Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02691:Vipr2'

303726

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vipr2

Ensembl Gene

ENSMUSG00000011171

Gene Name

vasoactive intestinal peptide receptor 2

Synonyms

VPAC2R, VPAC2, VIP receptor subtype 2, Vip2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.067) question?

Stock #

IGL02691

Quality Score

Status

Chromosome

Chromosomal Location

116041346-116109881 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 116099849 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Serine at position 239 (C239S)

Ref Sequence

ENSEMBL: ENSMUSP00000011315 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000011315]

AlphaFold

P41588

Predicted Effect

probably benign
Transcript: ENSMUST00000011315
AA Change: C239S

PolyPhen 2 Score 0.108 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000011315
Gene: ENSMUSG00000011171
AA Change: C239S

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
HormR	47	117	8.35e-25	SMART
Pfam:7tm_2	122	370	1.5e-81	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000175871

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000176078

Predicted Effect

probably benign
Transcript: ENSMUST00000176433

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000177059

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000177199

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [provided by RefSeq, Aug 2011]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit enhanced delayed-type hypersensitivity (type IV) and reduced immediate-type hypersensitivity (type I). [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A3galt2	T	C	4: 128,655,457 (GRCm39)	S40P	probably benign	Het
Actl9	G	T	17: 33,652,092 (GRCm39)	V51L	probably damaging	Het
Adcy6	A	T	15: 98,502,185 (GRCm39)	F143Y	probably damaging	Het
Agps	A	T	2: 75,722,204 (GRCm39)	I465F	probably benign	Het
Armc3	T	A	2: 19,240,295 (GRCm39)	F17L	probably damaging	Het
Arsk	A	C	13: 76,223,069 (GRCm39)	M176R	probably damaging	Het
Asz1	G	A	6: 18,076,556 (GRCm39)	T212I	probably damaging	Het
Atp6v1a	A	G	16: 43,931,982 (GRCm39)	I102T	probably damaging	Het
Bpifb6	T	A	2: 153,744,565 (GRCm39)	L2Q	unknown	Het
Cad	A	G	5: 31,212,638 (GRCm39)	Y45C	probably damaging	Het
Ccdc93	A	G	1: 121,414,342 (GRCm39)	D451G	possibly damaging	Het
Cenpj	A	G	14: 56,789,547 (GRCm39)	I834T	probably benign	Het
Cyp2j12	C	T	4: 96,021,231 (GRCm39)		probably null	Het
Dhx8	G	A	11: 101,642,830 (GRCm39)		probably benign	Het
Dync1i1	A	G	6: 5,800,767 (GRCm39)		probably benign	Het
Ell2	T	A	13: 75,904,605 (GRCm39)	D99E	probably damaging	Het
Enpp1	G	T	10: 24,587,790 (GRCm39)	P34T	probably damaging	Het
Fras1	T	A	5: 96,892,564 (GRCm39)	V2888E	possibly damaging	Het
Gmfg	A	G	7: 28,144,295 (GRCm39)	Y40C	probably damaging	Het
Gnal	T	C	18: 67,355,746 (GRCm39)	I369T	probably damaging	Het
Gzmn	T	C	14: 56,404,370 (GRCm39)	T156A	probably benign	Het
H2-DMb2	A	T	17: 34,366,832 (GRCm39)	H88L	probably benign	Het
Ighv7-3	T	C	12: 114,117,016 (GRCm39)	T49A	probably benign	Het
Jakmip3	C	T	7: 138,628,573 (GRCm39)	Q450*	probably null	Het
Klhl20	A	T	1: 160,934,444 (GRCm39)		probably benign	Het
Klk6	A	G	7: 43,477,924 (GRCm39)	T99A	probably benign	Het
Lhx3	A	G	2: 26,093,097 (GRCm39)	C118R	probably damaging	Het
Mapkbp1	T	C	2: 119,803,655 (GRCm39)		probably benign	Het
Naa15	A	G	3: 51,358,747 (GRCm39)	E294G	probably damaging	Het
Nfia	C	T	4: 97,970,045 (GRCm39)	Q373*	probably null	Het
Notch2	C	A	3: 98,042,923 (GRCm39)	Y1429*	probably null	Het
Oc90	A	G	15: 65,754,410 (GRCm39)	S252P	probably damaging	Het
Or56a3b	A	G	7: 104,771,338 (GRCm39)	I225V	probably damaging	Het
Or8k37	T	C	2: 86,469,182 (GRCm39)	Y290C	probably damaging	Het
Pde3b	T	A	7: 114,107,320 (GRCm39)		probably benign	Het
Pdss1	G	A	2: 22,805,253 (GRCm39)	V211I	probably benign	Het
Phactr1	G	T	13: 43,231,213 (GRCm39)	M226I	probably benign	Het
Phf11c	A	G	14: 59,622,236 (GRCm39)	S259P	probably damaging	Het
Phf20l1	A	G	15: 66,476,713 (GRCm39)	N269S	probably damaging	Het
Piezo1	A	G	8: 123,228,688 (GRCm39)	V229A	possibly damaging	Het
Plcb2	T	C	2: 118,541,444 (GRCm39)	K997R	probably benign	Het
Ppm1m	A	T	9: 106,072,568 (GRCm39)	V449E	probably damaging	Het
Ppp1r36dn	T	C	12: 76,498,073 (GRCm39)		noncoding transcript	Het
Rbm12	C	T	2: 155,937,480 (GRCm39)		probably benign	Het
Rgs14	A	G	13: 55,526,836 (GRCm39)		probably null	Het
Rnf123	G	A	9: 107,945,501 (GRCm39)	R390*	probably null	Het
Scamp5	G	T	9: 57,358,660 (GRCm39)	R39S	probably damaging	Het
Slc5a6	C	T	5: 31,199,518 (GRCm39)	V15I	probably damaging	Het
Snx25	A	T	8: 46,558,302 (GRCm39)	V235E	possibly damaging	Het
Tdrd1	G	T	19: 56,832,284 (GRCm39)	E400D	probably damaging	Het
Tln1	T	C	4: 43,539,544 (GRCm39)	R1593G	probably benign	Het
Trdv2-2	T	C	14: 54,199,039 (GRCm39)	F110L	possibly damaging	Het
Ush2a	A	C	1: 188,466,949 (GRCm39)	Y2871S	probably damaging	Het
Vars2	A	C	17: 35,971,140 (GRCm39)	L592R	probably damaging	Het
Vmn1r200	A	T	13: 22,579,428 (GRCm39)	D68V	probably damaging	Het
Vmn1r7	A	T	6: 57,001,373 (GRCm39)	S296T	probably benign	Het
Vmn2r95	T	C	17: 18,672,120 (GRCm39)	I619T	probably benign	Het

Other mutations in Vipr2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00691:Vipr2	APN	12	116,102,368 (GRCm39)	splice site	probably null
IGL02233:Vipr2	APN	12	116,058,356 (GRCm39)	missense	probably damaging	0.99
PIT4377001:Vipr2	UTSW	12	116,058,418 (GRCm39)	missense	probably benign	0.01
R0135:Vipr2	UTSW	12	116,106,447 (GRCm39)	missense	probably benign	0.00
R0207:Vipr2	UTSW	12	116,106,502 (GRCm39)	missense	probably damaging	1.00
R1389:Vipr2	UTSW	12	116,100,950 (GRCm39)	missense	probably benign	0.01
R1560:Vipr2	UTSW	12	116,058,401 (GRCm39)	missense	probably benign	0.18
R1575:Vipr2	UTSW	12	116,107,892 (GRCm39)	missense	probably benign
R1696:Vipr2	UTSW	12	116,102,777 (GRCm39)	missense	probably benign	0.13
R1970:Vipr2	UTSW	12	116,099,826 (GRCm39)	missense	probably benign	0.01
R2010:Vipr2	UTSW	12	116,086,430 (GRCm39)	critical splice donor site	probably null
R3873:Vipr2	UTSW	12	116,099,724 (GRCm39)	unclassified	probably benign
R4713:Vipr2	UTSW	12	116,043,751 (GRCm39)	missense	probably benign	0.00
R4953:Vipr2	UTSW	12	116,107,876 (GRCm39)	missense	probably benign	0.07
R6041:Vipr2	UTSW	12	116,106,604 (GRCm39)	missense	probably damaging	1.00
R6337:Vipr2	UTSW	12	116,086,363 (GRCm39)	nonsense	probably null
R6902:Vipr2	UTSW	12	116,102,819 (GRCm39)	missense	possibly damaging	0.46
R6946:Vipr2	UTSW	12	116,102,819 (GRCm39)	missense	possibly damaging	0.46
R7763:Vipr2	UTSW	12	116,086,338 (GRCm39)	missense	probably damaging	1.00
R9339:Vipr2	UTSW	12	116,058,344 (GRCm39)	missense	probably damaging	0.96
R9523:Vipr2	UTSW	12	116,093,788 (GRCm39)	missense	probably damaging	1.00
X0066:Vipr2	UTSW	12	116,106,565 (GRCm39)	splice site	probably null
X0067:Vipr2	UTSW	12	116,102,792 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16