Incidental Mutation 'IGL02686:Vmn2r116'
ID 303553
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r116
Ensembl Gene ENSMUSG00000090966
Gene Name vomeronasal 2, receptor 116
Synonyms V2Rp5, EG619697
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # IGL02686
Quality Score
Status
Chromosome 17
Chromosomal Location 23603777-23620838 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 23607767 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 445 (N445S)
Ref Sequence ENSEMBL: ENSMUSP00000128106 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164856]
AlphaFold E9Q6I0
Predicted Effect probably damaging
Transcript: ENSMUST00000164856
AA Change: N445S

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000128106
Gene: ENSMUSG00000090966
AA Change: N445S

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 73 469 4.4e-30 PFAM
Pfam:NCD3G 511 564 1.2e-22 PFAM
low complexity region 589 594 N/A INTRINSIC
Pfam:7tm_3 595 832 8.7e-57 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Female mice homozygous for a knock-out allele stimulated with male pheromone (Gm6084) fail to exhibit an increase in lordosis behavior and successful intromission. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam4 C T 12: 81,468,448 (GRCm39) G58S possibly damaging Het
Adcyap1r1 G A 6: 55,458,110 (GRCm39) A304T probably benign Het
Adipoq A G 16: 22,975,865 (GRCm39) T110A possibly damaging Het
Ago2 T C 15: 72,985,591 (GRCm39) Y668C possibly damaging Het
Ampd2 A T 3: 107,983,811 (GRCm39) D575E possibly damaging Het
Anxa5 C T 3: 36,503,504 (GRCm39) E317K probably benign Het
Atf2 A T 2: 73,675,844 (GRCm39) M169K possibly damaging Het
Bicc1 C A 10: 70,779,190 (GRCm39) probably benign Het
Bicra A G 7: 15,721,840 (GRCm39) M559T probably benign Het
Bltp3a T C 17: 28,113,563 (GRCm39) I1245T probably benign Het
Bltp3b A T 10: 89,641,055 (GRCm39) Q742L probably benign Het
Cacna1e G A 1: 154,369,155 (GRCm39) A294V probably damaging Het
Cacna1h G A 17: 25,604,723 (GRCm39) P1197S possibly damaging Het
Cmya5 G A 13: 93,227,505 (GRCm39) Q2528* probably null Het
Csgalnact1 C A 8: 68,854,144 (GRCm39) G219V probably damaging Het
Cts8 T C 13: 61,398,784 (GRCm39) T241A probably benign Het
Cubn T C 2: 13,330,037 (GRCm39) I2615V possibly damaging Het
Cxcl12 A G 6: 117,150,546 (GRCm39) probably benign Het
Fig4 T C 10: 41,140,000 (GRCm39) D307G probably damaging Het
Flt1 T C 5: 147,525,412 (GRCm39) I909V probably damaging Het
Foxk1 T A 5: 142,439,340 (GRCm39) S427T probably damaging Het
Gosr1 G A 11: 76,641,688 (GRCm39) T130M probably benign Het
Grik1 G T 16: 87,806,649 (GRCm39) probably null Het
Hipk1 C T 3: 103,685,333 (GRCm39) S94N possibly damaging Het
Ints7 T C 1: 191,318,704 (GRCm39) L147P probably damaging Het
Nsd3 A G 8: 26,156,086 (GRCm39) D551G probably damaging Het
Or11g25 G A 14: 50,723,426 (GRCm39) M170I probably benign Het
Or5p81 A T 7: 108,267,093 (GRCm39) I157F probably benign Het
Prrc2c T C 1: 162,535,516 (GRCm39) probably benign Het
Ren1 A T 1: 133,286,207 (GRCm39) N250I possibly damaging Het
Ripply2 A C 9: 86,898,009 (GRCm39) probably benign Het
Ryr1 G T 7: 28,768,975 (GRCm39) probably benign Het
Smad3 T A 9: 63,575,064 (GRCm39) K51M probably damaging Het
Snapc1 C A 12: 74,011,370 (GRCm39) probably benign Het
Srfbp1 T G 18: 52,608,726 (GRCm39) V42G probably damaging Het
Srrm1 G A 4: 135,052,415 (GRCm39) P658L unknown Het
Tab1 T C 15: 80,033,031 (GRCm39) V105A probably benign Het
Tat T C 8: 110,723,481 (GRCm39) V323A probably damaging Het
Tdo2 T C 3: 81,875,462 (GRCm39) N164S probably benign Het
Tefm T A 11: 80,027,722 (GRCm39) L345F probably damaging Het
Tmem145 C A 7: 25,014,150 (GRCm39) N407K probably damaging Het
Vmn2r20 A G 6: 123,362,585 (GRCm39) M733T probably benign Het
Vmn2r93 G A 17: 18,533,526 (GRCm39) V477M possibly damaging Het
Zdhhc4 A G 5: 143,306,146 (GRCm39) F194S probably damaging Het
Zfp738 A T 13: 67,821,771 (GRCm39) S25T probably damaging Het
Other mutations in Vmn2r116
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00898:Vmn2r116 APN 17 23,604,969 (GRCm39) missense possibly damaging 0.94
IGL00985:Vmn2r116 APN 17 23,620,489 (GRCm39) missense probably damaging 1.00
IGL00990:Vmn2r116 APN 17 23,606,210 (GRCm39) missense probably benign 0.12
IGL00990:Vmn2r116 APN 17 23,616,701 (GRCm39) missense probably damaging 1.00
IGL01383:Vmn2r116 APN 17 23,620,575 (GRCm39) missense probably damaging 1.00
IGL01459:Vmn2r116 APN 17 23,603,903 (GRCm39) missense probably damaging 1.00
IGL01725:Vmn2r116 APN 17 23,605,619 (GRCm39) missense probably damaging 1.00
IGL02125:Vmn2r116 APN 17 23,616,601 (GRCm39) splice site probably benign
IGL02170:Vmn2r116 APN 17 23,603,907 (GRCm39) missense probably benign
IGL02209:Vmn2r116 APN 17 23,607,761 (GRCm39) missense probably damaging 1.00
IGL02226:Vmn2r116 APN 17 23,603,808 (GRCm39) missense probably null
IGL02272:Vmn2r116 APN 17 23,604,978 (GRCm39) missense probably damaging 1.00
IGL02272:Vmn2r116 APN 17 23,604,973 (GRCm39) missense probably benign 0.06
IGL02403:Vmn2r116 APN 17 23,606,338 (GRCm39) missense probably damaging 1.00
IGL02750:Vmn2r116 APN 17 23,616,608 (GRCm39) splice site probably benign
IGL02977:Vmn2r116 APN 17 23,607,748 (GRCm39) missense possibly damaging 0.90
PIT4449001:Vmn2r116 UTSW 17 23,607,921 (GRCm39) missense probably benign 0.41
R0015:Vmn2r116 UTSW 17 23,620,823 (GRCm39) missense probably benign 0.03
R0219:Vmn2r116 UTSW 17 23,605,072 (GRCm39) nonsense probably null
R0281:Vmn2r116 UTSW 17 23,620,387 (GRCm39) missense possibly damaging 0.90
R0415:Vmn2r116 UTSW 17 23,606,253 (GRCm39) missense possibly damaging 0.55
R0592:Vmn2r116 UTSW 17 23,605,889 (GRCm39) missense probably damaging 0.99
R0610:Vmn2r116 UTSW 17 23,606,286 (GRCm39) missense probably damaging 1.00
R0635:Vmn2r116 UTSW 17 23,605,861 (GRCm39) missense possibly damaging 0.95
R0843:Vmn2r116 UTSW 17 23,619,934 (GRCm39) missense probably benign 0.01
R1329:Vmn2r116 UTSW 17 23,606,162 (GRCm39) missense possibly damaging 0.89
R1396:Vmn2r116 UTSW 17 23,605,115 (GRCm39) missense probably benign
R1401:Vmn2r116 UTSW 17 23,605,570 (GRCm39) splice site probably benign
R1574:Vmn2r116 UTSW 17 23,606,063 (GRCm39) missense probably damaging 0.99
R1574:Vmn2r116 UTSW 17 23,606,063 (GRCm39) missense probably damaging 0.99
R1766:Vmn2r116 UTSW 17 23,620,740 (GRCm39) missense probably damaging 0.98
R2157:Vmn2r116 UTSW 17 23,620,443 (GRCm39) missense probably damaging 1.00
R3622:Vmn2r116 UTSW 17 23,605,025 (GRCm39) missense probably benign 0.11
R3690:Vmn2r116 UTSW 17 23,603,798 (GRCm39) missense unknown
R4298:Vmn2r116 UTSW 17 23,620,801 (GRCm39) missense possibly damaging 0.69
R4373:Vmn2r116 UTSW 17 23,620,395 (GRCm39) missense probably benign 0.01
R4860:Vmn2r116 UTSW 17 23,620,777 (GRCm39) missense probably benign
R4941:Vmn2r116 UTSW 17 23,620,116 (GRCm39) missense probably damaging 1.00
R5119:Vmn2r116 UTSW 17 23,606,138 (GRCm39) missense probably benign 0.01
R5503:Vmn2r116 UTSW 17 23,605,778 (GRCm39) missense probably benign 0.07
R5510:Vmn2r116 UTSW 17 23,605,095 (GRCm39) missense probably damaging 1.00
R5538:Vmn2r116 UTSW 17 23,620,041 (GRCm39) missense probably benign 0.00
R5689:Vmn2r116 UTSW 17 23,616,693 (GRCm39) missense probably benign 0.30
R5765:Vmn2r116 UTSW 17 23,620,378 (GRCm39) missense probably damaging 0.99
R5794:Vmn2r116 UTSW 17 23,604,942 (GRCm39) missense probably damaging 0.99
R5807:Vmn2r116 UTSW 17 23,606,281 (GRCm39) missense probably damaging 1.00
R5837:Vmn2r116 UTSW 17 23,606,054 (GRCm39) missense probably damaging 1.00
R6262:Vmn2r116 UTSW 17 23,606,351 (GRCm39) missense probably benign 0.03
R6298:Vmn2r116 UTSW 17 23,605,736 (GRCm39) missense probably damaging 1.00
R6651:Vmn2r116 UTSW 17 23,607,805 (GRCm39) nonsense probably null
R6667:Vmn2r116 UTSW 17 23,620,066 (GRCm39) missense probably damaging 1.00
R7393:Vmn2r116 UTSW 17 23,605,099 (GRCm39) missense probably benign 0.14
R7571:Vmn2r116 UTSW 17 23,603,830 (GRCm39) splice site probably null
R7940:Vmn2r116 UTSW 17 23,605,946 (GRCm39) missense probably damaging 0.99
R8510:Vmn2r116 UTSW 17 23,604,905 (GRCm39) nonsense probably null
R8950:Vmn2r116 UTSW 17 23,620,467 (GRCm39) missense probably damaging 1.00
R8956:Vmn2r116 UTSW 17 23,605,736 (GRCm39) missense probably damaging 1.00
R8977:Vmn2r116 UTSW 17 23,605,916 (GRCm39) missense possibly damaging 0.56
R9030:Vmn2r116 UTSW 17 23,603,864 (GRCm39) missense possibly damaging 0.82
R9077:Vmn2r116 UTSW 17 23,604,956 (GRCm39) missense probably benign 0.14
R9223:Vmn2r116 UTSW 17 23,620,141 (GRCm39) missense probably damaging 1.00
R9401:Vmn2r116 UTSW 17 23,620,566 (GRCm39) missense probably damaging 1.00
R9449:Vmn2r116 UTSW 17 23,605,919 (GRCm39) missense probably benign 0.01
R9746:Vmn2r116 UTSW 17 23,620,797 (GRCm39) missense probably benign 0.08
R9755:Vmn2r116 UTSW 17 23,620,065 (GRCm39) missense probably damaging 1.00
R9759:Vmn2r116 UTSW 17 23,620,360 (GRCm39) missense possibly damaging 0.90
R9800:Vmn2r116 UTSW 17 23,620,399 (GRCm39) missense probably damaging 0.97
S24628:Vmn2r116 UTSW 17 23,606,253 (GRCm39) missense possibly damaging 0.55
Z1176:Vmn2r116 UTSW 17 23,620,402 (GRCm39) missense probably damaging 1.00
Z1177:Vmn2r116 UTSW 17 23,607,866 (GRCm39) missense probably benign
Posted On 2015-04-16