Incidental Mutation 'IGL02690:Scly'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Scly
Ensembl Gene ENSMUSG00000026307
Gene Nameselenocysteine lyase
SynonymsSCL, Scly2, A930015N15Rik, Selenocysteine reductase, Scly1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.087) question?
Stock #IGL02690
Quality Score
Chromosomal Location91298338-91321075 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 91305325 bp
Amino Acid Change Threonine to Serine at position 109 (T109S)
Ref Sequence ENSEMBL: ENSMUSP00000114759 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027532] [ENSMUST00000137074] [ENSMUST00000142488] [ENSMUST00000145843] [ENSMUST00000147523] [ENSMUST00000154045]
Predicted Effect probably benign
Transcript: ENSMUST00000027532
AA Change: T107S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000027532
Gene: ENSMUSG00000026307
AA Change: T107S

Pfam:Aminotran_5 20 417 1.7e-58 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123651
Predicted Effect unknown
Transcript: ENSMUST00000124832
AA Change: T104S
SMART Domains Protein: ENSMUSP00000116382
Gene: ENSMUSG00000026307
AA Change: T104S

Pfam:Aminotran_5 18 215 2e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000137074
AA Change: T53S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000122449
Gene: ENSMUSG00000026307
AA Change: T53S

Pfam:Aminotran_5 48 216 7.4e-30 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000142488
AA Change: T129S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000119979
Gene: ENSMUSG00000026307
AA Change: T129S

Pfam:Aminotran_5 42 238 2.2e-32 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142802
Predicted Effect probably benign
Transcript: ENSMUST00000145843
SMART Domains Protein: ENSMUSP00000116824
Gene: ENSMUSG00000026307

Pfam:Aminotran_5 1 68 1.5e-15 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000147523
AA Change: T109S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000114759
Gene: ENSMUSG00000026307
AA Change: T109S

Pfam:Aminotran_5 22 249 2.5e-42 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153621
Predicted Effect probably benign
Transcript: ENSMUST00000154045
SMART Domains Protein: ENSMUSP00000137796
Gene: ENSMUSG00000026307

PDB:3A9Z|B 1 57 5e-30 PDB
SCOP:d1eg5a_ 20 57 3e-10 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000171768
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181737
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Selenocysteine lyase (SCLY; EC catalyzes the pyridoxal 5-prime phosphate-dependent conversion of L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000 [PubMed 10692412]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice fed a selenium-deficient diet exhibit mild learning impairment. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgre1 T C 17: 57,480,921 V896A probably damaging Het
Ahnak C A 19: 9,012,584 S3744* probably null Het
Aldh7a1 A G 18: 56,528,355 probably benign Het
Ankk1 T A 9: 49,421,900 I95F probably damaging Het
Borcs8 C A 8: 70,165,088 A32D probably damaging Het
Cdh1 T A 8: 106,657,884 I328N probably damaging Het
Cebpz C T 17: 78,922,557 D856N probably damaging Het
Clip2 T A 5: 134,510,159 probably benign Het
Dock7 C A 4: 98,969,635 V1451F possibly damaging Het
Edem3 T G 1: 151,804,799 C558W probably damaging Het
Eif3f T C 7: 108,934,718 V96A probably damaging Het
Gen1 A G 12: 11,241,575 S738P probably damaging Het
Gm12666 T A 4: 92,191,011 D191V probably damaging Het
Gm8906 C T 5: 11,505,261 Q66* probably null Het
Ipo8 A T 6: 148,777,363 S912R probably benign Het
Kcp G T 6: 29,484,999 probably benign Het
Lrrfip1 A G 1: 91,053,661 T2A probably damaging Het
Lyst A G 13: 13,641,125 E1198G possibly damaging Het
Maml1 A G 11: 50,258,630 L761P probably damaging Het
Mon2 T A 10: 123,009,627 E1392V possibly damaging Het
Nol12 A G 15: 78,937,174 E78G probably damaging Het
Nov A G 15: 54,747,802 Y111C probably damaging Het
Olfr156 G A 4: 43,821,190 T57M possibly damaging Het
Olfr181 G A 16: 58,925,851 T240I possibly damaging Het
Papd7 T A 13: 69,510,625 M364L probably benign Het
Rag2 A T 2: 101,629,494 I50L probably benign Het
Rasgrf2 T C 13: 92,030,765 N267D probably damaging Het
Rnf123 G A 9: 108,068,302 R390* probably null Het
Rsc1a1 A T 4: 141,685,301 V100D probably damaging Het
Rtp1 T C 16: 23,431,382 Y166H probably damaging Het
Scn8a A T 15: 100,970,254 S327C probably damaging Het
Sgsm1 T C 5: 113,286,767 probably benign Het
Slc4a9 A G 18: 36,531,987 Y463C probably damaging Het
Sptan1 A G 2: 29,998,183 M936V possibly damaging Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Tbx20 T A 9: 24,773,737 N37Y probably benign Het
Tex14 C T 11: 87,486,274 T148I probably benign Het
Ubxn7 A G 16: 32,381,605 E371G probably benign Het
Ugt2b35 T C 5: 87,001,237 F116L probably benign Het
Vmn2r111 C T 17: 22,559,042 probably null Het
Vmn2r26 T C 6: 124,026,132 L167P probably benign Het
Vps13b T C 15: 35,917,142 W3711R probably damaging Het
Wdr5 A T 2: 27,534,828 T326S probably benign Het
Other mutations in Scly
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02314:Scly APN 1 91319041 missense probably benign 0.00
R0597:Scly UTSW 1 91309833 missense probably damaging 1.00
R1782:Scly UTSW 1 91308380 missense probably damaging 1.00
R1950:Scly UTSW 1 91305394 missense probably benign 0.08
R1978:Scly UTSW 1 91320169 missense probably damaging 0.98
R2290:Scly UTSW 1 91298450 critical splice donor site probably null
R3861:Scly UTSW 1 91302851 utr 3 prime probably benign
R4508:Scly UTSW 1 91308325 missense possibly damaging 0.95
R4876:Scly UTSW 1 91320128 missense probably damaging 0.98
R7035:Scly UTSW 1 91308403 missense probably damaging 0.98
R7701:Scly UTSW 1 91308308 missense
R7887:Scly UTSW 1 91300641 critical splice donor site probably null
R8079:Scly UTSW 1 91308367 missense probably damaging 0.99
R8501:Scly UTSW 1 91319076 missense probably damaging 1.00
X0021:Scly UTSW 1 91320106 missense probably damaging 0.98
Z1176:Scly UTSW 1 91305313 missense probably benign 0.00
Posted On2015-04-16