Incidental Mutation 'IGL02684:Zfp977'
ID303473
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp977
Ensembl Gene ENSMUSG00000092335
Gene Namezinc finger protein 977
SynonymsGm7221
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.165) question?
Stock #IGL02684
Quality Score
Status
Chromosome7
Chromosomal Location42579783-42592547 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 42583015 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 7 (D7E)
Ref Sequence ENSEMBL: ENSMUSP00000134517 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000173283] [ENSMUST00000179470]
Predicted Effect probably damaging
Transcript: ENSMUST00000173283
AA Change: D7E

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000134517
Gene: ENSMUSG00000092335
AA Change: D7E

DomainStartEndE-ValueType
KRAB 4 66 3.82e-20 SMART
ZnF_C2H2 131 153 1.92e-2 SMART
ZnF_C2H2 159 181 6.32e-3 SMART
ZnF_C2H2 187 209 5.99e-4 SMART
ZnF_C2H2 215 237 2.4e-3 SMART
ZnF_C2H2 243 265 7.15e-2 SMART
ZnF_C2H2 271 293 5.21e-4 SMART
ZnF_C2H2 299 321 5.5e-3 SMART
ZnF_C2H2 327 349 2.75e-3 SMART
ZnF_C2H2 355 377 3.11e-2 SMART
ZnF_C2H2 383 405 4.87e-4 SMART
ZnF_C2H2 411 433 1.82e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000179470
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205970
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930596D02Rik A T 14: 35,810,063 L185* probably null Het
Actrt3 A T 3: 30,599,691 D53E probably benign Het
Ankrd34b T C 13: 92,438,508 S83P probably damaging Het
Asap1 A G 15: 64,094,169 V1029A probably benign Het
Blk T C 14: 63,379,694 E288G probably benign Het
Cep192 T G 18: 67,834,563 V706G probably damaging Het
Chd2 T C 7: 73,475,349 K908E probably damaging Het
Dnm1l A T 16: 16,321,657 I391N possibly damaging Het
Fam84a T C 12: 14,150,645 D27G probably damaging Het
Fmn1 A G 2: 113,525,277 R688G unknown Het
Gdap2 A G 3: 100,171,020 D100G probably benign Het
Gm43638 T C 5: 87,462,910 I522V possibly damaging Het
Gm438 A G 4: 144,778,185 probably benign Het
Gsap A T 5: 21,242,803 probably null Het
Hoxd12 A G 2: 74,675,561 S159G probably benign Het
Ints7 A G 1: 191,613,637 probably null Het
Iqsec3 G A 6: 121,412,941 Q524* probably null Het
Klra10 T A 6: 130,281,882 H14L possibly damaging Het
Mettl15 T C 2: 109,131,580 E228G probably damaging Het
Olfr466 G A 13: 65,152,396 M57I probably damaging Het
Olfr624 T C 7: 103,670,384 M216V probably benign Het
Pabpc1l A G 2: 164,031,277 N156D probably benign Het
Pkhd1l1 G T 15: 44,516,209 probably null Het
Pm20d1 T A 1: 131,804,959 N345K probably benign Het
Rasgrp1 A G 2: 117,282,576 V785A probably benign Het
Sos2 A G 12: 69,596,666 L980S probably damaging Het
Stam2 A T 2: 52,719,935 H56Q probably damaging Het
Trpm6 T A 19: 18,802,207 probably benign Het
Trpm7 A T 2: 126,846,159 D249E probably damaging Het
Vmn1r203 A T 13: 22,524,369 T107S possibly damaging Het
Vmn2r55 A G 7: 12,670,960 L172P probably damaging Het
Vrtn A G 12: 84,650,149 R558G probably benign Het
Other mutations in Zfp977
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01350:Zfp977 APN 7 42580666 missense probably damaging 1.00
IGL01541:Zfp977 APN 7 42580732 missense probably benign 0.01
IGL02034:Zfp977 APN 7 42580712 missense probably damaging 1.00
IGL02678:Zfp977 APN 7 42582995 missense probably damaging 1.00
IGL03178:Zfp977 APN 7 42582648 missense probably damaging 0.99
R0707:Zfp977 UTSW 7 42580534 missense probably damaging 1.00
R1640:Zfp977 UTSW 7 42580106 missense probably damaging 0.99
R1668:Zfp977 UTSW 7 42580646 missense probably benign 0.03
R1993:Zfp977 UTSW 7 42579985 missense probably benign 0.00
R3151:Zfp977 UTSW 7 42580446 missense probably benign 0.00
R4587:Zfp977 UTSW 7 42580190 missense probably damaging 0.98
R4678:Zfp977 UTSW 7 42580013 missense probably benign 0.04
R6073:Zfp977 UTSW 7 42580741 missense probably benign 0.34
R7054:Zfp977 UTSW 7 42580362 missense possibly damaging 0.82
R7436:Zfp977 UTSW 7 42580460 missense probably benign
R7500:Zfp977 UTSW 7 42580205 missense probably damaging 1.00
R8294:Zfp977 UTSW 7 42580265 missense probably benign
X0023:Zfp977 UTSW 7 42580119 nonsense probably null
Posted On2015-04-16