Incidental Mutation 'IGL02683:Map3k10'
ID 303425
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Map3k10
Ensembl Gene ENSMUSG00000040390
Gene Name mitogen-activated protein kinase kinase kinase 10
Synonyms Mlk2, mixed lineage kinase 2, MKN28 derived nonreceptor_type, MKN28 kinase, serine/threonine kinase
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02683
Quality Score
Status
Chromosome 7
Chromosomal Location 27355800-27374023 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 27358362 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Arginine at position 571 (K571R)
Ref Sequence ENSEMBL: ENSMUSP00000103978 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000008088] [ENSMUST00000036453] [ENSMUST00000108341]
AlphaFold Q66L42
Predicted Effect probably benign
Transcript: ENSMUST00000008088
SMART Domains Protein: ENSMUSP00000008088
Gene: ENSMUSG00000007944

DomainStartEndE-ValueType
low complexity region 12 36 N/A INTRINSIC
low complexity region 49 65 N/A INTRINSIC
Blast:TPR 66 95 2e-7 BLAST
low complexity region 101 117 N/A INTRINSIC
Blast:TPR 133 168 1e-10 BLAST
Pfam:TPR_2 169 202 3.3e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000036453
AA Change: K571R

PolyPhen 2 Score 0.058 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000037725
Gene: ENSMUSG00000040390
AA Change: K571R

DomainStartEndE-ValueType
low complexity region 2 14 N/A INTRINSIC
SH3 19 80 6e-20 SMART
Pfam:Pkinase 98 357 7.4e-59 PFAM
Pfam:Pkinase_Tyr 98 357 3.8e-62 PFAM
coiled coil region 378 449 N/A INTRINSIC
low complexity region 501 511 N/A INTRINSIC
low complexity region 524 550 N/A INTRINSIC
low complexity region 665 676 N/A INTRINSIC
low complexity region 761 778 N/A INTRINSIC
low complexity region 835 847 N/A INTRINSIC
low complexity region 870 881 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000108341
AA Change: K571R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000103978
Gene: ENSMUSG00000040390
AA Change: K571R

DomainStartEndE-ValueType
low complexity region 2 14 N/A INTRINSIC
SH3 19 80 6e-20 SMART
Pfam:Pkinase_Tyr 98 357 2e-62 PFAM
Pfam:Pkinase 98 358 4.8e-59 PFAM
coiled coil region 378 449 N/A INTRINSIC
low complexity region 501 511 N/A INTRINSIC
low complexity region 524 550 N/A INTRINSIC
low complexity region 665 676 N/A INTRINSIC
low complexity region 761 778 N/A INTRINSIC
low complexity region 837 849 N/A INTRINSIC
low complexity region 872 883 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit normal development, reproduction and lifespan. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars1 T C 8: 111,779,163 (GRCm39) probably benign Het
Abhd3 A G 18: 10,658,790 (GRCm39) S215P probably damaging Het
Adam20 G A 8: 41,248,621 (GRCm39) V244M probably damaging Het
Akr1c21 A C 13: 4,626,312 (GRCm39) D112A probably damaging Het
Ano6 A T 15: 95,846,193 (GRCm39) Y498F probably damaging Het
Aspscr1 T C 11: 120,592,052 (GRCm39) F263S probably damaging Het
Capn11 A G 17: 45,964,517 (GRCm39) F100S probably damaging Het
Cd63 T C 10: 128,746,299 (GRCm39) C9R probably damaging Het
Cenpj T C 14: 56,790,409 (GRCm39) K547E possibly damaging Het
Clasp1 A G 1: 118,466,996 (GRCm39) D793G probably benign Het
Cmya5 G A 13: 93,227,505 (GRCm39) Q2528* probably null Het
Crybg1 A G 10: 43,865,212 (GRCm39) S1422P possibly damaging Het
Csgalnact1 C A 8: 68,854,144 (GRCm39) G219V probably damaging Het
Dnal1 G A 12: 84,185,128 (GRCm39) G178D probably damaging Het
E2f7 T C 10: 110,618,320 (GRCm39) M795T probably benign Het
Glipr1l2 T C 10: 111,919,381 (GRCm39) V34A probably benign Het
Gsdmc2 C T 15: 63,705,261 (GRCm39) V151M probably damaging Het
Htr7 T C 19: 35,937,762 (GRCm39) T448A probably benign Het
Kcnj5 T C 9: 32,229,076 (GRCm39) T41A possibly damaging Het
Kcnt1 T C 2: 25,790,937 (GRCm39) M12T possibly damaging Het
Kif1c G A 11: 70,617,278 (GRCm39) A871T possibly damaging Het
Med23 C A 10: 24,746,615 (GRCm39) A45E probably benign Het
Nudt5 C A 2: 5,868,412 (GRCm39) S103R probably damaging Het
Or9m1 T A 2: 87,733,448 (GRCm39) T191S possibly damaging Het
Parp3 A G 9: 106,350,384 (GRCm39) S369P possibly damaging Het
Plxna4 A T 6: 32,494,541 (GRCm39) L25Q probably benign Het
Pon2 A G 6: 5,269,062 (GRCm39) V204A probably damaging Het
Ppfia1 A G 7: 144,067,095 (GRCm39) M463T probably damaging Het
Ppp1r14d T C 2: 119,049,303 (GRCm39) E95G probably damaging Het
Pramel18 T C 4: 101,767,551 (GRCm39) S267P probably benign Het
Prrc2a A G 17: 35,374,969 (GRCm39) V1227A probably benign Het
Rabgap1 T A 2: 37,392,951 (GRCm39) W536R probably damaging Het
Slco6d1 A G 1: 98,408,397 (GRCm39) N431S probably benign Het
Spen C T 4: 141,198,956 (GRCm39) V3224I probably benign Het
Srrm1 G A 4: 135,052,415 (GRCm39) P658L unknown Het
Ssh2 A G 11: 77,289,082 (GRCm39) D88G probably damaging Het
Stat5b T G 11: 100,695,772 (GRCm39) K70T probably benign Het
Tex44 A G 1: 86,355,465 (GRCm39) D458G probably benign Het
Tut1 T A 19: 8,942,622 (GRCm39) C570S probably benign Het
Usp42 T C 5: 143,701,101 (GRCm39) E974G possibly damaging Het
Vezf1 A T 11: 87,967,153 (GRCm39) Q310L probably benign Het
Vmn2r83 A T 10: 79,327,115 (GRCm39) R574S probably benign Het
Zfp664 T C 5: 124,963,386 (GRCm39) V260A probably benign Het
Other mutations in Map3k10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00422:Map3k10 APN 7 27,367,894 (GRCm39) missense probably damaging 1.00
IGL00672:Map3k10 APN 7 27,361,026 (GRCm39) missense probably damaging 0.98
IGL00913:Map3k10 APN 7 27,362,640 (GRCm39) unclassified probably benign
IGL01383:Map3k10 APN 7 27,357,424 (GRCm39) missense probably benign 0.15
R0039:Map3k10 UTSW 7 27,357,523 (GRCm39) missense possibly damaging 0.95
R0219:Map3k10 UTSW 7 27,356,156 (GRCm39) missense probably damaging 1.00
R0285:Map3k10 UTSW 7 27,373,325 (GRCm39) missense probably benign 0.00
R0368:Map3k10 UTSW 7 27,362,785 (GRCm39) missense probably damaging 0.98
R0724:Map3k10 UTSW 7 27,367,780 (GRCm39) missense probably damaging 1.00
R0729:Map3k10 UTSW 7 27,360,992 (GRCm39) missense probably damaging 1.00
R1734:Map3k10 UTSW 7 27,357,540 (GRCm39) missense probably damaging 1.00
R1847:Map3k10 UTSW 7 27,360,981 (GRCm39) splice site probably null
R2395:Map3k10 UTSW 7 27,373,418 (GRCm39) missense unknown
R2517:Map3k10 UTSW 7 27,362,688 (GRCm39) missense possibly damaging 0.92
R3841:Map3k10 UTSW 7 27,357,789 (GRCm39) missense possibly damaging 0.91
R4749:Map3k10 UTSW 7 27,357,786 (GRCm39) missense possibly damaging 0.78
R5269:Map3k10 UTSW 7 27,357,957 (GRCm39) missense probably benign 0.01
R5822:Map3k10 UTSW 7 27,356,159 (GRCm39) missense probably damaging 1.00
R6059:Map3k10 UTSW 7 27,356,247 (GRCm39) missense probably damaging 0.99
R6417:Map3k10 UTSW 7 27,362,709 (GRCm39) missense probably damaging 1.00
R6420:Map3k10 UTSW 7 27,362,709 (GRCm39) missense probably damaging 1.00
R7903:Map3k10 UTSW 7 27,357,382 (GRCm39) missense probably damaging 0.99
R8118:Map3k10 UTSW 7 27,372,842 (GRCm39) missense possibly damaging 0.91
R8191:Map3k10 UTSW 7 27,362,671 (GRCm39) missense probably damaging 0.99
R8336:Map3k10 UTSW 7 27,372,884 (GRCm39) missense probably benign 0.25
R8697:Map3k10 UTSW 7 27,362,784 (GRCm39) missense probably benign 0.13
R8699:Map3k10 UTSW 7 27,367,780 (GRCm39) missense probably damaging 0.99
R9237:Map3k10 UTSW 7 27,357,842 (GRCm39) nonsense probably null
R9526:Map3k10 UTSW 7 27,364,434 (GRCm39) missense probably damaging 1.00
X0020:Map3k10 UTSW 7 27,363,887 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16