Incidental Mutation 'IGL02687:Vmn1r199'
| ID |
303598 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r199
|
| Ensembl Gene |
ENSMUSG00000069292 |
| Gene Name |
vomeronasal 1 receptor 199 |
| Synonyms |
V1rh4 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.063)
|
| Stock # |
IGL02687
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
13 |
| Chromosomal Location |
22566708-22567811 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 22566961 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 85
(V85A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153918
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000091732]
[ENSMUST00000227685]
[ENSMUST00000227689]
[ENSMUST00000227846]
|
| AlphaFold |
Q8R280 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000091732
AA Change: V85A
PolyPhen 2
Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000089326
Gene: ENSMUSG00000069292
AA Change: V85A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
26 |
37 |
N/A |
INTRINSIC |
|
Pfam:TAS2R
|
43 |
338 |
3.3e-7 |
PFAM |
|
Pfam:V1R
|
75 |
340 |
1.6e-33 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000120663
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000227685
AA Change: V85A
PolyPhen 2
Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000227689
AA Change: V42A
PolyPhen 2
Score 0.886 (Sensitivity: 0.82; Specificity: 0.94)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000227846
AA Change: V42A
PolyPhen 2
Score 0.886 (Sensitivity: 0.82; Specificity: 0.94)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 28 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca9 |
A |
G |
11: 110,005,058 (GRCm39) |
V1315A |
probably damaging |
Het |
| Adam2 |
A |
T |
14: 66,306,639 (GRCm39) |
C117S |
probably damaging |
Het |
| Arpp21 |
T |
A |
9: 111,894,883 (GRCm39) |
R792* |
probably null |
Het |
| Atp13a3 |
A |
G |
16: 30,156,369 (GRCm39) |
M938T |
probably damaging |
Het |
| Atp6v0a2 |
C |
T |
5: 124,791,206 (GRCm39) |
T545M |
possibly damaging |
Het |
| BC051019 |
T |
C |
7: 109,315,559 (GRCm39) |
D84G |
possibly damaging |
Het |
| Bdkrb1 |
T |
A |
12: 105,571,091 (GRCm39) |
L219H |
probably damaging |
Het |
| Cdc45 |
C |
T |
16: 18,617,479 (GRCm39) |
M200I |
probably benign |
Het |
| Cfap46 |
T |
C |
7: 139,187,117 (GRCm39) |
D2415G |
probably damaging |
Het |
| Csgalnact2 |
T |
C |
6: 118,101,376 (GRCm39) |
|
probably null |
Het |
| Cyp4a29 |
T |
C |
4: 115,108,397 (GRCm39) |
C374R |
probably damaging |
Het |
| Dgkb |
C |
A |
12: 38,680,628 (GRCm39) |
P776Q |
possibly damaging |
Het |
| Duox1 |
A |
T |
2: 122,166,896 (GRCm39) |
K1005M |
probably damaging |
Het |
| Dusp6 |
C |
A |
10: 99,102,044 (GRCm39) |
F343L |
probably damaging |
Het |
| Espl1 |
C |
T |
15: 102,221,613 (GRCm39) |
|
probably benign |
Het |
| Filip1l |
T |
C |
16: 57,391,490 (GRCm39) |
S455P |
probably benign |
Het |
| Gm7995 |
A |
G |
14: 42,133,362 (GRCm39) |
I81V |
probably damaging |
Het |
| Lingo4 |
T |
C |
3: 94,309,404 (GRCm39) |
L114P |
probably damaging |
Het |
| Mfsd6 |
A |
G |
1: 52,747,834 (GRCm39) |
S344P |
probably damaging |
Het |
| Mpc1 |
G |
A |
17: 8,515,975 (GRCm39) |
S162N |
probably benign |
Het |
| Myh11 |
T |
A |
16: 14,030,482 (GRCm39) |
K1143* |
probably null |
Het |
| Nek10 |
T |
C |
14: 14,840,570 (GRCm38) |
L152P |
probably damaging |
Het |
| Or52ab7 |
C |
T |
7: 102,978,607 (GRCm39) |
R305* |
probably null |
Het |
| Or5ak25 |
T |
A |
2: 85,268,930 (GRCm39) |
N191Y |
possibly damaging |
Het |
| Or6c217 |
T |
C |
10: 129,737,971 (GRCm39) |
M203V |
probably benign |
Het |
| Rab11a |
A |
G |
9: 64,633,980 (GRCm39) |
I119T |
probably damaging |
Het |
| Spata31d1d |
T |
A |
13: 59,875,678 (GRCm39) |
H619L |
possibly damaging |
Het |
| Ulk4 |
A |
T |
9: 121,021,728 (GRCm39) |
V661E |
possibly damaging |
Het |
|
| Other mutations in Vmn1r199 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00930:Vmn1r199
|
APN |
13 |
22,567,029 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL01959:Vmn1r199
|
APN |
13 |
22,567,290 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02270:Vmn1r199
|
APN |
13 |
22,567,176 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03143:Vmn1r199
|
APN |
13 |
22,567,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0528:Vmn1r199
|
UTSW |
13 |
22,566,736 (GRCm39) |
missense |
probably benign |
|
|
R1411:Vmn1r199
|
UTSW |
13 |
22,567,671 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2075:Vmn1r199
|
UTSW |
13 |
22,567,435 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5057:Vmn1r199
|
UTSW |
13 |
22,567,575 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5824:Vmn1r199
|
UTSW |
13 |
22,567,748 (GRCm39) |
missense |
probably benign |
|
|
R5977:Vmn1r199
|
UTSW |
13 |
22,567,416 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6019:Vmn1r199
|
UTSW |
13 |
22,566,769 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R6419:Vmn1r199
|
UTSW |
13 |
22,567,777 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R7624:Vmn1r199
|
UTSW |
13 |
22,566,906 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7637:Vmn1r199
|
UTSW |
13 |
22,566,845 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8505:Vmn1r199
|
UTSW |
13 |
22,567,317 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8692:Vmn1r199
|
UTSW |
13 |
22,567,809 (GRCm39) |
makesense |
probably null |
|
|
R8735:Vmn1r199
|
UTSW |
13 |
22,567,537 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8791:Vmn1r199
|
UTSW |
13 |
22,567,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9054:Vmn1r199
|
UTSW |
13 |
22,567,724 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9258:Vmn1r199
|
UTSW |
13 |
22,566,822 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9586:Vmn1r199
|
UTSW |
13 |
22,567,716 (GRCm39) |
missense |
probably benign |
|
|
| Posted On |
2015-04-16 |
Incidental Mutation