19: 12,652,033 (GRCm39)	S155P	probably damaging	Het
Phkb	A	G	8: 86,602,275 (GRCm39)	*41W	probably null	Het
Rims1	T	C	1: 22,358,708 (GRCm39)	T1292A	probably damaging	Het
Rnf38	G	A	4: 44,133,745 (GRCm39)	A376V	probably damaging	Het
Slc34a2	T	C	5: 53,216,580 (GRCm39)	V117A	possibly damaging	Het
Slfn8	A	T	11: 82,894,517 (GRCm39)	F707L	probably damaging	Het
Snx16	G	A	3: 10,503,235 (GRCm39)	P4L	probably damaging	Het
Snx6	T	C	12: 54,801,130 (GRCm39)	D289G	probably damaging	Het
St8sia3	G	T	18: 64,402,750 (GRCm39)	V130F	probably damaging	Het
U2surp	A	G	9: 95,363,704 (GRCm39)		probably null	Het
Ubqln3	A	G	7: 103,791,272 (GRCm39)	F273L	probably benign	Het
Vmn2r101	A	T	17: 19,832,507 (GRCm39)	R834S	possibly damaging	Het
Vmn2r18	G	T	5: 151,508,102 (GRCm39)	H341N	probably damaging	Het
Vrk3	A	G	7: 44,403,244 (GRCm39)	I2V	probably benign	Het
Zglp1	A	G	9: 20,977,534 (GRCm39)	S94P	probably benign	Het

Other mutations in Prl5a1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01638:Prl5a1	APN	13	28,329,422 (GRCm39)	missense	possibly damaging	0.77
IGL01820:Prl5a1	APN	13	28,332,683 (GRCm39)	missense	probably benign	0.34
R0266:Prl5a1	UTSW	13	28,333,970 (GRCm39)	missense	possibly damaging	0.77
R1022:Prl5a1	UTSW	13	28,333,880 (GRCm39)	missense	probably damaging	0.97
R1024:Prl5a1	UTSW	13	28,333,880 (GRCm39)	missense	probably damaging	0.97
R2098:Prl5a1	UTSW	13	28,329,488 (GRCm39)	missense	probably damaging	1.00
R5467:Prl5a1	UTSW	13	28,333,994 (GRCm39)	missense	possibly damaging	0.92
R6002:Prl5a1	UTSW	13	28,329,465 (GRCm39)	missense	probably benign	0.00
R6026:Prl5a1	UTSW	13	28,335,247 (GRCm39)	missense	probably benign	0.43
R6242:Prl5a1	UTSW	13	28,326,538 (GRCm39)	nonsense	probably null
R6616:Prl5a1	UTSW	13	28,333,839 (GRCm39)	missense	probably benign	0.00
R6733:Prl5a1	UTSW	13	28,333,919 (GRCm39)	missense	possibly damaging	0.81
R6979:Prl5a1	UTSW	13	28,335,189 (GRCm39)	missense	probably benign	0.32
R7692:Prl5a1	UTSW	13	28,333,997 (GRCm39)	missense	probably damaging	1.00
R9610:Prl5a1	UTSW	13	28,329,492 (GRCm39)	missense	possibly damaging	0.71
R9611:Prl5a1	UTSW	13	28,329,492 (GRCm39)	missense	possibly damaging	0.71

Posted On

2015-04-16