Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02686:Vmn2r116'

303553

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r116

Ensembl Gene

ENSMUSG00000090966

Gene Name

vomeronasal 2, receptor 116

Synonyms

V2Rp5, EG619697

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

IGL02686

Quality Score

Status

Chromosome

Chromosomal Location

23384803-23401864 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 23388793 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 445 (N445S)

Ref Sequence

ENSEMBL: ENSMUSP00000128106 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164856]

AlphaFold

E9Q6I0

Predicted Effect

probably damaging
Transcript: ENSMUST00000164856
AA Change: N445S

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000128106
Gene: ENSMUSG00000090966
AA Change: N445S

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	4.4e-30	PFAM
Pfam:NCD3G	511	564	1.2e-22	PFAM
low complexity region	589	594	N/A	INTRINSIC
Pfam:7tm_3	595	832	8.7e-57	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Female mice homozygous for a knock-out allele stimulated with male pheromone (Gm6084) fail to exhibit an increase in lordosis behavior and successful intromission. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam4	C	T	12: 81,421,674	G58S	possibly damaging	Het
Adcyap1r1	G	A	6: 55,481,125	A304T	probably benign	Het
Adipoq	A	G	16: 23,157,115	T110A	possibly damaging	Het
Ago2	T	C	15: 73,113,742	Y668C	possibly damaging	Het
Ampd2	A	T	3: 108,076,495	D575E	possibly damaging	Het
Anxa5	C	T	3: 36,449,355	E317K	probably benign	Het
Atf2	A	T	2: 73,845,500	M169K	possibly damaging	Het
Bicc1	C	A	10: 70,943,360		probably benign	Het
Bicra	A	G	7: 15,987,915	M559T	probably benign	Het
Cacna1e	G	A	1: 154,493,409	A294V	probably damaging	Het
Cacna1h	G	A	17: 25,385,749	P1197S	possibly damaging	Het
Cmya5	G	A	13: 93,090,997	Q2528*	probably null	Het
Csgalnact1	C	A	8: 68,401,492	G219V	probably damaging	Het
Cts8	T	C	13: 61,250,970	T241A	probably benign	Het
Cubn	T	C	2: 13,325,226	I2615V	possibly damaging	Het
Cxcl12	A	G	6: 117,173,585		probably benign	Het
Fig4	T	C	10: 41,264,004	D307G	probably damaging	Het
Flt1	T	C	5: 147,588,602	I909V	probably damaging	Het
Foxk1	T	A	5: 142,453,585	S427T	probably damaging	Het
Gosr1	G	A	11: 76,750,862	T130M	probably benign	Het
Grik1	G	T	16: 88,009,761		probably null	Het
Hipk1	C	T	3: 103,778,017	S94N	possibly damaging	Het
Ints7	T	C	1: 191,586,592	L147P	probably damaging	Het
Nsd3	A	G	8: 25,666,070	D551G	probably damaging	Het
Olfr510	A	T	7: 108,667,886	I157F	probably benign	Het
Olfr741	G	A	14: 50,485,969	M170I	probably benign	Het
Prrc2c	T	C	1: 162,707,947		probably benign	Het
Ren1	A	T	1: 133,358,469	N250I	possibly damaging	Het
Ripply2	A	C	9: 87,015,956		probably benign	Het
Ryr1	G	T	7: 29,069,550		probably benign	Het
Smad3	T	A	9: 63,667,782	K51M	probably damaging	Het
Snapc1	C	A	12: 73,964,596		probably benign	Het
Srfbp1	T	G	18: 52,475,654	V42G	probably damaging	Het
Srrm1	G	A	4: 135,325,104	P658L	unknown	Het
Tab1	T	C	15: 80,148,830	V105A	probably benign	Het
Tat	T	C	8: 109,996,849	V323A	probably damaging	Het
Tdo2	T	C	3: 81,968,155	N164S	probably benign	Het
Tefm	T	A	11: 80,136,896	L345F	probably damaging	Het
Tmem145	C	A	7: 25,314,725	N407K	probably damaging	Het
Uhrf1bp1	T	C	17: 27,894,589	I1245T	probably benign	Het
Uhrf1bp1l	A	T	10: 89,805,193	Q742L	probably benign	Het
Vmn2r20	A	G	6: 123,385,626	M733T	probably benign	Het
Vmn2r93	G	A	17: 18,313,264	V477M	possibly damaging	Het
Zdhhc4	A	G	5: 143,320,391	F194S	probably damaging	Het
Zfp738	A	T	13: 67,673,652	S25T	probably damaging	Het

Other mutations in Vmn2r116

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00898:Vmn2r116	APN	17	23385995	missense	possibly damaging	0.94
IGL00985:Vmn2r116	APN	17	23401515	missense	probably damaging	1.00
IGL00990:Vmn2r116	APN	17	23397727	missense	probably damaging	1.00
IGL00990:Vmn2r116	APN	17	23387236	missense	probably benign	0.12
IGL01383:Vmn2r116	APN	17	23401601	missense	probably damaging	1.00
IGL01459:Vmn2r116	APN	17	23384929	missense	probably damaging	1.00
IGL01725:Vmn2r116	APN	17	23386645	missense	probably damaging	1.00
IGL02125:Vmn2r116	APN	17	23397627	splice site	probably benign
IGL02170:Vmn2r116	APN	17	23384933	missense	probably benign
IGL02209:Vmn2r116	APN	17	23388787	missense	probably damaging	1.00
IGL02226:Vmn2r116	APN	17	23384834	missense	probably null
IGL02272:Vmn2r116	APN	17	23385999	missense	probably benign	0.06
IGL02272:Vmn2r116	APN	17	23386004	missense	probably damaging	1.00
IGL02403:Vmn2r116	APN	17	23387364	missense	probably damaging	1.00
IGL02750:Vmn2r116	APN	17	23397634	splice site	probably benign
IGL02977:Vmn2r116	APN	17	23388774	missense	possibly damaging	0.90
PIT4449001:Vmn2r116	UTSW	17	23388947	missense	probably benign	0.41
R0015:Vmn2r116	UTSW	17	23401849	missense	probably benign	0.03
R0219:Vmn2r116	UTSW	17	23386098	nonsense	probably null
R0281:Vmn2r116	UTSW	17	23401413	missense	possibly damaging	0.90
R0415:Vmn2r116	UTSW	17	23387279	missense	possibly damaging	0.55
R0592:Vmn2r116	UTSW	17	23386915	missense	probably damaging	0.99
R0610:Vmn2r116	UTSW	17	23387312	missense	probably damaging	1.00
R0635:Vmn2r116	UTSW	17	23386887	missense	possibly damaging	0.95
R0843:Vmn2r116	UTSW	17	23400960	missense	probably benign	0.01
R1329:Vmn2r116	UTSW	17	23387188	missense	possibly damaging	0.89
R1396:Vmn2r116	UTSW	17	23386141	missense	probably benign
R1401:Vmn2r116	UTSW	17	23386596	splice site	probably benign
R1574:Vmn2r116	UTSW	17	23387089	missense	probably damaging	0.99
R1574:Vmn2r116	UTSW	17	23387089	missense	probably damaging	0.99
R1766:Vmn2r116	UTSW	17	23401766	missense	probably damaging	0.98
R2157:Vmn2r116	UTSW	17	23401469	missense	probably damaging	1.00
R3622:Vmn2r116	UTSW	17	23386051	missense	probably benign	0.11
R3690:Vmn2r116	UTSW	17	23384824	missense	unknown
R4298:Vmn2r116	UTSW	17	23401827	missense	possibly damaging	0.69
R4373:Vmn2r116	UTSW	17	23401421	missense	probably benign	0.01
R4860:Vmn2r116	UTSW	17	23401803	missense	probably benign
R4941:Vmn2r116	UTSW	17	23401142	missense	probably damaging	1.00
R5119:Vmn2r116	UTSW	17	23387164	missense	probably benign	0.01
R5503:Vmn2r116	UTSW	17	23386804	missense	probably benign	0.07
R5510:Vmn2r116	UTSW	17	23386121	missense	probably damaging	1.00
R5538:Vmn2r116	UTSW	17	23401067	missense	probably benign	0.00
R5689:Vmn2r116	UTSW	17	23397719	missense	probably benign	0.30
R5765:Vmn2r116	UTSW	17	23401404	missense	probably damaging	0.99
R5794:Vmn2r116	UTSW	17	23385968	missense	probably damaging	0.99
R5807:Vmn2r116	UTSW	17	23387307	missense	probably damaging	1.00
R5837:Vmn2r116	UTSW	17	23387080	missense	probably damaging	1.00
R6262:Vmn2r116	UTSW	17	23387377	missense	probably benign	0.03
R6298:Vmn2r116	UTSW	17	23386762	missense	probably damaging	1.00
R6651:Vmn2r116	UTSW	17	23388831	nonsense	probably null
R6667:Vmn2r116	UTSW	17	23401092	missense	probably damaging	1.00
R7393:Vmn2r116	UTSW	17	23386125	missense	probably benign	0.14
R7571:Vmn2r116	UTSW	17	23384856	splice site	probably null
R7940:Vmn2r116	UTSW	17	23386972	missense	probably damaging	0.99
R8510:Vmn2r116	UTSW	17	23385931	nonsense	probably null
R8950:Vmn2r116	UTSW	17	23401493	missense	probably damaging	1.00
R8956:Vmn2r116	UTSW	17	23386762	missense	probably damaging	1.00
R8977:Vmn2r116	UTSW	17	23386942	missense	possibly damaging	0.56
R9030:Vmn2r116	UTSW	17	23384890	missense	possibly damaging	0.82
R9077:Vmn2r116	UTSW	17	23385982	missense	probably benign	0.14
R9223:Vmn2r116	UTSW	17	23401167	missense	probably damaging	1.00
R9401:Vmn2r116	UTSW	17	23401592	missense	probably damaging	1.00
R9449:Vmn2r116	UTSW	17	23386945	missense	probably benign	0.01
R9746:Vmn2r116	UTSW	17	23401823	missense	probably benign	0.08
R9755:Vmn2r116	UTSW	17	23401091	missense	probably damaging	1.00
R9759:Vmn2r116	UTSW	17	23401386	missense	possibly damaging	0.90
R9800:Vmn2r116	UTSW	17	23401425	missense	probably damaging	0.97
S24628:Vmn2r116	UTSW	17	23387279	missense	possibly damaging	0.55
Z1176:Vmn2r116	UTSW	17	23401428	missense	probably damaging	1.00
Z1177:Vmn2r116	UTSW	17	23388892	missense	probably benign

Posted On

2015-04-16