Incidental Mutation 'IGL02687:Cyp4a29'
| ID |
303612 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Cyp4a29
|
| Ensembl Gene |
ENSMUSG00000083138 |
| Gene Name |
cytochrome P450, family 4, subfamily a, polypeptide 29 |
| Synonyms |
Cyp4a29-ps |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.062)
|
| Stock # |
IGL02687
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
4 |
| Chromosomal Location |
115099281-115111754 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 115108397 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Arginine
at position 374
(C374R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000139717
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000118278]
|
| AlphaFold |
A0A087WPC3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000118278
AA Change: C374R
PolyPhen 2
Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000139717
Gene: ENSMUSG00000083138
AA Change: C374R
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
9 |
31 |
N/A |
INTRINSIC |
|
Pfam:p450
|
51 |
504 |
1.1e-127 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 28 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca9 |
A |
G |
11: 110,005,058 (GRCm39) |
V1315A |
probably damaging |
Het |
| Adam2 |
A |
T |
14: 66,306,639 (GRCm39) |
C117S |
probably damaging |
Het |
| Arpp21 |
T |
A |
9: 111,894,883 (GRCm39) |
R792* |
probably null |
Het |
| Atp13a3 |
A |
G |
16: 30,156,369 (GRCm39) |
M938T |
probably damaging |
Het |
| Atp6v0a2 |
C |
T |
5: 124,791,206 (GRCm39) |
T545M |
possibly damaging |
Het |
| BC051019 |
T |
C |
7: 109,315,559 (GRCm39) |
D84G |
possibly damaging |
Het |
| Bdkrb1 |
T |
A |
12: 105,571,091 (GRCm39) |
L219H |
probably damaging |
Het |
| Cdc45 |
C |
T |
16: 18,617,479 (GRCm39) |
M200I |
probably benign |
Het |
| Cfap46 |
T |
C |
7: 139,187,117 (GRCm39) |
D2415G |
probably damaging |
Het |
| Csgalnact2 |
T |
C |
6: 118,101,376 (GRCm39) |
|
probably null |
Het |
| Dgkb |
C |
A |
12: 38,680,628 (GRCm39) |
P776Q |
possibly damaging |
Het |
| Duox1 |
A |
T |
2: 122,166,896 (GRCm39) |
K1005M |
probably damaging |
Het |
| Dusp6 |
C |
A |
10: 99,102,044 (GRCm39) |
F343L |
probably damaging |
Het |
| Espl1 |
C |
T |
15: 102,221,613 (GRCm39) |
|
probably benign |
Het |
| Filip1l |
T |
C |
16: 57,391,490 (GRCm39) |
S455P |
probably benign |
Het |
| Gm7995 |
A |
G |
14: 42,133,362 (GRCm39) |
I81V |
probably damaging |
Het |
| Lingo4 |
T |
C |
3: 94,309,404 (GRCm39) |
L114P |
probably damaging |
Het |
| Mfsd6 |
A |
G |
1: 52,747,834 (GRCm39) |
S344P |
probably damaging |
Het |
| Mpc1 |
G |
A |
17: 8,515,975 (GRCm39) |
S162N |
probably benign |
Het |
| Myh11 |
T |
A |
16: 14,030,482 (GRCm39) |
K1143* |
probably null |
Het |
| Nek10 |
T |
C |
14: 14,840,570 (GRCm38) |
L152P |
probably damaging |
Het |
| Or52ab7 |
C |
T |
7: 102,978,607 (GRCm39) |
R305* |
probably null |
Het |
| Or5ak25 |
T |
A |
2: 85,268,930 (GRCm39) |
N191Y |
possibly damaging |
Het |
| Or6c217 |
T |
C |
10: 129,737,971 (GRCm39) |
M203V |
probably benign |
Het |
| Rab11a |
A |
G |
9: 64,633,980 (GRCm39) |
I119T |
probably damaging |
Het |
| Spata31d1d |
T |
A |
13: 59,875,678 (GRCm39) |
H619L |
possibly damaging |
Het |
| Ulk4 |
A |
T |
9: 121,021,728 (GRCm39) |
V661E |
possibly damaging |
Het |
| Vmn1r199 |
T |
C |
13: 22,566,961 (GRCm39) |
V85A |
possibly damaging |
Het |
|
| Other mutations in Cyp4a29 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL03224:Cyp4a29
|
APN |
4 |
115,104,247 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03271:Cyp4a29
|
APN |
4 |
115,111,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03387:Cyp4a29
|
APN |
4 |
115,108,368 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R0304:Cyp4a29
|
UTSW |
4 |
115,110,129 (GRCm39) |
splice site |
probably benign |
|
|
R2656:Cyp4a29
|
UTSW |
4 |
115,106,921 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4012:Cyp4a29
|
UTSW |
4 |
115,105,707 (GRCm39) |
missense |
probably benign |
|
|
R4834:Cyp4a29
|
UTSW |
4 |
115,106,867 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4856:Cyp4a29
|
UTSW |
4 |
115,110,078 (GRCm39) |
missense |
probably benign |
|
|
R4886:Cyp4a29
|
UTSW |
4 |
115,110,078 (GRCm39) |
missense |
probably benign |
|
|
R4939:Cyp4a29
|
UTSW |
4 |
115,104,873 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4967:Cyp4a29
|
UTSW |
4 |
115,104,196 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5071:Cyp4a29
|
UTSW |
4 |
115,104,860 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5072:Cyp4a29
|
UTSW |
4 |
115,104,860 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5073:Cyp4a29
|
UTSW |
4 |
115,104,860 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5620:Cyp4a29
|
UTSW |
4 |
115,108,088 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5818:Cyp4a29
|
UTSW |
4 |
115,104,229 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6219:Cyp4a29
|
UTSW |
4 |
115,106,927 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6318:Cyp4a29
|
UTSW |
4 |
115,107,396 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6386:Cyp4a29
|
UTSW |
4 |
115,104,272 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6456:Cyp4a29
|
UTSW |
4 |
115,108,381 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7393:Cyp4a29
|
UTSW |
4 |
115,099,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7443:Cyp4a29
|
UTSW |
4 |
115,105,756 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7719:Cyp4a29
|
UTSW |
4 |
115,108,137 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7831:Cyp4a29
|
UTSW |
4 |
115,107,367 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7983:Cyp4a29
|
UTSW |
4 |
115,108,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8304:Cyp4a29
|
UTSW |
4 |
115,111,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8674:Cyp4a29
|
UTSW |
4 |
115,106,882 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9109:Cyp4a29
|
UTSW |
4 |
115,108,395 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9298:Cyp4a29
|
UTSW |
4 |
115,108,395 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9486:Cyp4a29
|
UTSW |
4 |
115,106,916 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9601:Cyp4a29
|
UTSW |
4 |
115,105,772 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9667:Cyp4a29
|
UTSW |
4 |
115,111,630 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9790:Cyp4a29
|
UTSW |
4 |
115,108,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9791:Cyp4a29
|
UTSW |
4 |
115,108,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
U24488:Cyp4a29
|
UTSW |
4 |
115,108,204 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
Z1088:Cyp4a29
|
UTSW |
4 |
115,105,693 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation