Incidental Mutation 'IGL02693:Slc35f1'
ID303818
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Slc35f1
Ensembl Gene ENSMUSG00000038602
Gene Namesolute carrier family 35, member F1
Synonyms
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02693
Quality Score
Status
Chromosome10
Chromosomal Location52690533-53111622 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 52933128 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Phenylalanine at position 70 (L70F)
Ref Sequence ENSEMBL: ENSMUSP00000101113 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105473]
Predicted Effect probably damaging
Transcript: ENSMUST00000105473
AA Change: L70F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000101113
Gene: ENSMUSG00000038602
AA Change: L70F

DomainStartEndE-ValueType
low complexity region 3 20 N/A INTRINSIC
Pfam:SLC35F 56 355 1.4e-151 PFAM
Pfam:CRT-like 66 315 2.3e-13 PFAM
Pfam:EamA 217 355 1.7e-9 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit no detectable phenotypic abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932415D10Rik T C 10: 82,285,258 I3973V probably benign Het
A830018L16Rik A G 1: 11,596,282 D271G probably damaging Het
Agl A T 3: 116,746,428 V1478E possibly damaging Het
Ckap5 C T 2: 91,570,211 P636L probably damaging Het
Cnot1 A G 8: 95,773,485 V127A probably damaging Het
Cs A G 10: 128,349,809 probably benign Het
Fbln1 G A 15: 85,229,574 E170K probably benign Het
Gm5866 A T 5: 52,583,216 noncoding transcript Het
Lpin3 T C 2: 160,905,055 V794A probably damaging Het
Ly86 T G 13: 37,375,029 I68S probably damaging Het
Mrps34 A G 17: 24,895,198 I11V probably benign Het
Nsmce4a A G 7: 130,542,808 S122P probably damaging Het
Olfm1 A G 2: 28,212,650 E112G probably damaging Het
Olfr1153 T G 2: 87,896,533 C111W probably damaging Het
Parp9 A G 16: 35,956,970 E428G probably benign Het
Phkb T G 8: 85,942,234 F297V probably damaging Het
Pianp T G 6: 125,001,635 F268V possibly damaging Het
Polr1a T C 6: 71,963,846 probably benign Het
Prune2 G A 19: 17,124,491 G2453E probably benign Het
Ptpn4 T C 1: 119,715,969 N350D probably damaging Het
Rbm12 C T 2: 156,095,560 probably benign Het
Rfc4 A G 16: 23,114,210 S326P probably damaging Het
Rnf123 G A 9: 108,068,302 R390* probably null Het
Slc5a7 T C 17: 54,276,919 T448A probably benign Het
Stoml1 T A 9: 58,257,076 I149N probably damaging Het
Sytl1 A T 4: 133,257,746 C180S probably benign Het
Tex37 C A 6: 70,913,504 R101S possibly damaging Het
Traf6 T C 2: 101,688,505 L113P possibly damaging Het
Trappc9 A G 15: 72,963,693 probably benign Het
Tubg2 T C 11: 101,160,899 Y317H probably damaging Het
Zfp334 T C 2: 165,380,513 T537A possibly damaging Het
Other mutations in Slc35f1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00434:Slc35f1 APN 10 53062452 missense probably damaging 1.00
IGL01073:Slc35f1 APN 10 53021960 missense probably benign 0.16
IGL01433:Slc35f1 APN 10 53073446 splice site probably benign
IGL01566:Slc35f1 APN 10 53089455 missense probably damaging 1.00
IGL02870:Slc35f1 APN 10 52933207 missense possibly damaging 0.82
IGL03082:Slc35f1 APN 10 52933138 missense probably benign
R0884:Slc35f1 UTSW 10 53089347 missense probably damaging 1.00
R1340:Slc35f1 UTSW 10 53089454 missense probably damaging 1.00
R1781:Slc35f1 UTSW 10 53062436 splice site probably null
R1813:Slc35f1 UTSW 10 52933195 missense probably damaging 1.00
R1908:Slc35f1 UTSW 10 53021904 missense possibly damaging 0.84
R2044:Slc35f1 UTSW 10 53089347 missense probably damaging 1.00
R2518:Slc35f1 UTSW 10 53073534 missense probably benign 0.07
R3872:Slc35f1 UTSW 10 53021910 missense possibly damaging 0.87
R3934:Slc35f1 UTSW 10 53108218 missense probably damaging 1.00
R3935:Slc35f1 UTSW 10 53108218 missense probably damaging 1.00
R3936:Slc35f1 UTSW 10 53108218 missense probably damaging 1.00
R4118:Slc35f1 UTSW 10 53089368 missense probably damaging 0.98
R4921:Slc35f1 UTSW 10 53062602 missense probably damaging 0.99
R5116:Slc35f1 UTSW 10 53021895 missense probably benign 0.39
R5378:Slc35f1 UTSW 10 52691061 missense possibly damaging 0.86
R5387:Slc35f1 UTSW 10 53108164 missense probably damaging 1.00
R5500:Slc35f1 UTSW 10 52933222 missense probably damaging 0.99
R5590:Slc35f1 UTSW 10 53108178 missense possibly damaging 0.63
R5743:Slc35f1 UTSW 10 53089450 missense probably benign 0.06
R5916:Slc35f1 UTSW 10 52933221 nonsense probably null
R6985:Slc35f1 UTSW 10 53021911 missense probably benign 0.02
R7068:Slc35f1 UTSW 10 53062500 missense probably damaging 1.00
R7295:Slc35f1 UTSW 10 53062541 missense probably benign 0.00
R7427:Slc35f1 UTSW 10 53089414 missense probably damaging 1.00
R7428:Slc35f1 UTSW 10 53089414 missense probably damaging 1.00
Posted On2015-04-16