Incidental Mutation 'IGL02694:Zfp944'
ID303856
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp944
Ensembl Gene ENSMUSG00000033972
Gene Namezinc finger protein 944
Synonyms6330416L07Rik
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.517) question?
Stock #IGL02694
Quality Score
Status
Chromosome17
Chromosomal Location22337989-22361400 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 22339918 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 116 (V116A)
Ref Sequence ENSEMBL: ENSMUSP00000111197 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000115535]
Predicted Effect probably benign
Transcript: ENSMUST00000115535
AA Change: V116A

PolyPhen 2 Score 0.047 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000111197
Gene: ENSMUSG00000033972
AA Change: V116A

DomainStartEndE-ValueType
KRAB 13 76 2.08e-21 SMART
ZnF_C2H2 183 205 1.01e-1 SMART
ZnF_C2H2 211 233 1.07e0 SMART
ZnF_C2H2 239 261 1.95e-3 SMART
ZnF_C2H2 267 289 1.22e-4 SMART
ZnF_C2H2 295 317 2.24e-3 SMART
ZnF_C2H2 323 345 1.82e-3 SMART
ZnF_C2H2 351 373 5.99e-4 SMART
ZnF_C2H2 379 401 4.79e-3 SMART
ZnF_C2H2 407 429 2.99e-4 SMART
ZnF_C2H2 435 457 4.17e-3 SMART
ZnF_C2H2 463 485 1.36e-2 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acer3 A G 7: 98,216,877 I213T probably benign Het
Alox8 T A 11: 69,186,629 T432S probably damaging Het
Col4a3 T C 1: 82,710,794 probably benign Het
Cyp2c54 A G 19: 40,047,543 Y308H possibly damaging Het
Dscam A G 16: 96,593,276 V1942A probably benign Het
F11 T C 8: 45,252,159 Y115C probably damaging Het
Fam13b A G 18: 34,451,206 probably null Het
Gm4778 A G 3: 94,266,152 M152V probably benign Het
Gykl1 A G 18: 52,694,185 H155R probably benign Het
Lmo7 T A 14: 101,887,170 V355D probably damaging Het
Lrtm2 T A 6: 119,320,885 D65V possibly damaging Het
Ly6g6f C T 17: 35,081,168 V235M possibly damaging Het
Mlxipl G A 5: 135,124,018 probably null Het
Olfr294 C T 7: 86,616,310 V112I probably benign Het
Olfr53 A G 7: 140,652,180 N67S probably damaging Het
Olfr736 A G 14: 50,392,800 I15V probably benign Het
Ppp2r1a A G 17: 20,951,440 probably benign Het
Psmb2 A G 4: 126,709,558 N193S probably benign Het
Rassf2 A T 2: 132,009,721 Y34N possibly damaging Het
Ryr2 A G 13: 11,605,189 F3841L probably damaging Het
Skint2 A G 4: 112,616,595 probably benign Het
Spdl1 T C 11: 34,813,621 I462V probably benign Het
Tlk2 A G 11: 105,221,235 E138G probably benign Het
Vmn1r89 A G 7: 13,220,129 E196G probably benign Het
Zfp142 A G 1: 74,570,148 L1496P probably damaging Het
Zfp689 T C 7: 127,448,401 D94G possibly damaging Het
Other mutations in Zfp944
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00595:Zfp944 APN 17 22339205 missense probably benign 0.10
IGL00917:Zfp944 APN 17 22339784 missense probably benign 0.00
IGL01093:Zfp944 APN 17 22343634 splice site probably benign
IGL02113:Zfp944 APN 17 22339066 missense possibly damaging 0.88
IGL03135:Zfp944 APN 17 22339756 missense probably benign 0.00
IGL03172:Zfp944 APN 17 22340037 missense probably damaging 0.98
R0121:Zfp944 UTSW 17 22339268 missense possibly damaging 0.69
R0336:Zfp944 UTSW 17 22339028 missense probably damaging 1.00
R0755:Zfp944 UTSW 17 22339908 missense possibly damaging 0.63
R1536:Zfp944 UTSW 17 22339716 nonsense probably null
R1708:Zfp944 UTSW 17 22339045 missense probably damaging 0.98
R1886:Zfp944 UTSW 17 22339979 missense probably benign 0.04
R1928:Zfp944 UTSW 17 22341084 missense probably damaging 0.96
R1950:Zfp944 UTSW 17 22339700 missense probably benign 0.16
R2075:Zfp944 UTSW 17 22339197 nonsense probably null
R2101:Zfp944 UTSW 17 22339828 missense probably benign 0.41
R2433:Zfp944 UTSW 17 22339212 nonsense probably null
R4698:Zfp944 UTSW 17 22339199 missense probably damaging 1.00
R4986:Zfp944 UTSW 17 22339230 missense probably damaging 1.00
R6451:Zfp944 UTSW 17 22338865 missense probably benign 0.40
R6566:Zfp944 UTSW 17 22339745 missense possibly damaging 0.96
R6752:Zfp944 UTSW 17 22339519 missense probably benign 0.01
R7064:Zfp944 UTSW 17 22339579 missense probably damaging 1.00
R8193:Zfp944 UTSW 17 22339880 nonsense probably null
R8323:Zfp944 UTSW 17 22339254 missense probably benign
R8328:Zfp944 UTSW 17 22339724 nonsense probably null
R8902:Zfp944 UTSW 17 22339780 missense probably benign 0.41
R8915:Zfp944 UTSW 17 22339526 missense probably benign 0.05
Posted On2015-04-16