Incidental Mutation 'IGL02687:Vmn1r199'
ID303598
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r199
Ensembl Gene ENSMUSG00000069292
Gene Namevomeronasal 1 receptor 199
SynonymsV1rh4
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.093) question?
Stock #IGL02687
Quality Score
Status
Chromosome13
Chromosomal Location22379818-22388102 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 22382791 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 85 (V85A)
Ref Sequence ENSEMBL: ENSMUSP00000153918 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091732] [ENSMUST00000227685] [ENSMUST00000227689] [ENSMUST00000227846]
Predicted Effect possibly damaging
Transcript: ENSMUST00000091732
AA Change: V85A

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000089326
Gene: ENSMUSG00000069292
AA Change: V85A

DomainStartEndE-ValueType
low complexity region 26 37 N/A INTRINSIC
Pfam:TAS2R 43 338 3.3e-7 PFAM
Pfam:V1R 75 340 1.6e-33 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000120663
Predicted Effect possibly damaging
Transcript: ENSMUST00000227685
AA Change: V85A

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000227689
AA Change: V42A

PolyPhen 2 Score 0.886 (Sensitivity: 0.82; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000227846
AA Change: V42A

PolyPhen 2 Score 0.886 (Sensitivity: 0.82; Specificity: 0.94)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 A G 11: 110,114,232 V1315A probably damaging Het
Adam2 A T 14: 66,069,190 C117S probably damaging Het
Arpp21 T A 9: 112,065,815 R792* probably null Het
Atp13a3 A G 16: 30,337,551 M938T probably damaging Het
Atp6v0a2 C T 5: 124,714,142 T545M possibly damaging Het
BC051019 T C 7: 109,716,352 D84G possibly damaging Het
Bdkrb1 T A 12: 105,604,832 L219H probably damaging Het
Cdc45 C T 16: 18,798,729 M200I probably benign Het
Cfap46 T C 7: 139,607,201 D2415G probably damaging Het
Csgalnact2 T C 6: 118,124,415 probably null Het
Cyp4a29 T C 4: 115,251,200 C374R probably damaging Het
Dgkb C A 12: 38,630,629 P776Q possibly damaging Het
Duox1 A T 2: 122,336,415 K1005M probably damaging Het
Dusp6 C A 10: 99,266,182 F343L probably damaging Het
Espl1 C T 15: 102,313,178 probably benign Het
Filip1l T C 16: 57,571,127 S455P probably benign Het
Gm7995 A G 14: 42,311,405 I81V probably damaging Het
Lingo4 T C 3: 94,402,097 L114P probably damaging Het
Mfsd6 A G 1: 52,708,675 S344P probably damaging Het
Mpc1 G A 17: 8,297,143 S162N probably benign Het
Myh11 T A 16: 14,212,618 K1143* probably null Het
Nek10 T C 14: 14,840,570 L152P probably damaging Het
Olfr598 C T 7: 103,329,400 R305* probably null Het
Olfr815 T C 10: 129,902,102 M203V probably benign Het
Olfr995 T A 2: 85,438,586 N191Y possibly damaging Het
Rab11a A G 9: 64,726,698 I119T probably damaging Het
Spata31d1d T A 13: 59,727,864 H619L possibly damaging Het
Ulk4 A T 9: 121,192,662 V661E possibly damaging Het
Other mutations in Vmn1r199
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00930:Vmn1r199 APN 13 22382859 missense possibly damaging 0.64
IGL01959:Vmn1r199 APN 13 22383120 missense probably benign 0.07
IGL02270:Vmn1r199 APN 13 22383006 missense probably damaging 1.00
IGL03143:Vmn1r199 APN 13 22383129 missense probably damaging 1.00
R0528:Vmn1r199 UTSW 13 22382566 missense probably benign
R1411:Vmn1r199 UTSW 13 22383501 missense probably benign 0.01
R2075:Vmn1r199 UTSW 13 22383265 missense probably damaging 1.00
R5057:Vmn1r199 UTSW 13 22383405 missense possibly damaging 0.93
R5824:Vmn1r199 UTSW 13 22383578 missense probably benign
R5977:Vmn1r199 UTSW 13 22383246 missense probably benign 0.08
R6019:Vmn1r199 UTSW 13 22382599 missense possibly damaging 0.85
R6419:Vmn1r199 UTSW 13 22383607 missense possibly damaging 0.66
R7624:Vmn1r199 UTSW 13 22382736 missense probably benign 0.00
R7637:Vmn1r199 UTSW 13 22382675 missense probably benign 0.05
Posted On2015-04-16