Incidental Mutation 'IGL02686:Vmn2r20'
ID303546
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r20
Ensembl Gene ENSMUSG00000094145
Gene Namevomeronasal 2, receptor 20
SynonymsEG667180
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.334) question?
Stock #IGL02686
Quality Score
Status
Chromosome6
Chromosomal Location123385262-123418061 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 123385626 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Threonine at position 733 (M733T)
Ref Sequence ENSEMBL: ENSMUSP00000129145 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000172199]
Predicted Effect probably benign
Transcript: ENSMUST00000172199
AA Change: M733T

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000129145
Gene: ENSMUSG00000094145
AA Change: M733T

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:ANF_receptor 81 473 5e-33 PFAM
Pfam:NCD3G 517 570 9.6e-24 PFAM
Pfam:7tm_3 601 838 1.4e-54 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam4 C T 12: 81,421,674 G58S possibly damaging Het
Adcyap1r1 G A 6: 55,481,125 A304T probably benign Het
Adipoq A G 16: 23,157,115 T110A possibly damaging Het
Ago2 T C 15: 73,113,742 Y668C possibly damaging Het
Ampd2 A T 3: 108,076,495 D575E possibly damaging Het
Anxa5 C T 3: 36,449,355 E317K probably benign Het
Atf2 A T 2: 73,845,500 M169K possibly damaging Het
Bicc1 C A 10: 70,943,360 probably benign Het
Bicra A G 7: 15,987,915 M559T probably benign Het
Cacna1e G A 1: 154,493,409 A294V probably damaging Het
Cacna1h G A 17: 25,385,749 P1197S possibly damaging Het
Cmya5 G A 13: 93,090,997 Q2528* probably null Het
Csgalnact1 C A 8: 68,401,492 G219V probably damaging Het
Cts8 T C 13: 61,250,970 T241A probably benign Het
Cubn T C 2: 13,325,226 I2615V possibly damaging Het
Cxcl12 A G 6: 117,173,585 probably benign Het
Fig4 T C 10: 41,264,004 D307G probably damaging Het
Flt1 T C 5: 147,588,602 I909V probably damaging Het
Foxk1 T A 5: 142,453,585 S427T probably damaging Het
Gosr1 G A 11: 76,750,862 T130M probably benign Het
Grik1 G T 16: 88,009,761 probably null Het
Hipk1 C T 3: 103,778,017 S94N possibly damaging Het
Ints7 T C 1: 191,586,592 L147P probably damaging Het
Nsd3 A G 8: 25,666,070 D551G probably damaging Het
Olfr510 A T 7: 108,667,886 I157F probably benign Het
Olfr741 G A 14: 50,485,969 M170I probably benign Het
Prrc2c T C 1: 162,707,947 probably benign Het
Ren1 A T 1: 133,358,469 N250I possibly damaging Het
Ripply2 A C 9: 87,015,956 probably benign Het
Ryr1 G T 7: 29,069,550 probably benign Het
Smad3 T A 9: 63,667,782 K51M probably damaging Het
Snapc1 C A 12: 73,964,596 probably benign Het
Srfbp1 T G 18: 52,475,654 V42G probably damaging Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Tab1 T C 15: 80,148,830 V105A probably benign Het
Tat T C 8: 109,996,849 V323A probably damaging Het
Tdo2 T C 3: 81,968,155 N164S probably benign Het
Tefm T A 11: 80,136,896 L345F probably damaging Het
Tmem145 C A 7: 25,314,725 N407K probably damaging Het
Uhrf1bp1 T C 17: 27,894,589 I1245T probably benign Het
Uhrf1bp1l A T 10: 89,805,193 Q742L probably benign Het
Vmn2r116 A G 17: 23,388,793 N445S probably damaging Het
Vmn2r93 G A 17: 18,313,264 V477M possibly damaging Het
Zdhhc4 A G 5: 143,320,391 F194S probably damaging Het
Zfp738 A T 13: 67,673,652 S25T probably damaging Het
Other mutations in Vmn2r20
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01915:Vmn2r20 APN 6 123393965 missense possibly damaging 0.89
IGL02653:Vmn2r20 APN 6 123385365 missense probably damaging 1.00
R0309:Vmn2r20 UTSW 6 123386104 missense probably benign 0.18
R3724:Vmn2r20 UTSW 6 123385747 missense probably benign 0.00
R6502:Vmn2r20 UTSW 6 123396383 missense possibly damaging 0.51
R7039:Vmn2r20 UTSW 6 123386123 missense probably damaging 0.98
R7218:Vmn2r20 UTSW 6 123386115 missense probably damaging 1.00
R7372:Vmn2r20 UTSW 6 123385509 missense probably damaging 1.00
R7509:Vmn2r20 UTSW 6 123385423 missense probably benign 0.00
Posted On2015-04-16